113 results on '"Wakatsuki, T."'
Search Results
2. Incidence, clinicopathological features, and clinical outcomes of low HER2 expressed, inoperable, advanced, or recurrent gastric/gastroesophageal junction adenocarcinoma
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Nakayama, I., Takahari, D., Chin, K., Wakatsuki, T., Takamatsu, M., Yamamoto, N., Ogura, M., Ooki, A., Fukuda, K., Osumi, H., Fukuoka, S., Shinozaki, E., and Yamaguchi, K.
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- 2023
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3. Real-time processing system of a two-color CO2 laser interferometer for density feedback control in JT-60SA.
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Ohtani, Y., Sasao, H., Nakano, T., Fukumoto, M., Wakatsuki, T., Inoue, S., Kojima, S., Urano, H., and Yoshida, M.
- Abstract
A real-time processing system for the two-color CO
2 laser interferometer on the JT-60SA has been developed for density feedback control. The system has a novel feature that can detect fringe jumps due to off-normal events, such as loss detection due to displacement of the beam axis and changes in the laser wavelengths. Because a phase change due to the JT-60SA plasma is smaller than π/2, corresponding to the line-integral electron density NL of ∼ 6 × 1 0 19 m−2 in a short interval of 500 ns, the threshold of the fringe jump detection is decided to be π/2. Hence, off-normal events can be detected from a fringe jump, leading to the abort of the real-time feedback control. In the density feedback control of the JT-60SA plasma, the system is employed as a density monitor, with NL being successfully controlled at 16.8% ± 6.6% lower than the reference. [ABSTRACT FROM AUTHOR]- Published
- 2024
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4. Two-year outcomes of drug-coated balloon only strategy for de novo lesions in large coronary vessels
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Bando, R, primary, Wakatsuki, T, additional, Yamaguchi, K, additional, Kawabata, Y, additional, Takahashi, T, additional, Saijo, Y, additional, Kadota, M, additional, Matsuura, T, additional, Ise, T, additional, Kusunose, K, additional, Yagi, S, additional, Yamada, H, additional, Soeki, T, additional, Akaike, M, additional, and Sata, M, additional
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- 2023
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5. Characterization of early current quench time during massive impurity injection in JT-60SA
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Yokoyama, T., primary, Matsuyama, A., additional, Yamamoto, Y., additional, Miyamoto, S., additional, Shibata, Y., additional, Inoue, S., additional, Kojima, S., additional, Nakamura, S., additional, Wakatsuki, T., additional, and Yoshida, M., additional
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- 2023
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6. Modelling of ohmic startup and runaway electron formation in support of JT-60SA initial operation
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Matsuyama, A., primary, Wakatsuki, T., additional, Inoue, S., additional, Yamamoto, Y., additional, Yoshida, M., additional, and Urano, H., additional
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- 2022
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7. 448TiP A multicenter single arm phase II trial evaluating the safety and the efficacy of panitumumab and irinotecan for patients with NeoRAS wild-type metastatic colorectal cancer (C-PROWESS trial)
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Osumi, H., primary, Ishizuka, N., additional, Takashima, A., additional, Kumekawa, Y., additional, Nakano, D., additional, Shiozawa, M., additional, Denda, T., additional, Sawada, R., additional, Ouchi, K., additional, Wakatsuki, T., additional, Boku, N., additional, Kato, K., additional, Yamaguchi, K., additional, and Shinozaki, E., additional
- Published
- 2022
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8. 1244P Prognostic impact of myeloid subsets in nivolumab monotherapy for advanced gastric cancer (WJOG10417GTR study)
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Boku, N., primary, Kudo-Saito, C., additional, Imazeki, H., additional, Shoji, H., additional, Tsugaru, K., additional, Takahashi, N., additional, Kawakami, T., additional, Amanuma, Y., additional, Wakatsuki, T., additional, Okano, N., additional, Narita, Y., additional, Yamamoto, Y., additional, Kizawa, R., additional, Nagashima, K., additional, Aoki, K., additional, and Muro, K., additional
- Published
- 2022
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9. 1217P Profiling of myeloid cells associated with prognosis in nivolumab monotherapy for advanced gastric cancer (WJOG10417GTR study)
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Shoji, H., primary, Boku, N., additional, Kudo-Saito, C., additional, Nagashima, K., additional, Tsugaru, K., additional, Takahashi, N., additional, Kawakami, T., additional, Amanuma, Y., additional, Wakatsuki, T., additional, Okano, N., additional, Narita, Y., additional, Yamamoto, Y., additional, Kizawa, R., additional, Imazeki, H., additional, Aoki, K., additional, and Muro, K., additional
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- 2022
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10. 1465P Potential impact of APC mutation on survival via immune evasion through WNT signaling activation in HER2-positive gastric cancer treated with trastuzumab (tmab), nivolumab (nivo), and chemotherapy
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Wakatsuki, T., Mashima, T., Yamamoto, N., Ooki, A., Shoji, H., Chin, K., Ogura, M., Kiyotani, K., Nakayama, I., Osumi, H., Fukuoka, S., Shinozaki, E., Minashi, K., Hara, H., Takeuchi, K., Seimiya, H., Kitano, S., Boku, N., Yamaguchi, K., and Takahari, D.
- Published
- 2024
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11. 1442P Correlation between intratumor HER2 heterogeneity and circulating tumor DNA in HER2 positive advanced gastric cancer: A phase Ib trial of HER2 and PD-1 dual targeted therapy (Ni-High) substudy
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Osumi, H., Wakatsuki, T., Yamamoto, N., Ooki, A., Chin, K., Shoji, H., Ogura, M., Nakayama, I., Hirano, H., Hara, H., Minashi, K., Shinozaki, E., Kato, K., Kitano, S., Takeuchi, K., Boku, N., Yamaguchi, K., and Takahari, D.
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- 2024
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12. 567P Interim endoscopic restaging after induction chemotherapy to predict complete response and survival after total neoadjuvant therapy in low rectal cancer: Ad-hoc analysis of the IMPACT trial
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Shinozaki, E., Osumi, H., Chino, A., Akiyoshi, T., Taguchi, S., Ooki, A., Udagawa, S., Fukuoka, S., Wakatsuki, T., Ogura, M., Chin, K., Matsui, S., Mukai, T., Yamaguchi, T., Miyazaki, N., Fukunaga, Y., Yamaguchi, K., and Konishi, T.
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- 2024
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13. Improving Soil Productivity and Increasing Lowland Rice Yields through the Integration of Organic and Inorganic Fertilizers in the Savannah and Forest Agro-ecological Zones of La Cote d’Ívoire
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Buri, M. M., Issaka, R. N., Zoromi, A., Adjei, E. O., and Wakatsuki, T.
- Subjects
forest ,savannah ,organic amendments ,agro-ecological zone ,mineral fertilizer ,lowland rice - Abstract
Sole mineral fertilizers use by poorly resourced farmers for rice production in the lowlands is usually low and unsustainable. Field experiments were therefore conducted within two contrasting environments (Forest and Savannah), using two common organic amendments (Poultry manure and Cattle manure) to establish an effective and integrated soil nutrient management system for improved lowland soil productivity and increased rice yields. The study was also partly intended to encourage and promote the effective and sustainable use of locally available organic amendments for nutrient management in lowland rice production. Results showed that organic amendments {cattle manure (CM) and poultry manure (PM)} contributed significantly to grain yield increases and total productivity with PM having a significantly greater and positive effect on grain yield than CM. In addition, the application of organic amendments in combination with mineral fertilizer significantly contributed to increased grain yield over the application of sole mineral fertilizer. Within the savannah agro- cological zone, there was a 130% (CM) and 203% (PM) grain yield increase over the control due to the application of organic amendments . When organic amendments were applied in combination with mineral fertilizer (MF), grain yield increased by 21% and 43% over sole MF for CM and PM respectively. However, sole CM contributed 12% increase in grain yield over the control while PM gave a 35% increase within the forest agro- cological zone. The combined application of MF and CM resulted in an 11% increase in grain yield while MF and PM combinations produced a 30% yield increase within the ecology. The non-addition of N, P, K as mineral fertilizer resulted in a yield reduction of about 84% at both sites. Resource poor farmers within the West African sub-region should therefore be encouraged to use organic amendments, which are not only available locally but also affordable. Proper storage and handling of these organic materials is very important to minimize nutrient losses. 
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- 2022
14. P-33 Prognostic impact of single organ pulmonary metastasis in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors as second-line chemotherapy
- Author
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Osumi, H., primary, Akira, O., additional, Shimozaki, K., additional, Nakayama, I., additional, Wakatsuki, T., additional, Takahari, D., additional, Chin, K., additional, Yamaguchi, K., additional, and Shinozaki, E., additional
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- 2022
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15. P-34 Does the chemotherapeutic efficacy of trifluridine/tipiracil plus bevacizumab change depend on pre-treatment vascular endothelial growth factor inhibitors?
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Osumi, H., primary, Akira, O., additional, Shimozaki, K., additional, Nakayama, I., additional, Wakatsuki, T., additional, Takahari, D., additional, Chin, K., additional, Yamaguchi, K., additional, and Shinozaki, E., additional
- Published
- 2022
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16. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
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Fenstermacher, M.E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., de Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., McArdle, G., McClenaghan, J., McCollam, K., McDevitt, C., McKay, K., McKee, G., McLean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., Zuin, M., Fenstermacher, M.E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., de Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., McArdle, G., McClenaghan, J., McCollam, K., McDevitt, C., McKay, K., McKee, G., McLean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., and Zuin, M.
- Abstract
DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limit
- Published
- 2022
17. Plasma physics and control studies planned in JT-60SA for ITER and DEMO operations and risk mitigation
- Author
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Yoshida, M, Giruzzi, G, Aiba, N, Artaud, J, Ayllon-Guerola, J, Balbinot, L, Beeke, O, Belonohy, E, Bettini, P, Bin, W, Bierwage, A, Bolzonella, T, Bonotto, M, Boulbe, C, Buermans, J, Chernyshova, M, Coda, S, Coelho, R, Davis, S, Day, C, De Tommasi, G, Dibon, M, Ejiri, A, Falchetto, G, Fassina, A, Faugeras, B, Figini, L, Fukumoto, M, Futatani, S, Galazka, K, Garcia, J, Garcia-Munoz, M, Garzotti, L, Giacomelli, L, Giudicotti, L, Hall, S, Hayashi, N, Hoa, C, Honda, M, Hoshino, K, Iafrati, M, Iantchenko, A, Ide, S, Iio, S, Imazawa, R, Inoue, S, Isayama, A, Joffrin, E, Kamiya, K, Ko, Y, Kobayashi, M, Kobayashi, T, Kocsis, G, Kovacsik, A, Kurki-Suonio, T, Lacroix, B, Lang, P, Lauber, P, Louzguiti, A, de la Luna, E, Marchiori, G, Mattei, M, Matsuyama, A, Mazzi, S, Mele, A, Michel, F, Miyata, Y, Morales, J, Moreau, P, Moro, A, Nakano, T, Nakata, M, Narita, E, Neu, R, Nicollet, S, Nocente, M, Nowak, S, Orsitto, F, Ostuni, V, Ohtani, Y, Oyama, N, Pasqualotto, R, Pegourie, B, Perelli, E, Pigatto, L, Piccinni, C, Pironti, A, Platania, P, Ploeckl, B, Ricci, D, Roussel, P, Rubino, G, Sano, R, Sarkimaki, K, Shinohara, K, Soare, S, Sozzi, C, Sumida, S, Suzuki, T, Suzuki, Y, Szabolics, T, Szepesi, T, Takase, Y, Takech, M, Tamura, N, Tanaka, K, Tanaka, H, Tardocchi, M, Terakado, A, Tojo, H, Tokuzawa, T, Torre, A, Tsujii, N, Tsutsui, H, Ueda, Y, Urano, H, Valisa, M, Vallar, M, Vega, J, Villone, F, Wakatsuki, T, Wauters, T, Wischmeier, M, Yamoto, S, Zani, L, Artaud, JF, Orsitto, FP, Yoshida, M, Giruzzi, G, Aiba, N, Artaud, J, Ayllon-Guerola, J, Balbinot, L, Beeke, O, Belonohy, E, Bettini, P, Bin, W, Bierwage, A, Bolzonella, T, Bonotto, M, Boulbe, C, Buermans, J, Chernyshova, M, Coda, S, Coelho, R, Davis, S, Day, C, De Tommasi, G, Dibon, M, Ejiri, A, Falchetto, G, Fassina, A, Faugeras, B, Figini, L, Fukumoto, M, Futatani, S, Galazka, K, Garcia, J, Garcia-Munoz, M, Garzotti, L, Giacomelli, L, Giudicotti, L, Hall, S, Hayashi, N, Hoa, C, Honda, M, Hoshino, K, Iafrati, M, Iantchenko, A, Ide, S, Iio, S, Imazawa, R, Inoue, S, Isayama, A, Joffrin, E, Kamiya, K, Ko, Y, Kobayashi, M, Kobayashi, T, Kocsis, G, Kovacsik, A, Kurki-Suonio, T, Lacroix, B, Lang, P, Lauber, P, Louzguiti, A, de la Luna, E, Marchiori, G, Mattei, M, Matsuyama, A, Mazzi, S, Mele, A, Michel, F, Miyata, Y, Morales, J, Moreau, P, Moro, A, Nakano, T, Nakata, M, Narita, E, Neu, R, Nicollet, S, Nocente, M, Nowak, S, Orsitto, F, Ostuni, V, Ohtani, Y, Oyama, N, Pasqualotto, R, Pegourie, B, Perelli, E, Pigatto, L, Piccinni, C, Pironti, A, Platania, P, Ploeckl, B, Ricci, D, Roussel, P, Rubino, G, Sano, R, Sarkimaki, K, Shinohara, K, Soare, S, Sozzi, C, Sumida, S, Suzuki, T, Suzuki, Y, Szabolics, T, Szepesi, T, Takase, Y, Takech, M, Tamura, N, Tanaka, K, Tanaka, H, Tardocchi, M, Terakado, A, Tojo, H, Tokuzawa, T, Torre, A, Tsujii, N, Tsutsui, H, Ueda, Y, Urano, H, Valisa, M, Vallar, M, Vega, J, Villone, F, Wakatsuki, T, Wauters, T, Wischmeier, M, Yamoto, S, Zani, L, Artaud, JF, and Orsitto, FP
- Abstract
A large superconducting machine, JT-60SA has been constructed to provide major contributions to the ITER program and DEMO design. For the success of the ITER project and fusion reactor, understanding and development of plasma controllability in ITER and DEMO relevant higher beta regimes are essential. JT-60SA has focused the program on the plasma controllability for scenario development and risk mitigation in ITER as well as on investigating DEMO relevant regimes. This paper summarizes the high research priorities and strategy for the JT-60SA project. Recent works on simulation studies to prepare the plasma physics and control experiments are presented, such as plasma breakdown and equilibrium controls, hybrid and steady-state scenario development, and risk mitigation techniques. Contributions of JT-60SA to ITER and DEMO have been clarified through those studies.
