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408 results on '"Wu, Xiaowen"'

3. Defect Identification Method Based on Casing Internal Temperature Variation

Author

Sun, Jingling, Wu, Xiaowen, Xiao, Wei, Peng, Ping, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Dong, Xuzhu, editor, and Cai, Li, editor

Published
2024
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4. Numerical Calculation of Temperature Field of Energy Storage Battery Based on Finite Element Method and Analysis of Influencing Factors

Author

Xiao, Wei, Wu, Xiaowen, Sun, Jingling, He, Li, Tan, Zhuangxi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Dong, Xuzhu, editor, and Cai, Li, editor

Published
2024
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6. Effect and mechanism of Sitravatinib combined with Niraparib on proliferation, apoptosis and autophagy in mucosal melanoma cell lines

Author

HU Zijin, KONG Yan, WU Xiaowen, GUO Qian, GUO Jun

Subjects
mucosal melanoma, anti-angiogenic drug, poly(adenosine diphosphate-ribose) polymerase inhibitor, homology-dependent recombination repair, Medicine
Abstract

Objective To investigate the effect of anti-angiogenic drug Sitravatinib combined with poly(adenosine diphosphate[ADP]-ribose) polymerase inhibitor(PARPi) Niraparib on mucosal melanoma cell lines and its possible mechanism. Methods The CCK8 assay was used to detect the maximal half inhibitory concentration (IC50) of Sitravatinib and Niraparib targeting at mucosal melanoma (MM) cell lines. CompuSyn was used to detect the Combination Index (CI) in different concentrations of the two drugs. Flow cytometry was used to detect the effect of drugs on cell apoptosis. Colony formation assay was used to detect the effect of drugs on cell proliferation. Western blot was used to detect the protein expressions and RT-qPCR was used to detect mRNA expression. Results CI values was respectively 0.19 and 0.15 for Sitravatinib (2 μmol/L) in combination with Niraparib (20 μmol/L) in a human vaginal maligant melanoma cell line (HMVII) and a metastasis inguinal lymph node of vulvar malignant melanoma cell line (GAK). Compared with the control group and single-drug groups, the cell proliferation of the combination group was significantly reduced (P＜0.05 or P＜0.01 or P＜0.001). The cell apoptosis rate was significantly increased (P＜0.01 or P＜0.001). The protein and mRNA expression of apoptosis-related biomarkers significantly increased (P＜0.001); In addition, the protein and mRNA expression of cell autophagy biomarkers significantly increased (P＜0.01 or P＜0.001). The protein expression of DNA damage marker significantly increased. Moreover, compared with the control group, The expression of radiation sensitive protein 51 (RAD51) recombinase in the Sitravatinib single-drug group and combination group significantly reduced. As the dose of Sitravatinib gradually increased up to 2 μmol/L, the protein and mRNA expression of RAD51 both significantly reduced (P＜0.05 or P＜0.01), the mRNA expression of BRCA1 and BRCA2 also significantly reduced (P＜0.05 or P＜0.01 or P＜0.001). Conclusions Sitravatinib combined with Niraparib inhibits the proliferation of mucosal melanoma cells, induces cell apoptosis and promotes autophagy. The mechanism is potentially related to the inhibition of homology-dependent recombination repairs(HRR).

Published
2024
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17. Influence of PTEN mutation on pathological features and prognosis of patients with mucosal melanoma

Author

GONG Ziqi, WU Xiaowen, GUO Qian, GUO Jun, KONG Yan

Subjects
mucosal melanoma, pten, gene mutation, pathological feature, prognosis, Medicine
Abstract

Objective To investigate the effects of PTEN (phosphatase and tensin homolog)mutation on pathological characteristics and prognosis of patients with mucosal melanoma. Methods Clinical and follow-up data of 66 patients with mucosal melanoma from the Department of Melanoma and Sarcoma, Peking University Cancer Hospital from April 2019 to March 2022 were collected and the mutation of PTEN was detected by next-generation sequencing to analyze the relationship between PTEN mutation and patients′ pathological characteristics and prognosis. Results Among 66 patients with mucosal melanoma, the frequency of PTEN mutation was 19.40% and the mutation frequency was significantly associated with age at diagnosis and primary tumor site(P＜0.05); In the cohort with 42 patients receiving immunotherapy, the median progression-free survival(mPFS) of PTEN-mutant patients was 3.37 months, which was significantly lower than that of wild-type patients(9.2 months)(P＜0.05). Multivariate Cox regression analysis further confirmed that PTEN mutation was an independent prognostic factor for poor prognosis of immunotherapy(P＜0.05). Conclusions The frequency of PTEN mutation is significantly higher in patient who were diagnosed at the aged less than 60 and in patients with tumors originated from gastrointestinal mucosa. PTEN mutation is also an independent risk factor for poorer prognosis in patients receiving immunotherapy.

Published
2023
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21. A Study on the Mechanisms and Risk Challenges of Fintech-Driven Financial Business Innovation

Author

Wang, Dong, Chen, Hao, Feng, Jingli, Huang, Jianping, Ma, Xiaoxiao, Wu, Xiaowen, Zhu, Aosen, Dou, Runliang, Editor-in-Chief, Liu, Jing, Editor-in-Chief, Khasawneh, Mohammad T., Editor-in-Chief, Balas, Valentina Emilia, Series Editor, Bhowmik, Debashish, Series Editor, Khan, Khalil, Series Editor, Masehian, Ellips, Series Editor, Mohammadi-Ivatloo, Behnam, Series Editor, Nayyar, Anand, Series Editor, Pamucar, Dragan, Series Editor, Shu, Dewu, Series Editor, Akhtar, Nadeem, editor, Draman, Azah Kamilah, editor, and Abdollah, Mohd Faizal, editor

Published
2023
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23. Multiple Chord Coding in China’s Minority Dance Music

Author

Wu Xiaowen and Shang Ke

Subjects
folk dance music, frequency features, spectral information, multivariate chord coding, recall, 00a65, Mathematics, QA1-939
Abstract

In this paper, we first use CNNS to collect rich samples of folk dance music, establish a model framework and a functional system framework, and conduct a comprehensive process analysis of the music. Then, the instrumental features, frequency features, and timbre features are extracted to obtain the spectral information. In the stage of chord analysis and encoding, a multivariate chord encoding model is established based on the acquired spectral information, including two parts: chord representation preprocessing and chord encoding. By utilizing this model, the chord structure of music was successfully and accurately encoded, allowing for analysis with up to 98% accuracy. Furthermore, significant recall results were achieved, reaching over 0.9, which suggests that the extracted chord features are highly reliable and accurate in recognizing musical chord information.

Published
2024
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39. PCT: A Relay-Based Privacy-Preserving Cross-Chain Transaction Scheme

Author

Li, Da, Guo, Qinglei, Wang, Yansong, Chen, Shuai, Wu, Xiaowen, Wang, Lei, Li, Xuan, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Sun, Yi, editor, Cai, Liang, editor, Wang, Wei, editor, Song, Xianhua, editor, and Lu, Zeguang, editor

Published
2022
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40. Research on Thrust Ripple Suppression Control Algorithm of Permanent Magnet Linear Synchronous Motor

Author

Hu, Jiawei, Guo, Liang, Yang, Yang, Wu, Xiaowen, Zhang, Peng, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Cao, Wenping, editor, Hu, Cungang, editor, Huang, Xiaoyan, editor, Chen, Xiangping, editor, and Tao, Jun, editor

Published
2022
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