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1,184 results on '"Wong, Kwok"'

1. Inequality and Nyman-Beurling-Baez-Duarte criteria

Author

Wong, Kwok Kwan

Subjects
Mathematics - General Mathematics, 11Mxx, 46Cxx
Abstract

We proposed a proof of the Riemann hypothesis. The proof is based on the Nyman-Beurling-Baez-Duarte condition. By proving existence of the solution for a system of inequalities, we can show that there is a sequence, which act as the coefficient of Beurling's sequence, can approximate the constant vector in a weighted Hilbert space., Comment: 9 pages, version 1 is wrong. Version 2 fixed an argument in the proof. This is version 4

Published
2023

2. TIP60 is required for tumorigenesis in non‐small cell lung cancer

Author

Shibahara, Daisuke, Akanuma, Naoki, Kobayashi, Ikei S, Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Jiang, Feng, Prin, P Nicholas, Pan, Gilbert, Wong, Kwok‐Kin, Costa, Daniel B, Bararia, Deepak, Tenen, Daniel G, Watanabe, Hideo, and Kobayashi, Susumu S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biotechnology, Cancer, Lung Cancer, Genetics, Lung, 2.1 Biological and endogenous factors, Aetiology, Animals, Mice, Carcinogenesis, Carcinoma, Non-Small-Cell Lung, Cell Transformation, Neoplastic, Histone Acetyltransferases, Lung Neoplasms, Humans, artemisinin, KAT5, lung cancer, TGM5, TIP60, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Histone modifications play crucial roles in transcriptional activation, and aberrant epigenetic changes are associated with oncogenesis. Lysine (K) acetyltransferases 5 (TIP60, also known as KAT5) is reportedly implicated in cancer development and maintenance, although its function in lung cancer remains controversial. Here we demonstrate that TIP60 knockdown in non-small cell lung cancer cell lines decreased tumor cell growth, migration, and invasion. Furthermore, analysis of a mouse lung cancer model with lung-specific conditional Tip60 knockout revealed suppressed tumor formation relative to controls, but no apparent effects on normal lung homeostasis. RNA-seq and ChIP-seq analyses of inducible TIP60 knockdown H1975 cells relative to controls revealed transglutaminase enzyme (TGM5) as downstream of TIP60. Investigation of a connectivity map database identified several candidate compounds that decrease TIP60 mRNA, one that suppressed tumor growth in cell culture and in vivo. In addition, TH1834, a TIP60 acetyltransferase inhibitor, showed comparable antitumor effects in cell culture and in vivo. Taken together, suppression of TIP60 activity shows tumor-specific efficacy against lung cancer, with no overt effect on normal tissues. Our work suggests that targeting TIP60 could be a promising approach to treating lung cancer.

Published
2023

3. Kaplansky Unit conjecture for complex numbers

Author

Wong, Kwok Kwan

Subjects
Mathematics - Algebraic Geometry, 20C07, 16S34, 46L05
Abstract

We show that Kaplansky's unit conjecture is true, under the assumption that the underlying field is complex., Comment: The second lemma contains flaws

Published
2021

5. Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Author

Dolgalev, Igor, Zhou, Hua, Murrell, Nina, Le, Hortense, Sakellaropoulos, Theodore, Coudray, Nicolas, Zhu, Kelsey, Vasudevaraja, Varshini, Yeaton, Anna, Goparaju, Chandra, Li, Yonghua, Sulaiman, Imran, Tsay, Jun-Chieh J., Meyn, Peter, Mohamed, Hussein, Sydney, Iris, Shiomi, Tomoe, Ramaswami, Sitharam, Narula, Navneet, Kulicke, Ruth, Davis, Fred P., Stransky, Nicolas, Smolen, Gromoslaw A., Cheng, Wei-Yi, Cai, James, Punekar, Salman, Velcheti, Vamsidhar, Sterman, Daniel H., Poirier, J. T., Neel, Ben, Wong, Kwok-Kin, Chiriboga, Luis, Heguy, Adriana, Papagiannakopoulos, Thales, Nadorp, Bettina, Snuderl, Matija, Segal, Leopoldo N., Moreira, Andre L., Pass, Harvey I., and Tsirigos, Aristotelis

