142 results on '"Vieira, Rafael José"'
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2. Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence–Assisted ARIA Care Pathways (ARIA 2024)
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Bousquet, Jean, Schünemann, Holger J., Sousa-Pinto, Bernardo, Zuberbier, Torsten, Togias, Alkis, Samolinski, Boleslaw, Bedbrook, Anna, Czarlewski, Wienczyslawa, Hofmann-Apitius, Martin, Litynska, Justyna, Vieira, Rafael José, Anto, Josep M., Fonseca, Joao A., Brozek, Jan, Bognanni, Antonio, Brussino, Luisa, Canonica, G. Walter, Cherrez-Ojeda, Ivan, Cruz, Alvaro A., Vecillas, Leticia de las, Dykewicz, Mark, Gemicioglu, Bilun, Giovannini, Mattia, Haahtela, Tari, Jacobs, Marc, Jacomelli, Cristina, Klimek, Ludger, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Louis, Gilles, Lourenço, Olga, Leemann, Lucas, Morais-Almeida, Mario, Neves, Ana Luisa, Nadeau, Kari C., Nowak, Artur, Palamarchuk, Yuliia, Palkonen, Susanna, Papadopoulos, Nikolaos G., Parmelli, Elena, Pereira, Ana Margarida, Pfaar, Oliver, Regateiro, Frederico S., Savouré, Marine, Taborda-Barata, Luis, Toppila-Salmi, Sanna K., Torres, Maria J., Valiulis, Arunas, Ventura, Maria Teresa, Williams, Sian, Yepes-Nuñez, Juan J., Yorgancioglu, Arzu, Zhang, Luo, Zuberbier, Jaron, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Agache, Ioana, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Al Shaikh, Nada A., Amaral, Rita, Ansotegui, Ignacio J., Asllani, Julijana, Balotro-Torres, Maria Cristina, Bergmann, Karl-Christian, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Blaiss, Michael S., Bonaglia, Cristina, Bonini, Matteo, Bossé, Isabelle, Braido, Fulvio, Caballero-Fonseca, Fernan, Camargos, Paulo, Carreiro-Martins, Pedro, Casale, Thomas, Castillo-Vizuete, José-Antonio, Cecchi, Lorenzo, Teixeira, Maria do Ceu, Chang, Yoon-Seok, Loureiro, Claudia Chaves, Christoff, George, Ciprandi, Giorgio, Cirule, Ieva, Correia-de-Sousa, Jaime, Costa, Elisio M., Cvetkovski, Biljana, de Vries, Govert, Del Giacco, Stefano, Devillier, Philippe, Dokic, Dejan, Douagui, Habib, Durham, Stephen R., Enecilla, Maria Lourdes, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean-François, Gawlik, Radoslaw, Gereda, Jose E., Gil-Mata, Sara, Giuliano, Antonio F.M., Gotua, Maia, Gradauskiene, Brigita, Guzman, Maria Antonieta, Hossny, Elham, Hrubiško, Martin, Iinuma, Tomohisa, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Jartti, Tuomas, Jeseňák, Miloš, Julge, Kaja, Jutel, Marek, Kaidashev, Igor, Bennoor, Kazi S., Khaltaev, Nicolai, Kirenga, Bruce, Kraxner, Helga, Kull, Inger, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Kurchenko, Andriy, La Grutta, Stefania, Lane, Stephen, Miculinic, Neven, Lee, Sang Min, Le Thi Tuyet, Lan, Lkhagvaa, Battur, Louis, Renaud, Mahboub, Bassam, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Eric, Milenkovic, Branislava, Mohammad, Yousser, Moniuszko, Marcin, Montefort, Stephen, Moreira, Andre, Moreno, Pablo, Mullol, Joaquim, Nadif, Rachel, Nakonechna, Alla, Navarro-Locsin, Cecilia Gretchen, Neffen, Hugo E., Nekam, Kristof, Niedoszytko, Marek, Nunes, Elizabete, Nyembue, Dieudonné, O’Hehir, Robyn, Ollert, Markus, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Olze, Heidi, Padukudru, Mahesh Anand, Palomares, Oscar, Pali-Schöll, Isabella, Panzner, Petr, Palosuo, Kati, Park, Hae S., Passalacqua, Giovanni, Patella, Vincenzo, Pawankar, Ruby, Pétré, Benoît, Pitsios, Constantinos, Plavec, Davor, Popov, Todor A., Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Ramonaité, Agné, Recto, Marysia, Repka-Ramirez, Susana, Roberts, Graham, Robles-Velasco, Karla, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romualdez, Joel A., Rottem, Menachem, Rouadi, Philip W., Salapatas, Marianella, Sastre, Joaquin, Serpa, Faradiba S., Sayah, Zineb, Scichilone, Nicola, Senna, Gianenrico, Sisul, Juan Carlos, Solé, Dirceu, Soto-Martinez, Manuel E., Sova, Milan, Sozinova, Olga, Stevanovic, Katarina, Ulrik, Charlotte Suppli, Szylling, Anna, Tan, Frances M., Tantilipikorn, Pongsakorn, Todo-Bom, Ana, Tomic-Spiric, Vesna, Tsaryk, Vladyslav, Tsiligianni, Ioanna, Urrutia-Pereira, Marilyn, Rostan, Marylin Valentin, Sofiev, Mikhail, Valovirta, Erkka, Van Eerd, Michiel, Van Ganse, Eric, Vasankari, Tuula, Vichyanond, Pakit, Viegi, Giovanni, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wong, Gary, Worm, Margitta, Yusuf, Osman M., Zaitoun, Fares, and Zidarn, Mihaela
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- 2024
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3. Intranasal antihistamines and corticosteroids in allergic rhinitis: A systematic review and meta-analysis
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Sousa-Pinto, Bernardo, Vieira, Rafael José, Brozek, Jan, Cardoso-Fernandes, António, Lourenço-Silva, Nuno, Ferreira-da-Silva, Renato, Ferreira, André, Gil-Mata, Sara, Bedbrook, Anna, Klimek, Ludger, Fonseca, João A., Zuberbier, Torsten, Schünemann, Holger J., and Bousquet, Jean
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- 2024
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4. Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study
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Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Canonica, G. Walter, Costa, Elisio M., Kupczyk, Maciej, Kvedariene, Violeta, Kulus, Marek, Larenas-Linnemann, Désirée E., Pfaar, Oliver, Papadopoulos, Nikolaos G., Pham-Thi, Nhân, Regateiro, Frederico S., Roche, Nicolas, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Valiulis, Arunas, Yorgancioglu, Arzu, Ventura, Maria Teresa, Almeida, Rute, Amaral, Rita, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Brussino, Luisa, Cardona, Victoria, Cecchi, Lorenzo, Loureiro, Claudia Chaves, Cingi, Cemal, Cruz, Alvaro A., Fokkens, Wytske J., de Vries, Govert, Gemicioglu, Bilun, Giuliana, Antonio F.M., Linuma, Tomohisa, Ivancevich, Juan Carlos, Jácome, Cristina, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Gilles, Lourenço, Olga, Makela, Mika, Makris, Michael, Mösges, Ralph, Maurer, Marcus, Mullol, Joaquim, Nadif, Rachel, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Ollert, Markus, Olze, Heidi, Patella, Vincenzo, Pétré, Benoit, Puggioni, Francesca, Romantowski, Jan, Rouadi, Philip W., Reitsma, Sietze, Rivero-Yeverino, Daniela, Rodriguez-Gonzalez, Monica, Sá-Sousa, Ana, Serpa, Faradiba S., Shamji, Mohamed H., Sheikh, Aziz, Ulrik, Charlotte Suppli, Sofiev, Mikhail, Sova, Milan, Sperl, Annette, Todo-Bom, Ana, Tomazic, Peter V., Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, van Eerd, Michiel, Zidarn, Mihaela, Blain, Hubert, Boulet, Louis-Philippe, Brusselle, Guy, Buhl, Roland, Charpin, Denis, Casale, Thomas, Chivato, Tomas, Correia-de-Sousa, Jaime, Corrigan, Christopher, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Dykewicz, Mark, Fiocchi, Alessandro, Giovannini, Mattia, Jassem, Ewa, Jutel, Marek, Keil, Thomas, La Grutta, Stefania, Lipworth, Brian, Papi, Alberto, Pépin, Jean-Louis, Quirce, Santiago, Cordeiro, Carlos Robalo, Torres, Maria J., Usmani, Omar S., Vieira, Rafael José, Leemann, Lucas, Briggs, Andrew, Pereira, Ana Margarida, Savouré, Marine, Kuna, Piotr, Morais-Almeida, Mário, Bewick, Michael, Azevedo, Luís Filipe, Louis, Renaud, Klimek, Ludger, Bahbah, Farah, Samolinski, Boleslaw, Anto, Josep M., Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
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- 2024
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5. Platelet transfusions in preterm infants: current concepts and controversies—a systematic review and meta-analysis
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Ribeiro, Helena Sofia, Assunção, André, Vieira, Rafael José, Soares, Paulo, Guimarães, Hercília, and Flor-de-Lima, Filipa
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- 2023
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6. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, Austin E, Kyu, Hmwe Hmwe, Aali, Amirali, Abbafati, Cristiana, Abbas, Jaffar, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abdurehman, Ame Mehadi, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abhilash, E S, Abiodun, Olugbenga Olusola, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abu Rumeileh, Samir, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Acuna, Juan Manuel, Adair, Tim, Addo, Isaac Yeboah, Adebayo, Oladimeji M, Adegboye, Oyelola A, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adeyeoluwa, Temitayo Esther, Adeyomoye, Olorunsola Israel, Adha, Rishan, Adibi, Amin, Adikusuma, Wirawan, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Abel, Afolabi, Aanuoluwapo Adeyimika, Afraz, Ali, Afyouni, Shadi, Afzal, Saira, Agasthi, Pradyumna, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmadzade, Mohadese, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Ajumobi, Olufemi, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akinosoglou, Karolina, Akkala, Sreelatha, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Al Homsi, Ammar, Al Qadire, Mohammad, Ala, Moein, Aladelusi, Timothy Olukunle, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Zufishan, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albashtawy, Mohammed, AlBataineh, Mohammad T, Aldridge, Robert W, Alemi, Sharifullah, Al-Eyadhy, Ayman, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Akhtar, Ali, Beriwan Abdulqadir, Ali, Hassam, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Zahid, Alian Samakkhah, Shohreh, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aligol, Mohammad, Alimi, Rasoul, Aliyi, Ahmednur Adem, Al-Jumaily, Adel, Aljunid, Syed Mohamed, Almahmeed, Wael, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Omar, Alomari, Mahmoud A, Alonso, Nivaldo, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Alvi, Farrukh