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3. Variables associated with in-hospital and postdischarge outcomes after postcardiotomy extracorporeal membrane oxygenation: Netherlands Heart Registration Cohort

Author

CTC, Circulatory Health, Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine M., Roefs, Maaike M., De Piero, Maria Elena, Di Mauro, Michele, Willers, Anne, Segers, Patrique, Delnoij, Thijs, van der Horst, Iwan C.C., Maessen, Jos, Lorusso, Roberto, Van der Kaaij, Niels P., The Netherlands Heart Registration Cardiothoracic Surgery Registration Committee, CTC, Circulatory Health, Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine M., Roefs, Maaike M., De Piero, Maria Elena, Di Mauro, Michele, Willers, Anne, Segers, Patrique, Delnoij, Thijs, van der Horst, Iwan C.C., Maessen, Jos, Lorusso, Roberto, Van der Kaaij, Niels P., and The Netherlands Heart Registration Cardiothoracic Surgery Registration Committee

Published
2023

4. Blood coagulation and beyond:Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

Akbulut, Asim Cengiz, Arisz, Ryanne A., Baaten, Constance C.F.M.J., Baidildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Berg, Jur ten, van den Broek, Wout W.A., Boer, H. C.de, Bonifay, Amandine, Bröker, Vanessa, Buka, Richard J., Cate, Hugo ten, Cate-Hoek, Arina J.ten, Cointe, S., Luca, C. De, Simone, Ilaria De, Diaz, Rocio Vacik, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric C.M., Habibi, Anxhela, Henskens, Yvonne M.C., Iding, Aaron F.J., Khan, Abdullah, Koenderink, Gijsje H., Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel E., Lorusso, Roberto, Luo, Qi, Maas, Coen, Mccarty, Owen J.T., van der Meijden, Paola E.J., Meijers, Joost C.M., Mohapatra, Adarsh K., Nevo, Neta, Robles, Alejandro Pallares, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schönichen, Claudia, Schutgens, Roger, Simioni, Paolo, Spada, Stefano, Spronk, Henri M.H., Tazhibayeva, Karlygash, Thachil, Jecko, Vallier, L., Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P., Wenzel, Philip, Willems, Ruth A.L., Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, Zonneveld, Anton Jan van, Akbulut, Asim Cengiz, Arisz, Ryanne A., Baaten, Constance C.F.M.J., Baidildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Berg, Jur ten, van den Broek, Wout W.A., Boer, H. C.de, Bonifay, Amandine, Bröker, Vanessa, Buka, Richard J., Cate, Hugo ten, Cate-Hoek, Arina J.ten, Cointe, S., Luca, C. De, Simone, Ilaria De, Diaz, Rocio Vacik, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric C.M., Habibi, Anxhela, Henskens, Yvonne M.C., Iding, Aaron F.J., Khan, Abdullah, Koenderink, Gijsje H., Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel E., Lorusso, Roberto, Luo, Qi, Maas, Coen, Mccarty, Owen J.T., van der Meijden, Paola E.J., Meijers, Joost C.M., Mohapatra, Adarsh K., Nevo, Neta, Robles, Alejandro Pallares, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schönichen, Claudia, Schutgens, Roger, Simioni, Paolo, Spada, Stefano, Spronk, Henri M.H., Tazhibayeva, Karlygash, Thachil, Jecko, Vallier, L., Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P., Wenzel, Philip, Willems, Ruth A.L., Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, and Zonneveld, Anton Jan van

Abstract

The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

Published
2023

6. Variables associated with in-hospital and postdischarge outcomes after postcardiotomy extracorporeal membrane oxygenation:Netherlands Heart Registration Cohort

Author

Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine M., Roefs, Maaike M., De Piero, Maria Elena, Di Mauro, Michele, Willers, Anne, Segers, Patrique, Delnoij, Thijs, van der Horst, Iwan C.C., Maessen, Jos, Lorusso, Roberto, Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine M., Roefs, Maaike M., De Piero, Maria Elena, Di Mauro, Michele, Willers, Anne, Segers, Patrique, Delnoij, Thijs, van der Horst, Iwan C.C., Maessen, Jos, and Lorusso, Roberto

