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The development of organic electronic applications has reached a critical point. While markets, including the Internet of Things, transparent solar and flexible displays, gain momentum, organic light-emitting diode displays lead the way, with a current market size of over $25 billion, helping to create the infrastructure and ecosystem for other applications to follow. It is imperative to design built-in sustainability into the materials selection, processing and device architectures of all of these emerging applications, and to close the loop for a circular approach. In this Perspective, we evaluate the status of embedded carbon in organic electronics, as well as options for more sustainable materials and manufacturing, including engineered recycling solutions that can be applied within the product architecture and at the end of life. This emerging industry has a responsibility to ensure a 'cradle-to-cradle' approach. We highlight that ease of dismantling and recycling needs to closely relate to the product lifetime, and that regeneration should be facilitated in product design. Materials choices should consider the environmental effects of synthesis, processing and end-product recycling as well as performance., (© 2023. Springer Nature Limited.)

Ancient fluvial deposits typically display repetitive changes in their depositional architecture such as alternating intervals of coarse-grained highly amalgamated (HA), laterally-stacked, channel bodies, and finer-grained less amalgamated (LA), vertically-stacked, channels encased in floodplain deposits. Such patterns are usually ascribed to slower, respectively higher, rates of base level rise (accommodation). However, "upstream" factors such as water discharge and sediment flux also play a potential role in determining stratigraphic architecture, yet this possibility has never been tested despite the recent advances in the field of palaeohydraulic reconstructions from fluvial accumulations. Here, we chronicle riverbed gradient evolution within three Middle Eocene (~ 40 Ma) fluvial HA-LA sequences in the Escanilla Formation in the south-Pyrenean foreland basin. This work documents, for the first time in a fossil fluvial system, how the ancient riverbed systematically evolved from lower slopes in coarser-grained HA intervals, and higher slopes in finer-grained LA intervals, suggesting that bed slope changes were determined primarily by climate-controlled water discharge variations rather than base level changes as often hypothesized. This highlights the important connection between climate and landscape evolution and has fundamental implications for our ability to reconstruct ancient hydroclimates from the interpretation of fluvial sedimentary sequences., (© 2023. The Author(s).)

First-line treatment for nonalcoholic fatty liver disease (NAFLD) focuses on weight loss through lifestyle modifications. 1,2 Weight loss ≥5% results in reduction of steatosis and weight loss ≥10% has been associated with improvement in hepatic inflammation and fibrosis. 3 The incidence and sustainability of weight loss among patients with NAFLD were estimated and associating factors identified., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Cryoprotection is of interest in many fields of research, necessitating a greater understanding of different cryoprotective agents. Antifreeze proteins have been identified that have the ability to confer cryoprotection in certain organisms. Antifreeze proteins are an evolutionary adaptation that contributes to the freeze resistance of certain fish, insects, bacteria and plants. These proteins adsorb to an ice crystal's surface and restrict its growth within a certain temperature range. We investigated the ability of an antifreeze protein from the desert beetle Anatolica polita, ApAFP752, to confer cryoprotection in the frog Xenopus laevis. Xenopus laevis eggs and embryos microinjected with ApAFP752 exhibited reduced damage and increased survival after a freeze-thaw cycle in a concentration-dependent manner. We also demonstrate that ApAFP752 localizes to the plasma membrane in eggs and embryonic blastomeres and is not toxic for early development. These studies show the potential of an insect antifreeze protein to confer cryoprotection in amphibian eggs and embryos., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2022. Published by The Company of Biologists Ltd.)

Diversity within science, technology, engineering, and mathematics (STEM) remains disturbingly low. Relative to larger, highly funded universities, smaller schools harbor more diverse student demographics and more limited resources. Here, we propose four strategies leveraging the unique advantages of smaller institutions to advance underrepresented scholars along STEM pathways., (Copyright © 2021 Elsevier Inc. All rights reserved.)