Published
2023
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6. Mitochondrial diseases in Hong Kong: prevalence, clinical characteristics and genetic landscape

Author

Wong, Tsz-sum, Belaramani, Kiran M., Chan, Chun-kong, Chan, Wing-ki, Chan, Wai-lun Larry, Chang, Shek-kwan, Cheung, Sing-ngai, Cheung, Ka-yin, Cheung, Yuk-fai, Chong, Shuk-ching Josephine, Chow, Chi-kwan Jasmine, Chung, Hon-yin Brian, Fan, Sin-ying Florence, Fok, Wai-ming Joshua, Fong, Ka-wing, Fung, Tsui-hang Sharon, Hui, Kwok-fai, Hui, Ting-hin, Hui, Joannie, Ko, Chun-hung, Kwan, Min-chung, Kwok, Mei-kwan Anne, Kwok, Sung-shing Jeffrey, Lai, Moon-sing, Lam, Yau-on, Lam, Ching-wan, Lau, Ming-chung, Law, Chun-yiu Eric, Lee, Wing-cheong, Lee, Han-chih Hencher, Lee, Chin-nam, Leung, Kin-hang, Leung, Kit-yan, Li, Siu-hung, Ling, Tsz-ki Jacky, Liu, Kam-tim Timothy, Lo, Fai-man, Lui, Hiu-tung, Luk, Ching-on, Luk, Ho-ming, Ma, Che-kwan, Ma, Karen, Ma, Kam-hung, Mew, Yuen-ni, Mo, Alex, Ng, Sui-fun, Poon, Wing-kit Grace, Rodenburg, Richard, Sheng, Bun, Smeitink, Jan, Szeto, Cheuk-ling Charing, Tai, Shuk-mui, Tse, Choi-ting Alan, Tsung, Li-yan Lilian, Wong, Ho-ming June, Wong, Wing-yin Winnie, Wong, Kwok-kui, Wong, Suet-na Sheila, Wong, Chun-nei Virginia, Wong, Wai-shan Sammy, Wong, Chi-kin Felix, Wu, Shun-ping, Wu, Hiu-fung Jerome, Yau, Man-mut, Yau, Kin-cheong Eric, Yeung, Wai-lan, Yeung, Hon-ming Jonas, Yip, Kin-keung Edwin, Young, Pui-hong Terence, Yuan, Gao, Yuen, Yuet-ping Liz, Yuen, Chi-lap, and Fung, Cheuk-wing

Published
2023
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7. FGFR inhibition augments anti-PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression

Author

Okato, Atsushi, Utsumi, Takanobu, Ranieri, Michela, Zheng, Xingnan, Zhou, Mi, Pereira, Luiza D., Chen, Ting, Kita, Yuki, Wu, Di, Hyun, Hyesun, Lee, Hyojin, Gdowski, Andrew S., Raupp, John D., Clark- Garvey, Sean, Manocha, Ujjawal, Chafitz, Alison, Sherman, Fiona, Stephens, Janaye, Rose, Tracy L., Milowsky, Matthew I., Wobker, Sara E., Serody, Jonathan S., Damrauer, Jeffrey S., Wong, Kwok-Kin, and Kim, William Y.

Subjects
Bladder cancer -- Drug therapy -- Models, Fibroblast growth factor receptors -- Health aspects, Monoclonal antibodies -- Dosage and administration -- Testing, Immunosuppression -- Methods, Health care industry
Abstract

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the bladder, in which FGFR3 is altered in 50% of cases. Using an FGFR3-driven, Trp53-mutant genetically engineered murine model (UPFL), we demonstrate that UPFL tumors recapitulate the histology and molecular subtype of their FGFR3-altered human counterparts. Additionally, UPFL1 allografts exhibit hyperprogression to ICI associated with an expansion of T regulatory cells (Tregs). Erdafitinib blocked Treg proliferation in vitro, while in vivo ICI-induced Treg expansion was fully abrogated by FGFR inhibition. Combined erdafitinib and ICI resulted in high therapeutic efficacy. In aggregate, our work establishes that, in mice, co-alteration of FGFR3 and Trp53 results in high-grade, non- muscle-invasive UC and presents a previously underappreciated role for FGFR inhibition in blocking ICI-induced Treg expansion., Introduction Bladder cancer is the sixth most common cancer in the United States, with an estimated 82,290 new cases and an estimated 16,710 deaths in 2023 (1). At diagnosis, approximately [...]

