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Since the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies and propose that future studies should explore a causal link with the risk of developing long COVID. Most importantly, randomized clinical trials are needed to determine if magnesium and vitamin D supplementation can improve long COVID symptoms, providing a safe and affordable support therapy to the benefit of patients and society. [ABSTRACT FROM AUTHOR]

The article presents the highlights of the hybrid XVI International Magnesium Symposium in Glasgow, Scotland in July 2022. Topics include updates on magnesium (Mg2+) research, the evaluation of pathologic hypo- or hyper-magnesemia conditions, and the role of Mg2+ in agriculture. Presenters include Roberta Cazzola of University of Milano, Stefano Iotti of University of Bologna, and Andrea Rosanoff of the Center for Magnesium Education & Research (CMER).