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Quasi-elastic (QEL) scattering measurements have been performed using a 28Si projectile off a 90Zr target at energies around the Coulomb barrier. A Bayesian analysis within the framework of coupled channels (CC) calculations is performed in a large parameter space of quadrupole and hexadecapole deformations (β2 and β4) of 28Si. Our results unambiguously show that 28Si is an oblate shaped nucleus with β2=-0.38±0.01 which is in excellent agreement with results from electromagnetic probes. The sign and magnitude of quadrupole deformation along with a precise value of hexadecapole deformation (β4=+0.03±0.01) of 28Si have been determined for the first time using QEL scattering. A remarkable agreement is obtained between the experimental and calculated β4 values of 28Si based on Skyrme-Hartree-Fock method. The present results demonstrate the strong sensitivity of the quasi-elastic scattering to the sign and magnitude to the ground state deformation parameters, thus affirming its suitability to be used for rare exotic nuclei using low intensity RIBs.

Background: Nephrotic syndrome appears as a group of symptoms like proteinuria, edema and hyperlipidemia. Identification of monogenic forms revealed the physiology and pathogenesis of the SRNS., Methods and Results: We performed Illumina panel sequencing of seven genes in 90 Indian patients to determine the role of these genetic mutations in nephrotic syndrome prognosis. Samtool was used for variants calling, and SnpEff and Snpsift did variants annotation. Clinical significance and variant classification were performed by the ClinVar database. In SSNS and SRNS patients, we found 0.78% pathogenic and 3.41% likely pathogenic mutations. Pathogenic mutations were found in LAMB2, LMX1B and WT1 genes, while likely pathogenic mutations were found in (6/13) LAMB2, (2/13) LMX1B, (2/13) TRPC6, (2/13) PTPRO and (1/13) PMM2 genes. Approximately 46% likely pathogenic mutations were contributed to the LAMB2 gene in SSNS and SRNS patients. We also detect 30 VUS (variants of uncertain significance), which were found (17/30) pathogenic and (13/30) likely pathogenic by different prediction tools., Conclusions: Multigene panels were used for genetic screening of heterogeneous disorders like nephrotic syndrome in the Indian population. We found pathogenic, likely pathogenic and certain VUS, which were responsible for the pathogenesis of the disease. Therefore, mutational analysis of SSNS and SRNS is necessary to avoid adverse effects of corticosteroids, modify the intensity of immunosuppressing agents, and prevent the disease's progression., (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)