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The present study was a prospective observational study done to evaluate elective induction of labour (e-IOL)* in overdate pregnancies (40 1/7 to 40 6/7 weeks) versus expectant management (EM)* up to 41 weeks. The primary objective was to compare rates of Caesarean section among the two groups. Study design: Women at 40 weeks of gestation satisfying the inclusion and exclusion criteria were recruited for the study. Total sample size was 112. The e-IOL group 1, included 56 participants who were induced at 40 1/7 to 40 6/7 weeks of gestation and EM group 2 had 56 participants, who were given expectant management till 41 weeks of gestation. Group 2 was further divided as group 2a who went into spontaneous labour while on expectant management and group 2b as those who were induced while on expectant management for maternal / fetal reasons or ≥ 41 0/7 weeks of gestation.Expectant management till 41 weeks of gestation beyond the due date increased the likelihood of spontaneous labour without adversely affecting the perinatal outcome. 73.2% of participants went into spontaneous labour in the EM group and 78% of them delivered vaginally. Caesarean section rates were lesser with EM (37.5%) as compared to e-IOL (58.9%) in our study (p=0.002).Caesarean section rates were lesser among women with post date pregnancies when expectant management was followed as compared to elective induction of labour. No difference in perinatal outcomes was noted amongst the two groups. Participants who went into spontaneous labour when on expectant management were more likely to deliver vaginally.

Reproductive tract infections (RTIs) such as vaginal candidiasis and bacterial vaginosis (BV) are common among sexually active women and can be both symptomatic or asymptomatic. The microbiota of the reproductive tract triggers immune response at the cervicovaginal interface resulting in secretion of cytokines during the course of these RTIs. The objective of this study was to evaluate the cytokine profile in cervicovaginal lavage of women having asymptomatic vaginal infections. Measurement of vaginal cytokines was done for various interleukins including IL-1β, IL-6, IL-8, IL-10, IL-12/IL23p40, IL-17A, tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) by ProcartaPlex™ Multiplex Immunoassay. Women having vaginal

Benign ovarian cysts comprise a majority of all ovarian masses presenting in women. Apart from functional cysts, dermoid cysts and benign cystadenomas are responsible for significant morbidity. Recurrent ovarian dermoid cysts are uncommon and attributed to incomplete surgical excision. Multiple benign cystadenomas, along with other large benign ovarian tumors arising from single ovary, are an extremely rare occurrence. We present a case with recurrent bilateral ovarian dermoids, co-occurring with multiple large benign cystadenomas from one ovary. This case was managed by laparoscopic surgery with successful enucleations and cystectomies. There are no such cases reported in the literature to the best of our knowledge. We also describe the various challenges in such surgery and implications of various surgical techniques.

To study the genome wide alterations in sperm DNA methylation in male partners of idiopathic recurrent pregnancy loss cases and note regions as potential diagnostic markers DESIGN: Case-Control study and methylome analysis of human sperm SUBJECTS: Control group consists of apparently healthy fertile men having fathered a child within the last 2 years (n = 39); and Case group consists of male partners of idiopathic recurrent pregnancy loss cases having two or more consecutive 1None MAIN OUTCOME MEASURES: Sperm DNA samples of controls and cases were selected for Whole Genome Bisulfite Sequencing analysis based on the previously set thresholds of global methylation levels and methylation levels of imprinted genes (KvDMR and ZAC). Whole Genome Bisulfite Sequencing of selected sperm genomic DNA was performed to identify differentially methylated CpG sites of idiopathic recurrent pregnancy loss cases compared to fertile controls. Pathway analysis of all the differentially methylated genes was done by DAVID functional annotation tool and Kyoto Encyclopedia of Genes and Genomes tool. Differentially methylated CpGs within genes relevant to embryo and placenta development were selected to further validate their methylation levels in study population by pyrosequencing.A total of 9497 differentially methylated CpGs with highest enrichment in intronic regions were obtained. 5352 differentially methylated regions and 2087 differentially methylated genes were noted. Signaling pathways involved in development were enriched upon pathway analysis. Select CpGs within genes PPARG, KCNQ1, SETD2 and MAP3K4 showed distinct hypomethylated sub-populations within idiopathic recurrent pregnancy loss study population.Our study highlights the altered methylation landscape of idiopathic recurrent pregnancy loss sperm and their possible implications in pathways of embryo and placental development. The CpG sites that are hypomethylated specifically in sperm of idiopathic recurrent pregnancy loss sub-population can be further assessed as predictive biomarkers.