- Published
- 2022
18. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- Author
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Fenstermacher, M, Abbate, J, Abe, S, Abrams, T, Adams, M, Adamson, B, Aiba, N, Akiyama, T, Aleynikov, P, Allen, E, Allen, S, Anand, H, Anderson, J, Andrew, Y, Andrews, T, Appelt, D, Arbon, R, Ashikawa, N, Ashourvan, A, Aslin, M, Asnis, Y, Austin, M, Ayala, D, Bak, J, Bandyopadhyay, I, Banerjee, S, Barada, K, Bardoczi, L, Barr, J, Bass, E, Battaglia, D, Battey, A, Baumgartner, W, Baylor, L, Beckers, J, Beidler, M, Belli, E, Berkery, J, Bernard, T, Bertelli, N, Beurskens, M, Bielajew, R, Bilgili, S, Biswas, B, Blondel, S, Boedo, J, Bogatu, I, Boivin, R, Bolzonella, T, Bongard, M, Bonnin, X, Bonoli, P, Bonotto, M, Bortolon, A, Bose, S, Bosviel, N, Bouwmans, S, Boyer, M, Boyes, W, Bradley, L, Brambila, R, Brennan, D, Bringuier, S, Brodsky, L, Brookman, M, Brooks, J, Brower, D, Brown, G, Brown, W, Burke, M, Burrell, K, Butler, K, Buttery, R, Bykov, I, Byrne, P, Cacheris, A, Callahan, K, Callen, J, Campbell, G, Candy, J, Canik, J, Cano-Megias, P, Cao, N, Carayannopoulos, L, Carlstrom, T, Carrig, W, Carter, T, Cary, W, Casali, L, Cengher, M, Paz, G, Chaban, R, Chan, V, Chapman, B, Char, I, Chattopadhyay, A, Chen, R, Chen, J, Chen, X, Chen, M, Chen, Z, Choi, M, Choi, W, Choi, G, Chousal, L, Chrobak, C, Chrystal, C, Chung, Y, Churchill, R, Cianciosa, M, Clark, J, Clement, M, Coda, S, Cole, A, Collins, C, Conlin, W, Cooper, A, Cordell, J, Coriton, B, Cote, T, Cothran, J, Creely, A, Crocker, N, Crowe, C, Crowley, B, Crowley, T, Cruz-Zabala, D, Cummings, D, Curie, M, Curreli, D, Dal Molin, A, Dannels, B, Dautt-Silva, A, Davda, K, De Tommasi, G, De Vries, P, Degrandchamp, G, Degrassie, J, Demers, D, Denk, S, Depasquale, S, Deshazer, E, Diallo, A, Diem, S, Dimits, A, Ding, R, Ding, S, Ding, W, Do, T, Doane, J, Dong, G, Donovan, D, Drake, J, Drews, W, Drobny, J, Du, X, Du, H, Duarte, V, Dudt, D, Dunn, C, Duran, J, Dvorak, A, Effenberg, F, Eidietis, N, Elder, D, Eldon, D, Ellis, R, Elwasif, W, Ennis, D, Erickson, K, Ernst, D, Fasciana, M, Fedorov, D, Feibush, E, Ferraro, N, Ferreira, J, Ferron, J, Fimognari, P, Finkenthal, D, Fitzpatrick, R, Fox, P, Fox, W, Frassinetti, L, Frerichs, H, Frye, H, Fu, Y, Gage, K, Quiroga, J, Gallo, A, Gao, Q, Garcia, A, Munoz, M, Garnier, D, Garofalo, A, Gattuso, A, Geng, D, Gentle, K, Ghosh, D, Giacomelli, L, Gibson, S, Gilson, E, Giroud, C, Glass, F, Glasser, A, Glibert, D, Gohil, P, Gomez, R, Gomez, S, Gong, X, Gonzales, E, Goodman, A, Gorelov, Y, Graber, V, Granetz, R, Gray, T, Green, D, Greenfield, C, Greenwald, M, Grierson, B, Groebner, R, Grosnickle, W, Groth, M, Grunloh, H, Gu, S, Guo, W, Guo, H, Gupta, P, Guterl, J, Guttenfelder, W, Guzman, T, Haar, S, Hager, R, Hahn, S, Halfmoon, M, Hall, T, Hallatschek, K, Halpern, F, Hammett, G, Han, H, Hansen, E, Hansen, C, Hansink, M, Hanson, J, Hanson, M, Hao, G, Harris, A, Harvey, R, Haskey, S, Hassan, E, Hassanein, A, Hatch, D, Hawryluk, R, Hayashi, W, Heidbrink, W, Herfindal, J, Hicok, J, Hill, D, Hinson, E, Holcomb, C, Holland, L, Holland, C, Hollmann, E, Hollocombe, J, Holm, A, Holmes, I, Holtrop, K, Honda, M, Hong, R, Hood, R, Horton, A, Horvath, L, Hosokawa, M, Houshmandyar, S, Howard, N, Howell, E, Hoyt, D, Hu, W, Hu, Y, Hu, Q, Huang, J, Huang, Y, Hughes, J, Human, T, Humphreys, D, Huynh, P, Hyatt, A, Ibanez, C, Ibarra, L, Icasas, R, Ida, K, Igochine, V, In, Y, Inoue, S, Isayama, A, Izacard, O, Izzo, V, Jackson, A, Jacobsen, G, Jaervinen, A, Jalalvand, A, Janhunen, J, Jardin, S, Jarleblad, H, Jeon, Y, Ji, H, Jian, X, Joffrin, E, Johansen, A, Johnson, C, Johnson, T, Jones, C, Joseph, I, Jubas, D, Junge, B, Kalb, W, Kalling, R, Kamath, C, Kang, J, Kaplan, D, Kaptanoglu, A, Kasdorf, S, Kates-Harbeck, J, Kazantzidis, P, Kellman, A, Kellman, D, Kessel, C, Khumthong, K, Kim, E, Kim, H, Kim, J, Kim, S, Kim, K, Kim, C, Kimura, W, King, M, King, J, Kinsey, J, Kirk, A, Kiyan, B, Kleiner, A, Klevarova, V, Knapp, R, Knolker, M, Ko, W, Kobayashi, T, Koch, E, Kochan, M, Koel, B, Koepke, M, Kohn, A, Kolasinski, R, Kolemen, E, Kostadinova, E, Kostuk, M, Kramer, 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- Abstract
DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I (p) steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at similar to 8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I (p) beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stab
- Published
- 2022
19. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- Author
-
Fenstermacher, M. E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., De Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., Effenberg, F., Eidietis, N., Elder, D., Eldon, D., Ellis, R., Elwasif, W., Ennis, D., Erickson, K., Ernst, D., Fasciana, M., Fedorov, D., Feibush, E., Ferraro, N., Ferreira, J., Ferron, J., Fimognari, P., Finkenthal, D., Fitzpatrick, R., Fox, P., Fox, W., Frassinetti, L., Frerichs, H., Frye, H., Fu, Y., Gage, K., Galdon Quiroga, J., Gallo, A., Gao, Q., Garcia, A., Garcia Munoz, M., Garnier, D., Garofalo, A., Gattuso, A., Geng, D., Gentle, K., Ghosh, D., Giacomelli, L., Gibson, S., Gilson, E., Giroud, C., Glass, F., Glasser, A., Glibert, D., Gohil, P., Gomez, R., Gomez, S., Gong, X., Gonzales, E., Goodman, A., Gorelov, Y., Graber, V., Granetz, R., Gray, T., Green, D., Greenfield, C., Greenwald, M., Grierson, B., Groebner, R., Grosnickle, W., Groth, M., Grunloh, H., Gu, S., Guo, W., Guo, H., Gupta, P., Guterl, J., Guttenfelder, W., Guzman, T., Haar, S., Hager, R., Hahn, S., Halfmoon, M., Hall, T., Hallatschek, K., Halpern, F., Hammett, G., Han, H., Hansen, E., Hansen, C., Hansink, M., Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., Lyons, B., Ma, X., Madruga, M., Madsen, B., Maggi, C., Maheshwari, K., Mail, A., Mailloux, J., Maingi, R., Major, M., Makowski, M., Manchanda, R., Marini, C., Marinoni, A., Maris, A., Markovic, T., Marrelli, L., Martin, E., Mateja, J., Matsunaga, G., Maurizio, R., Mauzey, P., Mauzey, D., McArdle, G., McClenaghan, J., McCollam, K., McDevitt, C., McKay, K., McKee, G., McLean, A., Mehta, V., Meier, E., Menard, J., Meneghini, O., Merlo, G., Messer, S., Meyer, W., Michael, C., Michoski, C., Milne, P., Minet, G., Misleh, A., Mitrishkin, Y., Moeller, C., Montes, K., Morales, M., Mordijck, S., Moreau, D., Morosohk, S., Morris, P., Morton, L., Moser, A., Moyer, R., Moynihan, C., Mrazkova, T., Mueller, D., Munaretto, S., Munoz Burgos, J., Murphy, C., Murphy, K., Muscatello, C., Myers, C., Nagy, A., Nandipati, G., Navarro, M., Nave, F., Navratil, G., Nazikian, R., Neff, A., Neilson, G., Neiser, T., Neiswanger, W., Nelson, D., Nelson, A., Nespoli, F., Nguyen, R., Nguyen, L., Nguyen, X., Nichols, J., Nocente, M., Nogami, S., Noraky, S., Norausky, N., Nornberg, M., Nygren, R., Odstrcil, T., Ogas, D., Ogorman, T., Ohdachi, S., Ohtani, Y., Okabayashi, M., Okamoto, M., Olavson, L., Olofsson, E., Omullane, M., Oneill, R., Orlov, D., Orvis, W., Osborne, T., Pace, D., Paganini Canal, G., Pajares Martinez, A., Palacios, L., Pan, C., Pan, Q., Pandit, R., Pandya, M., Pankin, A., Park, Y., Park, J., Parker, S., Parks, P., Parsons, M., Patel, B., Pawley, C., Paz-Soldan, C., Peebles, W., Pelton, S., Perillo, R., Petty, C., Peysson, Y., Pierce, D., Pigarov, A., Pigatto, L., Piglowski, D., Pinches, S., Pinsker, R., Piovesan, P., Piper, N., Pironti, A., Pitts, R., Pizzo, J., Plank, U., Podesta, M., Poli, E., Poli, F., Ponce, D., Popovic, Z., Porkolab, M., Porter, G., Powers, C., Powers, S., Prater, R., Pratt, Q., Pusztai, I., Qian, J., Qin, X., Ra, O., Rafiq, T., Raines, T., Raman, R., Rauch, J., Raymond, A., Rea, C., Reich, M., Reiman, A., Reinhold, S., Reinke, M., Reksoatmodjo, R., Ren, Q., Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., Van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., Zuin, M., Fenstermacher, M. E., Abbate, J., Abe, S., Abrams, T., Adams, M., Adamson, B., Aiba, N., Akiyama, T., Aleynikov, P., Allen, E., Allen, S., Anand, H., Anderson, J., Andrew, Y., Andrews, T., Appelt, D., Arbon, R., Ashikawa, N., Ashourvan, A., Aslin, M., Asnis, Y., Austin, M., Ayala, D., Bak, J., Bandyopadhyay, I., Banerjee, S., Barada, K., Bardoczi, L., Barr, J., Bass, E., Battaglia, D., Battey, A., Baumgartner, W., Baylor, L., Beckers, J., Beidler, M., Belli, E., Berkery, J., Bernard, T., Bertelli, N., Beurskens, M., Bielajew, R., Bilgili, S., Biswas, B., Blondel, S., Boedo, J., Bogatu, I., Boivin, R., Bolzonella, T., Bongard, M., Bonnin, X., Bonoli, P., Bonotto, M., Bortolon, A., Bose, S., Bosviel, N., Bouwmans, S., Boyer, M., Boyes, W., Bradley, L., Brambila, R., Brennan, D., Bringuier, S., Brodsky, L., Brookman, M., Brooks, J., Brower, D., Brown, G., Brown, W., Burke, M., Burrell, K., Butler, K., Buttery, R., Bykov, I., Byrne, P., Cacheris, A., Callahan, K., Callen, J., Campbell, G., Candy, J., Canik, J., Cano-Megias, P., Cao, N., Carayannopoulos, L., Carlstrom, T., Carrig, W., Carter, T., Cary, W., Casali, L., Cengher, M., Cespedes Paz, G., Chaban, R., Chan, V., Chapman, B., Char, I., Chattopadhyay, A., Chen, R., Chen, J., Chen, X., Chen, M., Chen, Z., Choi, M., Choi, W., Choi, G., Chousal, L., Chrobak, C., Chrystal, C., Chung, Y., Churchill, R., Cianciosa, M., Clark, J., Clement, M., Coda, S., Cole, A., Collins, C., Conlin, W., Cooper, A., Cordell, J., Coriton, B., Cote, T., Cothran, J., Creely, A., Crocker, N., Crowe, C., Crowley, B., Crowley, T., Cruz-Zabala, D., Cummings, D., Curie, M., Curreli, D., Dal Molin, A., Dannels, B., Dautt-Silva, A., Davda, K., De Tommasi, G., De Vries, P., Degrandchamp, G., Degrassie, J., Demers, D., Denk, S., Depasquale, S., Deshazer, E., Diallo, A., Diem, S., Dimits, A., Ding, R., Ding, S., Ding, W., Do, T., Doane, J., Dong, G., Donovan, D., Drake, J., Drews, W., Drobny, J., Du, X., Du, H., Duarte, V., Dudt, D., Dunn, C., Duran, J., Dvorak, A., 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Hanson, J., Hanson, M., Hao, G., Harris, A., Harvey, R., Haskey, S., Hassan, E., Hassanein, A., Hatch, D., Hawryluk, R., Hayashi, W., Heidbrink, W., Herfindal, J., Hicok, J., Hill, D., Hinson, E., Holcomb, C., Holland, L., Holland, C., Hollmann, E., Hollocombe, J., Holm, A., Holmes, I., Holtrop, K., Honda, M., Hong, R., Hood, R., Horton, A., Horvath, L., Hosokawa, M., Houshmandyar, S., Howard, N., Howell, E., Hoyt, D., Hu, W., Hu, Y., Hu, Q., Huang, J., Huang, Y., Hughes, J., Human, T., Humphreys, D., Huynh, P., Hyatt, A., Ibanez, C., Ibarra, L., Icasas, R., Ida, K., Igochine, V., In, Y., Inoue, S., Isayama, A., Izacard, O., Izzo, V., Jackson, A., Jacobsen, G., Jaervinen, A., Jalalvand, A., Janhunen, J., Jardin, S., Jarleblad, H., Jeon, Y., Ji, H., Jian, X., Joffrin, E., Johansen, A., Johnson, C., Johnson, T., Jones, C., Joseph, I., Jubas, D., Junge, B., Kalb, W., Kalling, R., Kamath, C., Kang, J., Kaplan, D., Kaptanoglu, A., Kasdorf, S., Kates-Harbeck, J., Kazantzidis, P., Kellman, A., Kellman, D., Kessel, C., Khumthong, K., Kim, E., Kim, H., Kim, J., Kim, S., Kim, K., Kim, C., Kimura, W., King, M., King, J., Kinsey, J., Kirk, A., Kiyan, B., Kleiner, A., Klevarova, V., Knapp, R., Knolker, M., Ko, W., Kobayashi, T., Koch, E., Kochan, M., Koel, B., Koepke, M., Kohn, A., Kolasinski, R., Kolemen, E., Kostadinova, E., Kostuk, M., Kramer, G., Kriete, D., Kripner, L., Kubota, S., Kulchar, J., Kwon, K., La Haye, R., Laggner, F., Lan, H., Lantsov, R., Lao, L., Lasa Esquisabel, A., Lasnier, C., Lau, C., Leard, B., Lee, J., Lee, R., Lee, M., Lee, Y., Lee, C., Lee, S., Lehnen, M., Leonard, A., Leppink, E., Lesher, M., Lestz, J., Leuer, J., Leuthold, N., Li, X., Li, K., Li, E., Li, G., Li, L., Li, Z., Li, J., Li, Y., Lin, Z., Lin, D., Liu, X., Liu, J., Liu, Y., Liu, T., Liu, C., Liu, Z., Liu, D., Liu, A., Loarte-Prieto, A., Lodestro, L., Logan, N., Lohr, J., Lombardo, B., Lore, J., Luan, Q., Luce, T., Luda Di Cortemiglia, T., Luhmann, N., Lunsford, R., Luo, Z., Lvovskiy, A., 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Ren, Y., Ren, J., Rensink, M., Renteria, J., Rhodes, T., Rice, J., Roberts, R., Robinson, J., Rodriguez Fernandez, P., Rognlien, T., Rosenthal, A., Rosiello, S., Rost, J., Roveto, J., Rowan, W., Rozenblat, R., Ruane, J., Rudakov, D., Ruiz Ruiz, J., Rupani, R., Saarelma, S., Sabbagh, S., Sachdev, J., Saenz, J., Saib, S., Salewski, M., Salmi, A., Sammuli, B., Samuell, C., Sandorfi, A., Sang, C., Sarff, J., Sauter, O., Schaubel, K., Schmitz, L., Schmitz, O., Schneider, J., Schroeder, P., Schultz, K., Schuster, E., Schwartz, J., Sciortino, F., Scotti, F., Scoville, J., Seltzman, A., Seol, S., Sfiligoi, I., Shafer, M., Sharapov, S., Shen, H., Sheng, Z., Shepard, T., Shi, S., Shibata, Y., Shin, G., Shiraki, D., Shousha, R., Si, H., Simmerling, P., Sinclair, G., Sinha, J., Sinha, P., Sips, G., Sizyuk, T., Skinner, C., Sladkomedova, A., Slendebroek, T., Slief, J., Smirnov, R., Smith, J., Smith, S., Smith, D., Snipes, J., Snoep, G., Snyder, A., Snyder, P., Solano, E., Solomon, W., Song, J., Sontag, A., Soukhanovskii, V., Spendlove, J., Spong, D., Squire, J., Srinivasan, C., Stacey, W., Staebler, G., Stagner, L., Stange, T., Stangeby, P., Stefan, R., Stemprok, R., Stephan, D., Stillerman, J., Stoltzfus-Dueck, T., Stonecipher, W., Storment, S., Strait, E., Su, D., Sugiyama, L., Sun, Y., Sun, P., Sun, Z., Sun, A., Sundstrom, D., Sung, C., Sungcoco, J., Suttrop, W., Suzuki, Y., Suzuki, T., Svyatkovskiy, A., Swee, C., Sweeney, R., Sweetnam, C., Szepesi, G., Takechi, M., Tala, T., Tanaka, K., Tang, X., Tang, S., Tao, Y., Tao, R., Taussig, D., Taylor, T., Teixeira, K., Teo, K., Theodorsen, A., Thomas, D., Thome, K., Thorman, A., Thornton, A., Ti, A., Tillack, M., Timchenko, N., Tinguely, R., Tompkins, R., Tooker, J., Torrezan De Sousa, A., Trevisan, G., Tripathi, S., Trujillo Ochoa, A., Truong, D., Tsui, C., Turco, F., Turnbull, A., Umansky, M., Unterberg, E., Vaezi, P., Vail, P., Valdez, J., Valkis, W., Van Compernolle, B., Van Galen, J., Van Kampen, R., Van Zeeland, M., Verdoolaege, G., Vianello, N., Victor, B., Viezzer, E., Vincena, S., Wade, M., Waelbroeck, F., Wai, J., Wakatsuki, T., Walker, M., Wallace, G., Waltz, R., Wampler, W., Wang, L., Wang, H., Wang, Y., Wang, Z., Wang, G., Ward, S., Watkins, M., Watkins, J., Wehner, W., Wei, Y., Weiland, M., Weisberg, D., Welander, A., White, A., White, R., Wiesen, S., Wilcox, R., Wilks, T., Willensdorfer, M., Wilson, H., Wingen, A., Wolde, M., Wolff, M., Woller, K., Wolz, A., Wong, H., Woodruff, S., Wu, M., Wu, Y., Wukitch, S., Wurden, G., Xiao, W., Xie, R., Xing, Z., Xu, X., Xu, C., Xu, G., Yan, Z., Yang, X., Yang, S., Yokoyama, T., Yoneda, R., Yoshida, M., You, K., Younkin, T., Yu, J., Yu, M., Yu, G., Yuan, Q., Zaidenberg, L., Zakharov, L., Zamengo, A., Zamperini, S., Zarnstorff, M., Zeger, E., Zeller, K., Zeng, L., Zerbini, M., Zhang, L., Zhang, X., Zhang, R., Zhang, B., Zhang, J., Zhao, L., Zhao, B., Zheng, Y., Zheng, L., Zhu, B., Zhu, J., Zhu, Y., Zsutty, M., and Zuin, M.
