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13 results on '"Wiebe, Thomas"'

1. Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Heymer, Emma J., Hawkins, Michael M., Winter, David L., Teepen, Jop C., Sunguc, Ceren, Ronckers, Cécile M., Allodji, Rodrigue S., Alessi, Daniela, Sugden, Elaine, Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Garwicz, Stanislaw, Grabow, Desiree, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Michel, Gisela, Schindera, Christina, Haddy, Nadia, Journy, Neige, Česen Mazić, Maja, Skinner, Roderick, Kok, Judith L., Gunnes, Maria W., Wiebe, Thomas, Sacerdote, Carlotta, Maule, Milena M., Terenziani, Monica, Jakab, Zsuzsanna, Winther, Jeanette F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Haupt, Riccardo, Kuehni, Claudia E., Kremer, Leontien C., de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2024
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2. Risk of severe esophageal stricture among childhood cancer survivors – A population-based case-cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS)

Author

Hansen, Helena K., Asdahl, Peter H., Christensen, Jane, Pedersen, Camilla, Krøyer, Anja, Pontoppidan, Celina S., Holmqvist, Anna S., Hjorth, Lars, Wiebe, Thomas, Gudmundsdottir, Thorgerdur, de fine Licht, Sofie, Lassen-Ramshad, Yasmin, Seiersen, Klaus, Jørgensen, Morten, Laursen, Michael RT, Øfstaas, Hilde, Lähteenmäki, Päivi M., Smith, Susan A., Howell, Rebecca, Rechnitzer, Catherine, Hasle, Henrik, Winther, Jeanette F., and Kenborg, Line

Published
2024
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3. Radiation Doses Received by Major Organs at Risk in Children and Young Adolescents Treated for Cancer with External Beam Radiation Therapy: A Large-scale Study from 12 European Countries

Author

Diallo, Ibrahima, Allodji, Rodrigue S., Veres, Cristina, Bolle, Stéphanie, Llanas, Damien, Ezzouhri, Safaa, Zrafi, Wael, Debiche, Ghazi, Souchard, Vincent, Fauchery, Romain, Haddy, Nadia, Journy, Neige, Demoor-Goldschmidt, Charlotte, Winter, David L., Hjorth, Lars, Wiebe, Thomas, Haupt, Riccardo, Robert, Charlotte, Kremer, Leontien, Bardi, Edit, Sacerdote, Carlotta, Terenziani, Monica, Kuehni, Claudia E., Schindera, Christina, Skinner, Roderick, Winther, Jeanette Falck, Lähteenmäki, Päivi, Byrn, Julianne, Jakab, Zsuzsanna, Cardis, Elisabeth, Pasqual, Elisa, Tapio, Soile, Baatout, Sarah, Atkinson, Mike, Benotmane, Mohammed Abderrafi, Sugden, Elaine, Zaletel, Lorna Zadravec, Ronckers, Cecile, Reulen, Raoul C., Hawkins, Mike M., and de Vathaire, Florent

Published
2024
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4. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garwicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Mazić, Maja Česen, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Gunnes, Maria Winther, Terenziani, Monica, Winther, Jeanette F., Lähteenmäki, Päivi M., Zaletel, Lorna Zadravec, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2023
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6. Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer

Author

Broberg, Olof, Feldreich, Tobias, Weismann, Constance G, Øra, Ingrid, Wiebe, Thomas, Ärnlöv, Johan, Liuba, Petru, Broberg, Olof, Feldreich, Tobias, Weismann, Constance G, Øra, Ingrid, Wiebe, Thomas, Ärnlöv, Johan, and Liuba, Petru

Abstract

INTRODUCTION: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease. METHODS: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index). RESULTS: Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p < 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p < 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p < 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005). CONCLUSION: This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.

Published
2024
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8. Ceramides: a potential cardiovascular biomarker in young adult childhood cancer survivors?

