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A growing number of studies indicate that mitochondrial dysfunction serves as a pathological mechanism for periodontitis. Therefore, this two-sample Mendelian randomization (MR) study was carried out to explore the causal associations between mitochondrial biological function and periodontitis, because the specific nature of this causal relationship remains inconclusive in existing MR studies. Inverse variance weighting, Mendelian randomization-Egger, weighted mode, simple mode, and weighted median analyses were performed to assess the causal relationships between the exposure factors and periodontitis. The results of the present study revealed a causal association between periodontitis and medium-chain specific acyl-CoA dehydrogenase (MCAD), malonyl-CoA decarboxylase (MLYCD), glutaredoxin 2 (Grx2), oligoribonuclease (ORN), and pyruvate carboxylase (PC). Notably, MCAD and MLYCD are causally linked to periodontitis, and serve as protective factors. However, Grx2, ORN, and PC function as risk factors for periodontitis. Our study established a causal relationship between mitochondrial biological function and periodontitis, and such insights may provide a promising approach for treating periodontitis via mitochondrial regulation.

Abstract A two-dimensional phononic crystal sensor model with high-quality factor and excellent sensitivity for sensing acetone solutions and operating at 25–45 kHz is proposed. The model for filling solution cavities is based on reference designs of quasi-crystal and gradient cavity structures. The transmission spectrum of sensor is simulated by the finite element method. High-quality factor of 45,793.06 and sensitivity of 80,166.67 Hz are obtained for the acetone concentration with 1–9.1%, and quality factor of 61,438.09 and sensitivity of 24,400.00 Hz are obtained for the acetone concentration range of 10–100%, which indicated the sensor could still achieve high sensitivity and quality factor at operating frequencies from 25 to 45 kHz. To verify the application of the sensor to sensing other solutions, the sensitivity for sound velocity and density is calculated as 24.61 m-1 and 0.7764 m3/(kg × s), respectively. It indicates the sensor is sensitive to acoustic impedance changes of the solution and equally suitable for sensing other solutions. The simulation results reveal the phononic crystal sensor possessed high-performance in composition capture in pharmaceutical production and petrochemical industry, which can provide theoretical reference for the design of new biochemical sensors for reliable detection of solution concentration.

A growing number of studies indicate that mitochondrial dysfunction serves as a pathological mechanism for periodontitis. Therefore, this two-sample Mendelian randomization (MR) study was carried out to explore the causal associations between mitochondrial biological function and periodontitis, because the specific nature of this causal relationship remains inconclusive in existing MR studies. Inverse variance weighting, Mendelian randomization-Egger, weighted mode, simple mode, and weighted median analyses were performed to assess the causal relationships between the exposure factors and periodontitis. The results of the present study revealed a causal association between periodontitis and medium-chain specific acyl-CoA dehydrogenase (MCAD), malonyl-CoA decarboxylase (MLYCD), glutaredoxin 2 (Grx2), oligoribonuclease (ORN), and pyruvate carboxylase (PC). Notably, MCAD and MLYCD are causally linked to periodontitis, and serve as protective factors. However, Grx2, ORN, and PC function as risk factors for periodontitis. Our study established a causal relationship between mitochondrial biological function and periodontitis, and such insights may provide a promising approach for treating periodontitis via mitochondrial regulation. [ABSTRACT FROM AUTHOR]

Most previously reported Dirac valley degeneracies in continuous phononic crystal plates originate from Bragg scattering of the structures and generally have only single-band elastic-wave topological edge states. In the present work, a pair of triangular prisms is used in the construction of hexagonal-lattice phononic crystal plates to mimic the dual-band elastic valley Hall effect. Based on the spatial inversion symmetry conditions, which are related to the intrinsic frequencies of the resonators, the valley degeneracies, topological nontrivial bandgaps, and energy band inversion characteristics of multiple resonance modes are investigated by using the finite element method. Edge passbands combining distinct topology phases exist in each of the two nontrivial bandgaps of the ribbon configuration. The full-field simulations for flexural waves in the waveguide structure are demonstrated to support topologically valley-protected edge transmission in both bands, which immunizes the transport against backscattering from large corners and defects in the route. This work provides a reference for valley edge protection in subwavelength continuous elastic plate media and for the manipulation of the elastic waves at multiple frequencies. [ABSTRACT FROM AUTHOR]

The boundary control problem of fractional ordinary differential equations coupled with a time fractional reaction–advection–diffusion equation with delay is studied in this paper. To ensure the asymptotic stability of the system we studied, a state feedback boundary controller is proposed. By backstepping method, we transform the fractional coupled system into a chosen target system under a controller. Furthermore, we obtain the existence and uniqueness of the state solution of the considered system. A Lyapunov functional is constructed to show the asymptotic stability of the fractional coupled system by the special fractional Halanay inequality. The asymptotic stability criterion of the fractional coupled system is described by Linear Matrix Inequalities (LIMs). Which can be easily solved and verified. Finally, the applicability of our theoretical results is showed by a numerical simulation. [ABSTRACT FROM AUTHOR]

A high-sensitivity liquid concentration-sensing structure based on a phoxonic crystal slot nanobeam with gradient cavities is presented and its sensing properties are investigated using the finite element method. The proposed sensing structure, which can be made from either isotropic or anisotropic materials, can have excellent sensing properties that are designed via geometric optimization. We investigate the influences of various solution concentrations on electromagnetic and elastic wave transmission spectra. The results demonstrate that the introduction of gradient cavities can enable the system to avoid lattice mutation and reduce energy loss, thereby concentrating light and sound energy in the slot and holes, enhancing interactions between the electromagnetic and elastic waves, and improving sensitivity. It is worth noting that the sensing characteristics are related to the electric field distribution in the light sensor. That is, the sensitivity is better when more electric energy is distributed in the liquid-filled slot and holes. The sensitivity can reach 238.1 nm/RIU. The acoustic sensing properties are related to the solid–liquid interaction. This is especially true for the modal sensing characteristics, where the acoustic energy is concentrated on the solid–liquid interface. Therefore, greater interaction strength implies better sensitivity. The acoustic sensitivity can reach 3167 kHz/ms−1. The proposed structure provides acoustic and optical cross-checks for different types of solutions. This helps us to improve sensing accuracy and reduce sensing uncertainty. [ABSTRACT FROM AUTHOR]