Abstract

Objectives: Extracorporeal membrane oxygenation (ECMO) for postcardiotomy cardiogenic shock has been increasingly used without concomitant mortality reduction. This study aims to investigate determinants of in-hospital and postdischarge mortality in patients requiring postcardiotomy ECMO in the Netherlands. Methods: The Netherlands Heart Registration collects nationwide prospective data from cardiac surgery units. Adults receiving intraoperative or postoperative ECMO included in the register from January 2013 to December 2019 were studied. Survival status was established through the national Personal Records Database. Multivariable logistic regression analyses were used to investigate determinants of in-hospital (3 models) and 12-month postdischarge mortality (4 models). Each model was developed to target specific time points during a patient's clinical course. Results: Overall, 406 patients (67.2% men, median age, 66.0 years [interquartile range, 55.0-72.0 years]) were included. In-hospital mortality was 51.7%, with death occurring in a median of 5 days (interquartile range, 2-14 days) after surgery. Hospital survivors (n = 196) experienced considerable rates of pulmonary infections, respiratory failure, arrhythmias, and deep sternal wound infections during a hospitalization of median 29 days (interquartile range, 17-51 days). Older age (odds ratio [OR], 1.02; 95% CI, 1.0-1.04) and preoperative higher body mass index (OR, 1.08; 95% CI, 1.02-1.14) were associated with in-hospital death. Within 12 months after discharge, 35.1% of hospital survivors (n = 63) died. Postoperative renal failure (OR, 2.3; 95% CI, 1.6-4.9), respiratory failure (OR, 3.6; 95% CI, 1.3-9.9), and re-thoracotomy (OR, 2.9; 95% CI, 1.3-6.5) were associated with 12-month postdischarge mortality. Conclusions: In-hospital and postdischarge mortality after postcardiotomy ECMO in adults remains high in the Netherlands. ECMO support in patients with higher age and body mass index, which drive associa

Published
2023

7. Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Poli Van Creveldkliniek Medisch, Child Health, Infection & Immunity, Akbalut, Cengiz, Arisz, Ryanne, Baaten, Constance, Baildildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Ten Berg, Jurriën M, van den Broek, Wout, de Boer, Hetty C, Broker, Vanessa, Buka, Richard, Ten Cate, Hugo, Cate, Arina Ten, De Luca, Ciro, De Simone, Ilaria, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric, Habibi, Anxhela, Henskens, Yvonne M C, Iding, Aaron F J, Khan, Abdullah, Koenderink, Gijsje, Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel, Lorusso, Roberto, Luo, Qi, Maas, Coen, McCarty, Owen J T, van der Meijden, Paola, Meijers, Joost, Mohapatra, Adarsh, Nevo, Neta, Pallares Robles, Alejandro, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schonichen, Claudia, Schutgens, Roger E G, Simioni, Paolo, Spada, Stefano, Spronk, Henri M H, Tazhibayeva, Karlygash, Thachil, Jecko, Vacik-Diaz, Rocio, Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P, Wenzel, Philip, Willems, Ruth, Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, van Zonneveld, Anton-Jan, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Poli Van Creveldkliniek Medisch, Child Health, Infection & Immunity, Akbalut, Cengiz, Arisz, Ryanne, Baaten, Constance, Baildildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Ten Berg, Jurriën M, van den Broek, Wout, de Boer, Hetty C, Broker, Vanessa, Buka, Richard, Ten Cate, Hugo, Cate, Arina Ten, De Luca, Ciro, De Simone, Ilaria, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric, Habibi, Anxhela, Henskens, Yvonne M C, Iding, Aaron F J, Khan, Abdullah, Koenderink, Gijsje, Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel, Lorusso, Roberto, Luo, Qi, Maas, Coen, McCarty, Owen J T, van der Meijden, Paola, Meijers, Joost, Mohapatra, Adarsh, Nevo, Neta, Pallares Robles, Alejandro, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schonichen, Claudia, Schutgens, Roger E G, Simioni, Paolo, Spada, Stefano, Spronk, Henri M H, Tazhibayeva, Karlygash, Thachil, Jecko, Vacik-Diaz, Rocio, Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P, Wenzel, Philip, Willems, Ruth, Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, and van Zonneveld, Anton-Jan

