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Soluble redox species that facilitate the oxygen reduction reaction by mediating the LiO2 intermediate and consequently the formation of the Li2O2 have attracted considerable interest for Li–O2 batteries. Based on extensive radical studies, this work discloses a distinct solution reaction route when a quinone derivative was employed as a redox mediator. [ABSTRACT FROM AUTHOR]

Catalytic nanomedicine, especially artificial enzymes, exhibit obvious merits over traditional nanomedicine. However, the lack of controllability over an enzymatic process seriously challenges the therapeutic performance. Herein, we present a concept of using piezoelectric enzymes in combination with biocomputation ability. As a paradigm, MnTiO 3 nanodisks were prepared with multiple enzyme-mimicking activity, including glutathione oxidase, peroxidase, and catalase. Different from the conventional artificial enzymes, the enzymatic activity of MnTiO 3 nanodisks was activated by ultrasound and switched by a tumor microenvironment, which allows precise control over enzymatic catalysis in tumors. By virtue of the multiple artificial enzyme activity of MnTiO 3 nanodisks, a biocomputing platform was constructed based on a Boolean logic-based algorithm. With ultrasound and tumor microenvironment as input signals, cytotoxicity was output via logic-based biocomputation for programed tumor killing. The concept of piezoelectric enzymes together with a biocomputation strategy provides an intelligent and effective approach for catalytic tumor eradication.

Soluble redox species that facilitate the oxygen reduction reaction by mediating the LiO 2 intermediate and consequently the formation of the Li 2 O 2 have attracted considerable interest for Li-O 2 batteries. Based on extensive radical studies, this work discloses a distinct solution reaction route when a quinone derivative was employed as a redox mediator.