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Gestational Age (GA) at birth plays a crucial role in identifying potential vulnerabilities to long-term difficulties in cognitive and behavioral development. The present study aims to explore the influence of gestational age on the efficiency of early visual attention orienting, as a potential marker for the development of specific high-level socio-cognitive skills. We administered the Gap-Overlap task to measure the attentional orienting and disengagement performance of 16-month-olds born between the 34th and 41st weeks of gestation. Our findings indicate that GA might be a significant predictor of attentional disengagement performance, with lower GAs associated with slower orienting of visual attention in the gap condition. Additionally, we discuss a possible influence of endogenous attention control on disengagement accuracy at this age, particularly among full-term infants. Overall, the findings highlight the role of GA as a key factor in evaluating early visual attention development, acting as a marker for detecting early vulnerabilities., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Attentional reorienting is dysfunctional not only in children with autism spectrum disorder (ASD), but also in infants who will develop ASD, thus constituting a potential causal factor of future social interaction and communication abilities. Following the research domain criteria framework, we hypothesized that the presence of subclinical autistic traits in parents should lead to atypical infants' attentional reorienting, which in turn should impact on their future socio-communication behavior in toddlerhood. During an attentional cueing task, we measured the saccadic latencies in a large sample (total enrolled n = 89; final sample n = 71) of 8-month-old infants from the general population as a proxy for their stimulus-driven attention. Infants were grouped in a high parental traits (HPT; n = 23) or in a low parental traits (LPT; n = 48) group, according to the degree of autistic traits self-reported by their parents. Infants (n = 33) were then longitudinally followed to test their socio-communicative behaviors at 21 months. Results show a sluggish reorienting system, which was a longitudinal predictor of future socio-communicative skills at 21 months. Our combined transgenerational and longitudinal findings suggest that the early functionality of the stimulus-driven attentional network-redirecting attention from one event to another-could be directly connected to future social and communication development., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Importance: Few investigations have evaluated rates of brain-based magnetic resonance imaging (MRI) incidental findings (IFs) in large lifespan samples, their stability over time, or their associations with health outcomes., Objectives: To examine rates of brain-based IFs across the lifespan, their persistence, and their associations with phenotypic indicators of behavior, cognition, and health; to compare quantified motion with radiologist-reported motion and evaluate its associations with IF rates; and to explore IF consistency across multiple visits., Design, Setting, and Participants: This cross-sectional study included participants from the Nathan Kline Institute-Rockland Sample (NKI-RS), a lifespan community-ascertained sample, and the Healthy Brain Network (HBN), a cross-sectional community self-referred pediatric sample focused on mental health and learning disorders. The NKI-RS enrolled participants (ages 6-85 years) between March 2012 and March 2020 and had longitudinal participants followed up for as long as 4 years. The HBN enrolled participants (ages 5-21 years) between August 2015 and October 2021. Clinical neuroradiology MRI reports were coded for radiologist-reported motion as well as presence, type, and clinical urgency (category 1, no abnormal findings; 2, no referral recommended; 3, consider referral; and 4, immediate referral) of IFs. MRI reports were coded from June to October 2021. Data were analyzed from November 2021 to February 2023., Main Outcomes and Measures: Rates and type of IFs by demographic characteristics, health phenotyping, and motion artifacts; longitudinal stability of IFs; and Euler number in projecting radiologist-reported motion., Results: A total of 1300 NKI-RS participants (781 [60.1%] female; mean [SD] age, 38.9 [21.8] years) and 2772 HBN participants (976 [35.2%] female; mean [SD] age, 10.0 [3.5] years) had health phenotyping and neuroradiology-reviewed MRI scans. IFs were common, with 284 of 2956 children (9.6%) and 608 of 1107 adults (54.9%) having IFs, but rarely of clinical concern (category 1: NKI-RS, 619 [47.6%]; HBN, 2561 [92.4%]; category 2: NKI-RS, 647 [49.8%]; HBN, 178 [6.4%]; category 3: NKI-RS, 79 [6.1%]; HBN, 30 [1.1%]; category 4: NKI-RS: 12 [0.9%]; HBN, 6 [0.2%]). Overall, 46 children (1.6%) and 79 adults (7.1%) required referral for their IFs. IF frequency increased with age. Elevated blood pressure and BMI were associated with increased T2 hyperintensities and age-related cortical atrophy. Radiologist-reported motion aligned with Euler-quantified motion, but neither were associated with IF rates., Conclusions and Relevance: In this cross-sectional study, IFs were common, particularly with increasing age, although rarely clinically significant. While T2 hyperintensity and age-related cortical atrophy were associated with BMI and blood pressure, IFs were not associated with other behavioral, cognitive, and health phenotyping. Motion may not limit clinical IF detection.