- Abstract
DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limit
- Published
- 2022
20. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
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Fenstermacher, M. E., primary, Abbate, J., additional, Abe, S., additional, Abrams, T., additional, Adams, M., additional, Adamson, B., additional, Aiba, N., additional, Akiyama, T., additional, Aleynikov, P., additional, Allen, E., additional, Allen, S., additional, Anand, H., additional, Anderson, J., additional, Andrew, Y., additional, Andrews, T., additional, Appelt, D., additional, Arbon, R., additional, Ashikawa, N., additional, Ashourvan, A., additional, Aslin, M., additional, Asnis, Y., additional, Austin, M., additional, Ayala, D., additional, Bak, J., additional, Bandyopadhyay, I., additional, Banerjee, S., additional, Barada, K., additional, Bardoczi, L., additional, Barr, J., additional, Bass, E., additional, Battaglia, D., additional, Battey, A., additional, Baumgartner, W., additional, Baylor, L., additional, Beckers, J., additional, Beidler, M., additional, Belli, E., additional, Berkery, J., additional, Bernard, T., additional, Bertelli, N., additional, Beurskens, M., additional, Bielajew, R., additional, Bilgili, S., additional, Biswas, B., additional, Blondel, S., additional, Boedo, J., additional, Bogatu, I., additional, Boivin, R., additional, Bolzonella, T., additional, Bongard, M., additional, Bonnin, X., additional, Bonoli, P., additional, Bonotto, M., additional, Bortolon, A., additional, Bose, S., additional, Bosviel, N., additional, Bouwmans, S., additional, Boyer, M., additional, Boyes, W., additional, Bradley, L., additional, Brambila, R., additional, Brennan, D., additional, Bringuier, S., additional, Brodsky, L., additional, Brookman, M., additional, Brooks, J., additional, Brower, D., additional, Brown, G., additional, Brown, W., additional, Burke, M., additional, Burrell, K., additional, Butler, K., additional, Buttery, R., additional, Bykov, I., additional, Byrne, P., additional, Cacheris, A., additional, Callahan, K., additional, Callen, J., additional, Campbell, G., additional, Candy, J., additional, Canik, J., additional, Cano-Megias, P., additional, Cao, N., additional, Carayannopoulos, L., additional, Carlstrom, T., additional, Carrig, W., additional, Carter, T., additional, Cary, W., additional, Casali, L., additional, Cengher, M., additional, Cespedes Paz, G., additional, Chaban, R., additional, Chan, V., additional, Chapman, B., additional, Char, I., additional, Chattopadhyay, A., additional, Chen, R., additional, Chen, J., additional, Chen, X., additional, Chen, M., additional, Chen, Z., additional, Choi, M., additional, Choi, W., additional, Choi, G., additional, Chousal, L., additional, Chrobak, C., additional, Chrystal, C., additional, Chung, Y., additional, Churchill, R., additional, Cianciosa, M., additional, Clark, J., additional, Clement, M., additional, Coda, S., additional, Cole, A., additional, Collins, C., additional, Conlin, W., additional, Cooper, A., additional, Cordell, J., additional, Coriton, B., additional, Cote, T., additional, Cothran, J., additional, Creely, A., additional, Crocker, N., additional, Crowe, C., additional, Crowley, B., additional, Crowley, T., additional, Cruz-Zabala, D., additional, Cummings, D., additional, Curie, M., additional, Curreli, D., additional, Dal Molin, A., additional, Dannels, B., additional, Dautt-Silva, A., additional, Davda, K., additional, De Tommasi, G., additional, De Vries, P., additional, Degrandchamp, G., additional, Degrassie, J., additional, Demers, D., additional, Denk, S., additional, Depasquale, S., additional, Deshazer, E., additional, Diallo, A., additional, Diem, S., additional, Dimits, A., additional, Ding, R., additional, Ding, S., additional, Ding, W., additional, Do, T., additional, Doane, J., additional, Dong, G., additional, Donovan, D., additional, Drake, J., additional, Drews, W., additional, Drobny, J., additional, Du, X., additional, Du, H., additional, Duarte, V., additional, Dudt, D., additional, Dunn, C., additional, Duran, J., additional, Dvorak, A., additional, Effenberg, F., additional, Eidietis, N., additional, Elder, D., additional, Eldon, D., additional, Ellis, R., additional, Elwasif, W., additional, Ennis, D., additional, Erickson, K., additional, Ernst, D., additional, Fasciana, M., additional, Fedorov, D., additional, Feibush, E., additional, Ferraro, N., additional, Ferreira, J., additional, Ferron, J., additional, Fimognari, P., additional, Finkenthal, D., additional, Fitzpatrick, R., additional, Fox, P., additional, Fox, W., additional, Frassinetti, L., additional, Frerichs, H., additional, Frye, H., additional, Fu, Y., additional, Gage, K., additional, Galdon Quiroga, J., additional, Gallo, A., additional, Gao, Q., additional, Garcia, A., additional, Garcia Munoz, M., additional, Garnier, D., additional, Garofalo, A., additional, Gattuso, A., additional, Geng, D., additional, Gentle, K., additional, Ghosh, D., additional, Giacomelli, L., additional, Gibson, S., additional, Gilson, E., additional, Giroud, C., additional, Glass, F., additional, Glasser, A., additional, Glibert, D., additional, Gohil, P., additional, Gomez, R., additional, Gomez, S., additional, Gong, X., additional, Gonzales, E., additional, Goodman, A., additional, Gorelov, Y., additional, Graber, V., additional, Granetz, R., additional, Gray, T., additional, Green, D., additional, Greenfield, C., additional, Greenwald, M., additional, Grierson, B., additional, Groebner, R., additional, Grosnickle, W., additional, Groth, M., additional, Grunloh, H., additional, Gu, S., additional, Guo, W., additional, Guo, H., additional, Gupta, P., additional, Guterl, J., additional, Guttenfelder, W., additional, Guzman, T., additional, Haar, S., additional, Hager, R., additional, Hahn, S., additional, Halfmoon, M., additional, Hall, T., additional, Hallatschek, K., additional, Halpern, F., additional, Hammett, G., additional, Han, H., additional, Hansen, E., additional, Hansen, C., additional, Hansink, M., additional, Hanson, J., additional, Hanson, M., additional, Hao, G., additional, Harris, A., additional, Harvey, R., additional, Haskey, S., additional, Hassan, E., additional, Hassanein, A., additional, Hatch, D., additional, Hawryluk, R., additional, Hayashi, W., additional, Heidbrink, W., additional, Herfindal, J., additional, Hicok, J., additional, Hill, D., additional, Hinson, E., additional, Holcomb, C., additional, Holland, L., additional, Holland, C., additional, Hollmann, E., additional, Hollocombe, J., additional, Holm, A., additional, Holmes, I., additional, Holtrop, K., additional, Honda, M., additional, Hong, R., additional, Hood, R., additional, Horton, A., additional, Horvath, L., additional, Hosokawa, M., additional, Houshmandyar, S., additional, Howard, N., additional, Howell, E., additional, Hoyt, D., additional, Hu, W., additional, Hu, Y., additional, Hu, Q., additional, Huang, J., additional, Huang, Y., additional, Hughes, J., additional, Human, T., additional, Humphreys, D., additional, Huynh, P., additional, Hyatt, A., additional, Ibanez, C., additional, Ibarra, L., additional, Icasas, R., additional, Ida, K., additional, Igochine, V., additional, In, Y., additional, Inoue, S., additional, Isayama, A., additional, Izacard, O., additional, Izzo, V., additional, Jackson, A., additional, Jacobsen, G., additional, Jaervinen, A., additional, Jalalvand, A., additional, Janhunen, J., additional, Jardin, S., additional, Jarleblad, H., additional, Jeon, Y., additional, Ji, H., additional, Jian, X., additional, Joffrin, E., additional, Johansen, A., additional, Johnson, C., additional, Johnson, T., additional, Jones, C., additional, Joseph, I., additional, Jubas, D., additional, Junge, B., additional, Kalb, W., additional, Kalling, R., additional, Kamath, C., additional, Kang, J., additional, Kaplan, D., additional, Kaptanoglu, A., additional, Kasdorf, S., additional, Kates-Harbeck, J., additional, Kazantzidis, P., additional, Kellman, A., additional, Kellman, D., additional, Kessel, C., additional, Khumthong, K., additional, Kim, E., additional, Kim, H., additional, Kim, J., additional, Kim, S., additional, Kim, K., additional, Kim, C., additional, Kimura, W., additional, King, M., additional, King, J., additional, Kinsey, J., additional, Kirk, A., additional, Kiyan, B., additional, Kleiner, A., additional, Klevarova, V., additional, Knapp, R., additional, Knolker, M., additional, Ko, W., additional, Kobayashi, T., additional, Koch, E., additional, Kochan, M., additional, Koel, B., additional, Koepke, M., additional, Kohn, A., additional, Kolasinski, R., additional, Kolemen, E., additional, Kostadinova, E., additional, Kostuk, M., additional, Kramer, G., additional, Kriete, D., additional, Kripner, L., additional, Kubota, S., additional, Kulchar, J., additional, Kwon, K., additional, La Haye, R., additional, Laggner, F., additional, Lan, H., additional, Lantsov, R., additional, Lao, L., additional, Lasa Esquisabel, A., additional, Lasnier, C., additional, Lau, C., additional, Leard, B., additional, Lee, J., additional, Lee, R., additional, Lee, M., additional, Lee, Y., additional, Lee, C., additional, Lee, S., additional, Lehnen, M., additional, Leonard, A., additional, Leppink, E., additional, Lesher, M., additional, Lestz, J., additional, Leuer, J., additional, Leuthold, N., additional, Li, X., additional, Li, K., additional, Li, E., additional, Li, G., additional, Li, L., additional, Li, Z., additional, Li, J., additional, Li, Y., additional, Lin, Z., additional, Lin, D., additional, Liu, X., additional, Liu, J., additional, Liu, Y., additional, Liu, T., additional, Liu, C., additional, Liu, Z., additional, Liu, D., additional, Liu, A., additional, Loarte-Prieto, A., additional, Lodestro, L., additional, Logan, N., additional, Lohr, J., additional, Lombardo, B., additional, Lore, J., additional, Luan, Q., additional, Luce, T., additional, Luda Di Cortemiglia, T., additional, Luhmann, N., additional, Lunsford, R., additional, Luo, Z., additional, Lvovskiy, A., additional, Lyons, B., additional, Ma, X., additional, Madruga, M., additional, Madsen, B., additional, Maggi, C., additional, Maheshwari, K., additional, Mail, A., additional, Mailloux, J., additional, Maingi, R., additional, Major, M., additional, Makowski, M., additional, Manchanda, R., additional, Marini, C., additional, Marinoni, A., additional, Maris, A., additional, Markovic, T., additional, Marrelli, L., additional, Martin, E., additional, Mateja, J., additional, Matsunaga, G., additional, Maurizio, R., additional, Mauzey, P., additional, Mauzey, D., additional, Mcardle, G., additional, Mcclenaghan, J., additional, Mccollam, K., additional, Mcdevitt, C., additional, Mckay, K., additional, Mckee, G., additional, Mclean, A., additional, Mehta, V., additional, Meier, E., additional, Menard, J., additional, Meneghini, O., additional, Merlo, G., additional, Messer, S., additional, Meyer, W., additional, Michael, C., additional, Michoski, C., additional, Milne, P., additional, Minet, G., additional, Misleh, A., additional, Mitrishkin, Y., additional, Moeller, C., additional, Montes, K., additional, Morales, M., additional, Mordijck, S., additional, Moreau, D., additional, Morosohk, S., additional, Morris, P., additional, Morton, L., additional, Moser, A., additional, Moyer, R., additional, Moynihan, C., additional, Mrazkova, T., additional, Mueller, D., additional, Munaretto, S., additional, Munoz Burgos, J., additional, Murphy, C., additional, Murphy, K., additional, Muscatello, C., additional, Myers, C., additional, Nagy, A., additional, Nandipati, G., additional, Navarro, M., additional, Nave, F., additional, Navratil, G., additional, Nazikian, R., additional, Neff, A., additional, Neilson, G., additional, Neiser, T., additional, Neiswanger, W., additional, Nelson, D., additional, Nelson, A., additional, Nespoli, F., additional, Nguyen, R., additional, Nguyen, L., additional, Nguyen, X., additional, Nichols, J., additional, Nocente, M., additional, Nogami, S., additional, Noraky, S., additional, Norausky, N., additional, Nornberg, M., additional, Nygren, R., additional, Odstrcil, T., additional, Ogas, D., additional, Ogorman, T., additional, Ohdachi, S., additional, Ohtani, Y., additional, Okabayashi, M., additional, Okamoto, M., additional, Olavson, L., additional, Olofsson, E., additional, Omullane, M., additional, Oneill, R., additional, Orlov, D., additional, Orvis, W., additional, Osborne, T., additional, Pace, D., additional, Paganini Canal, G., additional, Pajares Martinez, A., additional, Palacios, L., additional, Pan, C., additional, Pan, Q., additional, Pandit, R., additional, Pandya, M., additional, Pankin, A., additional, Park, Y., additional, Park, J., additional, Parker, S., additional, Parks, P., additional, Parsons, M., additional, Patel, B., additional, Pawley, C., additional, Paz-Soldan, C., additional, Peebles, W., additional, Pelton, S., additional, Perillo, R., additional, Petty, C., additional, Peysson, Y., additional, Pierce, D., additional, Pigarov, A., additional, Pigatto, L., additional, Piglowski, D., additional, Pinches, S., additional, Pinsker, R., additional, Piovesan, P., additional, Piper, N., additional, Pironti, A., additional, Pitts, R., additional, Pizzo, J., additional, Plank, U., additional, Podesta, M., additional, Poli, E., additional, Poli, F., additional, Ponce, D., additional, Popovic, Z., additional, Porkolab, M., additional, Porter, G., additional, Powers, C., additional, Powers, S., additional, Prater, R., additional, Pratt, Q., additional, Pusztai, I., additional, Qian, J., additional, Qin, X., additional, Ra, O., additional, Rafiq, T., additional, Raines, T., additional, Raman, R., additional, Rauch, J., additional, Raymond, A., additional, Rea, C., additional, Reich, M., additional, Reiman, A., additional, Reinhold, S., additional, Reinke, M., additional, Reksoatmodjo, R., additional, Ren, Q., additional, Ren, Y., additional, Ren, J., additional, Rensink, M., additional, Renteria, J., additional, Rhodes, T., additional, Rice, J., additional, Roberts, R., additional, Robinson, J., additional, Rodriguez Fernandez, P., additional, Rognlien, T., additional, Rosenthal, A., additional, Rosiello, S., additional, Rost, J., additional, Roveto, J., additional, Rowan, W., additional, Rozenblat, R., additional, Ruane, J., additional, Rudakov, D., additional, Ruiz Ruiz, J., additional, Rupani, R., additional, Saarelma, S., additional, Sabbagh, S., additional, Sachdev, J., additional, Saenz, J., additional, Saib, S., additional, Salewski, M., additional, Salmi, A., additional, Sammuli, B., additional, Samuell, C., additional, Sandorfi, A., additional, Sang, C., additional, Sarff, J., additional, Sauter, O., additional, Schaubel, K., additional, Schmitz, L., additional, Schmitz, O., additional, Schneider, J., additional, Schroeder, P., additional, Schultz, K., additional, Schuster, E., additional, Schwartz, J., additional, Sciortino, F., additional, Scotti, F., additional, Scoville, J., additional, Seltzman, A., additional, Seol, S., additional, Sfiligoi, I., additional, Shafer, M., additional, Sharapov, S., additional, Shen, H., additional, Sheng, Z., additional, Shepard, T., additional, Shi, S., additional, Shibata, Y., additional, Shin, G., additional, Shiraki, D., additional, Shousha, R., additional, Si, H., additional, Simmerling, P., additional, Sinclair, G., additional, Sinha, J., additional, Sinha, P., additional, Sips, G., additional, Sizyuk, T., additional, Skinner, C., additional, Sladkomedova, A., additional, Slendebroek, T., additional, Slief, J., additional, Smirnov, R., additional, Smith, J., additional, Smith, S., additional, Smith, D., additional, Snipes, J., additional, Snoep, G., additional, Snyder, A., additional, Snyder, P., additional, Solano, E., additional, Solomon, W., additional, Song, J., additional, Sontag, A., additional, Soukhanovskii, V., additional, Spendlove, J., additional, Spong, D., additional, Squire, J., additional, Srinivasan, C., additional, Stacey, W., additional, Staebler, G., additional, Stagner, L., additional, Stange, T., additional, Stangeby, P., additional, Stefan, R., additional, Stemprok, R., additional, Stephan, D., additional, Stillerman, J., additional, Stoltzfus-Dueck, T., additional, Stonecipher, W., additional, Storment, S., additional, Strait, E., additional, Su, D., additional, Sugiyama, L., additional, Sun, Y., additional, Sun, P., additional, Sun, Z., additional, Sun, A., additional, Sundstrom, D., additional, Sung, C., additional, Sungcoco, J., additional, Suttrop, W., additional, Suzuki, Y., additional, Suzuki, T., additional, Svyatkovskiy, A., additional, Swee, C., additional, Sweeney, R., additional, Sweetnam, C., additional, Szepesi, G., additional, Takechi, M., additional, Tala, T., additional, Tanaka, K., additional, Tang, X., additional, Tang, S., additional, Tao, Y., additional, Tao, R., additional, Taussig, D., additional, Taylor, T., additional, Teixeira, K., additional, Teo, K., additional, Theodorsen, A., additional, Thomas, D., additional, Thome, K., additional, Thorman, A., additional, Thornton, A., additional, Ti, A., additional, Tillack, M., additional, Timchenko, N., additional, Tinguely, R., additional, Tompkins, R., additional, Tooker, J., additional, Torrezan