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Your search keyword '"Vézina, Dani"' showing total 14 results
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14 results on '"Vézina, Dani"'

1. Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD

Author

Chen, Yaozong, Prévost, Jérémie, Ullah, Irfan, Romero, Hugo, Lisi, Veronique, Tolbert, William D., Grover, Jonathan R., Ding, Shilei, Gong, Shang Yu, Beaudoin-Bussières, Guillaume, Gasser, Romain, Benlarbi, Mehdi, Vézina, Dani, Anand, Sai Priya, Chatterjee, Debashree, Goyette, Guillaume, Grunst, Michael W., Yang, Ziwei, Bo, Yuxia, Zhou, Fei, Béland, Kathie, Bai, Xiaoyun, Zeher, Allison R., Huang, Rick K., Nguyen, Dung N., Sherburn, Rebekah, Wu, Di, Piszczek, Grzegorz, Paré, Bastien, Matthies, Doreen, Xia, Di, Richard, Jonathan, Kumar, Priti, Mothes, Walther, Côté, Marceline, Uchil, Pradeep D., Lavallée, Vincent-Philippe, Smith, Martin A., Pazgier, Marzena, Haddad, Elie, and Finzi, Andrés

Published
2023
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2. VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry

Author

Ding, Shilei, Ullah, Irfan, Gong, Shang Yu, Grover, Jonathan R., Mohammadi, Mohammadjavad, Chen, Yaozong, Vézina, Dani, Beaudoin-Bussières, Guillaume, Verma, Vijay Tailor, Goyette, Guillaume, Gaudette, Fleur, Richard, Jonathan, Yang, Derek, Smith, Amos B., III, Pazgier, Marzena, Côté, Marceline, Abrams, Cameron, Kumar, Priti, Mothes, Walther, Uchil, Pradeep D., Finzi, Andrés, and Baron, Christian

Published
2022
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3. Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2

Author

Gong, Shang Yu, primary, Ding, Shilei, additional, Benlarbi, Mehdi, additional, Chen, Yaozong, additional, Vézina, Dani, additional, Marchitto, Lorie, additional, Beaudoin-Bussières, Guillaume, additional, Goyette, Guillaume, additional, Bourassa, Catherine, additional, Bo, Yuxia, additional, Medjahed, Halima, additional, Levade, Inès, additional, Pazgier, Marzena, additional, Côté, Marceline, additional, Richard, Jonathan, additional, Prévost, Jérémie, additional, and Finzi, Andrés, additional

Published
2022
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4. Temsavir Treatment of HIV-1-Infected Cells Decreases Envelope Glycoprotein Recognition by Broadly Neutralizing Antibodies

Author

Boutin, Marianne, primary, Vézina, Dani, additional, Ding, Shilei, additional, Prévost, Jérémie, additional, Laumaea, Annemarie, additional, Marchitto, Lorie, additional, Anand, Sai Priya, additional, Medjahed, Halima, additional, Gendron-Lepage, Gabrielle, additional, Bourassa, Catherine, additional, Goyette, Guillaume, additional, Clark, Andrew, additional, Richard, Jonathan, additional, and Finzi, Andrés, additional

Published
2022
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5. Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

Author

Nayrac, Manon, primary, Dubé, Mathieu, additional, Sannier, Gérémy, additional, Nicolas, Alexandre, additional, Marchitto, Lorie, additional, Tastet, Olivier, additional, Tauzin, Alexandra, additional, Brassard, Nathalie, additional, Lima-Barbosa, Raphaël, additional, Beaudoin-Bussières, Guillaume, additional, Vézina, Dani, additional, Gong, Shang Yu, additional, Benlarbi, Mehdi, additional, Gasser, Romain, additional, Laumaea, Annemarie, additional, Prévost, Jérémie, additional, Bourassa, Catherine, additional, Gendron-Lepage, Gabrielle, additional, Medjahed, Halima, additional, Goyette, Guillaume, additional, Ortega-Delgado, Gloria-Gabrielle, additional, Laporte, Mélanie, additional, Niessl, Julia, additional, Gokool, Laurie, additional, Morrisseau, Chantal, additional, Arlotto, Pascale, additional, Richard, Jonathan, additional, Bélair, Justin, additional, Prat, Alexandre, additional, Tremblay, Cécile, additional, Martel-Laferrière, Valérie, additional, Finzi, Andrés, additional, and Kaufmann, Daniel E., additional

Published
2022
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6. SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between doses

