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Wastewater-based epidemiology (WBE) is an effective, non-invasive method for monitoring the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by tracking viral prevalence in water. This study aimed to investigate the presence of SARS-CoV-2 in surface water in Vietnam over two years. One-step quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays were employed to quantify SARS-CoV-2 and its variant-specific mutation sites (G339D/E484A) and pepper mild mottle virus (PMMoV) from a total of 315 samples (105 samples per site) to compare with reported Coronavirus disease 2019 (COVID-19) cases and environmental factors. SARS-CoV-2 was detected in 38 % (40/105), 43 % (45/105), and 39 % (41/105) of water samples from Sites A, B, and C, respectively, with concentrations of 3.0-5.6 log 10 copies/L. PMMoV concentrations were 5.1-8.9 log 10 copies/L. SARS-CoV-2 levels were higher in winter compared with summer. There was a strong positive association between the mutant type and SARS-CoV-2 concentrations (Spearman's rho = 0.77, p < 0.01). The mean concentrations of mutant and nonmutant types were 2.3 and 1.8 log 10 copies/L, respectively. Peaks in SARS-CoV-2 concentrations preceded reported COVID-19 cases by 2-4 weeks, with the highest association observed at a 4-week delay (Pearson's correlation coefficient: 0.46-0.53). Environmental factors, including temperature, pH, and electrical conductivity, correlated negatively with SARS-CoV-2 (Spearman's rho = -0.21, -0.28, and -0.21, respectively, p < 0.05), whereas average rainfall, humidity, and dissolved oxygen correlated positively (Spearman's rho = 0.20, 0.27, and 0.51, respectively, p < 0.05). These correlations highlight the significance of environmental variables in understanding viral prevalence in water. Our findings confirmed the utility of WBE as an early warning system for long-term monitoring. Future research should incorporate environmental factors to improve prediction accuracy for clinical cases and other waterborne diseases., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Eiji Haramoto received research funding from Takara Bio Inc. The other authors declare that they have no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Hepatitis A and E viruses (HAV and HEV, respectively) remain a significant global health concern despite advancements in healthcare and vaccination programs. Regular monitoring and vaccine efficacy of HAV are still lacking in different countries. This study aimed to investigate HAV and HEV prevalence in developed, developing, and least-developed Asian countries using wastewater as a surveillance tool. A total of 232 untreated wastewater samples were collected from six wastewater treatment plants, a sewage treatment plant, or an open drainage in six countries [Nepal (n = 51), Indonesia (n = 37), Thailand (n = 30), Vietnam (n = 27), the Philippines (n = 17), and Japan (n = 70)] between April and October 2022. Viruses in wastewater were concentrated by simple centrifugation or polyethylene glycol precipitation method, followed by viral RNA extraction and reverse transcription-quantitative polymerase chain reaction. HAV and HEV RNA were detected in the samples from Nepal (51 % for HAV and 2 % for HEV), Thailand (3 % for both viruses), and Japan (1 % for HAV and 24 % for HEV). Only HAV RNA was found in 11 % of the samples in Indonesia, whereas only HEV RNA was detected in Vietnam and the Philippines, with a positive ratio of 15 % and 12 %, respectively. These results highlighted the geographic variability in HAV and HEV prevalence, underscoring the need for localized public health strategies to address specific viral hepatitis challenges in each country., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Introduction: Bacterial vaginosis (BV) is the most frequent vaginal infection affecting women of childbearing age worldwide. It is associated with significant adverse healthcare outcomes, especially during pregnancy. Although screening for BV could reduce potential pregnancy-related obstetric complications, there is no routine screening of pregnant women for BV in Vietnam. We aimed to identify the prevalence of BV among pregnant women and the associated factors in two tertiary hospitals in Hue, Vietnam., Methodology: This cross-sectional descriptive study included 885 pregnant women in third trimester, who received routine antenatal care in the Hue Central Hospital and Hue University Hospital of Medicine and Pharmacy, Hue city, Thua Thien Hue province, Vietnam. Gram-stained vaginal smears were used for calculating the Nugent score and recording the fungal elements., Results: In total, 435 (49.1%) women had a normal BV score, 352 (39.8%) had intermediate vaginal microbiota, and 98 (11.1%) had BV. Among the 98 women with BV, 71 (72.4%) also had fungal infection. There was a significant association of BV with discharge (p = 0.004) and abnormal cervix (p = 0.014). BV was significantly more frequent among the women who reported previous abortion or miscarriage (p = 0.007)., Conclusions: About a tenth of women in Thua Thien Hue province have BV in the third trimester of pregnancy being associated with previous adverse outcome. Discharge with fishy odour is still a characteristic feature among subtle clinical presentations of BV. Better awareness about this disease and routine test-and-treat management during pregnancy may improve pregnancy outcome., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2024 Anh TC Nguyen, Na TL Nguyen, Trang TQ Tran, Tuyen T Nguyen, Thu TA Hoang, Linh M Tran, Khoi Tuan Tran, Thanh DC Phan, Xuan T Nguyen, Tam M Le, An V Le, Andres Salumets, Reet Mändar.)