Published
2023

8. Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

Akbulut, Asim Cengiz, additional, Arisz, Ryanne A., additional, Baaten, Constance C. F. M. J., additional, Baidildinova, Gaukhar, additional, Barakzie, Aarazo, additional, Bauersachs, Rupert, additional, ten Berg, Jur, additional, van den Broek, Wout W. A., additional, de Boer, H. C., additional, Bonifay, Amandine, additional, Bröker, Vanessa, additional, Buka, Richard J., additional, ten Cate, Hugo, additional, ten Cate-Hoek, Arina J., additional, Cointe, S., additional, De Luca, Ciro, additional, De Simone, Ilaria, additional, Diaz, Rocio Vacik, additional, Dignat-George, Françoise, additional, Freson, Kathleen, additional, Gazzaniga, Giulia, additional, van Gorp, Eric C. M., additional, Habibi, Anxhela, additional, Henskens, Yvonne M. C., additional, Iding, Aaron F. J., additional, Khan, Abdullah, additional, Koenderink, Gijsje H., additional, Konkoth, Akhil, additional, Lacroix, Romaric, additional, Lahiri, Trisha, additional, Lam, Wilbur, additional, Lamerton, Rachel E., additional, Lorusso, Roberto, additional, Luo, Qi, additional, Maas, Coen, additional, McCarty, Owen J. T., additional, van der Meijden, Paola E. J., additional, Meijers, Joost C. M., additional, Mohapatra, Adarsh K., additional, Nevo, Neta, additional, Robles, Alejandro Pallares, additional, Poncelet, Philippe, additional, Reinhardt, Christoph, additional, Ruf, Wolfram, additional, Saraswat, Ronald, additional, Schönichen, Claudia, additional, Schutgens, Roger, additional, Simioni, Paolo, additional, Spada, Stefano, additional, Spronk, Henri M. H., additional, Tazhibayeva, Karlygash, additional, Thachil, Jecko, additional, Vallier, L., additional, Veninga, Alicia, additional, Verhamme, Peter, additional, Visser, Chantal, additional, Watson, Steve P., additional, Wenzel, Philip, additional, Willems, Ruth A. L., additional, Willers, Anne, additional, Zhang, Pengyu, additional, Zifkos, Konstantinos, additional, and van Zonneveld, Anton Jan, additional

Published
2023
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9. Variables associated with in-hospital and postdischarge outcomes after postcardiotomy extracorporeal membrane oxygenation: Netherlands Heart Registration Cohort

Author

Mariani, Silvia, primary, van Bussel, Bas C.T., additional, Ravaux, Justine M., additional, Roefs, Maaike M., additional, De Piero, Maria Elena, additional, Di Mauro, Michele, additional, Willers, Anne, additional, Segers, Patrique, additional, Delnoij, Thijs, additional, van der Horst, Iwan C.C., additional, Maessen, Jos, additional, Lorusso, Roberto, additional, Bekkers, Jos A., additional, Van Boven, Wim Jan P., additional, Van Brakel, Thomas J., additional, Bramer, Sander, additional, Daeter, Edgar J., additional, Hoohenkerk, Gerard J.F., additional, Van der Kaaij, Niels P., additional, Koene, Bart M.J. A., additional, Li, Wilson W.L., additional, Markou, Thanasie A.L. P., additional, Douglas, Yvonne L., additional, Porta, Fabiano, additional, Speekenbrink, Ron G.H., additional, Stooker, Wim, additional, and Vonk, Alexander B.A., additional