Author

Chatterjee, Debashree, primary, Tauzin, Alexandra, additional, Marchitto, Lorie, additional, Gong, Shang Yu, additional, Boutin, Marianne, additional, Bourassa, Catherine, additional, Beaudoin-Bussières, Guillaume, additional, Bo, Yuxia, additional, Ding, Shilei, additional, Laumaea, Annemarie, additional, Vézina, Dani, additional, Perreault, Josée, additional, Gokool, Laurie, additional, Morrisseau, Chantal, additional, Arlotto, Pascale, additional, Fournier, Éric, additional, Guilbault, Aurélie, additional, Delisle, Benjamin, additional, Levade, Inès, additional, Goyette, Guillaume, additional, Gendron-Lepage, Gabrielle, additional, Medjahed, Halima, additional, De Serres, Gaston, additional, Tremblay, Cécile, additional, Martel-Laferrière, Valérie, additional, Kaufmann, Daniel E., additional, Bazin, Renée, additional, Prévost, Jérémie, additional, Moreira, Sandrine, additional, Richard, Jonathan, additional, Côté, Marceline, additional, and Finzi, Andrés, additional

Published
2022
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7. VE607 Stabilizes SARS-CoV-2 Spike In the “RBD-up” Conformation and Inhibits Viral Entry

Author

Ding, Shilei, primary, Gong, Shang Yu, additional, Grover, Jonathan, additional, Mohammadi, Mohammadjavad, additional, Chen, Yaozong, additional, Vézina, Dani, additional, Beaudoin-Bussières, Guillaume, additional, Verma, Vijay Tailor, additional, Goyette, Guillaume, additional, Richard, Jonathan, additional, Yang, Derek, additional, Smith, Amos B., additional, Pazgier, Marzena, additional, Côté, Marceline, additional, Abrams, Cameron, additional, Mothes, Walther, additional, Finzi, Andrés, additional, and Baron, Christian, additional

Published
2022
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8. A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Author

Beaudoin-Bussières, Guillaume, primary, Chen, Yaozong, additional, Ullah, Irfan, additional, Prévost, Jérémie, additional, Tolbert, William D., additional, Symmes, Kelly, additional, Ding, Shilei, additional, Benlarbi, Mehdi, additional, Gong, Shang Yu, additional, Tauzin, Alexandra, additional, Gasser, Romain, additional, Chatterjee, Debashree, additional, Vézina, Dani, additional, Goyette, Guillaume, additional, Richard, Jonathan, additional, Zhou, Fei, additional, Stamatatos, Leonidas, additional, McGuire, Andrew T., additional, Charest, Hughes, additional, Roger, Michel, additional, Pozharski, Edwin, additional, Kumar, Priti, additional, Mothes, Walther, additional, Uchil, Pradeep D., additional, Pazgier, Marzena, additional, and Finzi, Andrés, additional

Published
2022
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9. Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

Author

Li, Wenwei, primary, Chen, Yaozong, additional, Prévost, Jérémie, additional, Ullah, Irfan, additional, Lu, Maolin, additional, Gong, Shang Yu, additional, Tauzin, Alexandra, additional, Gasser, Romain, additional, Vézina, Dani, additional, Anand, Sai Priya, additional, Goyette, Guillaume, additional, Chaterjee, Debashree, additional, Ding, Shilei, additional, Tolbert, William D., additional, Grunst, Michael W., additional, Bo, Yuxia, additional, Zhang, Shijian, additional, Richard, Jonathan, additional, Zhou, Fei, additional, Huang, Rick K., additional, Esser, Lothar, additional, Zeher, Allison, additional, Côté, Marceline, additional, Kumar, Priti, additional, Sodroski, Joseph, additional, Xia, Di, additional, Uchil, Pradeep D., additional, Pazgier, Marzena, additional, Finzi, Andrés, additional, and Mothes, Walther, additional

Published
2022
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10. Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses

Author

Tauzin, Alexandra, primary, Gong, Shang Yu, additional, Beaudoin-Bussières, Guillaume, additional, Vézina, Dani, additional, Gasser, Romain, additional, Nault, Lauriane, additional, Marchitto, Lorie, additional, Benlarbi, Mehdi, additional, Chatterjee, Debashree, additional, Nayrac, Manon, additional, Laumaea, Annemarie, additional, Prévost, Jérémie, additional, Boutin, Marianne, additional, Sannier, Gérémy, additional, Nicolas, Alexandre, additional, Bourassa, Catherine, additional, Gendron-Lepage, Gabrielle, additional, Medjahed, Halima, additional, Goyette, Guillaume, additional, Bo, Yuxia, additional, Perreault, Josée, additional, Gokool, Laurie, additional, Morrisseau, Chantal, additional, Arlotto, Pascale, additional, Bazin, Renée, additional, Dubé, Mathieu, additional, De Serres, Gaston, additional, Brousseau, Nicholas, additional, Richard, Jonathan, additional, Rovito, Roberta, additional, Côté, Marceline, additional, Tremblay, Cécile, additional, Marchetti, Giulia C., additional, Duerr, Ralf, additional, Martel-Laferrière, Valérie, additional, Kaufmann, Daniel E., additional, and Finzi, Andrés, additional

Published
2022
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11. SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