Environmental activism is crucial for raising public awareness and support toward addressing the climate crisis. However, using climate change mitigation as the cause for blockade, vandalism, and harassment activities might be counterproductive and risk causing negative repercussions and declining public support. The paper describes a dataset of metadata of 89 blockade, vandalism, and harassment events happening 13 countries in recent years. The dataset comprises three main categories: 1) Events, 2) Activists, and 3) Consequences. For researchers interested in environmental activism, climate change, and sustainability, the dataset is helpful in studying the effectiveness and appropriateness of strategies to raise public awareness and support. For researchers in the field of security studies and green criminology, the dataset offers resources to study features and impacts of blockade, vandalism, and harassment events. The Bayesian Mindsponge Framework (BMF) analytics was employed to validate the dataset. Consequently, the estimated result aligns with the Mindsponge Theory's theoretical reasoning., (© 2024 The Author(s).)

In this study, the vertical distribution of mercury (Hg) in estuarine and marine sediment porewaters and solid phases was assessed by conventional and passive sampling techniques in the historically polluted Scheldt Estuary and Belgian Coastal Zone (BCZ). The Diffusive Gradients in Thin-films (DGT) measured labile Hg concentrations (Hg LA ) were mostly lower than the porewater Hg concentrations (Hg PW ), and they also presented different vertical distribution patterns. Still high Hg concentrations in the sediment solid phases, comparable to the historical ones, were observed. Even though pH, redox potential and dissolved sulfide concentration could influence the Hg biogeochemical behaviour, organic matter (OM) played a key role in governing Hg mobilization from sediment solid phase to porewater and in its partitioning between porewater and solid phase over depth. In the marine sediments, where OM had a marine signature, higher labile Hg concentrations in the porewater and faster resupply from the solid phase were observed. The DGT technique showed significant potential not only for the measurement of bioavailable Hg fractions in porewater, but also for the assessment of kinetic parameters governing the release of labile Hg species from the solid phase with the assistance of the DGT Induced Fluxes in Sediments (DIFS) model., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Tianhui Ma reports financial support was provided by Research Foundation Flanders. Vincent Perrot reports financial support was provided by Research Foundation Flanders., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Hand, foot, and mouth disease (HFMD) is contagious and predominantly affects children below the age of five. HFMD-associated serotypes of Enterovirus A (EVA) family include EVA71, Coxsackievirus A type 6 (CVA6), 10 (CVA10), and 16 (CVA16). Although prevalent in numerous Asian countries, studies on HFMD-causing agents in wastewater are scarce. This study aimed to conduct wastewater surveillance in various Asian communities to detect and quantify serotypes of EVA associated with HFMD. In total, 77 wastewater samples were collected from Indonesia, the Philippines, Thailand, and Vietnam from March 2022 to February 2023. The detection ratio for CVA6 RNA in samples from Vietnam was 40 % (8/20). The detection ratio for CVA6 and EVA71 RNA each was 25 % (5/20) for the Indonesian samples, indicating the need for clinical surveillance of CVA6, as clinical reports have been limited. For the Philippines, 12 % (2/17) of the samples were positive for CVA6 and EVA71 RNA each, with only one quantifiable sample each. Samples from Thailand had a lower detection ratio (1/20) for CVA6 RNA, and the concentration was