Jawad, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Alzoubi, Karem H, Amare, Azmeraw T, Ameyaw, Edward Kwabena, Amhare, Abebe Feyissa, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Aminian Dehkordi, Javad, Amiri, Sohrab, Amu, Hubert, Amugsi, Dickson A, Amzat, Jimoh, Ancuceanu, Robert, Anderlini, Deanna, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Angappan, Dhanalakshmi, Anil, Abhishek, Anjum, Afifa, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Iyadunni Adesola, Anwar, Sumadi Lukman, Anyasodor, Anayochukwu Edward, Appiah, Seth Christopher Yaw, Aqeel, Muhammad, Arabloo, Jalal, Arabzadeh Bahri, Razman, Arab-Zozani, Morteza, Arafat, Mosab, Araújo, Ana Margarida, Aravkin, Aleksandr Y, Aremu, Abdulfatai, Ariffin, Hany, Aripov, Timur, Armocida, Benedetta, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Arulappan, Judie, Aruleba, Idowu Thomas, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Asaad, Malke, Asgary, Saeed, Ashemo, Mubarek Yesse, Ashraf, Muhammad, Asika, Marvellous O, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Atreya, Alok, Attia, Sameh, Aujayeb, Avinash, Avan, Abolfazl, Awotidebe, Adedapo Wasiu, Ayala Quintanilla, Beatriz Paulina, Ayanore, Martin Amogre, Ayele, Getnet Melaku, Ayuso-Mateos, Jose L, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azhar, Gulrez Shah, Aziz, Shahkaar, Azzam, Ahmed Y, Babashahi, Mina, Babu, Abraham Samuel, Badar, Muhammad, Badawi, Alaa, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadorikhalili, Saeed, Bai, Jianjun, Bai, Ruhai, Baker, Jennifer L, Bakkannavar, Shankar M, Bako, Abdulaziz T, Balakrishnan, Senthilkumar, Balogun, Saliu A, Baltatu, Ovidiu Constantin, Bam, Kiran, Banach, Maciej, Bandyopadhyay, Soham, Banik, Biswajit, Banik, Palash Chandra, Bansal, Hansi, Barati, Shirin, Barchitta, Martina, Bardhan, Mainak, Barker-Collo, Suzanne Lyn, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barr, Ronald D, Barrero, Lope H, Basharat, Zarrin, Bashir, Asma'u I J, Bashiru, Hameed Akande, Baskaran, Pritish, Basnyat, Buddha, Bassat, Quique, Basso, João Diogo, Basu, Saurav, Batra, Kavita, Batra, Ravi, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Bedi, Neeraj, Begum, Tahmina, Behboudi, Emad, Behnoush, Amir Hossein, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Belgaumi, Uzma Iqbal, Bell, Michelle L, Bello, Aminu K, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bendak, Salaheddine, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berezvai, Zombor, Berman, Adam E, Bermudez, Amiel Nazer C, Bettencourt, Paulo J G, Beyene, Habtamu B, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Binmadi, Nada, Bintoro, Bagas Suryo, Biondi, Antonio, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Raaj Kishore, Bitaraf, Saeid, Bjørge, Tone, Bleyer, Archie, Boampong, Mary Sefa, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bolarinwa, Obasanjo Afolabi, Bonakdar Hashemi, Milad, Bonny, Aime, Bora, Kaustubh, Bora Basara, Berrak, Borodo, Safiya Bala, Borschmann, Rohan, Botero Carvajal, Alejandro, Bouaoud, Souad, Boudalia, Sofiane, Boyko, Edward J, Bragazzi, Nicola Luigi, Braithwaite, Dejana, Brenner, Hermann, Britton, Gabrielle, Browne, Annie J, Brunoni, Andre R, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Burugina Nagaraja, Sharath, Busse, Reinhard, Bustanji, Yasser, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cai, Tianji, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cardenas, Carlos Alberto, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cederroth, Christopher R, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chacón-Uscamaita, Pamela R Uscamaita, Chahine, Yaacoub, Chakraborty, Chiranjib, Chan, Jeffrey Shi Kai, Chang, Chin-Kuo, Charalampous, Periklis, Charan, Jaykaran, Chattu, Vijay Kumar, Chatzimavridou-Grigoriadou, Victoria, Chavula, Malizgani Paul, Cheema, Huzaifa Ahmad, Chen, An-Tian, Chen, Haowei, Chen, Lingxiao, Chen, Meng Xuan, Chen, Simiao, Cherbuin, Nicolas, Chew, Derek S, Chi, Gerald, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, So Mi Jemma, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhary, Rahul, Chowdhury, Rajiv, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Eunice, Chung, Sheng-Chia, Cini, Karly I, Clark, Cain C T, Coberly, Kaleb, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Conti, Sara, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Criqui, Michael H, Cruz-Martins, Natália, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, da Silva e Silva, Daniel, Dadana, Sriharsha, Dadras, Omid, Dai, Zhaoli, Dalal, Koustuv, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, Daneshvar, Sara, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, Debele, Aklilu Tamire, Degenhardt, Louisa, Dehbandi, Reza, Deitesfeld, Lee, Delgado-Enciso, Ivan, Delgado-Ortiz, Laura, Demant, Daniel, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Deuba, Keshab, Devanbu, Vinoth Gnana Chellaiyan, Dey, Sourav, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dhingra, Sameer, Dias da Silva, Diana, Diaz, Daniel, Dima, Adriana, Ding, Delaney D, Dirac, M Ashworth, Dixit, Abhinav, Dixit, Shilpi Gupta, Do, Thanh Chi, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dokova, Klara Georgieva, Dolecek, Christiane, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Douiri, Abdel, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dube, John, Dumith, Samuel C, Dunachie, Susanna J, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dutta, Sulagna, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Ebenezer, Oluwakemi, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Eghdami, Shayan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekpor, Emmanuel, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Morsi, Doaa Abdel Wahab, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Elshaer, Mohammed, Elsohaby, Ibrahim, Emami Zeydi, Amir, Emamverdi, Mehdi, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Eshetie, Tesfahun C, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Estep, Kara, Etaee, Farshid, Eze, Ugochukwu Anthony, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Falzone, Luca, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Farjoud Kouhanjani, Mohsen, Faro, Andre, Farrokhpour, Hossein, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Fekadu, Ginenus, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrara, Pietro, Ferreira, Nuno, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flaxman, Abraham D, Flor, Luisa S, Florin, Bobirca Teodor, Folayan, Morenike Oluwatoyin, Foley, Kristen Marie, Fomenkov, Artem Alekseevich, Force, Lisa M, Fornari, Carla, Foroutan, Behzad, Foschi, Matteo, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Gaal, Peter Andras, Gadanya, Muktar A, Gaihre, Santosh, Gaipov, Abduzhappar, Gakidou, Emmanuela, Galali, Yaseen, Galehdar, Nasrin, Gallus, Silvano, Gan, Quan, Gandhi, Aravind P, Ganesan, Balasankar, Garg, Jalaj, Gau, Shuo-Yan, Gautam, Prem, Gautam, Rupesh K, Gazzelloni, Federica, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay Brhane, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamirat, Gething, Peter W, Ghafourifard, Mansour, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghanbarnia, Mohammad Javad, Ghasemi, MohammadReza, Ghasemzadeh, Afsaneh, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Sailaja, Gholamian, Asadollah, Gholamrezanezhad, Ali, Ghorbani Vajargah, Pooyan, Ghozali, Ghozali, Ghozy, Sherief, Ghuge, Arun Digambarrao, Gialluisi, Alessandro, Gibson, Ruth Margaret, Gil, Artyom 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Izza, Shahid, Samiah, Shahid, Wajeehah, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shakeri, Alireza, Shakil, Husain, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamshirgaran, Mohammad Ali, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Shariff, Mariam, Sharifi-Rad, Javad, Sharma, Manoj, Sharma, Rajesh, Sharma, Saurab, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shaw, David H, Shayan, Amir Mehdi, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shenoy, Manjunath Mala, Shetty, B Suresh Kumar, Shetty, Ranjitha S, Shey, Robert Adamu, Shiani, Amir, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Jae Il, Shin, Min-Jeong, Shiri, Rahman, Shirkoohi, Reza, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shool, Sina, Shrestha, Sunil, Shuja, Kanwar Hamza, Shuval, Kerem, Si, Yafei, Sibhat, Migbar Mekonnen, Siddig, Emmanuel Edwar, Sigfusdottir, Inga Dora, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simões, Jorge Piano, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Aditya, Singh, Ambrish, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Mahendra, Singh, Mayank, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Slepak, Erica Leigh N, Sohrabi, Hanye, Soleimani, Hamidreza, Soliman, Sameh S M, Solmi, Marco, Solomon, Yonatan, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Starnes, Joseph R, Starodubov, Vladimir I, Starodubova, Antonina V, Stefan, Simona Cătălina, Stein, Dan J, Steinbeis, Fridolin, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Stranges, Saverio, Stroumpoulis, Konstantinos, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sunkersing, David, Susanty, Sri, Swain, Chandan Kumar, Sykes, Bryan L, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabish, Mohammad, Taborda-Barata, Luis M, Tabuchi, Takahiro, Tadesse, Birkneh Tilahun, Taheri, Amirmasoud, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Tajbakhsh, Ardeshir, Talaat, Iman M, Talukder, Ashis, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tang, Hong K, Tat, Nathan Y, Tat, Vivian Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tebeje, Tsion Mulat, Tefera, Yibekal Manaye, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesfaye, Solomon Hailemariam, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapa, Rajshree, Thapar, Rekha, Thomas, Nihal, Thrift, Amanda