Author

Broberg, Olof, Weismann, Constance G., Øra, Ingrid, Wiebe, Thomas, Laaksonen, Reijo, and Liuba, Petru

Subjects
YOUNG adults, CERAMIDES, CHILDHOOD cancer, CANCER survivors, CANCER patients
Abstract

Aims: The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods and results: Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardiotoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry. The coronary event risk test 2 (CERT2) score was calculated from the ceramide data. Cardiac and carotid artery ultrasound data and lipid data available from previous studies of this cohort were used to study partial correlations with ceramide and CERT2 score data. All four analysed ceramides were elevated in CCS compared with controls (P ≤ 0.012). The greatest difference was noted for C18:0, which was 33% higher in CCS compared with controls adjusted for sex, age, and body mass index (BMI) (P < 0.001). The CERT2 score was higher in CCS compared with controls (P < 0.001). In the CCS group, 35% had a high to very high CERT2 score (7-12) when compared with 9% in the control group (P < 0.001). The CCS subgroup with a CERT2 score ≥ 7 had higher heart rate, systolic blood pressure, and higher levels of apolipoprotein B compared with CCS with a CERT2 score < 6 (P ≤ 0.011). When adjusted for age, sex, and BMI, CERT2 score was significantly correlated with arterial stiffness, growth hormone, and cranial radiotherapy (P < 0.044). Conclusion: Ceramides could be important biomarkers in understanding the pathophysiology of CVD and in predicting CVD disease risk in young adult CCS. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Risk Factors for Primary Bone Cancer After Childhood Cancer: A PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies Nested Case-Control Study

Author

Reulen, Raoul C., primary, Winter, David L., additional, Diallo, Ibrahim, additional, Veres, Cristina, additional, Llanas, Damien, additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Feijen, Elizabeth A.M., additional, Alessi, Daniela, additional, Fidler-Benaoudia, Miranda M., additional, Høgsholt, Stine, additional, Teepen, Jop C., additional, Linge, Helena, additional, Haddy, Nadia, additional, Byrne, Julianne, additional, Debiche, Ghazi, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Fauchery, Romain, additional, Zrafi, Wael, additional, Michel, Gisela, additional, Øfstaas, Hilde, additional, Kaatsch, Peter, additional, Vu-Bezin, Giao, additional, Jenkinson, Helen, additional, Kaiser, Melanie, additional, Skinner, Roderick, additional, Cole, Trevor, additional, Waespe, Nicolas, additional, Sommer, Grit, additional, Nordenfelt, Susanne, additional, Jankovic, Momcilo, additional, Lähteenmäki Taalas, Tuomas, additional, Maule, Milena M., additional, van der Pal, Helena J.H., additional, Ronckers, Cécile M., additional, van Leeuwen, Flora E., additional, Kok, Judith L., additional, Terenziani, Monica, additional, Winther Gunnes, Maria, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M., additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E., additional, Falck Winther, Jeanette, additional, Kremer, Leontien C.M., additional, Hjorth, Lars, additional, de Vathaire, Florent, additional, and Hawkins, Michael M., additional

Published
2023
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11. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

Author

Dudley, Isabelle M., primary, Sunguc, Ceren, additional, Heymer, Emma J., additional, Winter, David L., additional, Teepen, Jop C., additional, Belle, Fabiën N., additional, Bárdi, Edit, additional, Bagnasco, Francesca, additional, Gudmundsdottir, Thorgerdur, additional, Skinner, Roderick, additional, Michel, Gisela, additional, Byrne, Julianne, additional, Øfstaas, Hilde, additional, Jankovic, Momcilo, additional, Mazić, Maja Česen, additional, Mader, Luzius, additional, Loonen, Jaqueline, additional, Garwicz, Stanislaw, additional, Wiebe, Thomas, additional, Alessi, Daniela, additional, Allodji, Rodrigue S., additional, Haddy, Nadia, additional, Grabow, Desiree, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Maule, Milena M., additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Lähteenmäki, Päivi M., additional, Winther, Jeanette F., additional, Hjorth, Lars, additional, Hawkins, Michael M., additional, and Reulen, Raoul C., additional