Published
2024
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8. Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

Author

Tong, Xinyuan, Patel, Ayushi S., Kim, Eejung, Li, Hongjun, Chen, Yueqing, Li, Shuai, Liu, Shengwu, Dilly, Julien, Kapner, Kevin S., Zhang, Ningxia, Xue, Yun, Hover, Laura, Mukhopadhyay, Suman, Sherman, Fiona, Myndzar, Khrystyna, Sahu, Priyanka, Gao, Yijun, Li, Fei, Li, Fuming, Fang, Zhaoyuan, Jin, Yujuan, Gao, Juntao, Shi, Minglei, Sinha, Satrajit, Chen, Luonan, Chen, Yang, Kheoh, Thian, Yang, Wenjing, Yanai, Itai, Moreira, Andre L., Velcheti, Vamsidhar, Neel, Benjamin G., Hu, Liang, Christensen, James G., Olson, Peter, Gao, Dong, Zhang, Michael Q., Aguirre, Andrew J., Wong, Kwok-Kin, and Ji, Hongbin

Published
2024
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22. KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

Author

Zavitsanou, Anastasia-Maria, Pillai, Ray, Hao, Yuan, Wu, Warren L., Bartnicki, Eric, Karakousi, Triantafyllia, Rajalingam, Sahith, Herrera, Alberto, Karatza, Angeliki, Rashidfarrokhi, Ali, Solis, Sabrina, Ciampricotti, Metamia, Yeaton, Anna H., Ivanova, Ellie, Wohlhieter, Corrin A., Buus, Terkild B., Hayashi, Makiko, Karadal-Ferrena, Burcu, Pass, Harvey I., Poirier, John T., Rudin, Charles M., Wong, Kwok-Kin, Moreira, Andre L., Khanna, Kamal M., Tsirigos, Aristotelis, Papagiannakopoulos, Thales, and Koralov, Sergei B.

Published
2023
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23. Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

Author

Du, Heng, Yang, Yu Chi, Liu, Heng-Jia, Yuan, Min, Asara, John M., Wong, Kwok- Kin, Henske, Elizabeth P., Singh, Mallika, and Kwiatkowski, David J.

Subjects
Thermo Fisher Scientific Inc., Biochemistry -- Models, Cancer -- Models, Apoptosis -- Models, Health care industry
Abstract

The PI3K/AKT/mTOR pathway is commonly dysregulated in cancer. Rapalogs exhibit modest clinical benefit, likely owing to their lack of effects on 4EBP1. We hypothesized that bi-steric mTORC1-selective inhibitors would have greater potential for clinical benefit than rapalogs in tumors with mTORC1 dysfunction. We assessed this hypothesis in tumor models with high mTORC1 activity both in vitro and in vivo. Bi-steric inhibitors had strong growth inhibition, eliminated phosphorylated 4EBP1, and induced more apoptosis than rapamycin or MLN0128. Multiomics analysis showed extensive effects of the bi-steric inhibitors in comparison with rapamycin. De novo purine synthesis was selectively inhibited by bi-sterics through reduction in JUN and its downstream target PRPS1 and appeared to be the cause of apoptosis. Hence, bi-steric mTORC1-selective inhibitors are a therapeutic strategy to treat tumors driven by mTORC1 hyperactivation., Introduction The PI3K/AKT/mTOR network is a critical intracellular signaling pathway directing cell growth and metabolism in physiological and pathological conditions (1). The evolutionarily conserved mammalian target of rapamycin (mTOR) is [...]

Published
2023
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25. MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

Author

Qian, Yu, Galan-Cobo, Ana, Guijarro, Irene, Dang, Minghao, Molkentine, David, Poteete, Alissa, Zhang, Fahao, Wang, Qi, Wang, Jing, Parra, Edwin, Panda, Apekshya, Fang, Jacy, Skoulidis, Ferdinandos, Wistuba, Ignacio I., Verma, Svena, Merghoub, Taha, Wolchok, Jedd D., Wong, Kwok-Kin, DeBerardinis, Ralph J., Minna, John D., Vokes, Natalie I., Meador, Catherine B., Gainor, Justin F., Wang, Linghua, Reuben, Alexandre, and Heymach, John V.