unquantifiable. Conversely, CVA10 and CVA16 RNAs were not detected in any of the samples. The minimum and maximum concentrations of CVA6 RNA were 2.7 and 3.9 log 10 copies/L and those for EVA71 RNA were 2.5 and 4.9 log 10 copies/L, respectively. This study underscores the importance of wastewater surveillance in understanding the epidemiology of HFMD-associated EVA serotypes in Asian communities. Long-term wastewater surveillance is recommended to monitor changes in dominant serotypes, understand seasonality, and develop effective prevention and control strategies for HFMD., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Silver nanoparticles (C. AgNPs) are synthesized by the biological reduction method using extracts from green tea leaves ( Camellia Sinensis ) collected from tea hills at an altitude of 100 m above the ground. The chemicals present in the tea leaf extract act as reducing agents used to reduce Ag + ions to silver atoms to form C. AgNPs in the solution. In this work, we optimized the C. AgNPs synthesis process by investigating the influence of reaction parameters such as concentration of tea leaf extract (1 ppm-50 ppm), reaction temperature (30 °C-60 °C), reaction time (5 min-100 min), and reaction rate (400 rpm-800 rpm) through absorption UV-Vis spectroscopy, TEM transmission electron microscopy, and spectroscopy X-ray. Organic compounds in tea leaf extract are detected by NMR measurement. The functional groups on the C. AgNPs are shown on the Fourier transform infrared (FTIR) spectrum. The C. AgNPs are used to degrade MB dye at 10 ppm concentration based on the photocatalytic effect using a 6500 K white light source. The C. AgNPs have also been studied for their antibacterial activity on two bacteria, Pseudomonas aeruginosa (P.A) and Staphylococcus aureus (S.A), while a positive control is Ampicillin 50 mg/ml and a negative control is H 2 O. The results reveal that the C. AgNPs with diameters in the range of 25 nm-55 nm degrade 10 ppm MB dye after 1 h with photodegradation efficiency up to 96 %. The antibacterial ability of C. AgNPs against both bacteria is good, even superior to that of Ampicillin . Furthermore, the particle synthesis efficiency and therefore the antibacterial activity as well as the photodegradation effect of C. AgNPs are higher than previously reported. At the same time, using green tea leaf extract to synthesize C. AgNPs creates environmentally friendly products. These useful behaviors are the potential to increase the scope and applicability of C. AgNPs, especially for biomedical applications in the near future., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)

Given the high fatality rate due to road traffic accidents in China, understanding the factors influencing aggressive driving behaviors among Chinese drivers is essential to alleviate the problem. The paper describes a dataset of 1039 Chinese drivers' driving behaviors and the socio-cultural factors associated with the behaviors. The dataset was collected through an online survey. The dataset comprises five main categories: 1) driving information, 2) aggressive driving behaviors, 3) friend/peer influence, 4) family influence, and 5) socio-demographic information. The dataset is valuable for public health and transportation researchers to explore factors influencing drivers' driving behaviors and public safety in China. The dataset's construct validity was confirmed by the Bayesian Mindsponge Framework (BMF) analytics. Specifically, the analysis shows that safe driving behaviors are affected by information promoting safe driving that is passively and actively absorbed from friends/peers (friends/peers being role models and friends'/peers' support, respectively). The result is consistent with the Mindsponge Theory's information-processing mechanism in human minds., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Author(s).)

