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Your search keyword '"Valerie Morris"' showing total 5 results
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5 results on '"Valerie Morris"'

1. Real-World Treatment Patterns, Sequencing, and Outcomes in Patients with Locally Advanced or Metastatic Urothelial Carcinoma Receiving Avelumab First-Line Maintenance in the United States

Author

Helen H. Moon, Mairead Kearney, Seyed Hamidreza Mahmoudpour, Chiemeka Ike, Valerie Morris, Andrew Rava, Sonia Kim, Haiyan Sun, Marley Boyd, and Gabriel Gomez Rey

Subjects
urothelial carcinoma, real world, treatment sequencing, clinical outcomes, survival, platinum-based chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

For patients with locally advanced/metastatic urothelial carcinoma (la/mUC), first-line (1L) treatment with platinum-based chemotherapy (PBC) followed by avelumab 1L maintenance (1LM) is a recommended therapy per treatment guidelines in patients without disease progression. However, contemporary real-world (rw) data among patients receiving this treatment are necessary to understand clinical outcomes and optimal treatment sequencing. This retrospective cohort study analyzed rw treatment patterns and clinical outcomes, including overall survival (rwOS) and progression-free survival (rwPFS), in patients with la/mUC receiving avelumab 1LM. From the Flatiron Health database, 214 patients who received avelumab 1LM following 1L PBC were included. From the start of avelumab 1LM, median rwOS was 23.8 months (95% CI: 18.2—not estimable [NE]) and median rwPFS was 5.1 months (95% CI: 4.1–7.0). A total of 96 patients received second-line (2L) therapy, with 53 receiving enfortumab vedotin (EV). From the start of 2L EV, median rwOS was 11.2 months (95% CI: 6.8—NE) and median rwPFS was 4.9 months (95% CI: 3.9–8.8). Treatment patterns and clinical outcomes in this study align with guidelines and outcomes observed in the JAVELIN Bladder 100 and EV-301 clinical trials and other rw studies, supporting the use of 1L PBC followed by avelumab 1LM and 2L EV for eligible patients.

Published
2024
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3. Seasonal Temperatures in West Antarctica During the Holocene

Author

Tyler R Jones, Kurt M Cuffey, William H G Roberts, Bradley R Markle, Eric J Steig, C Max Stevens, Paul J Valdes, T J Fudge, Michael Sigl, Abigail G Hughes, Valerie Morris, Bruce H Vaughn, Joshua Garland, Bo M Vinther, Kevin S Rozmiarek, Chloe A Brashear, and James W C White

Subjects
Meteorology and Climatology
Abstract

The recovery of long-term climate proxy records with seasonal resolution is rare because of natural smoothing processes, discontinuities, and limitations in measurement resolution. Yet insolation forcing, a primary driver of multi-millennial-scale climate change, acts through seasonal variations with direct impacts on seasonal climate. Whether the sensitivity of seasonal climate to insolation matches theoretical predictions has not been assessed over long timescales. Here, we analyze a continuous record of water-isotope ratios from the West Antarctic Ice Sheet (WAIS) Divide ice core to reveal summer and winter temperature changes through the last 11,000 years. Summer temperatures in West Antarctica increased through the early-to-mid Holocene, reached a peak at 4.1 ka, and then decreased to the present. Climate model simulations show that these variations primarily reflect changes in maximum summer insolation, confirming the general connection between seasonal insolation and warming, and demonstrating the importance of insolation intensity rather than seasonally integrated insolation or season duration. Winter temperatures varied less overall, consistent with predictions from insolation forcing, but also fluctuated in the early Holocene, likely owing to changes in meridional heat transport. The magnitudes of summer and winter temperature changes constrain the lowering of the WAIS surface since the early Holocene to less than 162 m, and most likely less than 58 m, consistent with geological constraints elsewhere in West Antarctica.

Published
2023
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4. Invaluable insights into the dynamics and water-vapor isotopes of the planetary boundary layer above the Greenland Ice Sheet from fixed-wing uncrewed aircraft samplings

Author

Laura Dietrich, Kevin Rozmiarek, Tyler Jones, Valerie Morris, Chloe Brashear, Hayley Bennett, Bruce Vaughn, Michael Town, Martin Werner, Xavier Fettweis, and Hans Christian Steen-Larsen

Abstract

The chemistry and aerosols in ice core records are used as proxy data for the past climate. Traditional interpretation of this recorded climate signal is that during formation snow captures a snapshot of the atmosphere. In recent years, observations have documented that the snow surface’s chemistry and isotopic composition change during the post-depositional interaction with the surface-near atmosphere. To more accurately interpret the climate signal in ice cores it is necessary to understand thesource of the water vapor in the planetary boundary layer (PBL), as well as the vertical mixing and transportation in the polar atmosphere. However, the dynamics in the polar PBL are poorly constrained in most climate models due to a lack of observations. Here we present insights from the first Arctic in-situ water-vapor isotope record both within and above the PBL up to 1500 meters above the Greenland Ice Sheet (GrIS) from the EastGRIP ice core camp 2022 field campaign. Flights were performed with a fixed-wing uncrewed aircraft recording high resolution atmospheric profiles. Moreover, air is sampled in glass flasks and brought to the surface for determination of δ18O and δDof water vapor. The observational set-up has been proven to guarantee reliable measurements of the isotopic composition of the atmospheric water vapor in remote locations and under extremely cold temperatures. Based on 105 observed temperature, humidity and isotopic profiles we identify different types of atmospheric structure above the GrIS. We evaluate the vertical atmospheric representation of the polar regional climate model MAR and the isotope-enabled global climate model ECHAM-wiso. Finally, from observations we estimate the height up to which the surface-near δ18O and δD isotopic values are affected by the atmosphere above.

Published
2023
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