Search

Background: Left-sided partial anomalous pulmonary venous connection (PAPVC) is a rare congenital abnormal cardiac defect. An intact atrial septum is more uncommon. As we know, a connection of the left pulmonary vein (LPV) to the coronary sinus (CS) with an intact atrial septum has not been previously reported. Case report: We report an 18-year-old woman with this rare anomaly. She showed no obvious clinical symptoms. An echocardiogram revealed the primary diagnosis, and this diagnosis was confirmed during the operation. This patient underwent a successful surgical repair. Artificial atrial septal defect (ASD) and coronary sinus orifice were inserted into the left atrium by patch. The patient recovered smoothly without complications after the operation. Conclusion: Given the high risk of developing congestive heart failure, we advocate for intervention at the preschool age. Surgical techniques depend on the number and location of abnormal veins or veins.

BackgroundChronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects. The role of B-cell lymphoma-2 (BCL-2) in CLL has been explored; however, few studies have examined its role in T cells in CLL patients. Herein, we have investigated the regulatory role of BCL-2 in T cells in the CLL tumor microenvironment.MethodsThe expression of BCL-2 in T cells was evaluated using flow cytometry. The regulatory roles of BCL-2 were investigated using single-cell RNA sequencing (scRNA-seq) and verified using multi-parameter flow cytometry on CD4 and CD8 T cells. The clinical features of BCL-2 expression in T cells in CLL were also explored.ResultsWe found a significant increase in BCL-2 expression in the T cells of CLL patients (n = 266). Single cell RNA sequencing (scRNA-seq) indicated that BCL-2+CD4+T cells had the gene signature of increased regulatory T cells (Treg); BCL-2+CD8+T cells showed the gene signature of exhausted cytotoxic T lymphocytes (CTL); and increased expression of BCL-2 was associated with T cell activation and cellular adhesion. The results from scRNA-seq were verified in peripheral T cells from 70 patients with CLL, wherein BCL-2+CD4+T cells were enriched with Tregs and had higher expression of interleukin-10 and transforming growth factor-β than BCL-2−CD4+T cells. BCL-2 expression in CD8+T cells was associated with exhausted cells (PD-1+Tim-3+) and weak expression of granzyme B and perforin. T cell–associated cytokine profiling revealed a negative association between BCL-2+T cells and T cell activation. Decreased frequencies and recovery functions of BCL-2+T cells were observed in CLL patients in complete remission after treatment with venetoclax.ConclusionBCL-2 expression in the T cells of CLL patients is associated with immunosuppression via promotion of Treg abundance and CTL exhaustion.

Geodiversity is considered as abiotic diversity, and it is the foundation of geopark, geotourism and geoconservation. Yunnan Province is the typical area abundant in geodiversity in China. Geodiversity of Yuanmou Basin, which is located in North Yunnan, possesses scientific, cultural, aesthetical, ecological values. Howerver, there are some problems, such as underexploitation, inadequate protection, even destruction in the area. Research of geodiversity will provide a new idea for sustainable development in Yuanmou Basin.

The Yunnan-Guizhou-Guangxi “Golden Triangle” is one of the famous Carlin-type gold deposits in China and even in the world. Manlonggou gold deposit is a newly discovered gold deposit in this area. The host rocks are mainly lithic quartz sandstone, siltstone and silty mudstone above Caledonian unconformity. The main minerals in ores are natural gold, limonite, hematite, pyrite and so on. The occurrence state of gold is fine exposed and semi-exposed natural gold, as well as gold encased by limonite, carbonate, quartz and silicate minerals. The deposit can be a fine grain hydrothermal altered gold deposit with the origin of tectonic-medium-low temperature hydrothermal percolation.

Debris flow is the mainly the geological disasters in Nujiang Prefecture, while precipitation is the trigger of it, how to implement debris flow forecast based on precipitation monitoring data or forecast data is a hot issue in current debris flow disaster research field. Because of the special geomorphology in Nujiang Prefecture, due to the influence of human activities, geological disasters occur frequently, severely affect the local economic development. As a demonstration area of geological disaster monitoring and early warning in Yunnan Province, to build a well-developed geological disaster warning system, it is very important to spread it to other parts of Yunnan province. Based on the analysis of the current situation of geological disasters in Nujiang Prefecture, adopt appropriate monitoring method and calculation method to select the primary sites for debris flow monitoring and early warning in the Nu River basin for research.