The expanding integration of artificial intelligence (AI) in various aspects of society makes the infosphere around us increasingly complex. Humanity already faces many obstacles trying to have a better understanding of our own minds, but now we have to continue finding ways to make sense of the minds of AI. The issue of AI's capability to have independent thinking is of special attention. When dealing with such an unfamiliar concept, people may rely on existing human properties, such as survival desire, to make assessments. Employing information-processing-based Bayesian Mindsponge Framework (BMF) analytics on a dataset of 266 residents in the United States, we found that the more people believe that an AI agent seeks continued functioning, the more they believe in that AI agent's capability of having a mind of its own. Moreover, we also found that the above association becomes stronger if a person is more familiar with personally interacting with AI. This suggests a directional pattern of value reinforcement in perceptions of AI. As the information processing of AI becomes even more sophisticated in the future, it will be much harder to set clear boundaries about what it means to have an autonomous mind.

Working in academia is challenging, even more so for those with limited resources and opportunities. Researchers around the world do not have equal working conditions. The paper presents the structure, operation method, and conceptual framework of the SM3D Portal's community coaching method, which is built to help Early Career Researchers (ECRs) and researchers in low-resource settings overcome the obstacle of inequality and start their career progress. The community coaching method is envisioned by three science philosophies (cost-effectiveness, transparency spirit, and proactive attitude) and established and operated based on the Serendipity-Mindsponge-3D knowledge (SM3D) management framework (i.e., mindsponge thinking and Bayesian Mindsponge Framework analytics serve as the coaching program's foundational theory and analytical tools). The coaching method also embraces Open Science's values for lowering the cost of doing science and encouraging the trainees to be transparent, which is expected to facilitate the self-correcting mechanism of science through open data, open review, and open dialogue. Throughout the training process, members are central beneficiaries by gaining research knowledge and skills, acquiring publication as the training's product, and shifting their mindsets from "I can't do it" to "I can do it," and at the same time transforming a mentee to be ready for a future mentor's role. The coaching method is thus one of the members, for the member, by the members.•The paper provides the structure, operation method, and conceptual framework of the SM3D Portal's community coaching method, which is built to help Early Career Researchers (ECRs) and researchers in low-resource settings overcome the obstacle of inequality and start their career progress.•The paper presents three major science philosophies envisioning the establishment and operation of scholarly community coaching.•The paper employs the mindsponge theory and BMF analytics to construct a conceptual framework explaining how an environment is created to help shift members' mindsets from "I can't do it" to "I can do it.", Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Author(s).)

Introduction: The goal of this study was to compare the results of LPD with those of open pancreaticoduodenectomy (OPD)., Method: Data were retrospectively collected from a database of patients who underwent PD from January 2010 to May 2020. Intraoperative, postoperative, and follow-up assessment studies were conducted., Results: A total of 149 patients were selected. Compared with OPD, LPD was fewer intraoperative blood transfusions (p = 0.015), a longer median operative time (p < 0.001), hospital stay (p = 0.034), a higher rate of bile leakage (p = 0.02), overall morbidity (p = 0.045), and re-operation (p = 0.044). There was no difference between the two groups in severe pancreatic fistula, postoperative bleeding, delayed gastric emptying, Clavien-Dindo classification ≥ III, or 30-day mortality. LPD had a similar number of excised lymph nodes, R0 resection rate, and long-term survival cases involving malignant tumors, ampulla of Vater cancer, and pancreatic ductal adenocarcinoma., Conclusion: In the early period, the benefit of LPD has not been found as there was a high rate of conversion to laparotomy, morbidity, and re-operation. Despite that, LPD is a feasible oncological approach with long-term survival comparable to OPD., Competing Interests: Declaration of competing interest Authors declare no conflict of interest., (Copyright © 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. Published by Elsevier B.V. All rights reserved.)

