31 results on '"Whelan D"'
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2. Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response
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Monson, E. A., Crosse, K. M., Duan, M., Chen, W., O’Shea, R. D., Wakim, L. M., Carr, J. M., Whelan, D. R., and Helbig, K. J.
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- 2021
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3. Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats
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Van Schaik, L., Kettle, C., Green, R., Sievers, W., Hale, M. W., Irving, H. R., Whelan, D. R., and Rathner, J. A.
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- 2021
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4. Additional file 1 of The effect of estrogen on brown adipose tissue activity in male rats
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Sievers, W., Kettle, C., Green, R. A., Van Schaik, L., Hale, M. W., Irving, H. R., Whelan, D. R., and Rathner, J. A.
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Additional file 1. Table S1: Mean changes in core temperature, iBAT temperature, heart rate and mean arterial pressure for the present study (Sievers et al.) and Van Schaik et al. (2). A t-test was used to assess statistical difference between means. Mean change in temperatures are represented in the centre column. P-values are reported in the right-most column. n = 6���8.Table S2: Animal research: Reporting of in vivo experiments (ARRIVE) checklist.
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- 2022
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5. Additional file 2 of The effect of estrogen on brown adipose tissue activity in male rats
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Sievers, W., Kettle, C., Green, R. A., Van Schaik, L., Hale, M. W., Irving, H. R., Whelan, D. R., and Rathner, J. A.
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digestive, oral, and skin physiology ,hormones, hormone substitutes, and hormone antagonists - Abstract
Additional file 2: Figure S1. Individual changes in temperature (�� Temperature ��C) of interscapular brown adipose tissue (iBAT) and core, in male rats following injection (time = zero) of estrogen or vehicle. Temperature of iBAT following A IP injection or B ICV injection. Core temperature following C IP injection or D ICV injection. n = 6 for IPcontrol; n = 7 for IP-estrogen and ICV-control; n = 8 for ICV-estrogen. One rat was excluded from the IP-control group due to a procedural error. Two rats were excluded from the ICV-estrogen group due to prolonged (< 7 h) surgical complications experienced.
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- 2022
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6. Additional file 3 of The effect of estrogen on brown adipose tissue activity in male rats
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Sievers, W., Kettle, C., Green, R. A., Van Schaik, L., Hale, M. W., Irving, H. R., Whelan, D. R., and Rathner, J. A.
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digestive, oral, and skin physiology ,hormones, hormone substitutes, and hormone antagonists - Abstract
Additional file 3: Figure S2. Individual changes in heart rate (�� Heart Rate) and mean arterial pressure (�� MAP), in male rats following injection (time = zero) of estrogen or vehicle. Heart rate following A IP injection or B ICV injection. Mean arterial pressure following C IP injection or D ICV injection. n = 6 for IP-control; n = 7 for IP-estrogen and ICV-control; n = 8 for ICV-estrogen. One rat was excluded from the IP-control group due to a procedural error. Two rats were excluded from the ICV-estrogen group due to prolonged (< 7 h) surgical complications experienced.
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- 2022
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7. Additional file 4 of The effect of estrogen on brown adipose tissue activity in male rats
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Sievers, W., Kettle, C., Green, R. A., Van Schaik, L., Hale, M. W., Irving, H. R., Whelan, D. R., and Rathner, J. A.
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Additional file 4: Figure S3. Number of cFos immunoreactive (cFos-ir) cells within thalamic and hypothalamic nuclei. n = 3 for all treatment groups. One rat was considered one experimental unit. VMH = ventromedial nucleus of the hypothalamus; Arc = arcuate nucleus of the hypothalamus; LH = lateral nucleus of the hypothalamus; PVN = Paraventricular nucleus of the hypothalamus; PVT = paraventricular nucleus of the thalamus; CM = centromedian nucleus of the thalamus; DMH = dorsomedial nucleus of the hypothalamus.
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- 2022
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8. Mental Health Homicide and Society: Understanding Health Care GovernanceD.P.Horton. Oxford: Hart (2019) 239pp. £70.00hb, £34.99pb ISBN 9781509912148, 9781509951994
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WHELAN, D., primary
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- 2021
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9. Mental Health Homicide and Society: Understanding Health Care GovernanceD.P.Horton. Oxford: Hart(2019) 239pp. £70.00hb, £34.99pb ISBN 9781509912148, 9781509951994
- Author
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WHELAN, D.
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- 2021
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10. The Minimum Patient Acceptable Symptom State for the ACL-Return to Sport after Injury Scale Among Patients Treated With Anterior Cruciate Ligament Reconstruction.
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Dwyer T, Ajrawat P, Lameire DL, Betsch M, Whelan D, Shahrokhi S, Theodoropoulos J, Hoit G, and Chahal J
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Background: Despite most patients reporting optimal knee function after anterior cruciate ligament reconstruction (ACLR), not all return to their pre-injury level of sport, often due to psychological factors. The ACL-Return to Sport after Injury Scale (ACL-RSI) was developed to measure the emotions, confidence in performance, and risk appraisal among athletes returning to sport. The purpose of this study was to determine the Patient Acceptable Symptom State (PASS) threshold for the ACL-RSI in patients undergoing ACLR., Materials and Methods: Patients with an ACL injury that required surgical reconstruction were included in this prospective study. All patients underwent ACLR with a bone-patellar tendon-bone autograft and completed the ACL-RSI 12 months postoperatively. An anchor-based approach was used to generate a receiver operating characteristic curve and establish the PASS threshold. Multivariable regression analyses were used to evaluate the effect of age, sex, and baseline score on likelihood of achieving PASS., Results: A total of 113 patients (37% female) with a mean age of 28.1±8.2 years and a mean body mass index of 24.7±3.5 kg/m
2 were included. At 12 months postoperatively, the threshold value for the PASS of the ACL-RSI was 40 (robust area under the curve: 0.89; sensitivity: 81%; specificity: 85%). Baseline score, sex, and age had no significant influence on achieving PASS at 12 months postoperatively., Conclusion: In a group of patients undergoing ACLR with bone-patellar tendon-bone autograft, the PASS threshold value was 40 for the ACL-RSI at 12 months postoperatively. The PASS value for the ACL-RSI established from this study can be useful for designing future clinical trials. [ Orthopedics . 202x;4x(x):xx-xx.].- Published
- 2024
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11. Mental Health Acts - Perspectives from Mental Health and Law in Ireland and in Portugal.