De Sousa, A., additional, Trevisan, G., additional, Tripathi, S., additional, Trujillo Ochoa, A., additional, Truong, D., additional, Tsui, C., additional, Turco, F., additional, Turnbull, A., additional, Umansky, M., additional, Unterberg, E., additional, Vaezi, P., additional, Vail, P., additional, Valdez, J., additional, Valkis, W., additional, Van Compernolle, B., additional, Van Galen, J., additional, Van Kampen, R., additional, Van Zeeland, M., additional, Verdoolaege, G., additional, Vianello, N., additional, Victor, B., additional, Viezzer, E., additional, Vincena, S., additional, Wade, M., additional, Waelbroeck, F., additional, Wai, J., additional, Wakatsuki, T., additional, Walker, M., additional, Wallace, G., additional, Waltz, R., additional, Wampler, W., additional, Wang, L., additional, Wang, H., additional, Wang, Y., additional, Wang, Z., additional, Wang, G., additional, Ward, S., additional, Watkins, M., additional, Watkins, J., additional, Wehner, W., additional, Wei, Y., additional, Weiland, M., additional, Weisberg, D., additional, Welander, A., additional, White, A., additional, White, R., additional, Wiesen, S., additional, Wilcox, R., additional, Wilks, T., additional, Willensdorfer, M., additional, Wilson, H., additional, Wingen, A., additional, Wolde, M., additional, Wolff, M., additional, Woller, K., additional, Wolz, A., additional, Wong, H., additional, Woodruff, S., additional, Wu, M., additional, Wu, Y., additional, Wukitch, S., additional, Wurden, G., additional, Xiao, W., additional, Xie, R., additional, Xing, Z., additional, Xu, X., additional, Xu, C., additional, Xu, G., additional, Yan, Z., additional, Yang, X., additional, Yang, S., additional, Yokoyama, T., additional, Yoneda, R., additional, Yoshida, M., additional, You, K., additional, Younkin, T., additional, Yu, J., additional, Yu, M., additional, Yu, G., additional, Yuan, Q., additional, Zaidenberg, L., additional, Zakharov, L., additional, Zamengo, A., additional, Zamperini, S., additional, Zarnstorff, M., additional, Zeger, E., additional, Zeller, K., additional, Zeng, L., additional, Zerbini, M., additional, Zhang, L., additional, Zhang, X., additional, Zhang, R., additional, Zhang, B., additional, Zhang, J., additional, Zhao, L., additional, Zhao, B., additional, Zheng, Y., additional, Zheng, L., additional, Zhu, B., additional, Zhu, J., additional, Zhu, Y., additional, Zsutty, M., additional, and Zuin, M., additional
- Published
- 2022
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21. Plasma physics and control studies planned in JT-60SA for ITER and DEMO operations and risk mitigation
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Yoshida, M, primary, Giruzzi, G, additional, Aiba, N, additional, Artaud, J F, additional, Ayllon-Guerola, J, additional, Balbinot, L, additional, Beeke, O, additional, Belonohy, E, additional, Bettini, P, additional, Bin, W, additional, Bierwage, A, additional, Bolzonella, T, additional, Bonotto, M, additional, Boulbe, C, additional, Buermans, J, additional, Chernyshova, M, additional, Coda, S, additional, Coelho, R, additional, Davis, S, additional, Day, C, additional, De Tommasi, G, additional, Dibon, M, additional, Ejiri, A, additional, Falchetto, G, additional, Fassina, A, additional, Faugeras, B, additional, Figini, L, additional, Fukumoto, M, additional, Futatani, S, additional, Galazka, K, additional, Garcia, J, additional, Garcia-Muñoz, M, additional, Garzotti, L, additional, Giacomelli, L, additional, Giudicotti, L, additional, Hall, S, additional, Hayashi, N, additional, Hoa, C, additional, Honda, M, additional, Hoshino, K, additional, Iafrati, M, additional, Iantchenko, A, additional, Ide, S, additional, Iio, S, additional, Imazawa, R, additional, Inoue, S, additional, Isayama, A, additional, Joffrin, E, additional, Kamiya, K, additional, Ko, Y, additional, Kobayashi, M, additional, Kobayashi, T, additional, Kocsis, G, additional, Kovacsik, A, additional, Kurki-Suonio, T, additional, Lacroix, B, additional, Lang, P, additional, Lauber, Ph, additional, Louzguiti, A, additional, de la Luna, E, additional, Marchiori, G, additional, Mattei, M, additional, Matsuyama, A, additional, Mazzi, S, additional, Mele, A, additional, Michel, F, additional, Miyata, Y, additional, Morales, J, additional, Moreau, P, additional, Moro, A, additional, Nakano, T, additional, Nakata, M, additional, Narita, E, additional, Neu, R, additional, Nicollet, S, additional, Nocente, M, additional, Nowak, S, additional, Orsitto, F P, additional, Ostuni, V, additional, Ohtani, Y, additional, Oyama, N, additional, Pasqualotto, R, additional, Pégourié, B, additional, Perelli, E, additional, Pigatto, L, additional, Piccinni, C, additional, Pironti, A, additional, Platania, P, additional, Ploeckl, B, additional, Ricci, D, additional, Roussel, P, additional, Rubino, G, additional, Sano, R, additional, Särkimäki, K, additional, Shinohara, K, additional, Soare, S, additional, Sozzi, C, additional, Sumida, S, additional, Suzuki, T, additional, Suzuki, Y, additional, Szabolics, T, additional, Szepesi, T, additional, Takase, Y, additional, Takech, M, additional, Tamura, N, additional, Tanaka, K, additional, Tanaka, H, additional, Tardocchi, M, additional, Terakado, A, additional, Tojo, H, additional, Tokuzawa, T, additional, Torre, A, additional, Tsujii, N, additional, Tsutsui, H, additional, Ueda, Y, additional, Urano, H, additional, Valisa, M, additional, Vallar, M, additional, Vega, J, additional, Villone, F, additional, Wakatsuki, T, additional, Wauters, T, additional, Wischmeier, M, additional, Yamoto, S, additional, and Zani, L, additional
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- 2022
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22. Completion of JT-60SA construction and contribution to ITER
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Kamada Y., Di Pietro E., Hanada M., Barabaschi P., Ide S., Davis S., Yoshida M., Giruzzi G., Sozzi C., Abdel Maksoud W., Abe H., Aiba N., Akiyama T., Ayllon-Guerola J., Arai T., Artaud J. -F., Asakura N., Ashikawa N., Balbinot L., Bando T., Baulaigue O., Belonohy E., Bin W., Bombarda F., Bolzonella T., Bonne F., Bonotto M., Botija J., Cabrera-Perez S., Cardella A., Carraro L., Cavalier J., Chernyshova M., Chiba S., Clement-Lorenzo S., Cocilovo V., Coda S., Coelho R., Coffey I., Collin B., Corato V., Cucchiaro A., Czarski T., Dairaku M., Day C., de la Luna E., De Tommasi G., Decool P., Di Pace L., Dibon M., Disset G., Ejiri A., Endo Y., Ezumi N., Falchetto G., Fassina A., Fejoz P., Ferro A., Fietz W., Figini L., Fornal T., Frello G., Fujita T., Fukuda T., Fukui K., Fukumoto M., Furukawa M., Futatani S., Gabellieri L., Gaio E., Galazka K., Garcia J., Garcia-Dominguez J., Garcia-Lopez J., Garcia-Munoz M., Garzotti L., Gasparini F., Gharafi S., Giacomelli L., Ginoulhiac G., Giudicotti L., Guillen Gonzalez R., Hajnal N., Hall S., Hamada K., Hanada K., Hasegawa K., Hatae T., Hatakeyama S., Hauer V., Hayashi N., Hayashi T., Heller R., Higashijima S., Hinata J., Hiranai S., Hiratsuka J., Hiwatari R., Hoa C., Homma H., Honda A., Honda M., Horiike H., Hoshino K., Hurzlmeier H., Iafrati M., Ibano K., Ichige H., Ichikawa M., Ichimura M., Ida K., Idei H., Iijima T., Iio S., Ikeda R., Ikeda Y., Imai T., Imazawa R., Inagaki S., Inomoto M., Inoue S., Isayama A., Ishida S., Ishii Y., Isobe M., Janky F., Joffrin E., Jokinen A., Kado S., Kajita S., Kajiwara K., Kamata I., Kaminaga A., Kamiya K., Kanapienyte D., Kashiwa Y., Kashiwagi M., Katayama K., Kawamata Y., Kawamura G., Kawano K., Kawashima H., Kin F., Kitajima S., Kiyono K., Kizu K., Kobayashi K., Kobayashi M., Kobayashi S., Kobayashi T., Kocsis G., Koide Yo., Koide Yu., Kojima A., Kokusen S., Komuro K., Konishi S., Kovacsik A., Ksiazek I., Kubkowska M., Kuhner G., Kuramochi M., Kurihara K., Kurki-Suonio T., Kurniawan A. B., Kuwata T., Lacroix B., Lamaison V., Lampasi A., Lang P., Lauber P., Lawson K., Louzguiti A., Maekawa R., Maekawa T., Maeyama S., Maffia G., Maget P., Mailloux J., Maione I., Maistrello A., Malinowski K., Marchiori G., Marechal J. -L., Massaut V., Masuzaki S., Matsunaga G., Matsunaga S., Mayri Ch., Mattei M., Medrano M., Mele A., Meyer I., Michel F., Minami T., Miyata Y., Miyazawa J., Miyo Y., Mizuuchi T., Mogaki K., Morales J., Moreau P., Mori M., Morisaki T., Morishima S., Moriyama S., Moro A., Murakami H., Murayama M., Murakami S., Nagasaki K., Naito O., Nakamura S., Nakano T., Nakashima Y., Nardino V., Narita E., Narushima Y., Natsume K., Nemoto S., Neu R., Nicollet S., Nishikawa M., Nishimura S., Nishiura M., Nishiyama T., Nocente M., Nobuta Y., Novello L., Nunio F., Ochoa S., Ogawa T., Ogawa Y., Ohdachi S., Ohmori Y., Ohno N., Ohtani Y., Ohzeki M., Oishi T., Okano F., Okano J., Okano K., Onishi Y., Osakabe M., Oshima T., Ostuni V., Oya M., Oya Y., Oyama N., Ozeki T., Pasqualotto R., Pelli S., Peretti E., Phillips G., Piccinni C., Pigatto L., Pironti A., Pizzuto A., Plockl B., Polli G., Poncet J. -M., Ponsot P., Puiatti M., Radloff D., Raimondi V., Ramos F., Rancsik P., Ricci D., Ricciarini S., Rincon E., Romano A., Rossi P., Roussel P., Rubino G., Saeki H., Sagara A., Sakakibara S., Sakamoto H., Sakamoto M., Sakamoto Y., Sakasai A., Sakata S., Sakuma T., Sakurai S., Salanon B., Salmi A., Sannazzaro G., Sano R., Sanpei A., Sasajima T., Sasaki S., Sasao H., Sato F., Sato M., Sawahata M., Scherber A., Scully S., Seki M., Seki S., Shibama Y., Shibata Y., Shikama T., Shimada K., Shimono M., Shinde J., Shinya T., Shinohara K., Shirai H., Shiraishi J., Soare S., Soleto A., Someya Y., Streciwilk-Kowalska E., Strobel H., Sueoka M., Sukegawa A., Sulistyanintyas D., Sumida S., Sunaoshi H., Suzuki H., Suzuki M., Suzuki S., Suzuki T., Suzuki Y., Svoboda J., Szabolics T., Szepesi T., Takahashi K., Takase Y., Takechi M., Takeda K., Takeiri Y., Takenaga H., Taliercio C., Tamura N., Tanaka H., Tanaka K., Tani K., Tanigawa H., Tardocchi M., Terakado A., Terakado M., Terakado T., Teuchner B., Tilia B., Tobita K., Toi K., Toida N., Tojo H., Tokitani M., Tokuzawa T., Tormarchio V., Tomine M., Torre A., Totsuka T., Tsuchiya K., Tsujii N., Tsuru D., Tsutsui H., Uchida M., Ueda Y., Uno J., Urano H., Usui K., Utoh H., Valisa M., Vallar M., Vallcorba-Carbonell R., Vallet J. -C., Varela J., Vega J., Verrecchia M., Vieillard L., Villone F., Vincenzi P., Wada K., Wada R., Wakatsuki T., Wanner M., Watanabe F., Watanabe K., Wauters T., Wiesen S., Wischmeier M., Yagi M., Yagyu J., Yajima M., Yokooka S., Yokoyama M., Yamamoto S., Yamanaka H., Yamauchi K., Yamauchi Y., Yamazaki H., Yamazaki K., Yamazaki R., Yamoto S., Yanagi S., Yanagihara K., Yoshizawa N., Zani L., Zito P., Kamada, Y., Di Pietro, E., Hanada, M., Barabaschi, P., Ide, S., Davis, S., Yoshida, M., Giruzzi, G., Sozzi, C., Abdel Maksoud, W., Abe, H., Aiba, N., Akiyama, T., Ayllon-Guerola, J., Arai, T., Artaud, J. -F., Asakura, N., Ashikawa, N., Balbinot, L., Bando, T., Baulaigue, O., Belonohy, E., Bin, W., Bombarda, F., Bolzonella, T., Bonne, F., Bonotto, M., Botija, J., Cabrera-Perez, S., Cardella, A., Carraro, L., Cavalier, J., Chernyshova, M., Chiba, S., Clement-Lorenzo, S., Cocilovo, V., Coda, S., Coelho, R., Coffey, I., Collin, B., Corato, V., Cucchiaro, A., Czarski, T., Dairaku, M., Day, C., de la Luna, E., De Tommasi, G., Decool, P., Di Pace, L., Dibon, M., Disset, G., Ejiri, A., Endo, Y., Ezumi, N., Falchetto, G., Fassina, A., Fejoz, P., Ferro, A., Fietz, W., Figini, L., Fornal, T., Frello, G., Fujita, T., Fukuda, T., Fukui, K., Fukumoto, M., Furukawa, M., Futatani, S., Gabellieri, L., Gaio, E., Galazka, K., Garcia, J., Garcia-Dominguez, J., Garcia-Lopez, J., Garcia-Munoz, M., Garzotti, L., Gasparini, F., Gharafi, S., Giacomelli, L., Ginoulhiac, G., Giudicotti, L., Guillen Gonzalez, R., Hajnal, N., Hall, S., Hamada, K., Hanada, K., Hasegawa, K., Hatae, T., Hatakeyama, S., Hauer, V., Hayashi, N., Hayashi, T., Heller, R., Higashijima, S., Hinata, J., Hiranai, S., Hiratsuka, J., Hiwatari, R., Hoa, C., Homma, H., Honda, A., Honda, M., Horiike, H., Hoshino, K., Hurzlmeier, H., Iafrati, M., Ibano, K., Ichige, H., Ichikawa, M., Ichimura, M., Ida, K., Idei, H., Iijima, T., Iio, S., Ikeda, R., Ikeda, Y., Imai, T., Imazawa, R., Inagaki, S., Inomoto, M., Inoue, S., Isayama, A., Ishida, S., Ishii, Y., Isobe, M., Janky, F., Joffrin, E., Jokinen, A., Kado, S., Kajita, S., Kajiwara, K., Kamata, I., Kaminaga, A., Kamiya, K., Kanapienyte, D., Kashiwa, Y., Kashiwagi, M., Katayama, K., Kawamata, Y., Kawamura, G., Kawano, K., Kawashima, H., Kin, F., Kitajima, S., Kiyono, K., Kizu, K., Kobayashi, K., Kobayashi, M., Kobayashi, S., Kobayashi, T., Kocsis, G., Koide, Yo., Koide, Yu., Kojima, A., Kokusen, S., Komuro, K., Konishi, S., Kovacsik, A., Ksiazek, I., Kubkowska, M., Kuhner, G., Kuramochi, M., Kurihara, K., Kurki-Suonio, T., Kurniawan, A. B., Kuwata, T., Lacroix, B., Lamaison, V., Lampasi, A., Lang, P., Lauber, P., Lawson, K., Louzguiti, A., Maekawa, R., Maekawa, T., Maeyama, S., Maffia, G., Maget, P., Mailloux, J., Maione, I., Maistrello, A., Malinowski, K., Marchiori, G., Marechal, J. -L., Massaut, V., Masuzaki, S., Matsunaga, G., Matsunaga, S., Mayri, Ch., Mattei, M., Medrano, M., Mele, A., Meyer, I., Michel, F., Minami, T., Miyata, Y., Miyazawa, J., Miyo, Y., Mizuuchi, T., Mogaki, K., Morales, J., Moreau, P., Mori, M., Morisaki, T., Morishima, S., Moriyama, S., Moro, A., Murakami, H., Murayama, M., Murakami, S., Nagasaki, K., Naito, O., Nakamura, S., Nakano, T., Nakashima, Y., Nardino, V., Narita, E., Narushima, Y., Natsume, K., Nemoto, S., Neu, R., Nicollet, S., Nishikawa, M., Nishimura, S., Nishiura, M., Nishiyama, T., Nocente, M., Nobuta, Y., Novello, L., Nunio, F., Ochoa, S., Ogawa, T., Ogawa, Y., Ohdachi, S., Ohmori, Y., Ohno, N., Ohtani, Y., Ohzeki, M., Oishi, T., Okano, F., Okano, J., Okano, K., Onishi, Y., Osakabe, M., Oshima, T., Ostuni, V., Oya, M., Oya, Y., Oyama, N., Ozeki, T., Pasqualotto, R., Pelli, S., Peretti, E., Phillips, G., Piccinni, C., Pigatto, L., Pironti, A., Pizzuto, A., Plockl, B., Polli, G., Poncet, J. -M., Ponsot, P., Puiatti, M., Radloff, D., Raimondi, V., Ramos, F., Rancsik, P., Ricci, D., Ricciarini, S., Rincon, E., Romano, A., Rossi, P., Roussel, P., Rubino, G., Saeki, H., Sagara, A., Sakakibara, S., Sakamoto, H., Sakamoto, M., Sakamoto, Y., Sakasai, A., Sakata, S., Sakuma, T., Sakurai, S., Salanon, B., Salmi, A., Sannazzaro, G., Sano, R., Sanpei, A., Sasajima, T., Sasaki, S., Sasao, H., Sato, F., Sato, M., Sawahata, M., Scherber, A., Scully, S., Seki, M., Seki, S., Shibama, Y., Shibata, Y., Shikama, T., Shimada, K., Shimono, M., Shinde, J., Shinya, T., Shinohara, K., Shirai, H., Shiraishi, J., Soare, S., Soleto, A., Someya, Y., Streciwilk-Kowalska, E., Strobel, H., Sueoka, M., Sukegawa, A., Sulistyanintyas, D., Sumida, S., Sunaoshi, H., Suzuki, H., Suzuki, M., Suzuki, S., Suzuki, T., Suzuki, Y., Svoboda, J., Szabolics, T., Szepesi, T., Takahashi, K., Takase, Y., Takechi, M., Takeda, K., Takeiri, Y., Takenaga, H., Taliercio, C., Tamura, N., Tanaka, H., Tanaka, K., Tani, K., Tanigawa, H., Tardocchi, M., Terakado, A., Terakado, M., Terakado, T., Teuchner, B., Tilia, B., Tobita, K., Toi, K., Toida, N., Tojo, H., Tokitani, M., Tokuzawa, T., Tormarchio, V., Tomine, M., Torre, A., Totsuka, T., Tsuchiya, K., Tsujii, N., Tsuru, D., Tsutsui, H., Uchida, M., Ueda, Y., Uno, J., Urano, H., Usui, K., Utoh, H., Valisa, M., Vallar, M., Vallcorba-Carbonell, R., Vallet, J. -C., Varela, J., Vega, J., Verrecchia, M., Vieillard, L., Villone, F., Vincenzi, P., Wada, K., Wada, R., Wakatsuki, T., Wanner, M., Watanabe, F., Watanabe, K., Wauters, T., Wiesen, S., Wischmeier, M., Yagi, M., Yagyu, J., Yajima, M., Yokooka, S., Yokoyama, M., Yamamoto, S., Yamanaka, H., Yamauchi, K., Yamauchi, Y., Yamazaki, H., Yamazaki, K., Yamazaki, R., Yamoto, S., Yanagi, S., Yanagihara, K., Yoshizawa, N., Zani, L., and Zito, P.