Family caregivers in Canadian long-term care homes are estimated to provide 10 h per week of direct care to approximately 30% of residents through roles including mobility support, mealtime assistance, personal care, social interaction, psychological care, care coordination, and advocacy. Despite these contributions, they continue to be viewed as visitors rather than as key participants in the interdependent relationships that support the long-term care sector. Their marginalization was evident during the COVID-19 pandemic, as Canadian public health policy focused on preventing them from entering long-term care, rather than supporting personal risk management, symptom screening, personal protective equipment, and other mechanisms for safe involvement in care. Several iatrogenic resident outcomes have been attributed to this, including decreased cognitive function, decreased mobility, increased incontinence, weight loss, increased depression and anxiety, increased responsive behaviours amongst those living with dementia, and increased delirium. In this commentary article, we argue that family caregiver presence was conflated as a risk when instead, it contributed to unintended harm. We identify nine well-known human social cognitive predispositions that may have contributed to this. We then examine their implications for trust in long-term care, and consider how quality and safety can be further fostered in long-term care by working in partnership with family caregivers to rebuild trust through enquiry and collaboration. We advocate incorporating trust as an essential measure of quality health service., Competing Interests: Declarations of Competing Interest None., (Copyright © 2022. Published by Elsevier B.V.)

PM 2.5 pollution is a serious problem in Vietnam and around the world, having bad impacts on human health, animals and environment. Regular monitoring at a large scale is important to assess the status of air pollution, develop solutions and evaluate the effectiveness of policy implementation. However, air quality monitoring stations in Vietnam are limited. In this article, we propose an approach to estimate daily PM 2.5 concentration from 2012 to 2020 over the Vietnamese territory, which is strongly affected by cloudy conditions, using a modern statistical model named Mixed Effect Model (MEM) on a dataset consisting of ground PM 2.5 measurements, integrated satellite Aerosol Optical Depth (AOD), meteorological and land use maps. The result of this approach is the first long-term, full coverage and high quality PM 2.5 dataset of Vietnam. The daily mean PM 2.5 maps have high validation results in comparison with ground PM 2.5 measurement (Pearson r of 0.87, R 2 of 0.75, RMSE of 11.76 μg/m 3 , and MRE of 36.57 % on a total of 13,886 data samples). The aggregated monthly and annual average maps from 2012 to 2020 in Vietnam have outstanding quality when compared with another global PM 2.5 product. The PM 2.5 concentration maps has shown spatial distribution and seasonal variations of PM 2.5 concentration in Vietnam in a long period from 2012 to 2020 and has been used in other studies and applications in the environment and public health at the national scale, which has not been possible before because of the lack of monitoring stations and an appropriate PM 2.5 modeling approach., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Background: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors., Methods: The analyses were performed on data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, globally and by sex. We used Cox proportional hazards models together with mediation analysis to disentangle the total effect (TE) of educational level [measured through the Relative Index of Inequality (RII)] on cancer incidence into pure direct (PDE) and total indirect (TIE) effect, unexplained and explained by mediators, respectively. PDE and TIE were then combined to compute the proportions mediated (PM)., Results: After an average of 14 years of follow-up, 52,422 malignant tumors were ascertained. Low educated participants showed higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, and, conversely, lower risk of melanoma and breast cancer (in post-menopausal women), when compared with more educated participants. Mediation analyses showed that portions of the TE of RII on cancer could be explained by site-specific related lifestyle behaviors for stomach, lung, and breast (in women)., Conclusions: Cancer incidence in Europe is determined at least in part by a socioeconomically stratified distribution of risk factors., Impact: These observational findings support policies to reduce cancer occurrence by altering mediators, such as lifestyle behaviors, particularly focusing on underprivileged strata of the population., (©2022 American Association for Cancer Research.)