G, Thum, Chern Choong Chern, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Tohidast, Seyed Abolfazl, Tonelli, Marcello, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tram, Khai Hoan, Tran, Nghia Minh, Trico, Domenico, Trihandini, Indang, Tromans, Samuel Joseph, Truong, Vien T, Truyen, Thien Tan Tri Tai, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Ubah, Chukwudi S, Udoakang, Aniefiok John, Udoh, Arit, Ulhaq, Inam, Ullah, Saeed, Ullah, Sana, Umair, Muhammad, Umar, Tungki Pratama, Umeokonkwo, Chukwuma David, Umesh, Anushri, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Urso, Daniele, Vacante, Marco, Vahdani, Amir Mohammad, Vaithinathan, Asokan Govindaraj, Valadan Tahbaz, Sahel, Valizadeh, Rohollah, Van den Eynde, Jef, Varavikova, Elena, Varga, Orsolya, Varma, Siddhartha Alluri, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Veerman, Lennert J, Venketasubramanian, Narayanaswamy, Venugopal, Deneshkumar, Verghese, Nicholas Alexander, Verma, Madhur, Verma, Pratibha, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Vieira, Rafael José, Villafañe, Jorge Hugo, Villani, Leonardo, Villanueva, Gabriela Ines, Villeneuve, Paul J, Violante, Francesco S, Visontay, Rachel, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Volovat, Simona Ruxandra, Volovici, Victor, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wado, Yohannes Dibaba, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Denny, Wang, Fang, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weiss, Daniel J, Weldemariam, Abrha Hailay, Wells, Katherine M, Wen, Yi Feng, Werdecker, Andrea, Westerman, Ronny, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wijeratne, Tissa, Wilson, Shadrach, Wojewodzic, Marcin W, Wool, Eve E, Woolf, Anthony D, Wu, Dongze, Wulandari, Ratna Dwi, Xiao, Hong, Xu, Bin, Xu, Xiaoyue, Yadav, Lalit, Yaghoubi, Sajad, Yang, Lin, Yano, Yuichiro, Yao, Yao, Ye, Pengpeng, Yesera, Gesila Endashaw, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zahedi, Mohammad, Zahid, Muhammad Nauman, Zahir, Mazyar, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Burhan Abdullah, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zandi, Milad, Zandieh, Ghazal G Z, Zanghì, Aurora, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zeng, Youjie, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Hongwei, Zhang, Yunquan, Zhang, Zhaofeng, Zhang, Zhenyu, Zhao, Hanqing, Zhao, Yang, Zhao, Yong, Zheng, Peng, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Zhaohua, Ziaeefar, Pardis, Zielińska, Magdalena, Zou, Zhiyong, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Lim, Stephen S, and Murray, Christopher J L
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7. Intranasal Versus Oral Treatments for Allergic Rhinitis: A Systematic Review With Meta-Analysis
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Neves, Ana Luísa, Pereira, Ana Margarida, Bedbrook, Anna, Valiulis, Arunas, Jacomelli, Cristina, Azzolini, Elena, Parmelli, Elena, Canonica, Giorgio Walter, Zuberbier, Jaron, Vecillas, Leticia de las, Gilles, Louis, Leemann, Lucas, Klimek, Ludger, Ventura, Maria Teresa, Savoure, Marine, Dykewicz, Mark, Hofmann-Apitius, Martin, Papadopoulos, Nikolaos, Lourenço, Olga, Salmi, Sanna K., Williams, Sian, Palamarchuk, Yuliia, Torres, Maria Inês, Gil-Mata, Sara, Bognanni, Antonio, Ferreira-da-Silva, Renato, Yepes-Nuñez, Juan José, Lourenço-Silva, Nuno, Cardoso-Fernandes, António, Ferreira, André, Ferreira-Cardoso, Henrique, Portela, Diana, Teles, João, Kvedariene, Violeta, Torres, María Jose, Pfaar, Oliver, Brussino, Luisa, Zuberbier, Torsten, Fonseca, João A., Schünemann, Holger, Bousquet, Jean, Sousa-Pinto, Bernardo, and Vieira, Rafael José
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- 2024
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8. Methodologic lessons from published systematic reviews
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Ferreira, André, Vieira, Rafael José, and Sousa-Pinto, Bernardo
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- 2023
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9. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
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Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S, Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H, Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G Walter, Cruz, Alvaro A, Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C, Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Luna Pech, Jorge, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E, Ohta, Ken, Papadopoulos, Nikolaos G, Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S, Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M, Fonseca, João A, and Bousquet, Jean
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- 2023
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10. Cutoff Values of MASK-air Patient-Reported Outcome Measures
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Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Pereira, Ana Margarida, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chivato, Tomas, Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
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- 2023
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11. Detection of subclinical microvascular changes in systemic lupus erythematous using optical coherence tomography angiography: A systematic review and meta-analysis
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Ferreira, André, Vieira, Rafael José, Furtado, Maria João, Lume, Miguel, Andrade, José P., and Menéres, Pedro
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- 2023
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12. Embedding patients' values and preferences in guideline development for allergic diseases: The case study of Allergic Rhinitis and its Impact on Asthma 2024
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Vieira, Rafael José, primary, Sousa‐Pinto, Bernardo, additional, Bognanni, Antonio, additional, Yepes‐Nuñez, Juan José, additional, Zhang, Yuan, additional, Lityńska, Justyna, additional, Sadowska, Ewelina, additional, Borowiack, Ewa, additional, Samolinski, Boleslaw, additional, Togias, Alkis, additional, Zuberbier, Torsten, additional, Bousquet, Jean, additional, and Schünemann, Holger J., additional
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- 2024
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13. Academic Productivity of Young People With Allergic Rhinitis: A MASK-air Study
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Vieira, Rafael José, Pham-Thi, Nhân, Anto, Josep M., Czarlewski, Wienczyslawa, Sá-Sousa, Ana, Amaral, Rita, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cecchi, Lorenzo, Cruz, Alvaro A., Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pfaar, Oliver, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Ventura, Maria Teresa, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
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- 2022
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14. Efficacy and safety of intranasal medications for allergic rhinitis: Network meta‐analysis.
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Sousa‐Pinto, Bernardo, Vieira, Rafael José, Bognanni, Antonio, Gil‐Mata, Sara, Ferreira‐da‐Silva, Renato, Ferreira, André, Cardoso‐Fernandes, António, Ferreira‐Cardoso, Henrique, Marques‐Cruz, Manuel, Duarte, Vítor Henrique, Castro‐Teles, João, Campos‐Lopes, Miguel, Teixeira‐Ferreira, Ana, Lourenço‐Silva, Nuno, Chérrez‐Ojeda, Ivan, Bedbrook, Anna, Klimek, Ludger, Nuñez, Juan Jose Yepes, Zuberbier, Torsten, and Fonseca, João A.
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INTRANASAL medication , *RANDOMIZED controlled trials , *ALLERGIC rhinitis , *PHYSICIANS , *BIBLIOGRAPHIC databases - Abstract
Background Methods Results Conclusion Intranasal antihistamines (INAH), corticosteroids (INCS), and their fixed combinations (INAH+INCS) are one of the cornerstones of the treatment of allergic rhinitis (AR). We performed a systematic review and network‐meta‐analysis comparing the efficacy and safety of INAH, INCS, and INAH+INCS in patients with AR.We searched four electronic bibliographic databases and three clinical trial databases for randomised controlled trials assessing the use of INAH, INCS, and INAH+INCS in adults with seasonal or perennial AR. We performed a network meta‐analysis on the Total Nasal Symptom Score, Total Ocular Symptom Score, Rhinoconjunctivitis Quality‐of‐Life Questionnaire, development of adverse events, and withdrawals due to adverse events. Certainty of evidence was assessed using GRADE‐NMA.We included 167 primary studies, most of which assessed patients with seasonal AR. Among individual medications, azelastine‐fluticasone, and fluticasone furoate were the most frequently highest‐ranked interventions for efficacy outcomes, being regularly associated with clinically meaningful larger improvements when compared to other active treatments. Considering drug classes, INAH+INCS were the highest‐ranked interventions for all outcomes in which they were assessed, followed in most cases by INCS. In 105 out of 184 comparisons in seasonal AR, and 28 out of 97 comparisons in perennial AR, certainty of evidence was considered “high” or “moderate”.Intranasal medications for AR display clinically relevant differences in their efficacy, but all show a good safety profile. To our knowledge, this is the first network meta‐analysis comparing INAH, INCS, and INAH+INCS in AR, providing relevant evidence for guideline developers and practising physicians on the most efficacious treatments. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Artificial Intelligence–Supported Development of Health Guideline Questions.