- Subjects
assembly ,Cryostat ,Nuclear and High Energy Physics ,Materials science ,Tokamak ,Nuclear engineering ,Plasma ,Condensed Matter Physics ,Field coil ,ITER risk mitigation ,Overcurrent ,law.invention ,Control theory ,law ,Electromagnetic coil ,research plan ,broader approach ,Voltage - Abstract
Construction of the JT-60SA tokamak was completed on schedule in March 2020. Manufacture and assembly of all the main tokamak components satisfied technical requirements, including dimensional accuracy and functional performances. Development of the plasma heating systems and diagnostics have also progressed, including the demonstration of the favourable electron cyclotron range of frequency (ECRF) transmission at multiple frequencies and the achievement of long sustainment of a high-energy intense negative ion beam. Development of all the tokamak operation control systems has been completed, together with an improved plasma equilibrium control scheme suitable for superconducting tokamaks including ITER. For preparation of the tokamak operation, plasma discharge scenarios have been established using this advanced equilibrium controller. Individual commissioning of the cryogenic system and the power supply system confirmed that these systems satisfy design requirements including operational schemes contributing directly to ITER, such as active control of heat load fluctuation of the cryoplant, which is essential for dynamic operation in superconducting tokamaks. The integrated commissioning (IC) is started by vacuum pumping of the vacuum vessel and cryostat, and then moved to cool-down of the tokamak and coil excitation tests. Transition to the super-conducting state was confirmed for all the TF, EF and CS coils. The TF coil current successfully reached 25.7 kA, which is the nominal operating current of the TF coil. For this nominal toroidal field of 2.25 T, ECRF was applied and an ECRF plasma was created. The IC was, however, suspended by an incident of over current of one of the superconducting equilibrium field coil and He leakage caused by insufficient voltage holding capability at a terminal joint of the coil. The unique importance of JT-60SA for H-mode and high-β steady-state plasma research has been confirmed using advanced integrated modellings. These experiences of assembly, IC and plasma operation of JT-60SA contribute to ITER risk mitigation and efficient implementation of ITER operation.
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- 2022
23. Modelling of ohmic startup and runaway electron formation in support of JT-60SA initial operation.
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Matsuyama, A., Wakatsuki, T., Inoue, S., Yamamoto, Y., Yoshida, M., and Urano, H.
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ELECTRON density , *POWER resources , *GAS as fuel , *ELECTRONS , *NEW business enterprises , *SUPERCONDUCTING coils , *RESISTANCE heating - Abstract
The plasma startup with ITER-relevant sub-mPa neutral pressures in the JT-60SA superconducting tokamak is studied using a zero-dimensional (0D) power balance model for the plasma burn-through phase. In the ohmic startup scenario assumed here, the lower limit of the operational neutral pressure is determined by the condition for the Townsend avalanche at a high E / p limit, whereas the upper limit depends on the available ohmic heating power for the burn-through with the base power supply (PS) of the superconducting coils, corresponding to 0.2–0.3 V m−1. The operational conditions that lead to RE generation are evaluated to mitigate the risk of RE discharges. The simulation shows that startup REs are generated during the temperature rise immediately after the burn-through under relatively low-density conditions, and then the RE current value is gradually increased in balance with the RE loss processes on the timescale of I p ramp-up. Therefore, it is expected that REs can be avoided or mitigated if the electron density during the early build-up phase is tuned by a combination of prefill gas and additional fuelling. However, a startup with an excessive prefill gas will lose the margin of the density control, and a full RE discharge can be triggered when the plasma burn-through fails owing to a high concentration of impurities such as oxygen, if the operational point is marginal to the burn-through limit. The present modelling work implies that preparing the operation with sufficient margins against the failure of impurity burn-through is important for mitigating the risk of unintended plasma termination. Although the carbon wall environment may have a lower risk of RE generation, to alleviate the operational uncertainties of the new device, strategies for expanding the operational window are also discussed in support of JT-60SA initial operation. [ABSTRACT FROM AUTHOR]
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- 2023
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24. 1561P APC mutation (mt.), MYC, and GATA6 amplifications (amp.) were associated with worse survival in HER2-positive advanced gastric cancer patients treated with S-1/capecitabine plus oxaliplatin combined with trastuzumab (T-mab) and nivolumab (N-mab)
- Author
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Wakatsuki, T., Takahari, D., Yamamoto, N., Ooki, A., Chin, K., Kurihara, N., Mashima, T., Ogura, M., Nakayama, I., Fukuoka, S., Hirano, H., Minashi, K., Hara, H., Kato, K., Ishizuka, N., Kitano, S., Seimiya, H., Takeuchi, K., Boku, N., and Yamaguchi, K.
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- 2023
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25. 1566P Clinical relevance of circulating tumor DNA in HER2 -positive advanced gastric cancer: Results from phase Ib trial of HER2 and PD-1 dual targeted therapy (Ni-High)
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Osumi, H., Wakatsuki, T., Takahari, D., Ooki, A., Chin, K., Shoji, H., Ogura, M., Nakayama, I., Yamamoto, N., Hirano, H., Hara, H., Minashi, K., Shinozaki, E., Kato, K., Kurihara, N., Kitano, S., Takeuchi, K., Boku, N., and Yamaguchi, K.
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- 2023
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26. 1554P Clinical Impact of ERBB2 copy number and tumor mutation burden (TMB) in patients with HER2- positive advanced gastric cancer treated by nivolumab (N-mab) plus trastuzumab (T-mab) and standard chemotherapy
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Shoji, H., Wakatsuki, T., Takahari, D., Yamamoto, N., Ooki, A., Chin, K., Kurihara, N., Kiyotani, K., Mashima, T., Ogura, M., Nakayama, I., Minashi, K., Hara, H., Shinozaki, E., Ishizuka, N., Kitano, S., Seimiya, H., Takeuchi, K., Boku, N., and Yamaguchi, K.
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- 2023
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27. P-118 Clinical significance of primary tumor sites and epithelial tumor markers in patients with unresectable/recurrent gastrointestinal neuroendocrine carcinoma treated with combined chemotherapy with irinotecan and cisplatin
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Fukuda, K., Osumi, H., Akira, O., Udagawa, S., Nakayama, I., Fukuoka, S., Wakatsuki, T., Ogura, M., Takahari, D., Chin, K., Yamaguchi, K., and Shinozaki, E.
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- 2023
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28. P-87 A multi-institutional observational study evaluating the efficacy of anti-epidermal growth factor antibody re-challenge in tissue RAS/BRAF wild-type metastatic colorectal cancer
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Sawada, R., Osumi, H., Yoshinami, Y., Takashima, A., Ouchi, K., Wakatsuki, T., Ooki, A., Nakayama, I., Fukuoka, S., Ogura, M., Takahari, D., Chin, K., Hirano, H., Shoji, H., Okita, N., Kato, K., Ishizuka, N., Saruta, M., Boku, N., Yamaguchi, K., and Shinozaki, E.
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- 2023
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29. DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
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M. E. Fenstermacher, J. Abbate, S. Abe, T. Abrams, M. Adams, B. Adamson, N. Aiba, T. Akiyama, P. Aleynikov, E. Allen, S. Allen, H. Anand, J. Anderson, Y. Andrew, T. Andrews, D. Appelt, R. Arbon, N. Ashikawa, A. Ashourvan, M. Aslin, Y. Asnis, M. Austin, D. Ayala, J. Bak, I. Bandyopadhyay, S. Banerjee, K. Barada, L. Bardoczi, J. Barr, E. Bass, D. Battaglia, A. Battey, W. Baumgartner, L. Baylor, J. Beckers, M. Beidler, E. Belli, J. Berkery, T. Bernard, N. Bertelli, M. Beurskens, R. Bielajew, S. Bilgili, B. Biswas, S. Blondel, J. Boedo, I. Bogatu, R. Boivin, T. Bolzonella, M. Bongard, X. Bonnin, P. Bonoli, M. Bonotto, A. Bortolon, S. Bose, N. Bosviel, S. Bouwmans, M. Boyer, W. Boyes, L. Bradley, R. Brambila, D. Brennan, S. Bringuier, L. Brodsky, M. Brookman, J. Brooks, D. Brower, G. Brown, W. Brown, M. Burke, K. Burrell, K. Butler, R. Buttery, I. Bykov, P. Byrne, A. Cacheris, K. Callahan, J. Callen, G. Campbell, J. Candy, J. Canik, P. Cano-Megias, N. Cao, L. Carayannopoulos, T. Carlstrom, W. Carrig, T. Carter, W. Cary, L. Casali, M. Cengher, G. Cespedes Paz, R. Chaban, V. Chan, B. Chapman, I. Char, A. Chattopadhyay, R. Chen, J. Chen, X. Chen, M. Chen, Z. Chen, M. Choi, W. Choi, G. Choi, L. Chousal, C. Chrobak, C. Chrystal, Y. Chung, R. Churchill, M. Cianciosa, J. Clark, M. Clement, S. Coda, A. Cole, C. Collins, W. Conlin, A. Cooper, J. Cordell, B. Coriton, T. Cote, J. Cothran, A. Creely, N. Crocker, C. Crowe, B. Crowley, T. Crowley, D. Cruz-Zabala, D. Cummings, M. Curie, D. Curreli, A. Dal Molin, B. Dannels, A. Dautt-Silva, K. Davda, G. De Tommasi, P. De Vries, G. Degrandchamp, J. Degrassie, D. Demers, S. Denk, S. Depasquale, E. Deshazer, A. Diallo, S. Diem, A. Dimits, R. Ding, S. Ding, W. Ding, T. Do, J. Doane, G. Dong, D. Donovan, J. Drake, W. Drews, J. Drobny, X. Du, H. Du, V. Duarte, D. Dudt, C. Dunn, J. Duran, A. Dvorak, F. Effenberg, N. Eidietis, D. Elder, D. Eldon, R. Ellis, W. Elwasif, D. Ennis, K. Erickson, D. Ernst, M. Fasciana, D. Fedorov, E. 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S, Kulchar, J, Kwon, K, La Haye, R, Laggner, F, Lan, H, Lantsov, R, Lao, L, Esquisabel, A, Lasnier, C, Lau, C, Leard, B, Lee, J, Lee, R, Lee, M, Lee, Y, Lee, C, Lee, S, Lehnen, M, Leonard, A, Leppink, E, Lesher, M, Lestz, J, Leuer, J, Leuthold, N, Li, X, Li, K, Li, E, Li, G, Li, L, Li, Z, Li, J, Li, Y, Lin, Z, Lin, D, Liu, X, Liu, J, Liu, Y, Liu, T, Liu, C, Liu, Z, Liu, D, Liu, A, Loarte-Prieto, A, Lodestro, L, Logan, N, Lohr, J, Lombardo, B, Lore, J, Luan, Q, Luce, T, Di Cortemiglia, T, Luhmann, N, Lunsford, R, Luo, Z, Lvovskiy, A, Lyons, B, Ma, X, Madruga, M, Madsen, B, Maggi, C, Maheshwari, K, Mail, A, Mailloux, J, Maingi, R, Major, M, Makowski, M, Manchanda, R, Marini, C, Marinoni, A, Maris, A, Markovic, T, Marrelli, L, Martin, E, Mateja, J, Matsunaga, G, Maurizio, R, Mauzey, P, Mauzey, D, Mcardle, G, Mcclenaghan, J, Mccollam, K, Mcdevitt, C, Mckay, K, Mckee, G, Mclean, A, Mehta, V, Meier, E, Menard, J, Meneghini, O, Merlo, G, Messer, S, Meyer, W, Michael, C, Michoski, C, Milne, P, Minet, G, Misleh, A, Mitrishkin, Y, Moeller, C, Montes, K, Morales, M, Mordijck, S, Moreau, D, Morosohk, S, Morris, P, Morton, L, Moser, A, Moyer, R, Moynihan, C, Mrazkova, T, Mueller, D, Munaretto, S, Burgos, J, Murphy, C, Murphy, K, Muscatello, C, Myers, C, Nagy, A, Nandipati, G, Navarro, M, Nave, F, Navratil, G, Nazikian, R, Neff, A, Neilson, G, Neiser, T, Neiswanger, W, Nelson, D, Nelson, A, Nespoli, F, Nguyen, R, Nguyen, L, Nguyen, X, Nichols, J, Nocente, M, Nogami, S, Noraky, S, Norausky, N, Nornberg, M, Nygren, R, Odstrcil, T, Ogas, D, Ogorman, T, Ohdachi, S, Ohtani, Y, Okabayashi, M, Okamoto, M, Olavson, L, Olofsson, E, Omullane, M, Oneill, R, Orlov, D, Orvis, W, Osborne, T, Pace, D, Canal, G, Martinez, A, Palacios, L, Pan, C, Pan, Q, Pandit, R, Pandya, M, Pankin, A, Park, Y, Park, J, Parker, S, Parks, P, Parsons, M, Patel, B, Pawley, C, Paz-Soldan, C, Peebles, W, Pelton, S, Perillo, R, Petty, C, Peysson, Y, Pierce, D, Pigarov, A, Pigatto, L, Piglowski, D, Pinches, S, Pinsker, R, Piovesan, P, Piper, N, Pironti, A, Pitts, R, Pizzo, J, Plank, U, Podesta, M, Poli, E, Poli, F, Ponce, D, Popovic, Z, Porkolab, M, Porter, G, Powers, C, Powers, S, Prater, R, Pratt, Q, Pusztai, I, Qian, J, Qin, X, Ra, O, Rafiq, T, Raines, T, Raman, R, Rauch, J, Raymond, A, Rea, C, Reich, M, Reiman, A, Reinhold, S, Reinke, M, Reksoatmodjo, R, Ren, Q, Ren, Y, Ren, J, Rensink, M, Renteria, J, Rhodes, T, Rice, J, Roberts, R, Robinson, J, Fernandez, P, Rognlien, T, Rosenthal, A, Rosiello, S, Rost, J, Roveto, J, Rowan, W, Rozenblat, R, Ruane, J, Rudakov, D, Ruiz, J, Rupani, R, Saarelma, S, Sabbagh, S, Sachdev, J, Saenz, J, Saib, S, Salewski, M, Salmi, A, Sammuli, B, Samuell, C, Sandorfi, A, Sang, C, Sarff, J, Sauter, O, Schaubel, K, Schmitz, L, Schmitz, O, Schneider, J, Schroeder, P, Schultz, K, Schuster, E, Schwartz, J, Sciortino, F, Scotti, F, Scoville, J, Seltzman, A, Seol, S, Sfiligoi, I, Shafer, M, Sharapov, S, Shen, H, Sheng, Z, Shepard, T, Shi, S, Shibata, Y, Shin, G, Shiraki, D, Shousha, R, Si, H, Simmerling, P, Sinclair, G, Sinha, J, Sinha, P, Sips, G, Sizyuk, T, Skinner, C, Sladkomedova, A, Slendebroek, T, Slief, J, Smirnov, R, Smith, J, Smith, S, Smith, D, Snipes, J, Snoep, G, Snyder, A, Snyder, P, Solano, E, Solomon, W, Song, J, Sontag, A, Soukhanovskii, V, Spendlove, J, Spong, D, Squire, J, Srinivasan, C, Stacey, W, Staebler, G, Stagner, L, Stange, T, Stangeby, P, Stefan, R, Stemprok, R, Stephan, D, Stillerman, J, Stoltzfus-Dueck, T, Stonecipher, W, Storment, S, Strait, E, Su, D, Sugiyama, L, Sun, Y, Sun, P, Sun, Z, Sun, A, Sundstrom, D, Sung, C, Sungcoco, J, Suttrop, W, Suzuki, Y, Suzuki, T, Svyatkovskiy, A, Swee, C, Sweeney, R, Sweetnam, C, Szepesi, G, Takechi, M, Tala, T, Tanaka, K, Tang, X, Tang, S, Tao, Y, Tao, R, Taussig, D, Taylor, T, Teixeira, K, Teo, K, Theodorsen, A, Thomas, D, Thome, K, Thorman, A, Thornton, A, Ti, A, Tillack, M, Timchenko, N, Tinguely, R, Tompkins, R, Tooker, J, De