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Moreira ALR, Whelan D, Colón MF, and Fouto AC
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- Humans, Portugal, Ireland, Mental Health legislation & jurisprudence, Human Rights legislation & jurisprudence, Mental Health Services legislation & jurisprudence, Commitment of Mentally Ill legislation & jurisprudence, Mental Disorders therapy
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Mental health legislation is a cornerstone to ensure that individuals with severe mental illness access proper care and treatment. Each country establishes their own legislation. We aimed to compare the Portuguese and Irish Mental Health Acts (MHAs). We reviewed the respective MHA and the literature. While the definition of mental disorder is similar in general, who, where, when and how one can be detained differ. Judges decide on detentions in Portugal, while consultant psychiatrists may do so in Ireland. Community-based compulsory treatment is possible and used in Portugal while it is not possible in Ireland. Pros and cons of each approach are discussed with a reflection on the protection of human rights. Further theoretical and empirical studies comparing systems in different jurisdictions would be helpful to deepen our understanding of the legislation and guide on how to better serve individuals with severe mental illness.
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- 2024
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12. How Important are Psychological Measures to Determine Readiness to Return to Sports after Reconstruction of the Anterior Cruciate Ligament? An Online Survey Study.
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Newmarch T, Betsch M, Michalik R, Dwyer T, Whelan D, Chahal J, and Theodoropoulos J
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- Humans, Anterior Cruciate Ligament, Return to Sport psychology, Surveys and Questionnaires, Anterior Cruciate Ligament Injuries surgery, Sports
- Abstract
Background: Recent studies have suggested that psychological factors are important components of a successful return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to survey physicians with respect to their criteria used to determine readiness to RTS after ACLR and to understand the significance of psychological factors on RTS., Methods: A survey was designed to understand the practices of clinicians managing rehabilitation after ACLR, consisting of 25 questions divided into 3 different sections, including one section about psychological scores and factors affecting RTS. The survey was delivered to three North American organizations for orthopedic sports medicine., Results: The total number of respondents was 113. Of the respondents, 95% considered psychological tests at least "somewhat important" (33% "important", 23% selected "very important"). Routine use of psychological tests in practice was only reported by 35% of respondents. The ACL-Return to Sport after Injury Scale was the most frequently used psychological test (23%). Fear of reinjury was considered the most common patient-cited psychological factor affecting RTS. Psychological factors ranked 8th out of 9 outcomes measures in determining readiness to RTS., Conclusion: This study demonstrates a discrepancy between the importance of psychological tests and the frequency of use in practice. Additional education on this topic, web-based applications, and a multidisciplinary approach may increase the usage of psychological tests to determine RTS after ACLR., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
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- 2024
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13. Description of spatiotemporal patterns of infectious salmon anemia virus (ISAV) detections in marine Atlantic Salmon farms in Newfoundland and Labrador.
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Gautam M, Hammell KL, Burnley H, O'Brien N, Whelan D, and Thakur KK
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- Animals, Newfoundland and Labrador epidemiology, Isavirus genetics, Salmo salar, Orthomyxoviridae Infections epidemiology, Orthomyxoviridae Infections veterinary, Anemia veterinary, Fish Diseases epidemiology
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Objective: The objectives of this study were to describe spatiotemporal patterns of infectious salmon anemia virus (ISAV) detections in marine salmonid production sites in the province of Newfoundland and Labrador in Canada., Methods: Infectious salmon anemia virus surveillance data between 2012 and 2020 from the province of Newfoundland and Labrador were used. Data comprised a total of 94 sampling events from 20 Atlantic Salmon Salmo salar production sites in which ISAV was detected. Using linear regression models, factors influencing time to detection (days from stocking to first ISAV detection) and time to depopulation (days from first detection to production site depopulation) were investigated., Result: Based on 28 unique cases, site-level annual incidence risk of ISAV detection ranged from 3% to 29%. The proportion of ISAV detection by PCR in fish samples ranged from 2% to 45% annually. Overall, ISAV variants from the European clade were more common than variants from the North American clade. The type of ISAV clade, detections of ISAV in nearest production sites based on seaway distances, and year of infectious salmon anemia cases were not associated with time to first ISAV detection. Time to depopulation for sites infected with the ISAV-HPRΔ variant was not associated with ISAV North American or European clades., Conclusion: Our results contribute to the further understanding of the changing dynamics of infectious salmon anemia detections in Newfoundland and Labrador since its first detection in 2012 and will likely assist in the design of improved disease surveillance and control programs in the province., (© 2023 The Authors. Journal of Aquatic Animal Health published by Wiley Periodicals LLC on behalf of American Fisheries Society.)
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- 2023
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14. Medical fitness to drive, emergency service vehicles and crash risk.