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Sousa-Pinto, Bernardo, Vieira, Rafael José, Marques-Cruz, Manuel, Bognanni, Antonio, Gil-Mata, Sara, Jankin, Slava, Amaro, Joana, Pinheiro, Liliane, Mota, Marta, Giovannini, Mattia, de las Vecillas, Leticia, Pereira, Ana Margarida, Lityńska, Justyna, Samolinski, Boleslaw, Bernstein, Jonathan, Dykewicz, Mark, Hofmann-Apitius, Martin, Jacobs, Marc, Papadopoulos, Nikolaos, and Williams, Sian
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LANGUAGE models , *ALLERGIC rhinitis , *RESEARCH personnel , *ELECTRONIC information resource searching , *ARIA - Abstract
Evidence-based health guidelines should address questions that patients have. Current practice is that the questions driving guidelines are proposed by expert panels. In this article, authors studied how 2 alternative approaches, supported by large language models, could augment the usual approach to identify additional patient-centered questions. Background: Guideline questions are typically proposed by experts. Objective: To assess how large language models (LLMs) can support the development of guideline questions, providing insights on approaches and lessons learned. Design: Two approaches for guideline question generation were assessed: 1) identification of questions conveyed by online search queries and 2) direct generation of guideline questions by LLMs. For the former, the researchers retrieved popular queries on allergic rhinitis using Google Trends (GT) and identified those conveying questions using both manual and LLM-based methods. They then manually structured as guideline questions the queries that conveyed relevant questions. For the second approach, they tasked an LLM with proposing guideline questions, assuming the role of either a patient or a clinician. Setting: Allergic Rhinitis and its Impact on Asthma (ARIA) 2024 guidelines. Participants: None. Measurements: Frequency of relevant questions generated. Results: The authors retrieved 3975 unique queries using GT. From these, they identified 37 questions, of which 22 had not been previously posed by guideline panel members and 2 were eventually prioritized by the panel. Direct interactions with LLMs resulted in the generation of 22 unique relevant questions (11 not previously suggested by panel members), and 4 were eventually prioritized by the panel. In total, 6 of 39 final questions prioritized for the 2024 ARIA guidelines were not initially thought of by the panel. The researchers provide a set of practical insights on the implementation of their approaches based on the lessons learned. Limitation: Single case study (ARIA guidelines). Conclusion: Approaches using LLMs can support the development of guideline questions, complementing traditional methods and potentially augmenting questions prioritized by guideline panels. Primary Funding Source: Fraunhofer Cluster of Excellence for Immune-Mediated Diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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16. English tweets on allergy: Content analysis and association with surveillance data
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Sousa‐Pinto, Bernardo, primary, Jankin, Slava, additional, Vieira, Rafael José, additional, Marques‐Cruz, Manuel, additional, Fonseca, João Almeida, additional, and Bousquet, Jean, additional
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- 2024
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17. Regional, sex, and age inequities in asthma hospital admissions in Spain and Portugal
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Vieira, Rafael José, primary, Pereira, Ana Margarida, additional, Taborda‐Barata, Luís, additional, Regateiro, Frederico S., additional, Marques‐Cruz, Manuel, additional, Robalo Cordeiro, Carlos, additional, Loureiro, Cláudia Chaves, additional, Dávila, Ignacio J., additional, Bousquet, Jean, additional, Fonseca, João A., additional, and Sousa‐Pinto, Bernardo, additional
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- 2024
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18. Patients' values and preferences for health states in allergic rhinitis—An artificial intelligence supported systematic review
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Brozek, Jan, primary, Borowiack, Ewa, additional, Sadowska, Ewelina, additional, Nowak, Artur, additional, Sousa‐Pinto, Bernardo, additional, Vieira, Rafael José, additional, Bognanni, Antonio, additional, Yepes Nuñez, Juan Jose, additional, Zhang, Yuan, additional, Zuberbier, Torsten, additional, Bousquet, Jean, additional, and Schünemann, Holger J., additional
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- 2024
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19. Poor rhinitis and asthma control is associated with decreased health-related quality-of-life and utilities: A MASK-air study
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Vieira, Rafael José, primary, Leemann, Lucas, additional, Briggs, Andrew, additional, Pereira, Ana Margarida, additional, Savouré, Marine, additional, Kuna, Piotr, additional, Morais-Almeida, Mário, additional, Bewick, Michael, additional, Azevedo, Luís Filipe, additional, Louis, Renaud, additional, Klimek, Ludger, additional, Bahbah, Farah, additional, Samolinski, Boleslaw, additional, Anto, Josep M., additional, Zuberbier, Torsten, additional, Fonseca, João A., additional, Bousquet, Jean, additional, Sousa-Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Canonica, G Walter, additional, Costa, Elisio M., additional, Kupczyk, Maciej, additional, Kvedariene, Violeta, additional, Kulus, Marek, additional, Larenas-Linnemann, Désirée E., additional, Pfaar, Oliver, additional, Papadopoulos, Nikolaos G., additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Roche, Nicolas, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Taborda-Barata, Luis, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Ventura, Maria Teresa, additional, Almeida, Rute, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic-Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Loureiro, Claudia Chaves, additional, Cingi, Cemal, additional, Cruz, Alvaro A., additional, Fokkens, Wytske J., additional, de Vries, Govert, additional, Gemicioglu, Bilun, additional, Giuliana, Antonio FM., additional, Linuma, Tomohisa, additional, Ivancevich, Juan Carlos, additional, Jácome, Cristina, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Gilles, additional, Lourenço, Olga, additional, Makela, Mika, additional, Makris, Michael, additional, Mösges, Ralph, additional, Maurer, Marcus, additional, Mullol, Joaquim, additional, Nadif, Rachel, additional, Niedoszytko, Marek, additional, O’Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Olze, Heidi, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Puggioni, Francesca, additional, Romantowski, Jan, additional, Rouadi, Philip W., additional, Reitsma, Sietze, additional, Rivero-Yeverino, Daniela, additional, Rodriguez-Gonzalez, Monica, additional, Sá-Sousa, Ana, additional, Serpa, Faradiba S., additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Sofiev, Mikhail, additional, Sova, Milan, additional, Sperl, Annette, additional, Todo-Bom, Ana, additional, Tomazic, Peter V., additional, Toppila-Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, van Eerd, Michiel, additional, Zidarn, Mihaela, additional, Blain, Hubert, additional, Boulet, Louis-Philippe, additional, Brusselle, Guy, additional, Buhl, Roland, additional, Charpin, Denis, additional, Casale, Thomas, additional, Chivato, Tomas, additional, Correia-de-Sousa, Jaime, additional, Corrigan, Christopher, additional, de Blay, Frédéric, additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Dykewicz, Mark, additional, Fiocchi, Alessandro, additional, Giovannini, Mattia, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, La Grutta, Stefania, additional, Lipworth, Brian, additional, Papi, Alberto, additional, Pépin, Jean-Louis, additional, Quirce, Santiago, additional, Cordeiro, Carlos Robalo, additional, Torres, Maria J., additional, and Usmani, Omar S., additional
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- 2024
- Full Text
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20. Poor rhinitis and asthma control is associated with decreased health-related quality-of-life and utilities: A MASK-air study
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Vieira, Rafael José, Leemann, Lucas, Briggs, Andrew, Pereira, Ana Margarida, Savouré, Marine, Kuna, Piotr, Morais-Almeida, Mário, Bewick, Michael, Azevedo, Luís Filipe, Louis, Renaud, Klimek, Ludger, Bahbah, Farah, Samolinski, Boleslaw, Anto, Josep M., Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Vieira, Rafael José, Leemann, Lucas, Briggs, Andrew, Pereira, Ana Margarida, Savouré, Marine, Kuna, Piotr, Morais-Almeida, Mário, Bewick, Michael, Azevedo, Luís Filipe, Louis, Renaud, Klimek, Ludger, Bahbah, Farah, Samolinski, Boleslaw, Anto, Josep M., Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
- Abstract
Background Allergic rhinitis (AR) and asthma may impact health-related quality-of-life. However, national estimates on the quality-of-life of patients with AR or asthma are lacking. Objective To provide estimates for utility scores and EQ-5D Visual Analog Scale (VAS) for patients with AR or asthma. Methods We conducted a cross-sectional study using direct patient data from the MASK-air® app on European MASK-air® users with self-reported AR or asthma. We used a multiattribute instrument (EQ-5D) to measure quality-of-life (as utility scores and EQ-5D VAS values). Mean scores were calculated per country and disease control level using multilevel regression models with post-stratification, accounting for age and sex biases. Results We assessed data from up to 7905 MASK-air® users reporting a total of up to 82,737 days. For AR, utilities ranged from 0.86-0.99 for good control versus 0.72-0.85 for poor control; EQ-5D VAS levels ranged from 78.9-87.9 for good control versus 55.3-64.2 for poor control. For asthma, utilities ranged from 0.84-0.97 for good control versus 0.73-0.87 for poor control; EQ-5D VAS levels ranged from 68.4-81.5 for good control versus 51.4-64.2 for poor control. Poor disease control was associated with a mean loss of 0.14 utilities for both AR and asthma. For the same control levels, AR and asthma were associated with similar utilities and EQ-5D VAS levels. However, lower values were observed for asthma+AR when compared to AR alone. Conclusion Poor AR or asthma control are associated with reduced quality-of-life. The estimates obtained from mHealth data may provide valuable insights for health technology assessment studies.