Sousa, A, Trevisan, G, Tripathi, S, Ochoa, A, Truong, D, Tsui, C, Turco, F, Turnbull, A, Umansky, M, Unterberg, E, Vaezi, P, Vail, P, Valdez, J, Valkis, W, Van Compernolle, B, Van Galen, J, Van Kampen, R, Van Zeeland, M, Verdoolaege, G, Vianello, N, Victor, B, Viezzer, E, Vincena, S, Wade, M, Waelbroeck, F, Wai, J, Wakatsuki, T, Walker, M, Wallace, G, Waltz, R, Wampler, W, Wang, L, Wang, H, Wang, Y, Wang, Z, Wang, G, Ward, S, Watkins, M, Watkins, J, Wehner, W, Wei, Y, Weiland, M, Weisberg, D, Welander, A, White, A, White, R, Wiesen, S, Wilcox, R, Wilks, T, Willensdorfer, M, Wilson, H, Wingen, A, Wolde, M, Wolff, M, Woller, K, Wolz, A, Wong, H, Woodruff, S, Wu, M, Wu, Y, Wukitch, S, Wurden, G, Xiao, W, Xie, R, Xing, Z, Xu, X, Xu, C, Xu, G, Yan, Z, Yang, X, Yang, S, Yokoyama, T, Yoneda, R, Yoshida, M, You, K, Younkin, T, Yu, J, Yu, M, Yu, G, Yuan, Q, Zaidenberg, L, Zakharov, L, Zamengo, A, Zamperini, S, Zarnstorff, M, Zeger, E, Zeller, K, Zeng, L, Zerbini, M, Zhang, L, Zhang, X, Zhang, R, Zhang, B, Zhang, J, Zhao, L, Zhao, B, Zheng, Y, Zheng, L, Zhu, B, Zhu, J, Zhu, Y, Zsutty, M, Zuin, M, Lawrence Livermore National Laboratory, Princeton Plasma Physics Laboratory, Princeton University, General Atomics, Max-Planck-Institut für Plasmaphysik, Imperial College London, National Institute for Fusion Science, Universidade de São Paulo, University of Texas at Austin, ITER, College of William and Mary, University of California Los Angeles, University of California San Diego, Columbia University, Massachusetts Institute of Technology, Oak Ridge National Laboratory, Eindhoven University of Technology, Oak Ridge Associated Universities, West Virginia University, University of Tennessee, Knoxville, National Research Council of Italy, Stony Brook University, Purdue University, University of Seville, University of Science and Technology of China, Carnegie Mellon University, Institute for Plasma Research, Peking University, University of California Davis, University of California Irvine, Commonwealth Fusion Systems, University of Liverpool, University of Illinois at Urbana-Champaign, University of Milan - Bicocca, Georgia Institute of Technology, Southwestern Institute of Physics, University of Toronto, Auburn University, Polytechnic University of Turin, Universidade Lisboa, Association CCFE, KTH Royal Institute of Technology, San Diego State University, Durham University, Lehigh University, Fusion and Plasma Physics, University of Washington, Department of Applied Physics, Sandia National Laboratories, Ghent University, Technical University of Denmark, CEA, University of Colorado Boulder, Harvard University, National Technical University of Athens, Coventry University, University of Stuttgart, Czech Academy of Sciences, Harvey Mudd College, Seoul National University, Donghua University, University of York, Dalian University of Technology, University of California Berkeley, Los Alamos National Laboratory, United States Department of Energy, University of British Columbia, Pacific Northwest National Laboratory, University of Wisconsin, Michigan State University, University of Strathclyde, Pennsylvania State University, Rensselaer Polytechnic Institute, University of Southern California, Chalmers University of Technology, University of Virginia, University of Naples Federico II, University of Oxford, VTT Technical Research Centre of Finland, National Institute of Technology, University of Connecticut, DIFFER, CIEMAT, Hanyang University, Brigham Young University, UiT The Arctic University of Norway, Australian National University, Russian Research Centre Kurchatov Institute, Forschungszentrum Jülich, Zhejiang University, The University of Tokyo, University of Michigan, Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile, Aalto-yliopisto, Aalto University, DIII-D Team, Complex Ionized Media, Elementary Processes in Gas Discharges, Applied Physics and Science Education, Science and Technology of Nuclear Fusion, and Control Systems Technology
- Subjects
Nuclear and High Energy Physics ,Tokamak ,Technology and Engineering ,DIII-D ,Nuclear engineering ,TOKAMAKS ,MITIGATION ,law.invention ,Plasma physics ,mitigation ,law ,plasma physic ,tokamak ,Physics ,Core-edge integration ,Basis (linear algebra) ,plasma physics ,core-edge integration ,scenarios ,Fusion power ,Condensed Matter Physics ,SCENARIOS ,fusion energy ,Fusion energy - Abstract
Funding Information: This material is based upon work supported by the US Department of Energy, Office of Science, Office of Fusion Energy Sciences, using the DIII-D National Fusion Facility, a DOE Office of Science user facility, under Awards DE-FC02-04ER54698 and DE-AC52-07NA27344. Publisher Copyright: © 2022 IAEA, Vienna. DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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- 2022
30. Plasma physics and control studies planned in JT-60SA for ITER and DEMO operations and risk mitigation
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M Yoshida, G Giruzzi, N Aiba, J F Artaud, J Ayllon-Guerola, L Balbinot, O Beeke, E Belonohy, P Bettini, W Bin, A Bierwage, T Bolzonella, M Bonotto, C Boulbe, J Buermans, M Chernyshova, S Coda, R Coelho, S Davis, C Day, G De Tommasi, M Dibon, A Ejiri, G Falchetto, A Fassina, B Faugeras, L Figini, M Fukumoto, S Futatani, K Galazka, J Garcia, M Garcia-Muñoz, L Garzotti, L Giacomelli, L Giudicotti, S Hall, N Hayashi, C Hoa, M Honda, K Hoshino, M Iafrati, A Iantchenko, S Ide, S Iio, R Imazawa, S Inoue, A Isayama, E Joffrin, K Kamiya, Y Ko, M Kobayashi, T Kobayashi, G Kocsis, A Kovacsik, T Kurki-Suonio, B Lacroix, P Lang, Ph Lauber, A Louzguiti, E de la Luna, G Marchiori, M Mattei, A Matsuyama, S Mazzi, A Mele, F Michel, Y Miyata, J Morales, P Moreau, A Moro, T Nakano, M Nakata, E Narita, R Neu, S Nicollet, M Nocente, S Nowak, F P Orsitto, V Ostuni, Y Ohtani, N Oyama, R Pasqualotto, B Pégourié, E Perelli, L Pigatto, C Piccinni, A Pironti, P Platania, B Ploeckl, D Ricci, P Roussel, G Rubino, R Sano, K Särkimäki, K Shinohara, S Soare, C Sozzi, S Sumida, T Suzuki, Y Suzuki, T Szabolics, T Szepesi, Y Takase, M Takech, N Tamura, K Tanaka, H Tanaka, M Tardocchi, A Terakado, H Tojo, T Tokuzawa, A Torre, N Tsujii, H Tsutsui, Y Ueda, H Urano, M Valisa, M Vallar, J Vega, F Villone, T Wakatsuki, T Wauters, M Wischmeier, S Yamoto, L Zani, Yoshida, M, Giruzzi, G, Aiba, N, Artaud, J F, Ayllon-Guerola, J, Balbinot, L, Beeke, O, Belonohy, E, Bettini, P, Bin, W, Bierwage, A, Bolzonella, T, Bonotto, M, Boulbe, C, Buermans, J, Chernyshova, M, Coda, S, Coelho, R, Davis, S, Day, C, De Tommasi, G, Dibon, M, Ejiri, A, Falchetto, G, Fassina, A, Faugeras, B, Figini, L, Fukumoto, M, Futatani, S, Galazka, K, Garcia, J, Garcia-Muñoz, M, Garzotti, L, Giacomelli, L, Giudicotti, L, Hall, S, Hayashi, N, Hoa, C, Honda, M, Hoshino, K, Iafrati, M, Iantchenko, A, Ide, S, Iio, S, Imazawa, R, Inoue, S, Isayama, A, Joffrin, E, Kamiya, K, Ko, Y, Kobayashi, M, Kobayashi, T, Kocsis, G, Kovacsik, A, Kurki-Suonio, T, Lacroix, B, Lang, P, Lauber, Ph, Louzguiti, A, de la Luna, E, Marchiori, G, Mattei, M, Matsuyama, A, Mazzi, S, Mele, A, Michel, F, Miyata, Y, Morales, J, Moreau, P, Moro, A, Nakano, T, Nakata, M, Narita, E, Neu, R, Nicollet, S, Nocente, M, Nowak, S, Orsitto, F P, Ostuni, V, Ohtani, Y, Oyama, N, Pasqualotto, R, Pégourié, B, Perelli, E, Pigatto, L, Piccinni, C, Pironti, A, Platania, P, Ploeckl, B, Ricci, D, Roussel, P, Rubino, G, Sano, R, Särkimäki, K, Shinohara, K, Soare, S, Sozzi, C, Sumida, S, Suzuki, T, Suzuki, Y, Szabolics, T, Szepesi, T, Takase, Y, Takech, M, Tamura, N, Tanaka, K, Tanaka, H, Tardocchi, M, Terakado, A, Tojo, H, Tokuzawa, T, Torre, A, Tsujii, N, Tsutsui, H, Ueda, Y, Urano, H, Valisa, M, Vallar, M, Vega, J, Villone, F, Wakatsuki, T, Wauters, T, Wischmeier, M, Yamoto, S, Zani, L, Artaud, J, Garcia-Munoz, M, Lauber, P, Orsitto, F, Pegourie, B, Sarkimaki, K, Control, Analysis and Simulations for TOkamak Research (CASTOR), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Alexandre Dieudonné (LJAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, National Institutes for Quantum and Radiological Science and Technology, CEA, University of Seville, National Research Council of Italy, University of Oxford, JET, CNR-ENEA-EURATOM Association, Université Côte d'Azur, Royal Military Academy, Soltan Institute for Nuclear Studies, Swiss Federal Institute of Technology Lausanne, Universidade Lisboa, Fusion for Energy, Karlsruhe Institute of Technology, University of Naples Federico II, Max-Planck-Institut für Plasmaphysik, The University of Tokyo, BarcelonaTech, Kyoto University, Keio University, Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile, Tokyo Institute of Technology, Nagoya University, Centre for Energy Research, Budapest University of Technology and Economics, Department of Applied Physics, CIEMAT, Physique des Interactions Ioniques et Moleculaires, National Institute for Fusion Science, University of Milan - Bicocca, Tuscia University, Institute of Cryogenics and Isotopic Technologies - ICIT, National Institutes for Quantum Science and Technology, Aalto-yliopisto, and Aalto University
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Scenario development ,Superconductivity ,Física [Àrees temàtiques de la UPC] ,Physics ,Risk mitigation ,risk mitigation ,JT-60SA ,Condensed Matter Physics ,Plasma control ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,plasma control ,scenario development ,Nuclear Energy and Engineering ,ddc:530 ,Superconductivitat - Abstract
Alarge superconducting machine, JT-60SA has been constructed to provide major contributions to the ITER program and DEMO design. For the success of the ITER project and fusion reactor, understanding and development of plasma controllability in ITER and DEMO relevant higher beta regimes are essential. JT-60SA has focused the program on the plasma controllability for scenario development and risk mitigation in ITER as well as on investigating DEMO relevant regimes. This paper summarizes the high research priorities and strategy for the JT-60SA project. Recent works on simulation studies to prepare the plasma physics and control experiments are presented, such as plasma breakdown and equilibrium controls, hybrid and steady-state scenario development, and risk mitigation techniques. Contributions of JT-60SA to ITER and DEMOhave been clarified through those studies. Peer Reviewed Article escrit per 127 autors/autores: M Yoshida, G Giruzzi, N Aiba, J F Artaud, J Ayllon-Guerola, L Balbinot, OBeeke, E Belonohy, P Bettini, W Bin, A Bierwage, T Bolzonella, M Bonotto, CBoulbe, J Buermans, M Chernyshova, S Coda, R Coelho, S Davis, C Day, GDeTommasi, M Dibon, A Ejiri, G Falchetto, A Fassina, B Faugeras, L Figini, M Fukumoto, S Futatani, K Galazka, J Garcia, M Garcia-Muñoz, L Garzotti, L Giacomelli, L Giudicotti, S Hall, N Hayashi, C Hoa, M Honda, K Hoshino, M Iafrati, A Iantchenko, S Ide, S Iio, R Imazawa, S Inoue, A Isayama, E Joffrin, K Kamiya, Y Ko, M Kobayashi, T Kobayashi, G Kocsis, A Kovacsik, T Kurki-Suonio, B Lacroix, P Lang, Ph Lauber, A Louzguiti, E de la Luna, G Marchiori, M Mattei, A Matsuyama, S Mazzi, A Mele, F Michel, Y Miyata, J Morales, P Moreau, A Moro, T Nakano, M Nakata, E Narita, R Neu, S Nicollet, M Nocente, S Nowak, F P Orsitto, V Ostuni, Y Ohtani, N Oyama, R Pasqualotto, B Pégourié, E Perelli, L Pigatto, C Piccinni, A Pironti, P Platania, B Ploeckl, D Ricci, P Roussel, G Rubino, R Sano, K Särkimäki, K Shinohara, S Soare, C Sozzi, S Sumida, T Suzuki, Y Suzuki, T Szabolics, T Szepesi, Y Takase, M Takech, N Tamura, K Tanaka, H Tanaka, M Tardocchi, A Terakado, H Tojo, T Tokuzawa, A Torre, N Tsujii, H Tsutsui, Y Ueda, H Urano, M Valisa, M Vallar, J Vega, F Villone, T Wakatsuki, T Wauters, M Wischmeier, S Yamoto, L Zani
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- 2022
31. Risk Factors for Intraoperative Instability in Sedated Patients Undergoing Pulmonary Vein Isolation Ablation.
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Hayashi M, Soeki T, Noda Y, Tamagami D, Morinishi K, Chikata Y, Takahashi T, Matsuura T, Ise T, Yamaguchi K, Yagi S, Yamada H, Wakatsuki T, and Sata M
- Abstract
Persistent or paroxysmal atrial fibrillation is typically treated with pulmonary vein isolation (PVI) ablation under deep sedation with propofol. Intraoperative hemodynamic or respiratory instability often interferes with the surgical procedure. We retrospectively investigated risk factors in 80 patients who underwent their first PVI ablation for atrial fibrillation at our hospital. Background and echocardiography findings were collected from their electronic charts and the questionnaires they completed during hospitalization. Total intraoperative propofol dose and bolus injections (total number and volume) were defined as surrogate measures of patient instability. Single and stepwise multiple regression were performed using each measure as the dependent variable. When total propofol dose was employed as the dependent variable, significant associations were observed with drinking status (P < 0.05) and body mass index (BMI) (P < 0.05). When total number or volume of intravenous propofol boluses were each used as the dependent variable, significant associations were noted with age (P < 0.05) and BMI (P < 0.05). Separately, statistical analyses were conducted using total propofol dose or total number of bolus injections as the dependent variable and echocardiography parameters as independent variables. A significant association was detected between total dose and left atrial dimension (P < 0.05). These results suggested that younger age, higher BMI (obesity), and current drinking status adversely affect patient stability under deep sedation. To ensure safe ablation, physicians should pay attention to these risk factors when administering deep sedation for PVI.
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- 2024
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32. Myeloid subsets impede the efficacy of anti-PD1 therapy in patients with advanced gastric cancer (WJOG10417GTR study).