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Noonan D, Ryan M, Whelan D, and O'Neill D
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- Humans, Accidents, Traffic, Ambulances, Automobile Driving, Alcoholism, Color Vision Defects
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Background: Emergency service vehicle (ESV) drivers are an important part of the health, fire and police services. ESV driving is associated with increased crash risk, but little guidance exists in the literature on relevant medical conditions among drivers and their potential for adding to higher crash risks., Aims: We undertook a narrative review to examine the role of medical and other conditions in crash risk of ESV drivers., Method: A literature search was conducted using the ScienceDirect and Transport Research International Documentation (TRID) databases. There was no time frame for the search, and results were restricted to review and research articles., Results: Of 570 papers identified, 13 remained after screening and full-text review. A range of factors have been shown to have an impact on increased crash risk, including the nature of the task, physical features of the equipment, training, experience, environmental conditions and secondary tasks. There was scant information on medical conditions other than alcohol use disorders., Conclusions: Given issues of speed, vehicle and environment, it would seem prudent to mandate levels of medical fitness to drive similar to and sometimes exceeding (i.e. colour blindness for traffic signals and alerts, hearing impairment as first responders) those for group 2 drivers with extra stipulations relating to specific service needs such as enhanced visual (such as colour blindness and contrast sensitivity) and auditory function. Further research is needed on the prevalence and emergence of relevant medical conditions among ESV drivers, with due consideration of their application to the driving tasks in each service., (© 2023. The Author(s).)
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- 2023
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15. The changing face of Capacity legislation in Ireland: algorithms for clinicians.
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Murphy VE, Gulati G, Whelan D, Dunne CP, and Kelly BD
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- Humans, Ireland, Decision Making, Computer-Assisted
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Capacity legislation in Ireland is evolving. The Assisted Decision-Making (Capacity) Act 2015 has been passed into law, but its main provisions are yet to be commenced. This paper compares the law and its practical implications currently and under the new legislation. Quick reference algorithms for frontline clinicians are proposed.
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- 2023
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16. Quantifying Jump Height Using Markerless Motion Capture with a Single Smartphone.
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Aderinola TB, Younesian H, Whelan D, Caulfield B, and Ifrim G
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Goal: The countermovement jump (CMJ) is commonly used to measure lower-body explosive power. This study evaluates how accurately markerless motion capture (MMC) with a single smartphone can measure bilateral and unilateral CMJ jump height. Methods: First, three repetitions each of bilateral and unilateral CMJ were performed by sixteen healthy adults (mean age: 30.87 [Formula: see text] 7.24 years; mean BMI: 23.14 [Formula: see text] 2.55 [Formula: see text]) on force plates and simultaneously captured using optical motion capture (OMC) and one smartphone camera. Next, MMC was performed on the smartphone videos using OpenPose. Then, we evaluated MMC in quantifying jump height using the force plate and OMC as ground truths. Results: MMC quantifies jump heights with ICC between 0.84 and 0.99 without manual segmentation and camera calibration. Conclusions: Our results suggest that using a single smartphone for markerless motion capture is promising.
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- 2023
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17. Predictors of Increased Fragility Index Scores in Surgical Randomized Controlled Trials: An Umbrella Review.
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Vivekanantha P, Shah A, Hoit G, Ayeni O, and Whelan D
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- Humans, Randomized Controlled Trials as Topic, Systematic Reviews as Topic, Sample Size, Research Design, Orthopedics
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Background: The fragility index (FI) is defined as the minimum number of patients or subjects needed to switch experimental groups for statistical significance to be lost in a randomized control trial (RCT). This index is used to determine the robustness of a study's findings and recently as a measure of evaluating RCT quality. The objective of this review was to identify and describe published systematic reviews utilizing FI to evaluate surgical RCTs and to determine if there were common factors associated with higher FI values., Methods: Three databases (PubMed, MEDLINE [Ovid], Embase) were searched, followed by a subsequent abstract/title and full-text screening to yield 50 reviews of surgical RCTs. Authors, year of publication, name of journal, study design, number of RCTs, subspecialty, sample size, median FI, patients lost to follow-up, and associations between variables and FI scores were collected., Results: Among 1007 of 2214 RCTs in 50 reviews reporting FI (median sample size 100), the pooled median FI was 3 (IQR: 1-7). Most reviews investigated orthopaedic surgery RCTs (n = 32). There was a moderate correlation between FI and p value (r = 0.-413), a mild correlation between FI and sample size (r = 0.188), and a mild correlation between FI and event number (r = 0.129)., Conclusion: Based on a limited sample of systematic reviews, surgical RCT FI values are still low (2-5). Future RCTs in surgery require improvement to study design in order to increase the robustness of statistically significant findings., (© 2023. The Author(s) under exclusive licence to Société Internationale de Chirurgie.)
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- 2023
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18. Hollow silicon microneedles, fabricated using combined wet and dry etching techniques, for transdermal delivery and diagnostics.
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O'Mahony C, Sebastian R, Tjulkins F, Whelan D, Bocchino A, Hu Y, O'Brien J, Scully J, Hegarty M, Blake A, Slimi I, Clover AJP, Lyness A, and Kelleher AM
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- Humans, Administration, Cutaneous, Drug Delivery Systems instrumentation, Microinjections instrumentation, Microinjections methods, Reproducibility of Results, Skin, Manufacturing Industry, Needles, Silicon, Equipment Design methods
- Abstract
Microneedle-based technologies are the subject of intense research and commercial interest for applications in transdermal delivery and diagnostics, primarily because of their minimally invasive and painless nature, which in turn could lead to increased patient compliance and self-administration. In this paper, a process for the fabrication of arrays of hollow silicon microneedles is described. This method uses just two bulk silicon etches - a front-side wet etch to define the 500 μm tall octagonal needle structure itself, and a rear-side dry etch to create a 50 μm diameter bore through the needle. This reduces the number of etches and process complexity over the approaches described elsewhere. Ex-vivo human skin and a customised applicator were used to demonstrate biomechanical reliability and the feasibility of using these microneedles for both transdermal delivery and diagnostics. Microneedle arrays show no damage even when applied to skin up to 40 times, are capable of delivering several mL of fluid at flowrates of 30 μL/min, and of withdrawing 1 μL of interstitial fluid using capillary action., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2023
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19. Use of an Artificial Intelligence Conversational Agent (Chatbot) for Hip Arthroscopy Patients Following Surgery.