Biometric technologies are becoming more pervasive in the workplace, augmenting managerial processes such as hiring, monitoring and terminating employees. Until recently, these devices consisted mainly of GPS tools that track location, software that scrutinizes browser activity and keyboard strokes, and heat/motion sensors that monitor workstation presence. Today, however, a new generation of biometric devices has emerged that can sense, read, monitor and evaluate the affective state of a worker. More popularly known by its commercial moniker, Emotional AI, the technology stems from advancements in affective computing. But whereas previous generations of biometric monitoring targeted the exterior physical body of the worker, concurrent with the writings of Foucault and Hardt, we argue that emotion-recognition tools signal a far more invasive disciplinary gaze that exposes and makes vulnerable the inner regions of the worker-self. Our paper explores attitudes towards empathic surveillance by analyzing a survey of 1015 responses of future job-seekers from 48 countries with Bayesian statistics. Our findings reveal affect tools, left unregulated in the workplace, may lead to heightened stress and anxiety among disadvantaged ethnicities, gender and income class. We also discuss a stark cross-cultural discrepancy whereby East Asians, compared to Western subjects, are more likely to profess a trusting attitude toward EAI-enabled automated management. While this emerging technology is driven by neoliberal incentives to optimize the worksite and increase productivity, ultimately, empathic surveillance may create more problems in terms of algorithmic bias, opaque decisionism, and the erosion of employment relations. Thus, this paper nuances and extends emerging literature on emotion-sensing technologies in the workplace, particularly through its highly original cross-cultural study., Supplementary Information: The online version contains supplementary material available at 10.1007/s00146-021-01290-1., (© The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021.)

Objective: Project NORTH compared real-world clinical and economic outcomes in Swedish patients with inflammatory bowel disease (IBD) who switched from originator infliximab to its biosimilar., Materials and Methods: Data from electronic medical records and Swedish national registries were linked. Switchers (patients switching from originator infliximab to its biosimilar between 1 April 2014, and 31 December 2017) and non-switchers (patients who received originator infliximab and did not switch to a biosimilar by 31 December 2017) were followed up until 31 October 2019., Results: Baseline concomitant medication use, disease duration, and inflammatory markers were lower among switchers than non-switchers. At 6 months, the proportion of patients with stable disease was higher among switchers than non-switchers (71/109 [65%] vs 54/107 [50%]; p  = .0385); differences were not significant in subsequent follow-ups. At 6 and 24 months, 98% and 93% of switchers, respectively, used concomitant medications versus 96% and 79% of non-switchers. Throughout the study, all-cause treatment discontinuation occurred in 74 (67%) switchers and 105 (95%) non-switchers. At 36-months, mean (SD) number of IBD-related in-patient care days was higher among non-switchers (2.95 [4.71]) than switchers (1.40 [4.20]), as were total medical costs (€16,740 vs €3,872)., Conclusions: No substantial differences in clinical outcomes or healthcare resource utilization were observed between switchers and non-switchers. Several analyses indicate that non-switchers might have more poorly controlled/severe disease than switchers at baseline. Overall, numerous difficulties might arise when executing a high-quality, real-world study, including possible selection bias for patients with better disease control for NMS, limiting the generalizability of the results.

Video games have the potential to be a tool for communicating pro-environmental values. The present study examines the correlation between players' environmental attitudes and their interaction with virtual natural resources. This study constructs Bayesian ordinal logistic models to analyze survey data of 640 Animal Crossing: New Horizon (ACNH) players from 29 countries. Results show that the frequency of catching in-game animals (fish and insects) is positively correlated with the level of human centeredness in environmental attitudes. In addition, less anthropocentric players tend to use more sustainable methods to collect woods in ACNH. Such a particular way of interacting with in-game animals and trees based on their species may be attributable to players' environmental attitudes and game designs. This paper discusses how game design can play a role in promoting pro-environmental behaviors and highlights the moral implications of interactions with non-human beings., (© 2022. The Author(s) under exclusive licence to Royal Swedish Academy of Sciences.)