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- 2024
21. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, A, Kyu, H, Aali, A, Abbafati, C, Abbas, J, Abbasgholizadeh, R, Abbasi, M, Abbasian, M, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdoun, M, Abdullahi, A, Abdurehman, A, Abebe, M, Abedi, A, Abegaz, T, Abeldaño Zuñiga, R, Abhilash, E, Abiodun, O, Aboagye, R, Abolhassani, H, Abouzid, M, Abreu, L, Abrha, W, Abrigo, M, Abtahi, D, Abu Rumeileh, S, Abu-Rmeileh, N, Aburuz, S, Abu-Zaid, A, Acuna, J, Adair, T, Addo, I, Adebayo, O, Adegboye, O, Adekanmbi, V, Aden, B, Adepoju, A, Adetunji, C, Adeyeoluwa, T, Adeyomoye, O, Adha, R, Adibi, A, Adikusuma, W, Adnani, Q, Adra, S, Afework, A, Afolabi, A, Afraz, A, Afyouni, S, Afzal, S, Agasthi, P, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmad, T, Ahmadi, K, Ahmadzade, A, Ahmadzade, M, Ahmed, A, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akalu, G, Akara, E, Akinosoglou, K, Akkala, S, Akyirem, S, Al Hamad, H, Al Hasan, S, Al 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S, Manjula, S N, Chandan, S Sunnerhagen, Katharina, Saad, Aly M A, Sabbatucci, Michela, Saber, Korosh, Saber-Ayad, Maha Mohamed, Sacco, Simona, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Masoumeh, Sadeghian, Saeid, Saeed, Umar, Saeedi, Maryam, Safi, Sare, Sagar, Rajesh, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Sahoo, Soumya Swaroop, Sahraian, Mohammad Ali, Sajedi, Seyed Aidin, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salahi, Saina, Salahi, Sarvenaz, Salamati, Payman, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Saleh, Mohamed A, Salehi, Sana, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salimi, Sohrab, Samadi Kafil, Hossein, Samadzadeh, Sara, Samara, Kamel A, Samargandy, Saad, Samodra, Yoseph Leonardo, Samuel, Vijaya Paul, Samy, Abdallah M, Sanabria, Juan, Sanadgol, Nima, Sanganyado, Edmond, Sanjeev, Rama Krishna, Sanmarchi, Francesco, Sanna, Francesca, Santri, Ichtiarini Nurullita, Santric-Milicevic, Milena M, Sarasmita, Made Ary, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarkar, Chinmoy, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saulam, Jennifer, Sawyer, Susan M, Saxena, Sonia, Saya, Ganesh Kumar, Sayadi, Yaser, Sayeed, Abu, Sayeed, Md Abu, Saylan, Mete, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schlee, Winfried, Schmidt, Maria Inês, Schuermans, Art, Schwebel, David C, Schwendicke, Falk, Šekerija, Mario, Selvaraj, Siddharthan, Semreen, Mohammad H, Senapati, Sabyasachi, Sengupta, Pallav, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Sertsu, Addisu, Sethi, Yashendra, SeyedAlinaghi, SeyedAhmad, Seyedi, Seyed Arsalan, Shafaat, Amir, Shafaat, Omid, Shafie, Mahan, Shafiee, Arman, Shah, Nilay S, Shah, Pritik A, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Izza, Shahid, Samiah, Shahid, Wajeehah, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shakeri, Alireza, Shakil, Husain, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamshirgaran, Mohammad Ali, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Shariff, Mariam, Sharifi-Rad, Javad, Sharma, Manoj, Sharma, Rajesh, Sharma, Saurab, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shaw, David H, Shayan, Amir Mehdi, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shenoy, Manjunath Mala, Shetty, B Suresh Kumar, Shetty, Ranjitha S, Shey, Robert Adamu, Shiani, Amir, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Jae Il, Shin, Min-Jeong, Shiri, Rahman, Shirkoohi, Reza, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shool, Sina, Shrestha, Sunil, Shuja, Kanwar Hamza, Shuval, Kerem, Si, Yafei, Sibhat, Migbar Mekonnen, Siddig, Emmanuel Edwar, Sigfusdottir, Inga Dora, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simões, Jorge Piano, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Aditya, Singh, Ambrish, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Mahendra, Singh, Mayank, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Slepak, Erica Leigh N, Sohrabi, Hanye, Soleimani, Hamidreza, Soliman, Sameh S M, Solmi, Marco, Solomon, Yonatan, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Sreeramareddy, Chandrashekhar T, Starnes, Joseph R, Starodubov, Vladimir I, Starodubova, Antonina V, Stefan, Simona Cătălina, Stein, Dan J, Steinbeis, Fridolin, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Stranges, Saverio, Stroumpoulis, Konstantinos, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sunkersing, David, Susanty, Sri, Swain, Chandan Kumar, Sykes, Bryan L, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabish, Mohammad, Taborda-Barata, Luis M, Tabuchi, Takahiro, Tadesse, Birkneh Tilahun, Taheri, Amirmasoud, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Tajbakhsh, Ardeshir, Talaat, Iman M, Talukder, Ashis, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tang, Hong K, Tat, Nathan Y, Tat, Vivian Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tebeje, Tsion Mulat, Tefera, Yibekal Manaye, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesfaye, Solomon Hailemariam, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapa, Rajshree, Thapar, Rekha, Thomas, Nihal, Thrift, Amanda G, Thum, Chern Choong Chern, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Tohidast, Seyed Abolfazl, Tonelli, Marcello, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tram, Khai Hoan, Tran, Nghia Minh, Trico, Domenico, Trihandini, Indang, Tromans, Samuel Joseph, Truong, Vien T, Truyen, Thien Tan Tri Tai, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Ubah, Chukwudi S, Udoakang, Aniefiok John, Udoh, Arit, Ulhaq, Inam, Ullah, Saeed, Ullah, Sana, Umair, Muhammad, Umar, Tungki Pratama, Umeokonkwo, Chukwuma David, Umesh, Anushri, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Urso, Daniele, Vacante, Marco, Vahdani, Amir Mohammad, Vaithinathan, Asokan Govindaraj, Valadan Tahbaz, Sahel, Valizadeh, Rohollah, Van den Eynde, Jef, Varavikova, Elena, Varga, Orsolya, Varma, Siddhartha Alluri, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Veerman, Lennert J, Venketasubramanian, Narayanaswamy, Venugopal, Deneshkumar, Verghese, Nicholas Alexander, Verma, Madhur, Verma, Pratibha, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Vieira, Rafael José, Villafañe, Jorge Hugo, Villani, Leonardo, Villanueva, Gabriela Ines, Villeneuve, Paul J, Violante, Francesco S, Visontay, Rachel, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Volovat, Simona Ruxandra, Volovici, Victor, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wado, Yohannes Dibaba, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Denny, Wang, Fang, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weiss, Daniel J, Weldemariam, Abrha Hailay, Wells, Katherine M, Wen, Yi Feng, Werdecker, Andrea, Westerman, Ronny, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wijeratne, Tissa, Wilson, Shadrach, Wojewodzic, Marcin W, Wool, Eve E, Woolf, Anthony D, Wu, Dongze, Wulandari, Ratna Dwi, Xiao, Hong, Xu, Bin, Xu, Xiaoyue, Yadav, Lalit, Yaghoubi, Sajad, Yang, Lin, Yano, Yuichiro, Yao, Yao, Ye, Pengpeng, Yesera, Gesila Endashaw, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zahedi, Mohammad, Zahid, Muhammad Nauman, Zahir, Mazyar, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Burhan Abdullah, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zandi, Milad, Zandieh, Ghazal G Z, Zanghì, Aurora, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zeng, Youjie, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Hongwei, Zhang, Yunquan, Zhang, Zhaofeng, Zhang, Zhenyu, Zhao, Hanqing, Zhao, Yang, Zhao, Yong, Zheng, Peng, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Zhaohua, Ziaeefar, Pardis, Zielińska, Magdalena, Zou, Zhiyong, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Lim, Stephen S, and Murray, Christopher J L
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- 2024
22. Impact of Uncontrolled Symptoms on the Health‐Related Quality of Life (EQ‐5D‐5L) of Patients With Allergic Rhinitis: A MASK‐air Study.