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Dwyer T, Hoit G, Burns D, Higgins J, Chang J, Whelan D, Kiroplis I, and Chahal J
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Purpose: The purpose of this study was to evaluate the use of an AI conversational agent during the postoperative recovery of patients undergoing elective hip arthroscopy., Methods: Patients undergoing hip arthroscopy were enrolled in a prospective cohort for their first 6 weeks following surgery. Patients used standard SMS text messaging to interact with an artificial intelligence (AI) chatbot ("Felix") used to initiate automated conversations regarding elements of postoperative recovery. Patient satisfaction was measured at 6 weeks after surgery using a Likert scale survey. Accuracy was determined by measuring the appropriateness of chatbot responses, topic recognition, and examples of confusion. Safety was measured by evaluating the chatbot's responses to any questions with potential medical urgency., Results: Twenty-six patients were enrolled with a mean age of 36 years, and 58% ( n = 15) were male. Overall, 80% of patients ( n = 20) rated the helpfulness of Felix as good or excellent. In the postoperative period, 12/25 (48%) patients reported being worried about a complication but were reassured by Felix and, thus, did not seek medical attention. Of a total of 128 independent patient questions, Felix handled 101/128 questions appropriately (79%), either by addressing them independently, or facilitating contact with the care team. Felix was able to adequately answer the patient question independently 31% of the time ( n = 40/128). Of 10 patient questions that were thought to potentially represent patient complications, in 3 cases Felix did not adequately address or recognize the health concern-none of these situations resulted in patient harm., Conclusion: The results of this study demonstrate that the use of a chatbot or conversational agent can enhance the postoperative experience for hip arthroscopy patients, as demonstrated by high levels of patient satisfaction., Levels of Evidence: Level IV, therapeutic case series., (© 2023 The Authors.)
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- 2023
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20. Video head impulse testing: Pitfalls in neurological patients.
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Koohi N, Mendis S, Lennox A, Whelan D, and Kaski D
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- Humans, Head Impulse Test methods, Reflex, Vestibulo-Ocular, Saccades, Reference Values, Nystagmus, Pathologic diagnosis, Nystagmus, Pathologic etiology, Ocular Motility Disorders
- Abstract
The video head impulse test (vHIT) assesses the vestibulo-ocular reflex (VOR) during a rapid high-velocity low amplitude (10°-20°) head rotation. Patients with peripheral vestibulopathy have a reduced VOR gain with corrective catch-up saccades during the head turn. There are several pitfalls, mainly technical, which may interfere with interpretation of vHIT data. In addition, intrusive eye movement disorders such as spontaneous nystagmus that affect normal eye position and tracking can affect the vHIT results. To date there has been little study of neurological saccadic eye movements that may interfere with the interpretation of vHIT data. Here, in ten patients with a range of central neurological disorders, we describe oculomotor abnormalities on vHIT in the presence of normal range VOR gain values, recorded at a tertiary vestibular neurology service., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2022
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21. The effect of approach bias modification during alcohol withdrawal treatment on craving, and its relationship to post-treatment alcohol use in a randomised controlled trial.
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Garfield JBB, Piccoli LR, Whelan D, Staiger PK, Reynolds J, Piercy H, Lubman DI, Verdejo-Garcia A, and Manning V
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- Aftercare, Australia, Craving, Humans, Patient Discharge, Recurrence, Alcoholism psychology, Alcoholism therapy, Substance Withdrawal Syndrome psychology, Substance Withdrawal Syndrome therapy
- Abstract
Background: Approach bias modification (ApBM) for alcohol use disorder helps prevent relapse, yet the psychological mechanisms underlying its efficacy remain unclear. Alcohol craving predicts relapse and appears to be related to the biased processing of alcohol stimuli which is reduced by ApBM. However, there is little research examining whether ApBM reduces alcohol craving., Methods: In a randomised controlled trial testing the effect of 4 ApBM sessions (vs. sham training) on post-treatment alcohol use in 300 alcohol withdrawal inpatients, we administered the Alcohol Craving Questionnaire - Short Form - Revised (ACQ-SF-R) pre and post-training and at 2-week, 3, 6 and 12-month follow ups; and a cue-induced craving measure pre and post training., Results: Groups did not significantly differ in terms of declines in ACQ-SF-R total scores (p = .712) or cue-induced craving (p = .841) between the first and last training session, nor in terms of ACQ-SF-R scores at follow-ups (p = .509). However, the ACQ-SF-R Expectancy subscale, which assesses craving based on anticipated positive reinforcement from alcohol, was significantly lower in the ApBM group than in controls following training (p = .030), although the group x time interaction for this subscale was non-significant (p = .062). Post-intervention Expectancy scores mediated only a small portion of ApBM's effect on post-discharge alcohol use (14% in intention-to-treat analysis, p = .046; 15% in per-protocol analysis, p = .020)., Conclusions: ApBM does not appear to have robust, sustained effects on alcohol craving. Reduced craving is unlikely to account for ApBM's relapse prevention effects. However, further research on whether ApBM's effects are related to devaluation of alcohol reward expectancy is warranted., Trial Registration: Australian New Zealand Clinical Trials Registry Identifier: ACTRN12617001241325., Competing Interests: Conflict of interest A/Prof Manning and Mr Piercy are founders, directors and shareholders of Cognitive Training Solutions Pty Ltd, which recently began commercialising the ‘SWiPE’ smartphone application, which offers approach bias modification. Dr Lubman has provided consultancy advice to Lundbeck and Indivior outside the submitted work; has received travel support and speaker honoraria from AstraZeneca, Camurus, Indivior, Janssen, Lundbeck, Shire, and Servier outside the submitted work; and has been an investigator on an untied education grant from Sequirus unrelated to the current work. Dr Reynolds has received grants from AbbVie outside the submitted work, being a former employee of Novartis AG (2009–2012), and holding shares in Novartis AG and ALCON. Dr Verdejo-Garcia has received personal fees from Servier and Elsevier outside the submitted work, and is part of the Scientific Advisory Board of Monclarity/Brainwell, which produces cognitive training games (but does not receive any honorarium for this role). No other authors have any conflicts of interest to declare., (Copyright © 2022 Elsevier B.V. All rights reserved.)