Author

Chatterjee, Debashree, primary, Tauzin, Alexandra, additional, Marchitto, Lorie, additional, Yu Gong, Shang, additional, Boutin, Marianne, additional, Bourassa, Catherine, additional, Beaudoin-Bussières, Guillaume, additional, Bo, Yuxia, additional, Ding, Shilei, additional, Laumaea, Annemarie, additional, Vézina, Dani, additional, Perreault, Josée, additional, Gokool, Laurie, additional, Morrisseau, Chantal, additional, Arlotto, Pascale, additional, Fournier, Éric, additional, Guilbault, Aurélie, additional, Delisle, Benjamin, additional, Levade, Inès, additional, Goyette, Guillaume, additional, Gendron-Lepage, Gabrielle, additional, Medjahed, Halima, additional, De Serres, Gaston, additional, Tremblay, Cécile, additional, Martel-Laferrière, Valérie, additional, Kaufmann, Daniel E., additional, Bazin, Renée, additional, Prévost, Jérémie, additional, Moreira, Sandrine, additional, Richard, Jonathan, additional, Côté, Marceline, additional, and Finzi, Andrés, additional

Published
2021
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12. Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

Author

Nayrac, Manon, primary, Dubé, Mathieu, additional, Sannier, Gérémy, additional, Nicolas, Alexandre, additional, Marchitto, Lorie, additional, Tastet, Olivier, additional, Tauzin, Alexandra, additional, Brassard, Nathalie, additional, Beaudoin-Bussières, Guillaume, additional, Vézina, Dani, additional, Gong, Shang Yu, additional, Benlarbi, Mehdi, additional, Gasser, Romain, additional, Laumaea, Annemarie, additional, Bourassa, Catherine, additional, Gendron-Lepage, Gabrielle, additional, Medjahed, Halima, additional, Goyette, Guillaume, additional, Ortega-Delgado, Gloria-Gabrielle, additional, Laporte, Mélanie, additional, Niessl, Julia, additional, Gokool, Laurie, additional, Morrisseau, Chantal, additional, Arlotto, Pascale, additional, Richard, Jonathan, additional, Tremblay, Cécile, additional, Martel-Laferrière, Valérie, additional, Finzi, Andrés, additional, and Kaufmann, Daniel E., additional

Published
2021
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13. VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry.

Author

Ding S, Gong SY, Grover J, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Richard J, Yang D, Smith AB, Pazgier M, Côté M, Abrams C, Mothes W, Finzi A, and Baron C

Abstract

SARS-CoV-2 infection of host cells starts by binding of the Spike glycoprotein (S) to the ACE2 receptor. The S-ACE2 interaction is a potential target for therapies against COVID-19 as demonstrated by the development of immunotherapies blocking this interaction. Here, we present the commercially available VE607, comprised of three stereoisomers, that was originally described as an inhibitor of SARS-CoV-1. We show that VE607 specifically inhibits infection of SARS-CoV-1 and SARS-CoV-2 S-expressing pseudoviral particles as well as authentic SARS-CoV-2. VE607 stabilizes the receptor binding domain (RBD) in its "up" conformation. In silico docking and mutational analysis map the VE607 binding site at the RBD-ACE2 interface. The IC 50 values are in the low micromolar range for pseudoparticles derived from SARS-CoV-2 Wuhan/D614G as well as from variants of concern (Alpha, Beta, Gamma, Delta and Omicron), suggesting that VE607 has potential for the development of drugs against SARS-CoV-2 infections.

Published
2022
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14. Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen.

Author

Nayrac M, Dubé M, Sannier G, Nicolas A, Marchitto L, Tastet O, Tauzin A, Brassard N, Beaudoin-Bussières G, Vézina D, Gong SY, Benlarbi M, Gasser R, Laumaea A, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Ortega-Delgado GG, Laporte M, Niessl J, Gokool L, Morrisseau C, Arlotto P, Richard J, Tremblay C, Martel-Laferrière V, Finzi A, and Kaufmann DE

Abstract

Spacing of the BNT162b2 mRNA doses beyond 3 weeks raised concerns about vaccine efficacy. We longitudinally analyzed B cell, T cell and humoral responses to two BNT162b2 mRNA doses administered 16 weeks apart in 53 SARS-CoV-2 naïve and previously-infected donors. This regimen elicited robust RBD-specific B cell responses whose kinetics differed between cohorts, the second dose leading to increased magnitude in naïve participants only. While boosting did not increase magnitude of CD4 + T cell responses further compared to the first dose, unsupervised clustering analyses of single-cell features revealed phenotypic and functional shifts over time and between cohorts. Integrated analysis showed longitudinal immune component-specific associations, with early Thelper responses post-first dose correlating with B cell responses after the second dose, and memory Thelper generated between doses correlating with CD8 T cell responses after boosting. Therefore, boosting elicits a robust cellular recall response after the 16-week interval, indicating functional immune memory.

Published
2021
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