Published
2023
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10. HEROES V‐A: HEmoRrhagic cOmplications in veno‐arterial Extracorporeal life Support: Development and internal validation of a multivariable prediction model in adult patients

Author

Willers, Anne, primary, Swol, Justyna, additional, van Kuijk, Sander M. J., additional, Buscher, Hergen, additional, McQuilten, Zoe, additional, ten Cate, Hugo, additional, Rycus, Peter T., additional, McKellar, Stephen, additional, Lorusso, Roberto, additional, and Tonna, Joseph E., additional

Published
2022
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11. Temporary mechanical circulatory support for COVID‐19 patients: A systematic review of literature

Author

Mariani, Silvia, primary, De Piero, Maria Elena, additional, Ravaux, Justine M., additional, Saelmans, Alexander, additional, Kawczynski, Michal J., additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Willers, Anne, additional, Swol, Justyna, additional, Kowalewski, Mariusz, additional, Li, Tong, additional, Delnoij, Thijs S. R., additional, van der Horst, Iwan C. C., additional, Maessen, Jos, additional, and Lorusso, Roberto, additional

Published
2022
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12. Longitudinal Trends in Bleeding Complications on Extracorporeal Life Support Over the Past Two Decades—Extracorporeal Life Support Organization Registry Analysis

Author

Willers, Anne, primary, Swol, Justyna, additional, Buscher, Hergen, additional, McQuilten, Zoe, additional, van Kuijk, Sander M. J., additional, ten Cate, Hugo, additional, Rycus, Peter T., additional, McKellar, Stephen, additional, Lorusso, Roberto, additional, and Tonna, Joseph E., additional

Published
2022
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13. HEROES V‐V—HEmorRhagic cOmplications in Veno‐Venous Extracorporeal life Support—Development and internal validation of multivariable prediction model in adult patients.

Author

Willers, Anne, Swol, Justyna, van Kuijk, Sander M. J., Buscher, Hergen, McQuilten, Zoe, ten Cate, Hugo, Rycus, Peter T., McKellar, Stephen, Lorusso, Roberto, and Tonna, Joseph E.

Subjects
*EXTRACORPOREAL membrane oxygenation, *PREDICTION models, *RECEIVER operating characteristic curves, *JUGULAR vein, *RENAL replacement therapy, *ARTIFICIAL blood circulation, *OXYGENATORS
Abstract

Background: During extracorporeal life support (ECLS), bleeding is one of the most frequent complications, associated with high morbidity and increased mortality, despite continuous improvements in devices and patient care. Risk factors for bleeding complications in veno‐venous (V‐V) ECLS applied for respiratory support have been poorly investigated. We aim to develop and internally validate a prediction model to calculate the risk for bleeding complications in adult patients receiving V‐V ECLS support. Methods: Data from adult patients reported to the extracorporeal life support organization (ELSO) registry between the years 2010 and 2020 were analyzed. The primary outcome was bleeding complications recorded during V‐V ECLS. Multivariable logistic regression with backward stepwise elimination was used to develop the predictive model. The performance of the model was tested by discriminative ability and calibration with receiver operating characteristic curves and visual inspection of the calibration plot. Results: In total, 18 658 adult patients were included, of which 3 933 (21.1%) developed bleeding complications. The prediction model showed a prediction of bleeding complications with an AUC of 0.63. Pre‐ECLS arrest, surgical cannulation, lactate, pO2, HCO3, ventilation rate, mean airway pressure, pre‐ECLS cardiopulmonary bypass or renal replacement therapy, pre‐ECLS surgical interventions, and different types of diagnosis were included in the prediction model. Conclusions: The model is based on the largest cohort of V‐V ECLS patients and reveals the most favorable predictive value addressing bleeding events given the predictors that are feasible and when compared to the current literature. This model will help identify patients at risk of bleeding complications, and decision making in terms of anticoagulation and hemostatic management. [ABSTRACT FROM AUTHOR]

Published
2022
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