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- 2022
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22. The analgesic benefit of Pericapsular Nerve Group (PENG) block in hip arthroscopic surgery: a retrospective pragmatic analysis at an academic health center.
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Patel V, Patel V, Abdallah F, Whelan D, Bansal S, Gabra M, and Brull R
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Introduction: The novel pericapsular nerve group (PENG) block has recently been reported to provide effective motor-sparing local anesthetic-based analgesia to the hip joint. We aimed to evaluate the analgesic efficacy and safety of a preoperative PENG block among patients undergoing ambulatory hip arthroscopic surgery where systemic analgesia is the gold standard., Methods: We conducted a single-center, retrospective pragmatic exploratory cohort study of consecutive outpatient hip arthroscopic surgery cases from January 2017 to March 2019. We identified 164 cases in which patients received general anesthesia with or without a preoperative PENG block. The primary analgesic outcome measures were time to first postoperative analgesic request, intraoperative and postoperative opioid consumption (intravenous morphine equivalent), and postoperative pain severity (visual analog scale 10 cm scale ranging from 0=no pain to 10=severe pain) in hospital. Secondary outcomes included duration of stay in the postanesthesia care unit, opioid-related side effects, time to discharge readiness, and block-related complications., Results: Seventy-five cases received a preoperative PENG block and 89 cases received systemic analgesia alone. The addition of a PENG block reduced intraoperative (6.6 mg vs 7.5 mg, difference: 0.9 mg; 95% CI 0.2 to 1.7; p=0.01) and postoperative (10.7 mg vs 13.9 mg, difference: 3.2 mg; 95% CI 0.9 to 5.5; p=0.01) intravenous morphine consumption, as well as the mean (3.5 vs 4.2, difference: 0.7; 95% CI 0.1 to 1.3; p=0.03) and highest (5.5 vs 6.5, difference: 1.0; 95% CI 0.2 to 1.7; p=0.02) postoperative pain severity scores in hospital. The PENG block did not prolong the time to first analgesic request (15.8 min vs 12.3 min, difference: 3.5 min; 95% CI -9.0 to 2.0; p=0.23). Fewer patients in the PENG group experienced postoperative nausea and vomiting compared with systemic analgesia alone (36% vs 52%, OR 1.9; 95% CI 1.0 to 3.6; p=0.02), while the PENG block expedited discharge readiness (165.0 min vs 202.8 min, difference: 37.8 min; 95% CI 2.9 to 72.3; p=0.04). No block-related complications were noted in any patient., Discussion: Based on our retrospective dataset, this pragmatic exploratory cohort study suggests that a preoperative PENG block is associated with questionable improvements in postoperative in-hospital analgesic outcomes which may or may not prove to be clinically relevant when compared with systemic analgesia alone for patients undergoing hip arthroscopic surgery. This small signal should be investigated in a prospective randomized trial., Competing Interests: Competing interests: None declared., (© American Society of Regional Anesthesia & Pain Medicine 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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23. Wide Variability in Return-to-Sport Criteria used by Team Physicians After Anterior Cruciate Ligament Reconstruction in Elite Athletes-A Qualitative Study.
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Betsch M, Darwich A, Chang J, Whelan D, Ogilvie-Harris D, Chahal J, and Theodoropoulos J
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Purpose: The purpose of this study is to explore currently used readiness to return to sport (RTS) criteria after anterior cruciate ligament reconstruction (ACLR) used in elite athletes to gain novel insights into the RTS decision-making process of professional team physicians., Methods: Eighteen qualitative semistructured interviews with professional team physicians were conducted by a single trained interviewer. The interviews were used to identify team physician concepts and themes regarding the criteria used to determine RTS after ACLR. General inductive analysis and a coding process were used to identify themes and subthemes arising from the data. A hierarchical approach in coding helped to link themes., Results: The most important RTS criteria included muscle strength, followed by satisfactory functional testing including hop tests, a satisfactory clinical examination, joint stability, psychological readiness, time since the ACLR surgery, absence of joint effusion, subjective feeling of knee stability, pain-free return to sporting movements, completion of a sport-specific rehabilitation, and at last allied team support., Conclusions: This study identified 4 main themes, including (1) objective findings, (2) informative feedback of the team members, (3) subjective findings, and (4) type of sport and time to surgery as having the most influence on RTS decision after ACLR. However, interviews showed that even among professional team physicians, the main criteria to RTS in these categories were inconsistent. A definitive set of conclusive guidelines could not be established and would be a fruitful and useful area for future research through further quantitative studies and international consensus meetings along the foundation of the presenting study., Level of Evidence: V, evidence-based practices, qualitative study., (© 2022 Published by Elsevier Inc. on behalf of the Arthroscopy Association of North America.)