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Vieira, Rafael José, Leemann, Lucas, Schünemann, Holger J., Azevedo, Luís Filipe, Fonseca, João A., Bousquet, Jean, and Sousa‐Pinto, Bernardo
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DIGITAL technology , *ALLERGIC rhinitis , *PATIENT preferences , *VISUAL analog scale , *RANK correlation (Statistics) - Abstract
This article explores the effects of uncontrolled symptoms on the quality of life of patients with allergic rhinitis (AR). The study used a questionnaire to assess the impact of individual symptoms on quality of life. The results showed that poorly controlled eye, nose, and asthma symptoms were consistently associated with lower quality of life measures. The study emphasizes the importance of symptom control in improving the quality of life for patients with AR. However, it is important to note that the findings may not apply to all patients. [Extracted from the article]
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- 2024
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23. Neurodevelopment outcomes in the first 5 years of the life of children with transposition of the great arteries surgically corrected in the neonatal period: systematic review and meta-analysis
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Soares, Catarina, primary, Vieira, Rafael José, additional, Costa, Sandra, additional, Moita, Rita, additional, Andrade, Mariana, additional, and Guimarães, Hercília, additional
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- 2023
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24. Intranasal antihistamines and corticosteroids in the treatment of allergic rhinitis: a systematic review and meta-analysis protocol
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Sousa-Pinto, Bernardo, primary, Vieira, Rafael José, additional, Brozek, Jan, additional, Cardoso-Fernandes, António, additional, Lourenço-Silva, Nuno, additional, Ferreira-da-Silva, Renato, additional, Ferreira, André, additional, Gil-Mata, Sara, additional, Bedbrook, Anna, additional, Klimek, Ludger, additional, Fonseca, Joao A, additional, Zuberbier, Torsten, additional, Schünemann, Holger J, additional, and Bousquet, Jean, additional
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- 2023
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25. Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report
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Bousquet, Jean, primary, Shamji, Mohamed H., additional, Anto, Josep M., additional, Schünemann, Holger J., additional, Canonica, G. Walter, additional, Jutel, Marek, additional, Del Giacco, Stefano, additional, Zuberbier, Torsten, additional, Pfaar, Oliver, additional, Fonseca, Joao A., additional, Sousa‐Pinto, Bernardo, additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Chaves Loureiro, Claudia, additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Kulus, Marek, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Matricardi, Paolo M., additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Sofiev, Mikhail, additional, Toppila‐Salmi, Sanna, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Barbara, Cristina, additional, Bergmann, Karl C., additional, Bewick, Michael, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Boulet, Louis‐Philippe, additional, Bourret, Rodolphe, additional, Brusselle, Guy, additional, Brussino, Luisa, additional, Buhl, Roland, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Dramburg, Stephanie, additional, Fokkens, Wytske J., additional, Gotua, Maia, additional, Heffler, Enrico, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Joos, Guy, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Lourenço, Olga, additional, Louis, Renaud, additional, Makela, Mika, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, O'Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Olze, Heidi, additional, Papadopoulos, Nikolaos G., additional, Papi, Alberto, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Pham‐Thi, Nhân, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Roche, Nicolas, additional, Rouadi, Philip W., additional, Sá‐Sousa, Ana, additional, Sagara, Hironori, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Suppli Ulrik, Charlotte, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Torres, Maria J., additional, Tsiligianni, Ioanna, additional, Usmani, Omar S., additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Zidarn, Mihaela, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Chivato, Tomas, additional, and Ollert, Markus, additional
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- 2023
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26. Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices
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UCL - SSS/IRSS - Institut de recherche santé et société, Charalampous, Periklis, Haagsma, Juanita A, Jakobsen, Lea S, Gorasso, Vanessa, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Santos, João Vasco, McDonald, Scott A, Plass, Dietrich, Wyper, Grant M A, Assunção, Ricardo, von der Lippe, Elena, Ádám, Balázs, AlKerwi, Ala'a, Arabloo, Jalal, Baltazar, Ana Lúcia, Bikbov, Boris, Borrell-Pages, Maria, Brus, Iris, Burazeri, Genc, Chaintoutis, Serafeim C, Chen-Xu, José, Chkhaberidze, Nino, Cilovic-Lagarija, Seila, Corso, Barbara, Cuschieri, Sarah, Di Bari, Carlotta, Dopelt, Keren, Economou, Mary, Emeto, Theophilus I, Fantke, Peter, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gissler, Mika, Gkitakou, Artemis, Gulmez, Hakan, Gunes, Sezgin, Haller, Sebastian, Haneef, Romana, Hincapié, Cesar A, Hynds, Paul, Idavain, Jane, Ilic, Milena, Ilic, Irena, Isola, Gaetano, Kabir, Zubair, Kamusheva, Maria, Kolkhir, Pavel, Konar, Naime Meriç, Kostoulas, Polychronis, Kulimbet, Mukhtar, La Vecchia, Carlo, Lauriola, Paolo, Levi, Miriam, Majer, Marjeta, Mechili, Enkeleint A, Monasta, Lorenzo, Mondello, Stefania, Muñoz Laguna, Javier, Nena, Evangelia, Ng, Edmond SW, Nguewa, Paul, Niranjan, Vikram, Nola, Iskra Alexandra, O'Caoimh, Rónán, Obradović, Marija, Pallari, Elena, Peyroteo, Mariana, Pinheiro, Vera, Pranjic, Nurka, Reina Ortiz, Miguel, Riva, Silvia, Santoso, Cornelia Melinda Adi, Santric Milicevic, Milena, Schmitt, Tugce, Speybroeck, Niko, Sprügel, Maximilian, Steiropoulos, Paschalis, Stevanovic, Aleksandar, Thygesen, Lau Caspar, Tozija, Fimka, Unim, Brigid, Bektaş Uysal, Hilal, Varga, Orsolya, Vasic, Milena, Vieira, Rafael José, Yigit, Vahit, Devleesschauwer, Brecht, Pires, Sara M, UCL - SSS/IRSS - Institut de recherche santé et société, Charalampous, Periklis, Haagsma, Juanita A, Jakobsen, Lea S, Gorasso, Vanessa, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Santos, João Vasco, McDonald, Scott A, Plass, Dietrich, Wyper, Grant M A, Assunção, Ricardo, von der Lippe, Elena, Ádám, Balázs, AlKerwi, Ala'a, Arabloo, Jalal, Baltazar, Ana Lúcia, Bikbov, Boris, Borrell-Pages, Maria, Brus, Iris, Burazeri, Genc, Chaintoutis, Serafeim C, Chen-Xu, José, Chkhaberidze, Nino, Cilovic-Lagarija, Seila, Corso, Barbara, Cuschieri, Sarah, Di Bari, Carlotta, Dopelt, Keren, Economou, Mary, Emeto, Theophilus I, Fantke, Peter, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gissler, Mika, Gkitakou, Artemis, Gulmez, Hakan, Gunes, Sezgin, Haller, Sebastian, Haneef, Romana, Hincapié, Cesar A, Hynds, Paul, Idavain, Jane, Ilic, Milena, Ilic, Irena, Isola, Gaetano, Kabir, Zubair, Kamusheva, Maria, Kolkhir, Pavel, Konar, Naime Meriç, Kostoulas, Polychronis, Kulimbet, Mukhtar, La Vecchia, Carlo, Lauriola, Paolo, Levi, Miriam, Majer, Marjeta, Mechili, Enkeleint A, Monasta, Lorenzo, Mondello, Stefania, Muñoz Laguna, Javier, Nena, Evangelia, Ng, Edmond SW, Nguewa, Paul, Niranjan, Vikram, Nola, Iskra Alexandra, O'Caoimh, Rónán, Obradović, Marija, Pallari, Elena, Peyroteo, Mariana, Pinheiro, Vera, Pranjic, Nurka, Reina Ortiz, Miguel, Riva, Silvia, Santoso, Cornelia Melinda Adi, Santric Milicevic, Milena, Schmitt, Tugce, Speybroeck, Niko, Sprügel, Maximilian, Steiropoulos, Paschalis, Stevanovic, Aleksandar, Thygesen, Lau Caspar, Tozija, Fimka, Unim, Brigid, Bektaş Uysal, Hilal, Varga, Orsolya, Vasic, Milena, Vieira, Rafael José, Yigit, Vahit, Devleesschauwer, Brecht, and Pires, Sara M
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- 2023
27. Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air approach.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Zuberbier, Torsten, Savouré, Marine, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S, Shamji, Mohamed H, Pépin, Jean-Louis, Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A, Pétré, Benoit, Bousquet, Jean, Anto, Josep M, Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A, Gemicioglu, Bilun, Fokkens, Wytske J, Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J, Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean-François, Gomez, R Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O'Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Zuberbier, Torsten, Savouré, Marine, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S, Shamji, Mohamed H, Pépin, Jean-Louis, Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A, Pétré, Benoit, Bousquet, Jean, Anto, Josep M, Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A, Gemicioglu, Bilun, Fokkens, Wytske J, Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J, Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean-François, Gomez, R Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O'Hehir, Robyn, Olze, Heidi, and Palamarchuk, Yuliia
- Abstract
MASK-air , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air results should lead to change management in rhinitis and asthma.
