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Analytical studies of the results of thermal imaging control using IAS TIK together with the corresponding values of the temperature control results obtained in the standard DGS condition monitoring system were carried out within the framework of R&D for the development of an integrated automated system for thermal imaging control (IAS TIK). Approbation of IAS TIK in NPP conditions was carried out by thermography of standby diesel generator sets of NPP type 12zv40/48+S2445-12. At the same time, the parameters of the diesel engine and the generator were measured using the standard control system. The methodology is proposed that provides an analysis of the uniformity of the operation of diesel cylinders, the condition of the crankshaft bearings, the condition and quality of the generated electricity of the generator, as well as the analysis of the operation of lubrication and cooling systems. The practical application of the technique demonstrates the correspondence between the temperatures measured by the standard system and the IAS TIK. A joint analysis of the results obtained by the standard and developed systems provides an increase in the depth of the diagnostic examination and confirms the information content of the thermographic parameters and the quality of the measurement channels of the standard systems. The parameter values obtained from the analysis of the indicators of the standard control system, recorded at a steady power value, will be used in subsequent diagnostics to establish trends in these parameters

Multimodal treatment has improved the outcome of many solid tumors, and in some cases the use of radiosensitizers has significantly contributed to this gain. Activation of the extracellular signaling kinase pathway (MEK/ERK) generally results in stimulation of cell growth and confers a survival advantage playing the major role in human cancer. The potential involvement of this pathway in cellular radiosensitivity remains unclear. We previously reported that the disruption of c-Myc through MEK/ERK inhibition blocks the expression of the transformed phenotype; affects in vitro and in vivo growth and angiogenic signaling; and induces myogenic differentiation in the embryonal rhabdomyosarcoma (ERMS) cell lines (RD). This study was designed to examine whether the ERK pathway affects intrinsic radiosensitivity of rhabdomyosarcoma cancer cells. Exponentially growing human ERMS, RD, xenograft-derived RD-M1, and TE671 cell lines were used. The specific MEK/ERK inhibitor, U0126, reduced the clonogenic potential of the three cell lines, and was affected by radiation. U0126 inhibited phospho-active ERK1/2 and reduced DNA protein kinase catalytic subunit (DNA-PKcs) suggesting that ERKs and DNA-PKcs cooperate in radioprotection of rhabdomyosarcoma cells. The TE671 cell line xenotransplanted in mice showed a reduction in tumor mass and increase in the time of tumor progression with U0126 treatment associated with reduced DNA-PKcs, an effect enhanced by radiotherapy. Thus, our results show that MEK/ERK inhibition enhances radiosensitivity of rhabdomyosarcoma cells suggesting a rational approach in combination with radiotherapy. Mol Cancer Ther; 10(1); 159–68. ©2011 AACR.

Supplementary Figure 6 from MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals

Supplementary Figure 3 from MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals