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3 results on '"Witkamp T"'

1. Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum

Author

Bartstra, J.W., primary, van den Beukel, T., additional, Kranenburg, G., additional, Geurts, L.J., additional, den Harder, A.M., additional, Witkamp, T., additional, Wolterink, J.M., additional, Zwanenburg, J.J.M., additional, van Valen, E., additional, Koek, H.L., additional, Mali, W.P.T.M., additional, de Jong, P.A., additional, Hendrikse, J., additional, and Spiering, W., additional

Published
2024
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2. Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum

Author

Researchgr. Systems Radiology, Interne Geneeskunde Vasculaire, Arts-assistenten Radiologie, Onderzoek Beeld, MS Radiologie, Neurovascular Imaging Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Infection & Immunity, Divisie Beeld & Oncologie, MS Interne Geneeskunde, Bartstra, J. W., van den Beukel, T., Kranenburg, G., Geurts, L. J., den Harder, A. M., Witkamp, T., Wolterink, J. M., Zwanenburg, J. J.M., van Valen, Evelien, Koek, H.L., Mali, W. P.T.M., de Jong, P. A., Hendrikse, J., Spiering, W., Researchgr. Systems Radiology, Interne Geneeskunde Vasculaire, Arts-assistenten Radiologie, Onderzoek Beeld, MS Radiologie, Neurovascular Imaging Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Infection & Immunity, Divisie Beeld & Oncologie, MS Interne Geneeskunde, Bartstra, J. W., van den Beukel, T., Kranenburg, G., Geurts, L. J., den Harder, A. M., Witkamp, T., Wolterink, J. M., Zwanenburg, J. J.M., van Valen, Evelien, Koek, H.L., Mali, W. P.T.M., de Jong, P. A., Hendrikse, J., and Spiering, W.

Published
2024

3. Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum.

Author

Bartstra JW, van den Beukel T, Kranenburg G, Geurts LJ, den Harder AM, Witkamp T, Wolterink JM, Zwanenburg JJM, van Valen E, Koek HL, Mali WPTM, de Jong PA, Hendrikse J, and Spiering W

Subjects
Male, Humans, Middle Aged, Carotid Artery, Internal pathology, Brain diagnostic imaging, Brain pathology, Infarction, Pseudoxanthoma Elasticum complications, Pseudoxanthoma Elasticum diagnostic imaging, Pseudoxanthoma Elasticum pathology, Calcinosis, Cerebrovascular Disorders diagnostic imaging, Cerebrovascular Disorders complications, Brain Injuries
Abstract

Background and Purpose: Carotid siphon calcification might contribute to the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum through increased arterial flow pulsatility. This study aimed to compare intracranial artery flow pulsatility, brain volumes, and small-vessel disease markers between patients with pseudoxanthoma elasticum and controls and the association between arterial calcification and pulsatility in pseudoxanthoma elasticum., Materials and Methods: Fifty patients with pseudoxanthoma elasticum and 40 age- and sex-matched controls underwent 3T MR imaging, including 2D phase-contrast acquisitions for flow pulsatility in the assessment of ICA and MCA and FLAIR acquisitions for brain volumes, white matter lesions, and infarctions. All patients with pseudoxanthoma elasticum underwent CT scanning to measure siphon calcification. Flow pulsatility (2D phase-contrast), brain volumes, white matter lesions, and infarctions (3D T1 and 3D T2 FLAIR) were compared between patients and controls. The association between siphon calcification and pulsatility in pseudoxanthoma elasticum was tested with linear regression models., Results: Patients with pseudoxanthoma elasticum (mean age, 57 [SD, 12] years; 24 men) had significantly higher pulsatility indexes (1.05; range, 0.94-1.21 versus 0.94; range, 0.82-1.04; P  = .02), lower mean GM volumes (597 [SD, 53] mL versus 632 [SD, 53] mL; P  < .01), more white matter lesions (2.6; range, 0.5-7.5 versus 1.1; range, 0.5-2.4) mL; P  = .05), and more lacunar infarctions (64 versus 8, P  = .04) than controls (mean age, 58 [SD, 11] years; 20 men). Carotid siphon calcification was associated with higher pulsatility indexes in patients with pseudoxanthoma elasticum (β = 0.10; 95% CI, 0.01-0.18)., Conclusions: Patients with pseudoxanthoma elasticum have increased intracranial artery flow pulsatility and measures of small-vessel disease. Carotid siphon calcification might underlie the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum., (© 2024 by American Journal of Neuroradiology.)

Published
2024
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