Rapid urbanization with poor city planning has resulted in severe air pollution in urban areas of low- and middle-income countries. Given the adverse impacts of air pollution, citizens may develop ideation of averting behaviors, including migration to another region. The current study explores the psychological mechanism and demographic predictors of internal migration intention among urban people in Hanoi, Vietnam-one of the most polluted capital cities in the world. The Bayesian Mindsponge Framework (BMF) analytics was used to construct a model and perform Bayesian analysis on a stratified random sampling dataset of 475 urban people. We found that migration intention was negatively associated with an individual's satisfaction with air quality. The association was moderated by the perceived availability of a nearby alternative (i.e., a nearby province/city with better air quality). The high migration cost due to geographical distance made the moderation effect of the perceived availability of a faraway alternative negligible. These results validate the proposed psychological mechanism behind the emergence of migration intention. Moreover, it was found that male and young people were more likely to migrate. While the brain drain effect did not clearly show, it is likely due to complex underlying interactions of various related factors (e.g., age and gender). The results hint that without air pollution mitigation measures, the dislocation of economic forces might occur and hinder sustainable urban development. Therefore, collaborative actions among levels of government, with the environmental semi-conducting principle at heart, are recommended to reduce air pollution.

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI., (© World Health Organization, 2022. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.)

A new snake of the genus Achalinus Peters, 1869 is described based on an adult male specimen from Son La Province, Vietnam. Achalinus vanhoensis sp. nov. can be distinguished from its congeners by a combination of the following characters: 1) maxillary teeth 32; 2) suture between the internasals distinctly longer than that between the prefrontals; 3) loreal fused with prefrontal, prefrontals stretch towards the supralabials; 4) dorsal scales in 252323 rows, keeled; 5) supralabials six (left) and seven (right); 6) infralabials six; 7) temporals 2+2, the two anterior temporals in broad contact with eye; 8) ventrals 176; 9) subcaudals 84, entire; 10) cloacal entire; 11) dorsum in preservative dark purple grey above; 12) venter somewhat lighter with yellow-edged scales in the chin region, including infralabials; 13) posterior edges of ventrals and subcaudals with yellow margin. In the molecular analysis, the new species is recovered as a sister taxon of Achalinus timi, a species endemic to Vietnam, and genetically the two species are around 5% divergent from each other based on a fragment of the mitochondrial COI gene. This discovery brings the number of Achalinus species known from Vietnam to nine.

Large scale supercapacitor electrodes were prepared by 3D-printing directly on a graphite paper substrate from ink solution containing manganese cobalt sulfide/reduced graphene oxide (MCS/rGO) nanocomposites. The MCS/rGO composite solution was synthesized through the dispersion of MCS NPs and rGO in dimethylformamide (DMF) solvent at room temperature. Their morphology and composition were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray diffraction (EDS). The role of rGO on decreasing charge transfer resistance and enhancing ion exchange was discussed. The MCS/rGO electrode exhibits an excellent specific capacitance of 3812.5 F g -1 at 2 A g -1 and it maintains 1780.8 F g -1 at a high current density of 50 A g -1 . The cycling stability of the electrodes reveals capacitance retention of over 92% after 22 000 cycles at 50 A g -1 ., Competing Interests: The authors declare that they have no competing interests., (This journal is © The Royal Society of Chemistry.)

Non-carious cervical lesions (NCCLs) are saucer-shaped abrasions of a tooth. NCCLs can form due to various etiologies, including toothbrushing wear, acid erosion, and mechanical stress. Owing to this complex interplay, the mechanism of NCCLs in tooth abrasion has not been established. This study aims to develop a numerical method using a computational toothbrush to simulate NCCLs. The forces acting on the teeth and the amount of abrasion generated were evaluated. The discrete element method using in-house code, connected particle model, and Archard wear model were applied for brushing. In the toothbrush model, 42 acrylic tufts were fixed into a toothbrush head. The teeth models with enamel properties comprised four flat plates and two grooves to simulate the anterior teeth and NCCLs. The brushing speed and depth for one cycle were established as simulation parameters. The force applied within the ununiform plane was concentrated on several bristles as the toothbrush passed through the interproximal space. The brushing force (depth) had a greater effect on tooth abrasion than the brushing speed. Toothbrushing abrasion was mainly concentrated in the interproximal space. Therefore, forceful tooth brushing can cause NCCLs from the interproximal space to the cervical area of the tooth.

