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Your search keyword '"Xicheng Zhou"' showing total 3 results
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3 results on '"Xicheng Zhou"'

1. Unraveling the pharmacological mechanisms of Shenqi Fuzheng injection in chronic obstructive pulmonary disease: a network pharmacology and molecular docking approach.

Author

Fanglin Liu, Chunjuan Zhang, Qiuyue Shen, Xicheng Zhou, Yue Zhao, Fengfeng Fu, and Fang Liu

Subjects
CHRONIC obstructive pulmonary disease, MOLECULAR docking, MOLECULAR pharmacology, ASTRAGALUS membranaceus, CHINESE medicine, POLYMER networks
Abstract

Copyright of Journal of Chinese Pharmaceutical Sciences is the property of Journal of Chinese Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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3. Histopathology, antioxidant responses, transcriptome and gene expression analysis in triangle sail mussel Hyriopsis cumingii after bacterial infection

Author

Xiaobo Yu, Weizhi Yao, Qinglin Yang, Zhengli Wu, Kefan Guo, Xicheng Zhou, and Xiaoqi Tang

Subjects
Unionidae, 0301 basic medicine, Virulence Factors, Stenotrophomonas maltophilia, Immunology, Gene Expression, Hepatopancreas, Aeromonas veronii, Aquaculture, Antioxidants, Microbiology, Transcriptome, 03 medical and health sciences, Immune system, Animals, Tissue Distribution, KEGG, Infectivity, Bacterial disease, biology, 04 agricultural and veterinary sciences, biology.organism_classification, 030104 developmental biology, Host-Pathogen Interactions, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Gram-Negative Bacterial Infections, Developmental Biology
Abstract

Bacterial disease outbreaks in filter feeder bivalve Hyriopsis cumingii as water contamination become more frequent in the water ecosystem, especially in intensive aquaculture habitats. To characterize host-pathogen interactions between H. cumingii and bacterial infection, we investigated the effects of Stenotrophomonas maltophilia HOP3 and Aeromonas veronii GL1 on the antioxidant response, tissue invasion and transcriptome expression of H. cumingii by infectivity trials. We showed that bacterial infections resulted in tubular necrosis of the hepatopancreas and induced the acute immune response in H. cumingii. The transcriptomic study identified a total of 5957 differentially expressed genes (DEGs) after A. veronii challenge. These DEGs were implicated in 302 KEGG pathways, notably in Apoptosis, Phagosome and Lysosome. The results showed that the relative expressions of all six immune-related DEGs were effectively stimulated with A. veronii, accompanied by tissue differences. Overall, these findings will contribute to an analysis of the immune response of H. cumingii to bacterial infection at the transcriptomic level and its genomic resource for research.

Published
2021

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