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- 2023
28. Consistent trajectories of rhinitis control and treatment in 16,177 weeks : the MASK-air® longitudinal study
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Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
- Abstract
Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
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- 2023
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29. Patient-centered digital biomarkers for allergic respiratory diseases and asthma:The ARIA-EAACI approach – ARIA-EAACI Task Force Report
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Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
- Abstract
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed., Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
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- 2023
30. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach
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Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
- Abstract
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
- Published
- 2023
- Full Text
- View/download PDF
31. Burden of infectious disease studies in Europe and the United Kingdom:a review of methodological design choices
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Charalampous, Periklis, Haagsma, Juanita A., Jakobsen, Lea S., Gorasso, Vanessa, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Santos, João Vasco, Mcdonald, Scott A., Plass, Dietrich, Wyper, Grant M.A., Assunção, Ricardo, Von Der Lippe, Elena, Ádám, Balázs, Alkerwi, Ala'a, Arabloo, Jalal, Baltazar, Ana Lúcia, Bikbov, Boris, Borrell-Pages, Maria, Brus, Iris, Burazeri, Genc, Chaintoutis, Serafeim C., Chen-Xu, José, Chkhaberidze, Nino, Cilovic-Lagarija, Seila, Corso, Barbara, Cuschieri, Sarah, Di Bari, Carlotta, Dopelt, Keren, Economou, Mary, Emeto, Theophilus I., Fantke, Peter, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gissler, Mika, Gkitakou, Artemis, Gulmez, Hakan, Gunes, Sezgin, Haller, Sebastian, Haneef, Romana, Hincapié, Cesar A., Hynds, Paul, Idavain, Jane, Ilic, Milena, Ilic, Irena, Isola, Gaetano, Kabir, Zubair, Kamusheva, Maria, Kolkhir, Pavel, Konar, Naime Meriç, Kostoulas, Polychronis, Kulimbet, Mukhtar, La Vecchia, Carlo, Lauriola, Paolo, Levi, Miriam, Majer, Marjeta, Mechili, Enkeleint A., Monasta, Lorenzo, Mondello, Stefania, Muñoz Laguna, Javier, Nena, Evangelia, Ng, Edmond S.W., Nguewa, Paul, Niranjan, Vikram, Nola, Iskra Alexandra, O'caoimh, Rónán, Obradović, Marija, Pallari, Elena, Peyroteo, Mariana, Pinheiro, Vera, Pranjic, Nurka, Reina Ortiz, Miguel, Riva, Silvia, Santoso, Cornelia Melinda Adi, Santric Milicevic, Milena, Schmitt, Tugce, Speybroeck, Niko, Sprügel, Maximilian, Steiropoulos, Paschalis, Stevanovic, Aleksandar, Thygesen, Lau Caspar, Tozija, Fimka, Unim, Brigid, Bektaş Uysal, Hilal, Varga, Orsolya, Vasic, Milena, Vieira, Rafael José, Yigit, Vahit, Devleesschauwer, Brecht, Pires, Sara M., Charalampous, Periklis, Haagsma, Juanita A., Jakobsen, Lea S., Gorasso, Vanessa, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Santos, João Vasco, Mcdonald, Scott A., Plass, Dietrich, Wyper, Grant M.A., Assunção, Ricardo, Von Der Lippe, Elena, Ádám, Balázs, Alkerwi, Ala'a, Arabloo, Jalal, Baltazar, Ana Lúcia, Bikbov, Boris, Borrell-Pages, Maria, Brus, Iris, Burazeri, Genc, Chaintoutis, Serafeim C., Chen-Xu, José, Chkhaberidze, Nino, Cilovic-Lagarija, Seila, Corso, Barbara, Cuschieri, Sarah, Di Bari, Carlotta, Dopelt, Keren, Economou, Mary, Emeto, Theophilus I., Fantke, Peter, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gissler, Mika, Gkitakou, Artemis, Gulmez, Hakan, Gunes, Sezgin, Haller, Sebastian, Haneef, Romana, Hincapié, Cesar A., Hynds, Paul, Idavain, Jane, Ilic, Milena, Ilic, Irena, Isola, Gaetano, Kabir, Zubair, Kamusheva, Maria, Kolkhir, Pavel, Konar, Naime Meriç, Kostoulas, Polychronis, Kulimbet, Mukhtar, La Vecchia, Carlo, Lauriola, Paolo, Levi, Miriam, Majer, Marjeta, Mechili, Enkeleint A., Monasta, Lorenzo, Mondello, Stefania, Muñoz Laguna, Javier, Nena, Evangelia, Ng, Edmond S.W., Nguewa, Paul, Niranjan, Vikram, Nola, Iskra Alexandra, O'caoimh, Rónán, Obradović, Marija, Pallari, Elena, Peyroteo, Mariana, Pinheiro, Vera, Pranjic, Nurka, Reina Ortiz, Miguel, Riva, Silvia, Santoso, Cornelia Melinda Adi, Santric Milicevic, Milena, Schmitt, Tugce, Speybroeck, Niko, Sprügel, Maximilian, Steiropoulos, Paschalis, Stevanovic, Aleksandar, Thygesen, Lau Caspar, Tozija, Fimka, Unim, Brigid, Bektaş Uysal, Hilal, Varga, Orsolya, Vasic, Milena, Vieira, Rafael José, Yigit, Vahit, Devleesschauwer, Brecht, and Pires, Sara M.
- Abstract
This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the Disability-Adjusted Life Years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3,053 studies of which 2,948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.
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- 2023
32. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach
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Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., and Zuberbier, Torsten
- Abstract
MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co‐operation and Development). MASK‐air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK‐air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as‐needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom‐medication score (ARIA‐EAACI‐CSMS) has been validated for clinical practice and trials. The implications of the novel MASK‐air® results should lead to change management in rhinitis and asthma.
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- 2023
33. Development and validation of an electronic daily control score for asthma (e-DASTHMA):a real-world direct patient data study
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Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., and Bousquet, Jean
- Abstract
Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high
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- 2023
34. Consistent trajectories of rhinitis control and treatment in 16,177 weeks
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Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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rhinitis ,real-world data ,patient-reported outcomes ,Immunology ,Immunology and Allergy ,mobile health - Abstract
Funding Information: MASK‐air® has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Twinning, EIP on AHA and H2020) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis and Uriach. Publisher Copyright: © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms. publishersversion published
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- 2023
35. MASK‐air® direct patient data support the ARIA‐MeDALL hypothesis on allergic phenotypes.
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Bousquet, Jean, Sousa‐Pinto, Bernardo, Regateiro, Frederico S., Pereira, Ana Margarida, Brussino, Luisa, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Taborda‐Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Fonseca, Joao A., Zuberbier, Torsten, Anto, Josep M., Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, and Kupczyk, Maciej
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PHENOTYPES - Published
- 2023
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36. Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices
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Charalampous, Periklis, primary, Haagsma, Juanita A., additional, Jakobsen, Lea S., additional, Gorasso, Vanessa, additional, Noguer, Isabel, additional, Padron-Monedero, Alicia, additional, Sarmiento, Rodrigo, additional, Santos, João Vasco, additional, McDonald, Scott A., additional, Plass, Dietrich, additional, Wyper, Grant M. A., additional, Assunção, Ricardo, additional, von der Lippe, Elena, additional, Ádám, Balázs, additional, AlKerwi, Ala'a, additional, Arabloo, Jalal, additional, Baltazar, Ana Lúcia, additional, Bikbov, Boris, additional, Borrell-Pages, Maria, additional, Brus, Iris, additional, Burazeri, Genc, additional, Chaintoutis, Serafeim C., additional, Chen-Xu, José, additional, Chkhaberidze, Nino, additional, Cilovic-Lagarija, Seila, additional, Corso, Barbara, additional, Cuschieri, Sarah, additional, Di Bari, Carlotta, additional, Dopelt, Keren, additional, Economou, Mary, additional, Emeto, Theophilus I., additional, Fantke, Peter, additional, Fischer, Florian, additional, Freitas, Alberto, additional, García-González, Juan Manuel, additional, Gazzelloni, Federica, additional, Gissler, Mika, additional, Gkitakou, Artemis, additional, Gulmez, Hakan, additional, Gunes, Sezgin, additional, Haller, Sebastian, additional, Haneef, Romana, additional, Hincapié, Cesar A., additional, Hynds, Paul, additional, Idavain, Jane, additional, Ilic, Milena, additional, Ilic, Irena, additional, Isola, Gaetano, additional, Kabir, Zubair, additional, Kamusheva, Maria, additional, Kolkhir, Pavel, additional, Konar, Naime Meriç, additional, Kostoulas, Polychronis, additional, Kulimbet, Mukhtar, additional, La Vecchia, Carlo, additional, Lauriola, Paolo, additional, Levi, Miriam, additional, Majer, Marjeta, additional, Mechili, Enkeleint A., additional, Monasta, Lorenzo, additional, Mondello, Stefania, additional, Muñoz Laguna, Javier, additional, Nena, Evangelia, additional, Ng, Edmond S. W., additional, Nguewa, Paul, additional, Niranjan, Vikram, additional, Nola, Iskra Alexandra, additional, O'Caoimh, Rónán, additional, Obradović, Marija, additional, Pallari, Elena, additional, Peyroteo, Mariana, additional, Pinheiro, Vera, additional, Pranjic, Nurka, additional, Reina Ortiz, Miguel, additional, Riva, Silvia, additional, Santoso, Cornelia Melinda Adi, additional, Santric Milicevic, Milena, additional, Schmitt, Tugce, additional, Speybroeck, Niko, additional, Sprügel, Maximilian, additional, Steiropoulos, Paschalis, additional, Stevanovic, Aleksandar, additional, Thygesen, Lau Caspar, additional, Tozija, Fimka, additional, Unim, Brigid, additional, Bektaş Uysal, Hilal, additional, Varga, Orsolya, additional, Vasic, Milena, additional, Vieira, Rafael José, additional, Yigit, Vahit, additional, Devleesschauwer, Brecht, additional, and Pires, Sara M., additional
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- 2023
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37. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach
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Bousquet, Jean, primary, Anto, Josep M., additional, Sousa‐Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chaves‐Loureiro, Claudia, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Gemicioglu, Bilun, additional, Fokkens, Wytske J., additional, Ivancevich, Juan Carlos, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Rouadi, Philip W., additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Zidarn, Mihaela, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bédard, Annabelle, additional, Benveniste, Samuel, additional, Bewick, Michael, additional, Bindslev‐Jensen, Carsten, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Bourret, Rodolphe, additional, Braido, Fulvio, additional, Carreiro‐Martins, Pedro, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Del Giacco, Stefano, additional, de Blay, Frédéric, additional, Devillier, Philippe, additional, De Vries, Govert, additional, Doulaptsi, Maria, additional, Doyen, Virginie, additional, Dray, Gérard, additional, Fontaine, Jean‐François, additional, Gomez, R. Maximiliano, additional, Hagemann, Jan, additional, Heffler, Enrico, additional, Hofmann, Maja, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, Kritikos, Vicky, additional, Kull, Inger, additional, Kulus, Marek, additional, Lourenço, Olga, additional, Mathieu‐Dupas, Eve, additional, Menditto, Enrica, additional, Mösges, Ralph, additional, Murray, Ruth, additional, Nadif, Rachel, additional, Neffen, Hugo, additional, Nicola, Stefania, additional, O’Hehir, Robyn, additional, Olze, Heidi, additional, Palamarchuk, Yuliia, additional, Pépin, Jean‐Louis, additional, Pétré, Benoit, additional, Picard, Robert, additional, Pitsios, Constantinos, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Raciborski, Filip, additional, Reitsma, Sietze, additional, Roche, Nicolas, additional, Rodriguez‐Gonzalez, Monica, additional, Romantowski, Jan, additional, Sá‐Sousa, Ana, additional, Serpa, Faradiba S., additional, Savouré, Marine, additional, Shamji, Mohamed H., additional, Sova, Milan, additional, Sperl, Annette, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Vandenplas, Olivier, additional, Van Eerd, Michiel, additional, Vasankari, Tuula, additional, Viart, Frédéric, additional, Waserman, Susan, additional, Fonseca, Joao A., additional, and Zuberbier, Torsten, additional
