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Muscle-specific kinase (MuSK) myasthenia gravis (MG) is relatively rare and has a higher incidence of myasthenic crisis compared with other subtypes. However, there is still a lack of effective treatment for refractory MuSK MG. We report the case of a 70-year-old female MuSK MG patient with recurrent fluctuations who stabilized on telitacicept in combination with anti-CD20 B-cell depletion therapy. This combination regimen deserves further investigation. Furthermore, we summarized the treatment protocols of 14 previously reported cases of MuSK MG. [ABSTRACT FROM AUTHOR]

An electrooxidative reconstruction of the indole core under ambient conditions is reported, resulting in the construction of tryptanthrins. This electrochemical strategy simplifies molecular skeleton‐hopping by employing commercially available NH‐indole feedstock as the starting materials. Furthermore, the synthetic value of this skeletal reconstruction was demonstrated by divergent further transformations. A preliminary mechanistic investigation involving control experiments and cyclovoltammetric studies showed the indispensability of electricity, as well as the importance of oxygen and TEMPO, thereby revealing a possible reaction pathway. [ABSTRACT FROM AUTHOR]

Herein, we present the first highly regio- and chemoselective C2 C–H acyloxylation of indole under rhodium catalysis and an N-quinolinyl auxiliary. This strategy accommodates a wide range of indoles and structurally diverse carboxylic acids with good reaction efficiencies to yield functionalized indoles. The utility of this logic was demonstrated by the concise synthesis of the functionalized 2-oxindole derivatives. Preliminary mechanistic studies indicate that catalyst turnover of RhIII–RhIV/V–RhII/III–RhIII might be involved in this catalytic C–H transformation. [ABSTRACT FROM AUTHOR]

The pore structure of coal affects spontaneous combustion to a certain extent. The pore structure of the coal body will be altered after prolonged waterlogging and is highly susceptible to spontaneous combustion in the presence of elevated ground temperatures. To study the pore structure changes in the coal body after immersion and drying. The coal samples from the Jinjitan coal mine in Yulin, Shaanxi Province, the Tangkou coal mine in Jining, Shandong Province, and the Gaojiapu coal mine in Shaanxi Province were scanned by electron microscopy and low-temperature nitrogen adsorption experiments. This study indicates that after water immersion, the fracture pores of the coal body are developed, the morphology changes, and the percentage of pore fracture area increases significantly. With the increase in immersion time, the pore types of Coal samples A and C did not change, being delicate necked bottle-shaped pores and open, permeable pores, respectively. Coal sample B pore type developed from impermeable pores to open pores. The cumulative pore volume of coals from all three areas increased for the same pore size. The contribution of micropores to the BET specific surface area and total BJH pore volume was more significant than the original coal samples. The specific surface area of A90, B30, and C60 was larger than that of the other coal samples for the soaking time, so it can be assumed that A90, B30, and C60 have a higher propensity for spontaneous combustion. Underwater immersion, the pore type of coal samples from coal mines in Northwest China did not change, but the pore types of coal samples from coal mines in East China changed. Therefore, the pore structure of gas coal was easily changed underwater dissolution. [ABSTRACT FROM AUTHOR]