Published
2022
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12. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, primary, Hawkins, Michael M., additional, Winter, David L., additional, Dudley, Isabelle M., additional, Heymer, Emma J., additional, Teepen, Jop C., additional, Allodji, Rodrigue S., additional, Belle, Fabiën N., additional, Bagnasco, Francesca, additional, Byrne, Julianne, additional, Bárdi, Edit, additional, Ronckers, Cécile M., additional, Haddy, Nadia, additional, Gudmundsdottir, Thorgerdur, additional, Garwicz, Stanislaw, additional, Jankovic, Momcilo, additional, van der Pal, Helena J. H., additional, Mazić, Maja Česen, additional, Schindera, Christina, additional, Grabow, Desiree, additional, Maule, Milena M., additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Fresneau, Brice, additional, Michel, Gisela, additional, Skinner, Roderick, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Winther, Jeanette F., additional, Lähteenmäki, Päivi M., additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Kremer, Leontien C., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Hjorth, Lars, additional, and Reulen, Raoul C., additional

Published
2022
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13. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study.

Author

Dudley, Isabelle M., Sunguc, Ceren, Heymer, Emma J., Winter, David L., Teepen, Jop C., Belle, Fabiën N., Bárdi, Edit, Bagnasco, Francesca, Gudmundsdottir, Thorgerdur, Skinner, Roderick, Michel, Gisela, Byrne, Julianne, Øfstaas, Hilde, Jankovic, Momcilo, Mazić, Maja Česen, Mader, Luzius, Loonen, Jaqueline, Garwicz, Stanislaw, Wiebe, Thomas, and Alessi, Daniela

Subjects
CHILDHOOD cancer, MEDICAL personnel, NEPHROBLASTOMA, OSTEOSARCOMA, HODGKIN'S disease
Abstract

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan‐European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and Follow‐Up Studies (PanCareSurFup) cohort includes 69,460 five‐year survivors of childhood cancer, diagnosed during 1940 through 2008, from 12 European countries. Risks of SPLs were quantified by standardized incidence ratios (SIRs) and relative risks (RRs) using multivariable Poisson regression. Results: Overall, 140 SPLs, including 104 NHLs and 36 HLs, were identified. Survivors were at 60% increased risk of an SPL compared with the general population (SIR, 1.6; 95% confidence interval [CI], 1.4–1.9). Survivors were twice as likely to develop NHL (SIR, 2.3; 95% CI, 1.9–2.8), with the greatest risks among survivors of HL (SIR, 7.1; 95% CI, 5.1–10.0), Wilms tumor (SIR, 3.1; 95% CI, 1.7–5.7), leukemia (SIR, 2.8; 95% CI, 1.8–4.4), and bone sarcoma (SIR, 2.7; 95% CI, 1.4–5.4). Treatment with chemotherapy for any cancer doubled the RR of NHL (RR, 2.1; 95% CI, 1.2–3.9), but treatment with radiotherapy did not (RR, 1.2; 95% CI, 0.7–2.0). Survivors were at similar risk of developing a subsequent HL as the general population (SIR, 1.1; 95% CI, 0.8–1.5). Conclusions: In addition to HL, the authors show here for the first time that survivors of Wilms tumor, leukemia, and bone sarcoma are at risk of NHL. Survivors and health care professionals should be aware of the risk of NHL in these survivors and in any survivors treated with chemotherapy. Using data from 69,460 five‐year survivors of childhood cancer across Europe, the authors investigated the risks of subsequent primary lymphoma within the largest cohort reported to date. Novel findings include the identification of an increased risk of non‐Hodgkin lymphoma among survivors of Wilms tumor, leukemia, and bone sarcoma and in any survivors treated with chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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