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Shoji H, Kudo-Saito C, Nagashima K, Imazeki H, Tsugaru K, Takahashi N, Kawakami T, Amanuma Y, Wakatsuki T, Okano N, Narita Y, Yamamoto Y, Kizawa R, Muro K, Aoki K, and Boku N
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- Humans, Male, Female, Middle Aged, Aged, Immune Checkpoint Inhibitors therapeutic use, Immune Checkpoint Inhibitors pharmacology, Adult, Programmed Cell Death 1 Receptor antagonists & inhibitors, Nivolumab therapeutic use, Nivolumab pharmacology, Stomach Neoplasms drug therapy, Stomach Neoplasms immunology, Stomach Neoplasms pathology, Myeloid Cells metabolism, Myeloid Cells immunology, Myeloid Cells drug effects
- Abstract
Background: Gastric cancer (GC) is one of the most common and deadly malignant diseases worldwide. Despite revolutionary advances, the therapeutic efficacy of anti-PD1/PDL1 monoclonal antibodies in advanced GC is still low due to the emergence of innate and acquired resistance to treatment. Myeloid cells represent the majority of human immune cells. Therefore, their increase, decrease, and abnormality could have a significant impact on the patient's immune system and the progression of cancer, and reprogramming, inhibiting, and eliminating the tumor-supportive types may improve the immunological situation and efficacy of immunotherapy. However, the significance of myeloid cells in anti-PD1/PDL1 therapy remains unclear in GC. In the WJOG10417GTR study on GC, we sought to identify myeloid determinants that could predict anti-PD1 therapeutic efficacy and also serve as potential therapeutic targets., Methods: We collected tumor tissues and peripheral blood from 96 patients with advanced GC before and 1 month after anti-PD1 nivolumab monotherapy, and the isolated whole leucocytes were analyzed by flow cytometry for various immune cell populations, including many myeloid subsets. Then, the relationship between the cellular levels and progression-free survival (PFS) or overall survival (OS) was statistically analyzed., Results: We found that high levels of several myeloid subsets expressing molecules that have been targeted in drug discovery but not yet approved for clinical use were significantly associated with shorter PFS/OS as compared with low levels: PDL1
+ and CTLA4+ myeloid subsets within tumors at baseline, PDL1+ , B7H3+ and CD115+ myeloid subsets in peripheral blood at baseline, and LAG3+ , CD155+ and CD115+ myeloid subsets in peripheral blood at post-treatment., Conclusions: This study revealed that these myeloid subsets are significant risk factors in nivolumab therapy for advanced GC. Targeting them may be useful as diagnostic biomarkers to predict potential anti-PD1 therapeutic efficacy, and also as therapeutic targets for accelerating the development of new drugs to improve clinical outcomes in immunotherapy for GC., Competing Interests: Competing interests: HS received research grants from Ono Pharmaceutical and Takeda Pharmaceutical, and honoraria from Ono Pharmaceutical and Bristol-Myers Squibb. CK-S received a grant from Chiome Bioscience, and honoraria from Ono Pharmaceutical and Bristol-Myers Squibb. KN received honoraria from Pfizer, Fujimoto Pharmaceutical, Senju Pharmaceutical, and Toray. HI received honoraria from Ono Pharmaceutical. NT received honoraria from Ono Pharmaceutical, Bristol-Myers Squibb, and Taiho Pharmaceutical. TK received honoraria from Ono Pharmaceutical and Bristol-Myers Squibb. NO received honoraria from Taiho Pharmaceutical, Eli Lilly Japan, Eisai, Bayer, Chugai Pharmaceutical, Ono Pharmaceutical, Takeda Pharmaceutical, and GlaxoSmithKline. YN received honoraria from Eli Lilly, Daiichi Sankyo, Taiho, Ono Pharmaceutical, and Bristol-Myers Squibb. YY received honoraria from Chugai Pharmaceutical, Ono Pharmaceutical, Takeda Pharmaceutical, Taiho, Sanofi, Yakult, Nihon Servier, Lilly, Asahi Kasei Parma. KA received grants from Ono Pharmaceutical, Chugai Pharmaceutical, Eisai, Daiichi Sankyo, and Chiome Bioscience. KM received honoraria from Amgen, AstraZeneca, Chugai Pharmaceutical, Ono Pharmaceutical, Eli Lilly, Daiichi Sankyo, Taiho, and Bristol-Myers Squibb. NB received honoraria from Ono Pharmaceutical, Bristol-Myers Squibb, Taiho Pharmaceutical, Eli Lilly, and Daiichi Sankyo. Other authors have no competing financial interests., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2024
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33. Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa-A Case Report.
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Yagi I, Yagi S, Nakanishi K, Tezuka K, Matsuyama K, Aibara Y, Ishida T, Yoneda H, Yamamoto M, Ise T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Kitagawa T, Nishioka Y, and Sata M
- Abstract
A delayed diagnosis of polyarteritis nodosa may lead to critical limb-threatening ischemia (CLTI). A 74-year-old woman presented with left-foot pain and was treated with oral vasodilators and antiplatelet agents. However, the distal ischemia progressed to CLTI, including gangrene of the fingers and toes, and bilateral foot dropping appeared because of peroneal nerve paralysis. Angiography of the extremities revealed obstruction and stenosis of medium-sized arteries. Based on the progressive distal gangrene, mononeuropathy multiplex, and pathological findings of necrotic vasculitis, polyarteritis nodosa was diagnosed, and the patient's condition improved. A biopsy and neurological examination are essential for the appropriate diagnosis of PAN and immediate treatment.
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- 2024
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34. Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments.
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Yang J, Daily NJ, Pullinger TK, Wakatsuki T, and Sobie EA
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- Humans, Computational Biology methods, Algorithms, Ion Channels metabolism, Models, Cardiovascular, Myocytes, Cardiac physiology, Myocytes, Cardiac cytology, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells physiology, Cell Differentiation physiology, Computer Simulation
- Abstract
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have gained traction as a powerful model in cardiac disease and therapeutics research, since iPSCs are self-renewing and can be derived from healthy and diseased patients without invasive surgery. However, current iPSC-CM differentiation methods produce cardiomyocytes with immature, fetal-like electrophysiological phenotypes, and the variety of maturation protocols in the literature results in phenotypic differences between labs. Heterogeneity of iPSC donor genetic backgrounds contributes to additional phenotypic variability. Several mathematical models of iPSC-CM electrophysiology have been developed to help to predict cell responses, but these models individually do not capture the phenotypic variability observed in iPSC-CMs. Here, we tackle these limitations by developing a computational pipeline to calibrate cell preparation-specific iPSC-CM electrophysiological parameters. We used the genetic algorithm (GA), a heuristic parameter calibration method, to tune ion channel parameters in a mathematical model of iPSC-CM physiology. To systematically optimize an experimental protocol that generates sufficient data for parameter calibration, we created in silico datasets by simulating various protocols applied to a population of models with known conductance variations, and then fitted parameters to those datasets. We found that calibrating to voltage and calcium transient data under 3 varied experimental conditions, including electrical pacing combined with ion channel blockade and changing buffer ion concentrations, improved model parameter estimates and model predictions of unseen channel block responses. This observation also held when the fitted data were normalized, suggesting that normalized fluorescence recordings, which are more accessible and higher throughput than patch clamp recordings, could sufficiently inform conductance parameters. Therefore, this computational pipeline can be applied to different iPSC-CM preparations to determine cell line-specific ion channel properties and understand the mechanisms behind variability in perturbation responses., Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: "Tetsuro Wakatsuki and Neil Daily are employees with an ownership stake in Invivo Sciences. This company received an NIH SBIR grant that partially funded the research described in the study.", (Copyright: © 2024 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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35. The APOA1 p.Leu202Arg variant potentially causes autosomal recessive cardiac amyloidosis.
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Yagi S, Miyamoto R, Tasaki M, Morino H, Otani R, Kadota M, Ise T, Yamazaki H, Kusunose K, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Fukuda D, Ueda M, and Sata M
- Abstract
ApoA-I amyloidosis is an extremely rare form of systemic amyloidosis that commonly involves the heart, kidneys, and liver. ApoA-I amyloidosis is caused by amyloidogenic variants of APOA1 that are inherited in an autosomal dominant manner. Here, we report a 69-year-old man with sporadic cardiac amyloidosis who was born to consanguineous parents and carried a homozygous variant of p.Leu202Arg in APOA1., (© 2024. The Author(s).)
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- 2024
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36. Aspirin-Free Strategy for Percutaneous Coronary Intervention in Patients With Oral Anticoagulation: Prespecified Subgroup Analysis From the STOPDAPT-3 Trial.
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Natsuaki M, Watanabe H, Morimoto T, Yamamoto K, Obayashi Y, Nishikawa R, Ando K, Suwa S, Isawa T, Takenaka H, Ishikawa T, Yamada M, Wakatsuki T, Nozaki Y, Kitahara H, Kato R, Kawai R, Kobayashi Y, Ishii M, Goto Y, Ono K, and Kimura T
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- Humans, Male, Female, Aged, Middle Aged, Administration, Oral, Treatment Outcome, Risk Factors, Risk Assessment, Time Factors, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods, Aspirin administration & dosage, Aspirin adverse effects, Aspirin therapeutic use, Hemorrhage chemically induced, Anticoagulants administration & dosage, Anticoagulants adverse effects, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors adverse effects, Dual Anti-Platelet Therapy methods, Prasugrel Hydrochloride administration & dosage, Prasugrel Hydrochloride therapeutic use, Prasugrel Hydrochloride adverse effects, Acute Coronary Syndrome therapy, Acute Coronary Syndrome complications, Acute Coronary Syndrome mortality
- Abstract
Background: The effects of aspirin-free strategy on bleeding and cardiovascular events in patients undergoing percutaneous coronary intervention with oral anticoagulation (OAC) have not been fully elucidated., Methods and Results: We conducted the prespecified subgroup analysis based on the use of OAC, including vitamin K antagonist and direct oral anticoagulants, within 7 days before percutaneous coronary intervention in the STOPDAPT-3 (Short and Optimal Duration of Dual Antiplatelet Therapy-3) trial, which randomly compared prasugrel monotherapy (2984 patients) to dual antiplatelet therapy (DAPT) with prasugrel and aspirin (2982 patients) in patients with acute coronary syndrome or high bleeding risk. The coprimary end points were major bleeding events (Bleeding Academic Research Consortium types 3 or 5) and cardiovascular events (a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, or ischemic stroke) at 1 month. Among 5966 study patients, there were 530 patients (8.9%) with OAC (no aspirin: N=248, and DAPT: N=282) and 5436 patients (91.1%) without OAC (no aspirin: N=2736, and DAPT: N=2700). Regardless of the use of OAC, the effects of no aspirin compared with DAPT were not significant for the bleeding end point (OAC: 4.45% and 4.27%, hazard ratio [HR], 1.04 [95% CI, 0.46-2.35]; no-OAC: 4.47% and 4.75%, HR, 0.94 [95% CI, 0.73-1.20]; P for interaction=0.82), and for the cardiovascular end point (OAC: 4.84% and 3.20%, HR, 1.53 [95% CI, 0.64-3.62]; no-OAC: 4.06% and 3.74%, HR, 1.09 [95% CI 0.83-1.42]; P for interaction =0.46)., Conclusions: The no-aspirin strategy compared with the DAPT strategy failed to reduce major bleeding events irrespective of the use of OAC. There was a numerical excess risk of the no-aspirin strategy relative to the DAPT strategy for cardiovascular events in patients with OAC.
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- 2024
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37. Clinical outcomes and prognostic factors of concurrent chemoradiotherapy for anal squamous cell carcinoma in Japan.
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Takahashi R, Osumi H, Wakatsuki T, Yamamoto N, Taguchi S, Nakayama I, Ooki A, Ogura M, Takahari D, Chin K, Yamaguchi K, and Shinozaki E
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- Humans, Male, Female, Middle Aged, Aged, Japan, Prognosis, Adult, Fluorouracil therapeutic use, Fluorouracil administration & dosage, Mitomycin administration & dosage, Mitomycin therapeutic use, Disease-Free Survival, Aged, 80 and over, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclin-Dependent Kinase Inhibitor p16 analysis, Retrospective Studies, Neoplasm Recurrence, Local, Anus Neoplasms therapy, Anus Neoplasms pathology, Anus Neoplasms mortality, Chemoradiotherapy, Carcinoma, Squamous Cell therapy, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell drug therapy, B7-H1 Antigen metabolism
- Abstract
Background: Concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregional anal squamous cell carcinoma (ASCC) in western countries. However, there have been few reports on the clinical outcomes of CCRT in Japan. This study aimed to evaluate the clinical outcomes of CCRT, prognostic factors, and the clinical impact of programmed cell death-ligand 1 (PD-L1) expression of ASCC in Japan., Methods: Patients with locoregional ASCC were enrolled between 2007 and 2017. All patients received CCRT consisting of ≥ 45 Gy of radiation, 5-fluorouracil, and mitomycin C. Disease-free survival (DFS), overall survival (OS), and adverse events (AEs) were estimated. Expression of p16 and PD-L1 were assessed by immunohistochemical staining (IHC)., Results: This study included 36 patients, of whom 30 (83.3%) were female. Among the participants, 32 (88.9%) achieved complete clinical remission, while six (16.7%) experienced recurrence. The five-year DFS and five-year OS were 72.2% and 84.7%, respectively. Grades ≥ 3 serious AEs included neutropenia in 10 (27.7%) and perianal dermatitis in eight (22.2%). In a univariate analysis, male sex, lymph node metastasis, and large tumor size were significantly associated with worse outcome. In a multivariate analysis, tumor size was an independent factor associated with short DFS. Of the 30 patients whose biopsy specimens were available for IHC, 29 (96.7%) were positive for p16, and 13 (43.3%) were positive for PD-L1. However, PD-L1 expression did not show any clinical impact., Conclusions: The comparative etiology, clinical outcomes, and prognostic factors of CCRT observed in Japanese patients with locoregional ASCC were consistent with western data., (© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.)
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- 2024
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38. Efficacy of anti-epidermal growth factor antibody rechallenge in RAS/BRAF wild-type metastatic colorectal cancer: a multi-institutional observational study.
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Fukuda K, Osumi H, Yoshinami Y, Ooki A, Takashima A, Wakatsuki T, Hirano H, Nakayama I, Ouchi K, Sawada R, Fukuoka S, Ogura M, Takahari D, Chin K, Shoji H, Okita N, Kato K, Ishizuka N, Boku N, Yamaguchi K, and Shinozaki E
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Adult, Aged, 80 and over, Mutation, Circulating Tumor DNA genetics, Antineoplastic Agents, Immunological therapeutic use, Antineoplastic Agents, Immunological administration & dosage, Colorectal Neoplasms drug therapy, Colorectal Neoplasms pathology, Colorectal Neoplasms genetics, Proto-Oncogene Proteins B-raf genetics, ErbB Receptors antagonists & inhibitors, ErbB Receptors genetics
- Abstract
Purpose: To investigate circulating tumor DNA (ctDNA) RAS mutant (MT) incidence before salvage-line treatment and the clinicopathological features and molecular biological factors associated with the efficacy of anti-epithelial growth factor receptor (EGFR) monoclonal antibody (mAb) rechallenge for tissue RAS/BRAF wild type (WT) metastatic colorectal cancer (mCRC)., Methods: This multi-institutional retrospective observational study included 74 patients with mCRC with tissue RAS/BRAF WT refractory to first-line chemotherapy containing anti-EGFR mAb. ctDNA RAS status was assessed using the OncoBEAM™ RAS CRC Kit. We explored the clinicopathological features associated with ctDNA RAS status and the factors related to anti-EGFR mAb rechallenge efficacy in multivariate Cox proportional hazard regression., Results: The incidence of RAS MT in ctDNA was 40.5% (30/74), which was associated with primary tumor resection (P = 0.016), liver metastasis (P < 0.001), and high tumor marker levels (P < 0.001). Among the 39 patients treated with anti-EGFR mAb rechallenge, those with ctDNA RAS WT showed significantly longer progression-free survival (PFS) than those with ctDNA RAS MT (median 4.1 vs. 2.7 months, hazard ratio [HR] = 0.39, P = 0.045). Patients who responded to first-line anti-EGFR mAb showed significantly longer PFS (HR = 0.21, P = 0.0026) and overall survival (OS) (HR = 0.23, P = 0.026) than those with stable disease., Conclusions: The incidence of ctDNA RAS MT mCRC was 40.5%, which was associated with liver metastases and high tumor volumes. Anti-EGFR mAb rechallenge may be effective for patients with mCRC who responded to first-line chemotherapy containing anti-EGFR mAb. No patients with RAS MT in ctDNA responded to anti-EGFR mAb rechallenge., (© 2024. The Author(s).)
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- 2024
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39. Pulmonary Arterial Hypertension in Neurofibromatosis Type 1: A Case with a Novel NF1 Gene Mutation.
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Yagi S, Kadota M, Bando R, Miyamoto R, Morino H, Kakutani A, Kubo Y, Ise T, Ueno R, Hara T, Kusunose K, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Fukuda D, and Sata M
- Abstract
Neurofibromatosis type 1 (NF1) is an autosomal dominant multi-organ disease. The clinical manifestations include not only skin lesions and malignant tumors but also lung complications, including pulmonary arterial hypertension (PAH). However, the association between gene mutations in NF1 and the occurrence of PAH has not yet been elucidated. We herein report a case of isolated PAH in a 67-year-old woman with NF1, presumably caused by a novel heterozygous mutation, c.4485_4486delinsAT (p.Lys1496Ter), in the NF1 gene.
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- 2024
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40. Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.
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Wakatsuki T, Daily N, Hisada S, Nunomura K, Lin B, Zushida K, Honda Y, Asyama M, and Takasuna K
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- Humans, Cell Line, Calcium metabolism, Computer Simulation, Ion Channels drug effects, Myocytes, Cardiac drug effects, Induced Pluripotent Stem Cells drug effects, Bayes Theorem, Arrhythmias, Cardiac chemically induced
- Abstract
The one-size-fits-all approach has been the mainstream in medicine, and the well-defined standards support the development of safe and effective therapies for many years. Advancing technologies, however, enabled precision medicine to treat a targeted patient population (e.g., HER2+ cancer). In safety pharmacology, computational population modeling has been successfully applied in virtual clinical trials to predict drug-induced proarrhythmia risks against a wide range of pseudo cohorts. In the meantime, population modeling in safety pharmacology experiments has been challenging. Here, we used five commercially available human iPSC-derived cardiomyocytes growing in 384-well plates and analyzed the effects of ten potential proarrhythmic compounds with four concentrations on their calcium transients (CaTs). All the cell lines exhibited an expected elongation or shortening of calcium transient duration with various degrees. Depending on compounds inhibiting several ion channels, such as hERG, peak and late sodium and L-type calcium or IKs channels, some of the cell lines exhibited irregular, discontinuous beating that was not predicted by computational simulations. To analyze the shapes of CaTs and irregularities of beat patterns comprehensively, we defined six parameters to characterize compound-induced CaT waveform changes, successfully visualizing the similarities and differences in compound-induced proarrhythmic sensitivities of different cell lines. We applied Bayesian statistics to predict sample populations based on experimental data to overcome the limited number of experimental replicates in high-throughput assays. This process facilitated the principal component analysis to classify compound-induced sensitivities of cell lines objectively. Finally, the association of sensitivities in compound-induced changes between phenotypic parameters and ion channel inhibitions measured using patch clamp recording was analyzed. Successful ranking of compound-induced sensitivity of cell lines was in lined with visual inspection of raw data., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. T.W. is a cofounder and shareholder of InvivoSciences, Inc. N.D. is an employee of InvivoSciences, Inc., (Copyright © 2023. Published by Elsevier Inc.)
- Published
- 2024
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41. Clinical utility of the carcinoembryonic antigen level in patients with stage III colon cancer after surgery and adjuvant chemotherapy.