Digital healthcare has been greatly benefiting the public health system, especially during the COVID-19 pandemic. In digital healthcare, information communication through the Internet is crucial. The current study explores how patients' accessibility and trust in Internet information influence their decisions and ex-post assessment of healthcare providers by employing the Bayesian Mindsponge Framework (BMF) on a dataset of 1,459 Vietnamese patients. We find that patients' accessibility to Internet information positively affects the perceived sufficiency of information for choosing a healthcare provider, and their trust in the information intensifies this effect. Internet information accessibility is negatively associated with post-treatment assessment of healthcare providers, and trust also moderates this effect. Moreover, patients considering professional reputation important while making a decision are more likely to regard their choices as optimal, whereas patients considering services important have contradicting tendencies. Based on these findings, a concern about the risk of eroding trust toward Internet sources about healthcare information is raised. Thus, quality control and public trust-building measures need to be taken to improve the effectiveness of healthcare-related communication through the Internet and facilitate the implementation of digital healthcare., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)

Air pollution is a major problem that severely affects the health of inhabitants in developing countries' urban areas. To deal with the problem, they may consider migration to another place as an option, which can result in the loss of skillful and talented workforces. This situation is called the brain drain phenomenon. The current study employed the Bayesian mindsponge framework (BMF) on the responses of 475 urban inhabitants in Hanoi, Vietnam-one of the most polluted capital cities in the world-to examine the risk of losing talented workforces due to air pollution. Our results show that people with higher educational levels are more likely to have intentions to migrate both domestically and internationally due to air pollution. Regarding the domestic migration intention, younger people and males have a higher probability of migrating than their counterparts. Age and gender also moderate the association between educational level and international migration intention, but their reliability needs further justification. Based on these findings, we suggest that environmental stressors caused by air pollution can influence citizen displacement intention on a large scale through the personal psychological mechanism of cost-benefit judgment. Due to the risk of air pollution on human resources, building an eco-surplus culture is crucial for enhancing environmental and socio-economic resilience.

A simple and economical process for producing amantadine hydrochloride ( 1 ) on a 250 g scale, an antiviral and anti-Parkinson drug, has been developed. Several methods for the preparation of 1 through intermediate N -(1-adamantyl)-acetamide ( 4 ) in four or three steps were reported. These procedures started with adamantine ( 2 ) or 1-bromoadamantane ( 3 ), acetonitrile, and sulfuric acid by using the Ritter-type reaction to obtain N -(1-adamantyl)-acetamide, which was deacetylated to afford 1-amino-adamantane ( 5 ) and then the salt formed with anhydrous HCl gives 1 with the overall yield of 1 being 50-58%. In this article, a two-step procedure for the synthesis of 1 from 1-bromadamantane ( 3 ) and formamide via N -(1-adamantyl)-formamide ( 6 ) in two steps with an overall yield of 88% was reported. In this procedure, the preparation of 6 from 3 is a key step with a yield of 94%, followed by the hydrolysis of 6 with an aq. solution of HCl to give 1 in high yield (93%). The procedure was also carried out under optimal conditions established to reduce the use of toxic reagents or solvents and was carried out in one pot to make it more environmentally friendly. The procedure can be considered as more suitable for the large-scale production of 1 . The structures of product 1 and intermediate 6 were confirmed by IR, MS, 1 H NMR, 13 C NMR., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)