First experiences with rhythm occur in the womb, with different rhythmic sources being available to the human fetus. Among sensory modalities, vestibular, tactile, and somatosensory perception plays a crucial role in early processing. However, a limited number of studies so far have specifically focused on VTS rhythms in language development. The present work investigated VTS rhythmic abilities and their role in language acquisition through two experiments with 45 infants (21 females, sex assigned at birth; M age = 661.6 days, SD = 192.6) with middle/high socioeconomic status. Specifically, 37 infants from the original sample completed Experiment 1, assessing VTS rhythmic abilities through a vibrotactile tool for music perception. In Experiment 2, linguistic abilities were evaluated in 40 participants from the same cohort, specifically testing phonological and prosodic processing. Discrimination abilities for rhythmic and linguistic stimuli were inferred from changes in pupil diameter to contingent visual stimuli over time, through a Tobii X-60 eye-tracker. The predictive effect of VTS rhythmic abilities on linguistic processing and the developmental changes occurring across ages were explored in the 32 infants who completed both Experiments 1 and 2 by means of generalized, additive and linear, mixed-effect models. Results are discussed in terms of cross-sensory (i.e., haptic to hearing) and cross-domain (i.e., music to language) effects of rhythm on language acquisition, with implications for typical and atypical development., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

Previous research has highlighted an interplay between postural abilities and linguistic skills during infancy. However, this relationship could undergo further radical transformations in other periods of development. This current study explored a plausible network of relationships among postural abilities and vocabulary skills in a substantial cohort (N = 222) of preschoolers aged between 2 and 5 years-a developmental phase critical for refining both language and motor competencies. Here, postural stability was measured in terms of balance duration and accuracy, alongside an assessment of comprehension and expressive vocabulary skills. Employing a diverse set of techniques, i.e., data and missing data visualization and multilevel regression analysis, task complexity and age emerged as crucial factors explaining our data. In addition, network analysis indicates that language production plays a central role within postural and language interdomain networks. The resulting discussion focuses on the useful implications of this study for the assessment of typical preschool development, which would benefit from tailored methodological inspections guided by developmental theories that are framed in inter-domain approaches.

The rise of pupillometry in infant research over the last decade is associated with a variety of methods for data preprocessing and analysis. Although pupil diameter is increasingly recognized as an alternative measure of the popular cumulative looking time approach used in many studies (Jackson & Sirois, 2022), an open question is whether the many approaches used to analyse this variable converge. To this end, we proposed a crowdsourced approach to pupillometry analysis. A dataset from 30 9-month-old infants (15 girls; M age = 282.9 days, SD = 8.10) was provided to 7 distinct teams for analysis. The data were obtained from infants watching video sequences showing a hand, initially resting between two toys, grabbing one of them (after Woodward, 1998). After habituation, infants were shown (in random order) a sequence of four test events that varied target position and target toy. Results show that looking times reflect primarily the familiar path of the hand, regardless of target toy. Gaze data similarly show this familiarity effect of path. The pupil dilation analyses show that features of pupil baseline measures (duration and temporal location) as well as data retention variation (trial and/or participant) due to different inclusion criteria from the various analysis methods are linked to divergences in findings. Two of the seven teams found no significant findings, whereas the remaining five teams differ in the pattern of findings for main and interaction effects. The discussion proposes guidelines for best practice in the analysis of pupillometry data., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

The possibility of predicting the specific features of forthcoming environmental events is fundamental for our survival since it allows us to proactively regulate our behaviour, enhancing our chance of survival. This is particularly crucial for stimuli providing socially relevant information for communication and interaction, such as faces. While it has been consistently demonstrated that the human brain shows preferential and ontogenetically early face-evoked activity, it is unknown whether specialized neural routes are engaged by face-predictive activity early in life. In this study, we recorded high-density electrophysiological (ERP) activity in adults and 9- and 4-month-old infants undergoing an audio-visual paradigm purposely designed to predict the appearance of faces or objects starting from congruent auditory cues (i.e., human voice vs nonhuman sounds). Contingent negative variation or CNV was measured to investigate anticipatory activity as a reliable marker of stimulus expectancy even in the absence of explicit motor demand. The results suggest that CNV can also be reliably elicited in the youngest group of 4-month-old infants, providing further evidence that expectation-related anticipatory activity is an intrinsic, early property of the human cortex. Crucially, the findings also indicate that the predictive information provided by the cue (i.e., human voice vs nonhuman sounds) turns into the recruitment of different anticipatory neural dynamics for faces and objects., (© 2022. The Author(s).)