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- 2022
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24. The current evidence for substance use disorder apps.
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Manning V, Whelan D, and Piercy H
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- Behavior Therapy, Humans, Smartphone, Mobile Applications, Substance-Related Disorders therapy, Telemedicine methods
- Abstract
Purpose of Review: New mHealth (smartphone) apps for substance use disorders (SUD) are emerging at an accelerated rate, with consumer choice typically guided by app-store user ratings rather than their effectiveness. The expansive reach, low-cost and accessibility of mHealth apps have driven their popularity and appeal as alternatives to traditional treatment; as such, rigorously establishing their effectiveness is of paramount importance., Recent Findings: Several systematic reviews conclude that the evidence-base for mHealth SUD apps is weak, inconclusive and hampered by substantial heterogeneity in study designs. However, there have been a number of interesting and novel developments in this area in recent years, which have not been synthesised to date., Summary: Most mHealth apps deliver either multiple-component behaviour change techniques, discrete psychological interventions or cognitive training interventions, or are designed to act as adjuncts to facilitate the delivery of clinical or continuing care. There are promising signals of their feasibility, acceptability and preliminary effectiveness in numerous open-label pilot studies of mHealth apps targeting alcohol and smoking. However, only a handful of sufficiently-powered, well-designed randomised controlled trials have been conducted to date with mixed findings. Furthermore, there has been limited recent attention on mHealth apps aiming to improve outcomes for individuals using other drugs., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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25. Single and double bundle posterior cruciate ligament reconstruction yield comparable clinical and functional outcomes: a systematic review and meta-analysis.
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Krott NL, Wengle L, Whelan D, Wild M, and Betsch M
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- Humans, Knee Joint surgery, Lysholm Knee Score, Treatment Outcome, Anterior Cruciate Ligament Injuries surgery, Joint Instability surgery, Posterior Cruciate Ligament surgery, Posterior Cruciate Ligament Reconstruction methods
- Abstract
Purpose: To perform a systematic review and compare the functional and objective outcomes after single-bundle (SB) vs. double-bundle (DB) posterior cruciate ligament reconstruction (PCLR). Where possible to pool outcomes and arrive at summary estimates of treatment effect for DB PCLR vs. SB PCLR via an embedded meta-analysis., Methods: A comprehensive PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) literature search identified 13 eligible studies evaluating clinical outcomes of both techniques for PCLR. Clinical outcome measures included in the meta-analysis were functional outcomes (Lysholm Score, Tegner Activity Scale) and objective measurements of posterior laxity of the operated knee (arthrometer and stress radiographs)., Results: The meta-analysis included 603 patients. Three hundred and fifteen patients were treated with SB and two hundred and eighty-eight patients with DB PCLR. There were no significant differences between SB and DB PCLR in postoperative functional Lysholm Scores (CI [- 0.18, 0.17]), Tegner Activity Scales (CI [- 0.32, 0.12]) and IKDC objective grades (CI [- 0.13, 1.17]). Regarding posterior stability using KT-1000 and Kneelax III arthrometer measurements, there were no differences between the SB and DB group. However, double-bundle reconstruction provided better objective outcome of measurement of posterior laxity (CI [0.02, 0.46]) when measured with Telos stress radiography., Conclusion: A systematic review was conducted to identify current best evidence pertaining to DB and SB PCLR. An embedded meta-analysis arrived at similar summary estimates of treatment effect for motion, stability and overall function for both techniques. There is no demonstrable clinically relevant difference between techniques based on the currently available evidence., Level of Evidence: III., (© 2022. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA).)
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- 2022
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26. Descriptive epidemiology of variants of infectious salmon anaemia virus in four Atlantic salmon farms in Newfoundland and Labrador, Canada.
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Romero JF, Gardner IA, Hammell L, Groman D, Whelan D, O'Brien N, Hawkins LJ, Burnley H, and Thakur K
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- Animals, Canada, Newfoundland and Labrador, Phylogeny, Fish Diseases epidemiology, Isavirus genetics, Orthomyxoviridae Infections epidemiology, Orthomyxoviridae Infections veterinary, Salmo salar
- Abstract
An incursion of infectious salmon anaemia virus (ISAV) was detected in 2020 in southern Newfoundland, Canada. This resulted in an outbreak affecting four marine farms stocking Atlantic salmon (Salmo salar L.) vaccinated against ISAV. This study provides the first description of epidemiologic characteristics of an ISAV outbreak in 2020 and 2021, and detected ISAV variants at the population level. Fish kidneys were screened for ISAV by real-time RT-PCR and non-negative samples were submitted for genotyping and further diagnostic testing. Nine distinct ISAV variants were identified: five European and three North American (NA) HPRΔ ISAV, and one NA-HPR0 ISAV variant. A notable finding was the concurrent detection of both an HPR0 and an HPRΔ ISAV variant in one individual fish. In two farms, both European and NA variants were simultaneously detected, while in the other two farms either NA or European variants were identified, but not both together. Generally, mortality increases followed rises in ISAV prevalence and cycle threshold values on RT-PCR decreased with time. Epidemiologic descriptions of ISAV outbreaks in Atlantic Canada contributes to the understanding of local disease dynamics and identification of changes thereof. Such insights are essential for the strengthening of disease management plans., (© 2022 John Wiley & Sons Ltd.)
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- 2022
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27. Effect of Osteochondroplasty on Time to Reoperation After Arthroscopic Management of Femoroacetabular Impingement: Analysis of a Randomized Controlled Trial.