Published
2023
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27. Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC

Author

Zhang, Hua, Nabel, Christopher S., Li, Dezhi, O’Connor, Ruth Í., Crosby, Caroline R., Chang, Sarah M., Hao, Yuan, Stanley, Robyn, Sahu, Soumyadip, Levin, Daniel S., Chen, Ting, Tang, Sittinon, Huang, Hsin-Yi, Meynardie, Mary, Stephens, Janaye, Sherman, Fiona, Chafitz, Alison, Costelloe, Naoise, Rodrigues, Daniel A., Fogarty, Hilda, Kiernan, Miranda G., Cronin, Fiona, Papadopoulos, Eleni, Ploszaj, Magdalena, Weerasekara, Vajira, Deng, Jiehui, Kiely, Patrick, Bardeesy, Nabeel, Vander Heiden, Matthew G., Chonghaile, Triona Ni, Dowling, Catríona M., and Wong, Kwok-Kin

Published
2023
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39. Utilization of circulating tumor DNA (ctDNA) testing by race and ethnicity in more than 135,000 patients.

Author

Davis, Andrew A., primary, Bucheit, Leslie A, additional, Zhang, Nicole, additional, Pretz, Christopher, additional, Strickler, John H, additional, Chachoua, Abraham, additional, Wise, David R, additional, Wong, Kwok-Kin, additional, Aviki, Emeline Mariam, additional, Zhang, Tian, additional, Qin, Qian, additional, and Clemens, Keelia M., additional

Published
2024
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40. Supplementary Figure S9 from Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

Author

Pal Choudhuri, Shreoshi, primary, Girard, Luc, primary, Lim, Jun Yi Stanley, primary, Wise, Jillian F., primary, Freitas, Braeden, primary, Yang, Di, primary, Wong, Edmond, primary, Hamilton, Seth, primary, Chien, Victor D., primary, Kim, Yoon Jung, primary, Gilbreath, Collin, primary, Zhong, Jun, primary, Phat, Sarah, primary, Myers, David T., primary, Christensen, Camilla L., primary, Mazloom-Farsibaf, Hanieh, primary, Stanzione, Marcello, primary, Wong, Kwok-Kin, primary, Hung, Yin P., primary, Farago, Anna F., primary, Meador, Catherine B., primary, Dyson, Nicholas J., primary, Lawrence, Michael S., primary, Wu, Sihan, primary, and Drapkin, Benjamin J., primary

Published
2024
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41. Supplementary Tables from Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

Author

Pal Choudhuri, Shreoshi, primary, Girard, Luc, primary, Lim, Jun Yi Stanley, primary, Wise, Jillian F., primary, Freitas, Braeden, primary, Yang, Di, primary, Wong, Edmond, primary, Hamilton, Seth, primary, Chien, Victor D., primary, Kim, Yoon Jung, primary, Gilbreath, Collin, primary, Zhong, Jun, primary, Phat, Sarah, primary, Myers, David T., primary, Christensen, Camilla L., primary, Mazloom-Farsibaf, Hanieh, primary, Stanzione, Marcello, primary, Wong, Kwok-Kin, primary, Hung, Yin P., primary, Farago, Anna F., primary, Meador, Catherine B., primary, Dyson, Nicholas J., primary, Lawrence, Michael S., primary, Wu, Sihan, primary, and Drapkin, Benjamin J., primary

Published
2024
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49. Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

Author

Mucha, Bartosz, Qie, Shuo, Bajpai, Sagar, Tarallo, Vincenzo, Diehl, J. Nathaniel, Tedeschi, Frank, Zhou, Gao, Gao, Zhaofeng, Flashner, Samuel, Klein-Szanto, Andres J., Hibshoosh, Hanina, Masataka, Shimonosono, Chajewski, Olga S., Majsterek, Ireneusz, Pytel, Dariusz, Hatzoglou, Maria, Der, Channing J., Nakagawa, Hiroshi, Bass, Adam J., Wong, Kwok-Kin, Fuchs, Serge Y., Rustgi, Anil K., Jankowsky, Eckhard, and Diehl, J. Alan

Published
2022
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