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- 2023
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38. Cutoff Values of MASK-air Patient-Reported Outcome Measures
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Sousa-Pinto, Bernardo, primary, Sá-Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Pereira, Ana Margarida, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas-Linnemann, Desirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Ansotegui, Ignacio J., additional, Bosnic-Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais-Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Taborda-Barata, Luis, additional, Toppila-Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
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- 2022
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39. The ARIA-MASK-air® approach
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Bousquet, Jean, Anto, Josep M., Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS
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Pulmonary and Respiratory Medicine ,rhinitis ,mHealth ,digital ,Immunology ,Immunology and Allergy ,asthma ,MASK-air - Abstract
Funding Information: The authors thank Ms Véronique Pretschner for submitting the paper. MASK‐air has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. None for the study. ® Publisher Copyright: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. MASK-air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma. publishersversion published
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- 2023
40. A study using MASK-air® real-world data
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Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC), and Comprehensive Health Research Centre (CHRC) - pólo NMS
- Abstract
Funding: This study was funded by ARIA. MASK-air® has been supported by EU grants (EU Structural and Development grant, POLLAR: EIT Health and Structural and Development Funds) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open Access funding enabled and organized by Projekt DEAL. BACKGROUND: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. METHODS: We analysed 2015-2020 MASK-air® European data. We compared days under no medication, monotherapy, and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ("VAS Global Symptoms") and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within one year. RESULTS: We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy, and 38,315 (17.3%) under co-medication. The median "VAS Global Symptoms" was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p
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- 2022
41. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK‐air® longitudinal study
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Sousa‐Pinto, Bernardo, primary, Schünemann, Holger J., additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Eklund, Patrik, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
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- 2022
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42. Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities
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Sousa‐Pinto, Bernardo, primary, Anto, Aram, additional, Berger, Markus, additional, Dramburg, Stephanie, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Jutel, Marek, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Valiulis, Arunas, additional, Agache, Ioana, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bastl, Katharina, additional, Berger, Uwe, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Canonica, G. Walter, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Chivato, Tomás, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Durham, Stephen R., additional, Ebisawa, Motohiro, additional, Fiocchi, Alessandro, additional, Fokkens, Wytske J., additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guzmán, Maria‐Antonieta, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Lipworth, Brian, additional, Laune, Daniel, additional, Matricardi, Paolo M., additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Neffen, Hugo, additional, Nekam, Kristoff, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Park, Hae‐Sim, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Pelosi, Simone, additional, Pham‐Thi, Nhân, additional, Popov, Ted A., additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rodriguez‐Gonzales, Monica, additional, Rosario, Nelson, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sá‐Sousa, Ana, additional, Sastre, Joaquin, additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Tripodi, Salvatore, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Valero, Antonio A., additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Williams, Sian, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Zidarn, Mihaela, additional, Zuberbier, Jaron, additional, Olze, Heidi, additional, Antó, Josep M., additional, Zuberbier, Torsten, additional, Fonseca, João A., additional, and Bousquet, Jean, additional
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- 2022
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43. Control of Allergic Rhinitis and Asthma Test: A systematic review of measurement properties and COSMIN analysis
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Vieira, Rafael José, primary, Sousa‐Pinto, Bernardo, additional, Cardoso‐Fernandes, António, additional, Jácome, Cristina, additional, Portela, Diana, additional, Amaral, Rita, additional, Sá‐Sousa, Ana, additional, Pereira, Ana Margarida, additional, Bousquet, Jean, additional, and Fonseca, João Almeida, additional
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- 2022
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44. Usage patterns of oral H1-antihistamines in 10 European countries: A study using MASK-air® and Google Trends real-world data
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Vieira, Rafael José, primary, Sousa-Pinto, Bernardo, additional, Anto, Josep M., additional, Sheikh, Aziz, additional, Klimek, Ludger, additional, Zuberbier, Torsten, additional, Fonseca, João Almeida, additional, and Bousquet, Jean, additional
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- 2022
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45. Comparison of rhinitis treatments using MASK ‐air® data and considering the minimal important difference
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Sousa‐Pinto, Bernardo, primary, Schünemann, Holger J., additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Desirée, additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brozek, Jan, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Eklund, Patrik, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
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- 2022
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46. Behavioural patterns in allergic rhinitis medication in Europe : a study using 28 MASK-air® real-world data
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Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antò i Boquè, Josep M., Pfaar, Oliver, Bedbrook, Anna, Zidarn, Mihaela, Fonseca, Joao A., and Bousquet, Jean
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antihistamines ,histaminski antagonisti ,real-world data ,rinitis -- terapija z zdravili ,behavioural patterns ,allergic rhinitis -- drug therapy ,udc:616-097 ,antihistaminiki ,alergijski rinitis -- terapija z zdravili ,visual analogue scale ,histamine antagonists ,vedenjski vzorci ,vzorci zdravljenja ,vizualna analogna lestvica ,podatki iz resničnega življenja ,asthma -- drug therapy ,medication patterns ,rhinitis -- drug therapy ,astma -- terapija z zdravili - Abstract
Background. Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. Methods. We analysed 2015-2020 MASK-air® European data. We compared days under no medication, monotherapy, and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms (“VAS Global Symptoms”) and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within one year. Results. We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy, and 38,315 (17.3%) under co-medication. The median “VAS Global Symptoms” was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p
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- 2022
47. Results of a Bayesian mixed-effects model
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Sousa-Pinto, Bernardo, Azevedo, Luís Filipe, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Anto, Josep M., Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bergmann, Karl Christian, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J., Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E., Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michaël, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, Pfaar, Oliver, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS
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Pulmonary and Respiratory Medicine ,allergic rhinitis ,patient-reported outcomes ,Immunology ,Immunology and Allergy ,real-life data analysis ,immunotherapy ,mobile health - Abstract
Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. Background: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods: We assessed the MASK-air® data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. Results: We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion: In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its ‘real-world’ effectiveness. publishersversion published
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- 2022
48. Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference
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Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
- Abstract
Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real-world data”). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. Methods: We assessed the MASK-air® app data (May 2015–December 2020) by users self-reporting AR (16–90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. Results: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71–0.80). Conclusion: Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.
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- 2022
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49. Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air real-world data.
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, and Bousquet, Jean
- Abstract
Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. We analysed 2015-2020 MASK-air European data. We compared days under no medication, monotherapy, and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ("VAS Global Symptoms") and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within one year. We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy, and 38,315 (17.3%) under co-medication. The median "VAS Global Symptoms" was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p<0.001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H -antihistamines were the most common medication in single and co-medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. AR medication patterns are similar across European regions. One third of treatment days involved co-medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR), and that co-medication use is driven by symptom severity.
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- 2022
50. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study.
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, Bousquet, Jean, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, and Bousquet, Jean
- Abstract
Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. We analyzed MASK-air® data, assessing weeks when patients answered a rhinitis daily questionnaire on all seven days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used latent class mixture model to assess robustness of results. We analyzed 113,239 days (16,177 complete weeks) from 2,590 patients (mean age±SD=39.1±13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week, and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed higher frequency of rhinitis co-medication, more frequent change of medication schemes, and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
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- 2022
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