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Kay J, Simunovic N, Ayeni OR, Bhandari M, Bedi A, Järvinen T, Musahl V, Naudie D, Seppänen M, Slobogean G, Thabane L, Duong A, Skelly M, Shanmugaraj A, Crouch S, Sprague S, Heels-Ansdell D, Buckingham L, Ramsay T, Lee J, Kousa P, Carsen S, Choudur H, Sim Y, Johnston K, Wong I, Murphy R, Sparavalo S, Whelan D, Khan R, Wood GCA, Howells F, Grant H, Zomar B, Pollock M, Willits K, Firth A, Wanlin S, Remtulla A, Kaniki N, Belzile EL, Turmel S, Jørgensen U, Gam-Pedersen A, Sihvonen R, Raivio Sihvonen M, Toivonen Sihvonen P, and Pirjetta Routapohja M
- Abstract
Background: A subset of patients with femoroacetabular impingement (FAI) fail arthroscopic management. It is not clear which patients will fail surgical management; however, several surgical and patient factors, such as type of procedure and age, are thought to be important predictors., Purpose: This time-to-event analysis with a 27-month follow-up analysis compared the effect of (1) arthroscopic osteochondroplasty with or without labral repair versus (2) arthroscopic lavage with or without labral repair on the time to reoperation in adults aged 18 to 50 years with FAI., Study Design: Randomized controlled trial; Level of evidence, 1., Methods: Eligible participants had been randomized in a previous study trial to a treatment of arthroscopic osteochondroplasty or arthroscopic lavage with or without labral repair. Using the comprehensive data set from the Multinational Femoroacetabular Impingement Randomized controlled Trial, all reoperations until 27 months after surgery were identified. The analysis was conducted using a Cox proportional hazards model, with percentage of patients with a reoperation evaluated in a time-to-event analysis as the outcome. The independent variable was the procedure, with age and impingement subtype explored as potential covariates. The effects from the Cox model were expressed as the hazard ratio (HR). All tests were 2-sided, with an alpha level of .05., Results: A total of 108 patients in the osteochondroplasty group and 106 patients in the lavage group were included. The mean age of the patients included in the study was 36 ± 8.5 years. Overall, 27 incident reoperations were identified within the 27-month follow-up, with an incidence rate of 6 per 100 person-years. Within the osteochondroplasty group, 8 incident reoperations were identified (incidence rate, 3.4 per 100 person-years), while within the lavage group, 19 incident reoperations were identified (incidence rate, 8.7 per 100 person-years). The hazard of reoperation for patients undergoing osteochondroplasty was 40% of that of patients undergoing lavage (HR, 0.40 [95% CI, 0.17-0.91] P = .029)., Conclusion: This study demonstrated that for adults between the ages of 18 and 50 years with FAI, arthroscopic osteochondroplasty was associated with a 2.5-fold decrease in the hazard of reoperation at any point in time compared with arthroscopic lavage., Registration: NCT01623843 (ClinicalTrials.gov identifier)., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: Research grants were received from the Canadian Institutes of Health Research (to O.R.A., M.B.); the American Orthopaedic Society for Sports Medicine (to O.R.A.); the Canadian Orthopaedic Foundation (to O.R.A.); McMaster Surgical Associates (to O.R.A.); and Hamilton Health Sciences Department of Surgery (to O.R.A.) for the Femoroacetabular Impingement Randomized controlled Trial. V.M. has received education payments from Arthrex; consulting fees from Smith & Nephew and Stryker; and nonconsulting fees from Smith & Nephew. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto., (© The Author(s) 2022.)
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- 2022
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28. A Survey of Treatment Trends for Acute Quadriceps Tendon Ruptures Among North American Surgeons.
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Matthies NF, Paul RA, Dwyer T, Chahal J, and Whelan D
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Background: To date, little clinical evidence exists to support a specific surgical technique or postoperative rehabilitation protocol for quadriceps tendon ruptures. With a lack of evidence-based superiority, assessment of clinical practices and surgeon preferences is pertinent., Purpose: To describe the current surgical technique and rehabilitation preferences among members of the Canadian Orthopaedic Association and American Orthopaedic Society for Sports Medicine pertaining to acute quadriceps tendon rupture., Study Design: Cross-sectional study., Methods: Orthopaedic staff members of the Canadian Orthopaedic Association and American Orthopaedic Society for Sports Medicine were invited to complete an internet-based survey composed of 26 questions assessing current trends in the management and rehabilitation of acute quadriceps tendon rupture. Survey questions were developed after a thorough review of current literature. Survey responses were analyzed and reported using descriptive statistics (absolute values, frequencies, and percentages) where appropriate. Statistical comparisons and contrasts between Canadian and American surgeons were made using chi-square analyses and Student t tests., Results: A total of 264 surgeons participated in the survey (136 Canadians; 128 Americans). Canadian surgeons were more likely to obtain a preoperative ultrasound as compared with Americans (43.0% vs 6.7%; P < .00001), while American respondents were more likely to obtain magnetic resonance imaging scans (65.8% vs 10.2%; P < .00001). The transosseous drill hole technique was the most commonly utilized (70.2%); the suture anchor technique was used 20.6% of the time. Canadian respondents trended toward a higher use of transosseous tunnels; however, this was not statistically significant (75.8% vs 64.2%; P = .068). American respondents were more likely to utilize suture anchors (27.5% vs 14.1%; P = .0096). Most respondents advanced range of motion goals stepwise in 2-week intervals of 30° (Canadians, 54.0% vs Americans, 58.5%; P = .3091); timing of range of motion initiation varied., Conclusion: Among North American surgeons who responded to this study, the transosseous technique was the most commonly used, and range of motion was generally advanced in a 2-week stepwise fashion. We found several differences in practice between Canadian and American respondents, including the type of preoperative imaging and the frequency of using the suture anchor technique., Competing Interests: The authors have declared that there are no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto., (© The Author(s) 2022.)
