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Your search keyword '"Ungvari, Zoltan I."' showing total 5 results
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5 results on '"Ungvari, Zoltan I."'

2. COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment.

Author

Owens, Cameron D., Pinto, Camila B., Szarvas, Zsofia, Muranyi, Mihaly, da C. Pinaffi-Langley, Ana Clara, Peterfi, Anna, Mukli, Peter, Detwiler, Sam, Olay, Lauren, Kaposzta, Zalan, Smith, Kenneth, Kirkpatrick, Angelia C., Saleh Velez, Faddi, Tarantini, Stefano, Csiszar, Anna, Ungvari, Zoltan I., Prodan, Calin I., and Yabluchanskiy, Andriy

Subjects
POST-acute COVID-19 syndrome, COVID-19 pandemic, MILD cognitive impairment, OLDER people, NEUROBEHAVIORAL disorders, BRACHIAL artery
Abstract

Mild cognitive impairment (MCI) affects nearly 20% of older adults worldwide, with no targetable interventions for prevention. COVID-19 adversely affects cognition, with >70% of older adults with Long COVID presenting with cognitive complaints. Neurovascular coupling (NVC), an essential mechanism of cognitive function, declines with aging and is further attenuated in neurocognitive disorders. The effect of COVID-19 on NVC responses has yet to be addressed in older adults who are vulnerable to dementia progression. Participants with MCI and a history of COVID-19 (COV+, N = 31) and MCI participants with no history of infection (COV− N = 11) participated in this cross-sectional study to determine if COVID-19 affects cerebrocortical NVC responses and vascular function. Functional near-infrared spectroscopy was used to measure cerebrocortical NVC responses, and endothelial function was assessed via insonation of the brachial artery during a flow-mediated dilation protocol. NVC responses were elicited by the working memory n-back paradigm. NVC in the left dorsolateral prefrontal cortex and endothelial function was decreased in the COV+ group compared to the COV− group. These data provide mechanistic insight into how COVID-19 may exacerbate long-term cognitive sequela seen in older adults, highlighting the urgent need for further research and clinical trials to explore novel therapeutic interventions aimed at preserving/restoring NVC. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging

Author

Miller, Lauren R., primary, Tarantini, Stefano, additional, Nyúl-Tóth, Ádám, additional, Johnston, Morgan P., additional, Martin, Teryn, additional, Bullen, Elizabeth C., additional, Bickel, Marisa A., additional, Sonntag, William E., additional, Yabluchanskiy, Andriy, additional, Csiszar, Anna, additional, Ungvari, Zoltan I., additional, Elliott, Michael H., additional, and Conley, Shannon M., additional

Published
2022
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5. Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Ozdoes not support the hypothesis linking hypopituitary dwarfism to longevity

Author

Fazekas-Pongor, Vince, Péterfi, Anna, Major, Dávid, Szarvas, Zsófia, Fekete, Monika, Tabak, Adam G., Csiszar, Anna, Sonntag, William E., Austad, Steven N., and Ungvari, Zoltan I.

Abstract

In laboratory mice, pituitary dwarfism caused by genetic reduction or elimination of the activity of growth hormone (GH) significantly extends lifespan. The effects of congenital pituitary dwarfism on human longevity are not well documented. To analyse the effects of untreated pituitary dwarfism on human lifespan, the longevity of a diverse group of widely known little people, the 124 adults who played “Munchkins” in the 1939 movie The Wizard of Ozwas investigated. Survival of “Munchkin” actors with those of controls defined as cast members of The Wizard of Ozand those of other contemporary Academy Award winning Hollywood movies was compared. According to the Kaplan–Meier survival curves, survival of female and male “Munchkin” actors was shorter than cast controls and Hollywood controls of respective sexes. Cox regression analyses showed that female “Munchkin” actors had significantly higher risk ratios compared to both female cast controls (RR, 1.70; 95% CI, 1.05 to 2.77) and female Hollywood controls (RR, 1.52; 95% CI, 1.03 to 2.24). Similar trends were also discernible for men, albeit point estimates were not significant. The lack of lifespan extension in “Munchkin” actors does not support the hypothesis that hereditary GH deficiency regulates longevity in humans.

Published
2022
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