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Udagawa S, Osumi H, Kozuki R, Ooki A, Wakatsuki T, Kurihara N, Mukai T, Yamaguchi T, Akiyoshi T, Fukunaga Y, Yamaguchi K, and Shinozaki E
- Subjects
- Humans, Chemotherapy, Adjuvant, Female, Male, Retrospective Studies, Aged, Prognosis, Middle Aged, Risk Factors, Survival Rate, Neoplasm Recurrence, Local, Aged, 80 and over, Adult, Biomarkers, Tumor blood, Postoperative Period, Carcinoembryonic Antigen blood, Colonic Neoplasms surgery, Colonic Neoplasms mortality, Colonic Neoplasms pathology, Colonic Neoplasms blood, Colonic Neoplasms drug therapy, Neoplasm Staging
- Abstract
Purpose: The association between perioperative and post-adjuvant carcinoembryonic antigen (CEA) levels and recurrence and prognosis remains unclear. We aimed to evaluate whether perioperative CEA levels are an integral component of the assessment of recurrence and prognosis of patients with stage III colon cancer (CC)., Methods: This retrospective study was conducted at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research from 2005 to 2013. We enrolled patients with stage III CC who underwent complete resection of a primary tumor and received adjuvant chemotherapy. We analyzed the association between perioperative and post-adjuvant CEA levels and recurrence-free survival (RFS) and overall survival (OS)., Results: A total of 564 consecutive patients were included in the analysis. The RFS and OS of patients with high postoperative CEA levels were significantly worse than those of patients with normal postoperative CEA levels. In the multivariate analysis, high postoperative CEA levels were associated with shorter RFS and OS. The number of risk factors, postoperative CEA levels, and T/N-stage all had a cumulative effect on RFS and OS., Conclusions: High postoperative CEA levels and the number of risk factors are associated with recurrence and worse prognosis for patients with stage III CC., (© 2023. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.)
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- 2024
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42. Real-time processing system of a two-color CO2 laser interferometer for density feedback control in JT-60SA.
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Ohtani Y, Sasao H, Nakano T, Fukumoto M, Wakatsuki T, Inoue S, Kojima S, Urano H, and Yoshida M
- Abstract
A real-time processing system for the two-color CO2 laser interferometer on the JT-60SA has been developed for density feedback control. The system has a novel feature that can detect fringe jumps due to off-normal events, such as loss detection due to displacement of the beam axis and changes in the laser wavelengths. Because a phase change due to the JT-60SA plasma is smaller than π/2, corresponding to the line-integral electron density NL of ∼6×1019 m-2 in a short interval of 500 ns, the threshold of the fringe jump detection is decided to be π/2. Hence, off-normal events can be detected from a fringe jump, leading to the abort of the real-time feedback control. In the density feedback control of the JT-60SA plasma, the system is employed as a density monitor, with NL being successfully controlled at 16.8% ± 6.6% lower than the reference., (© 2024 Author(s). Published under an exclusive license by AIP Publishing.)
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- 2024
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43. Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab.
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Wakatsuki T, Ishizuka N, Hironaka S, Minashi K, Kadowaki S, Goto M, Shoji H, Hirano H, Nakayama I, Osumi H, Ogura M, Chin K, Yamaguchi K, and Takahari D
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Adult, Prospective Studies, Biomarkers, Tumor blood, Progression-Free Survival, Stomach Neoplasms drug therapy, Stomach Neoplasms blood, Receptor, ErbB-2 blood, Trastuzumab therapeutic use, Trastuzumab administration & dosage, Oxonic Acid administration & dosage, Oxonic Acid therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Oxaliplatin therapeutic use, Oxaliplatin administration & dosage, Tegafur administration & dosage, Tegafur therapeutic use, Drug Combinations
- Abstract
Background: The aim of this study was to explore the clinical utility of serum HER2 extracellular domain (sHER2 ECD) using data from a clinical trial evaluating trastuzumab combined S-1 plus oxaliplatin (SOX) in HER2 positive gastric cancer., Methods: sHER2 ECD were prospectively measured at baseline and subsequent treatment courses. Based on each quantile point of baseline sHER2 ECD levels and its early changes, patients were divided into two groups and compared clinical outcomes., Results: 43 patients were enrolled, and 17 patients (39.5%) were positive for baseline sHER2 ECD. Higher baseline sHER2 ECD levels tended to have lower hazard ratios (HRs). When divided into two groups by baseline sHER2 ECD of 19.1 ng/ml, median progression-free survival (PFS) and overall survival (OS) was longer in the higher group (mPFS: 16.8 vs 8.7 months, p = 0.359. mOS: 35.5 vs 20.6 months, p = 0.270), respectively. After initiation of treatment, sHER2 ECD significantly decreased up until the third cycle. Higher reduction rates of sHER2 ECD within 3 cycles also tended to have lower HRs. When divided into two groups by reduction rate of 42.5%, mPFS and mOS was longer in the higher reduced group (mPFS: 17.2 vs 8.7 months, p = 0.095. mOS: 65.0 vs 17.8 months, p = 0.047), respectively. Furthermore, higher reduction rates could surrogate higher objective response rates (ORR) (ORR: 90% vs 63.2% for 29.5%, p = 0.065. 100% vs 70% for 42.5%, p = 0.085), respectively., Conclusions: Baseline sHER2 ECD levels and its early decline may be useful biomarkers for SOX plus trastuzumab efficacy in HER2 positive gastric cancer., (© 2024. The Author(s).)
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- 2024
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44. A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
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Ito S, Takuwa H, Kakehi S, Someya Y, Kaga H, Kumahashi N, Kuwata S, Wakatsuki T, Kadowaki M, Yamamoto S, Abe T, Takeda M, Ishikawa Y, Liu X, Otomo N, Suetsugu H, Koike Y, Hikino K, Tomizuka K, Momozawa Y, Ozaki K, Isomura M, Nabika T, Kaneko H, Ishijima M, Kawamori R, Watada H, Tamura Y, Uchio Y, Ikegawa S, and Terao C
- Subjects
- Humans, Aged, Male, Female, Middle Aged, Japan, Sarcopenia genetics, Sarcopenia physiopathology, Polymorphism, Single Nucleotide, Muscle, Skeletal metabolism, Knee, Asian People genetics, East Asian People, Genome-Wide Association Study, Muscle Strength genetics
- Abstract
Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10
-8 ). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia., (© 2024. The Author(s).)- Published
- 2024
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45. Pharmacologic Targeting of Histone H3K27 Acetylation/BRD4-dependent Induction of ALDH1A3 for Early-phase Drug Tolerance of Gastric Cancer.
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Lee J, Mashima T, Kawata N, Yamamoto N, Morino S, Inaba S, Nakamura A, Kumagai K, Wakatsuki T, Takeuchi K, Yamaguchi K, and Seimiya H
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- Animals, Female, Humans, Male, Mice, Acetylation drug effects, Antineoplastic Agents pharmacology, Bromodomain Containing Proteins drug effects, Bromodomain Containing Proteins metabolism, Cell Cycle Proteins drug effects, Cell Cycle Proteins metabolism, Cell Line, Tumor, Cell Proliferation drug effects, Gene Expression Regulation, Neoplastic drug effects, Mice, Inbred BALB C, Mice, Nude, Promoter Regions, Genetic drug effects, Xenograft Model Antitumor Assays, Aldehyde Oxidoreductases drug effects, Aldehyde Oxidoreductases metabolism, Drug Resistance, Neoplasm drug effects, Drug Resistance, Neoplasm genetics, Fluorouracil pharmacology, Fluorouracil therapeutic use, Histones drug effects, Histones metabolism, Stomach Neoplasms drug therapy, Stomach Neoplasms pathology, Stomach Neoplasms metabolism, Stomach Neoplasms genetics, Transcription Factors drug effects, Transcription Factors metabolism
- Abstract
Anticancer drug-tolerant persister (DTP) cells at an early phase of chemotherapy reshape refractory tumors. Aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is commonly upregulated by various anticancer drugs in gastric cancer patient-derived cells (PDC) and promotes tumor growth. However, the mechanism underlying the generation of ALDH1A3-positive DTP cells remains elusive. Here, we investigated the mechanism of ALDH1A3 expression and a combination therapy targeting gastric cancer DTP cells. We found that gastric cancer tissues treated with neoadjuvant chemotherapy showed high ALDH1A3 expression. Chromatin immunoprecipitation (ChIP)-PCR and ChIP sequencing analyses revealed that histone H3 lysine 27 acetylation was enriched in the ALDH1A3 promoter in 5-fluorouracil (5-FU)-tolerant persister PDCs. By chemical library screening, we found that the bromodomain and extraterminal (BET) inhibitors OTX015/birabresib and I-BET-762/molibresib suppressed DTP-related ALDH1A3 expression and preferentially inhibited DTP cell growth. In DTP cells, BRD4, but not BRD2/3, was recruited to the ALDH1A3 promoter and BRD4 knockdown decreased drug-induced ALDH1A3 upregulation. Combination therapy with 5-FU and OTX015 significantly suppressed in vivo tumor growth. These observations suggest that BET inhibitors are efficient DTP cell-targeting agents for gastric cancer treatment., Significance: Drug resistance hampers the cure of patients with cancer. To prevent stable drug resistance, DTP cancer cells are rational therapeutic targets that emerge during the early phase of chemotherapy. This study proposes that the epigenetic regulation by BET inhibitors may be a rational therapeutic strategy to eliminate DTP cells., (© 2024 The Authors; Published by the American Association for Cancer Research.)
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- 2024
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46. Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report.
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Takahashi T, Wakatsuki T, Ise T, and Sata M
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Background: A coronary-to-pulmonary artery fistula (CPAF) with a giant aneurysm is a rare clinical occurrence. The rupture of an aneurysm leads to a fatal outcome, thus prompting the incorporation of prophylactic measures, which have encompassed surgical resections or endovascular embolization procedures. The indications for these treatment strategies are controversial, and little has been elucidated regarding the salient characteristics underpinning the selection of a therapeutic strategy. We report a case of a giant aneurysm associated with CPAFs that was thrombosed before interventional treatment., Case Summary: A 43-year-old woman, who had previously undergone a right adrenalectomy for primary aldosteronism, was referred for an abnormal heart silhouette on a chest X-ray, which had not been seen three years earlier. Contrast-enhanced computed tomography and coronary angiography (CAG) revealed a giant aneurysm on the anterior aspect of the heart associated with two CPAFs. Because of the risk of rupture of the aneurysm, surgical resection was recommended; however, the patient requested endovascular therapy. On the day of intervention, CAG showed spontaneous occlusion of the feeding vessel to the aneurysm, and the aneurysm showed minimal contrast agent, suggesting spontaneous thrombosis. Because of possible recanalization of the aneurysm, coil embolization was performed, without complications. The patient remained asymptomatic, and the aneurysm was completely embolized at the one-year follow-up., Discussion: The case shows that minimally invasive endovascular treatment is feasible instead of surgical resection for giant aneurysms associated with CPAFs, depending on their morphological characteristics. This perspective may offer novel insights into treatment strategies for CPAF., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2024
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47. Pulmonary pressure-flow responses to exercise in heart failure treated with angiotensin receptor neprilysin inhibitor.
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Yamaguchi N, Hirata Y, Nishio S, Takahashi T, Saijo Y, Kadota M, Ise T, Yamaguchi K, Yagi S, Yamada H, Soeki T, Wakatsuki T, Sata M, and Kusunose K
- Subjects
- Humans, Valsartan, Tetrazoles pharmacology, Stroke Volume, Receptors, Angiotensin, Angiotensin Receptor Antagonists therapeutic use, Angiotensin Receptor Antagonists pharmacology, Drug Combinations, Aminobutyrates therapeutic use, Aminobutyrates pharmacology, Neprilysin, Heart Failure diagnostic imaging, Heart Failure drug therapy
- Abstract
Background: The role of the angiotensin receptor neprilysin inhibitor (ARNI) in cardiac function, particularly its impact on pulmonary circulation, remains underexplored. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (CO) responses as having the potential to assess the disease state. The aim of this study was to assess the effects of ARNI on pulmonary circulation in heart failure. We measured echocardiographic parameters post 6-min walk (6 MW) and compared the changes with baseline and follow-up. Our hypothesis was that pulmonary pressure-flow relationship of the pulmonary circulation obtained by 6 MW stress echocardiography would be improved with treatment., Methods: We prospectively enrolled 39 heart failure patients and conducted the 6 MW test indoors. Post-6 MW echocardiography measured echocardiographic variables, and CO was derived from electric cardiometry. Individualized ARNI doses were optimized, with follow-up echocardiographic evaluations after 1 year., Results: Left ventricular (LV) volume were significantly reduced (160.7 ± 49.6 mL vs 136.0 ± 54.3 mL, P < 0.001), and LV ejection fraction was significantly improved (37.6 ± 11.3% vs 44.9 ± 11.5%, P < 0.001). Among the 31 patients who underwent 6 MW stress echocardiographic study at baseline and 1 year later, 6 MW distance increased after treatment (380 m vs 430 m, P = 0.003). The ΔmPAP/ΔCO by 6 MW stress decreased with treatment (6.9 mmHg/L/min vs 2.8 mmHg/L/min, P = 0.002). The left atrial volume index was associated with the response group receiving ARNI treatment for pulmonary circulation., Conclusions: Initiation of ARNI was associated with improvement of left ventricular size and LVEF. Additionally, the 6 MW distance increased and the ΔmPAP/ΔCO was improved to within normal range with treatment., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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48. Acidic growth conditions stabilize the ribosomal RNA gene cluster and extend lifespan through noncoding transcription repression.
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Hasegawa Y, Ooka H, Wakatsuki T, Sasaki M, Yamamoto A, and Kobayashi T
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- Animals, Genes, rRNA, DNA, Ribosomal genetics, Plant Extracts, Mammals, Longevity, Transcription, Genetic
- Abstract
Blackcurrant (Ribes nigrum L.) is a classical fruit that has long been used to make juice, jam, and liqueur. Blackcurrant extract is known to relieve cells from DNA damage caused by hydrogen peroxide (H
2 O2 ), methyl methane sulfonate (MMS), and ultraviolet (UV) radiation. We found that blackcurrant extract (BCE) stabilizes the ribosomal RNA gene cluster (rDNA), one of the most unstable regions in the genome, through repression of noncoding transcription in the intergenic spacer (IGS) which extended the lifespan in budding yeast. Reduced formation of extrachromosomal circles (ERCs) after exposure to fractionated BCE suggested that acidity of the growth medium impacted rDNA stability. Indeed, alteration of the acidity of the growth medium to pH ~4.5 by adding HCl increased rDNA stability and extended the lifespan. We identified RPD3 as the gene responsible for this change, which was mediated by the RPD3L histone deacetylase complex. In mammals, as inflammation sites in a tissue are acidic, DNA maintenance may be similarly regulated to prevent genome instability from causing cancer., (© 2023 The Authors. Genes to Cells published by Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.)- Published
- 2024
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49. Effectiveness of surveillance by echocardiography for cancer therapeutics-related cardiac dysfunction of patients with breast cancer.
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Okushi Y, Saijo Y, Yamada H, Toba H, Zheng R, Seno H, Takahashi T, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M, and Kusunose K
- Subjects
- Humans, Middle Aged, Aged, Female, Cardiotoxicity etiology, Risk Factors, Echocardiography, Breast Neoplasms drug therapy, Antineoplastic Agents adverse effects, Heart Diseases
- Abstract
Background: Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients., Methods: We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint., Results: The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group., Conclusions: The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer., Competing Interests: Declaration of competing interest None., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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50. Meniscal Allograft Transplantation Concomitant With Cartilage Repair for Symptomatic Lateral Meniscus-Deficient Knees With Over Two Years of Follow-up.
- Author
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Uchio Y, Takuwa H, Wakatsuki T, and Kuwata S
- Abstract
Background and objective The treatment for symptomatic meniscus-deficient knees with cartilage defects remains challenging on account of insufficient meniscal substitutes. One solution for this might involve combining meniscal allograft transplantation (MAT) and cartilage repair. In this study, we aimed to analyze the effectiveness and safety of MAT concomitant with cartilage repair for symptomatic lateral meniscus-deficient knees in a setting with limited availability of meniscal transplants in Japan. Methods Nine patients who underwent MAT concomitant with osteochondral transplantation (five) and/or autologous chondrocyte implantations (seven) were followed up for at least two years (mean: 51.2 months, range: 24-84 months). Their demographic data and other characteristics were as follows - mean age: 51.7 years, range: 36-67 years; men/women: 4/5; cause: trauma/discoid meniscus: 8/1; cartilage defect size: mean: 6.7 cm
2 /knee, range: 1.0-11.3. The effectiveness and safety were evaluated clinically by using the Lysholm Knee Scoring Scale (LKSS) and Japanese Orthopaedic Association (JOA) knee score, physical examination, X-rays, and MRI preoperatively and at one, 12, and 24 months after the implantation. Differences between the variables were analyzed using the Friedman test and Scheffe's multiple comparisons. Results The median LKSS and JOA scores significantly improved from 70 points (range: 21-80) and 35 (25-45) preoperatively to 86.5 (65-98) and 87.5 (80-95) at 24 months after surgery, respectively (p<0.001, p=0.0013). The range of motion (ROM), femorotibial angle, and the lateral joint space showed no significant changes. However, lateral meniscal extrusions (LMEs) increased by 3.0 mm (range: 0-6.3 mm) at one month postoperatively and remained unchanged until two years postoperatively. Treatment failure occurred in one case, which was revised by total knee arthroplasty (TKA) at 18 months postoperatively. Additional surgeries were needed in some cases: lateral meniscal tear (three cases), contracture (two cases), and patellar instability (one case). However, neither infection nor allergic reaction was observed in the blood exams. Conclusions Although MAT concomitant with cartilage repair showed good clinical outcomes, half of the cases needed additional surgeries. Based on our findings, this technique should be adopted only in select cases and performed by a handful of highly experienced surgeons., Competing Interests: The authors have declared financial relationships, which are detailed in the next section., (Copyright © 2023, Uchio et al.)- Published
- 2023
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