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- 2022
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29. A special issue of the Australian society for Biophysics.
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Dos Remedios C, Cranfield C, Whelan D, Cox C, Shearwin K, Ho J, Allen T, Shibuya R, Hibino E, Hayashi K, and Li A
- Abstract
On behalf of the Australian Society for Biophysics (ASB) and the Editors of this Special Issue, I would like to express our appreciation to Editor-in-Chief, Damien Hall, for arranging the publication of this Special Issue. The ASB is about five times smaller than our sister the Biophysical Society for Japan (BSJ) and tenfold smaller than the US Biophysical Society (USBS), but our meetings are notable because of the encouragement the Society gives to emerging biophysicists. It can be a terrifying experience for a PhD student to have to face a roomful of professors and senior academics, but invariably they appreciate the experience. Another feature of the ASB meetings is the inclusion of contributions from the Asian Pacific region. We now have formal ties with our New Zealand colleagues and our meetings with the BSJ contain joint sessions (see below). In 2020, despite the impact of COVID-19 (see Adam Hill's Commentary), there is a joint session with the University of California Davis. This Special Issue comprises 2 Editorials, 3 Commentaries, and 25 reviews., Competing Interests: Competing interestsThe authors declare no competing interests., (© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2022.)
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- 2022
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30. Six Percent Incidence of Graft-Tunnel Mismatch in Anatomic Anterior Cruciate Ligament Reconstruction Using Bone-Patella Tendon-Bone Autograft and Anteromedial Portal Drilling.
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Dwyer T, Hoit G, Sellan M, Gopinath R, Whelan D, Theodoropoulos J, and Chahal J
- Abstract
Purpose: The purpose of this study was to determine the incidence of graft-tunnel mismatch (GTM) when performing anatomic anterior cruciate ligament reconstruction (ACLR) using bone-patella tendon-bone (BPTB) grafts and anteromedial portal drilling., Methods: Beginning in November 2018, 100 consecutive patients who underwent ACLR by two sports fellowship-trained, orthopedic surgeons using BPTB autograft and anteromedial portal drilling were prospectively identified. The BPTB graft dimensions and the femoral tunnel distance, tibial tunnel distance, intra-articular distance, and total distance were measured. Surgeons determined the depth and angle of tunnels based on the patella tendon graft length dimensions in each case. After passage of the graft, the distance from the distal graft tip to the tibial cortex aperture was measured. GTM was defined as the need for additional measures to obtain satisfactory tibial graft fixation (<15-20 mm of bone fixation)., Results: The incidence of mismatch was 6/100 (6%). Five cases involved the graft being too long, with the tibial bone plug protruding excessively from the tibial tunnel-4/5 had a patella tendon length ≥ 50 mm. Three cases were managed with femoral tunnel recession, and two were treated with a free bone plug technique. One patient with a patella tendon length of 35 mm had a graft that was too short, with the tibial bone plug recessed in the tibial tunnel. Of patients whose tibial tunnel distance was within 5 mm of the patella tendon length, only 1/46 (2%) patients had mismatch, whereas 5/54 (9%) of patients who had >5 mm difference had mismatch., Conclusions: The incidence of graft-tunnel mismatch after anatomic ACLR using BTPB and anteromedial portal drilling in this study is 6%. To limit the occurrence of GTM where the graft is too long, surgeons should drill tibial tunnel distances within 5 mm of the patella tendon length., Clinical Relevance: The results of this study provide surgeons with a technique of limiting graft tunnel mismatch when performing ACLR using BPTB and anteromedial portal drilling., (© 2021 The Authors.)
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- 2021
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31. Development and clinical translation of tubular constructs for tracheal tissue engineering: a review.
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Soriano L, Khalid T, Whelan D, O'Huallachain N, Redmond KC, O'Brien FJ, O'Leary C, and Cryan SA
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- Adult, Child, Humans, Tissue Scaffolds, Tissue Engineering, Trachea surgery
- Abstract
Effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or congenital abnormalities remains an unmet clinical need in respiratory medicine. The trachea is a 10-11 cm long fibrocartilaginous tube of the lower respiratory tract, with 16-20 tracheal cartilages anterolaterally and a dynamic trachealis muscle posteriorly. Tracheal resection is commonly offered to patients suffering from short-length tracheal defects, but replacement is required when the trauma exceeds 50% of total length of the trachea in adults and 30% in children. Recently, tissue engineering (TE) has shown promise to fabricate biocompatible tissue-engineered tracheal implants for tracheal replacement and regeneration. However, its widespread use is hampered by inadequate re-epithelialisation, poor mechanical properties, insufficient revascularisation and unsatisfactory durability, leading to little success in the clinical use of tissue-engineered tracheal implants to date. Here, we describe in detail the historical attempts and the lessons learned for tracheal TE approaches by contextualising the clinical needs and essential requirements for a functional tracheal graft. TE manufacturing approaches explored to date and the clinical translation of both TE and non-TE strategies for tracheal regeneration are summarised to fully understand the big picture of tracheal TE and its impact on clinical treatment of extensive tracheal defects., Competing Interests: Conflict of interest: L. Soriano has nothing to disclose. Conflict of interest: T. Khalid has nothing to disclose. Conflict of interest: D. Whelan has nothing to disclose. Conflict of interest: N. O'Huallachain has nothing to disclose. Conflict of interest: K.C. Redmond has nothing to disclose. Conflict of interest: F.J. O'Brien has nothing to disclose. Conflict of interest: C. O'Leary has nothing to disclose. Conflict of interest: S.A. Cryan has nothing to disclose., (Copyright ©The authors 2021.)
- Published
- 2021
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