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31 results on '"Uemura, Sho"'

1. SENSEI at SNOLAB: Single-Electron Event Rate and Implications for Dark Matter

Author

Bloch, Itay M., Botti, Ana M., Cababie, Mariano, Cancelo, Gustavo, Cervantes-Vergara, Brenda A., Daal, Miguel, Desai, Ansh, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Juan, Etzion, Erez, Moroni, Guillermo Fernandez, Holland, Stephen E., Kehat, Jonathan, Lawson, Ian, Luoma, Steffon, Orly, Aviv, Perez, Santiago E., Rodrigues, Dario, Saffold, Nathan A., Scorza, Silvia, Sofo-Haro, Miguel, Stifter, Kelly, Tiffenberg, Javier, Uemura, Sho, Villalpando, Edgar Marrufo, Volansky, Tomer, Winkel, Federico, Wu, Yikai, and Yu, Tien-Tien

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

We present results from data acquired by the SENSEI experiment at SNOLAB after a major upgrade in May 2023, which includes deploying 16 new sensors and replacing the copper trays that house the CCDs with a new light-tight design. We observe a single-electron event rate of $(1.39 \pm 0.11) \times 10^{-5}$ e$^-$/pix/day, corresponding to $(39.8 \pm 3.1)$ e$^-$/gram/day. This is an order-of-magnitude improvement compared to the previous lowest single-electron rate in a silicon detector and the lowest for any photon detector in the near-infrared-ultraviolet range. We use these data to obtain a 90% confidence level upper bound of $1.53 \times 10^{-5}$ e$^-$/pix/day and to set constraints on sub-GeV dark matter candidates that produce single-electron events. We hypothesize that the data taken at SNOLAB in the previous run, with an older tray design for the sensors, contained a larger rate of single-electron events due to light leaks. We test this hypothesis using data from the SENSEI detector located in the MINOS cavern at Fermilab.

Published
2024

2. Astronomical Spectroscopy with Skipper CCDs: First Results from a Skipper CCD Focal Plane Prototype at SIFS

Author

Villalpando, Edgar Marrufo, Drlica-Wagner, Alex, Roach, Brandon, Bonati, Marco, Bakshi, Abhishek, Campa, Julia, Cancelo, Gustavo, Cancino, Braulio, Chavez, Claudio R., Chierchie, Fernando, Estrada, Juan, Moroni, Guillermo Fernandez, Fraga, Luciano, Gaido, Manuel E., Holland, Stephen E., Hur, Rachel, Jonas, Michelle, Moore, Peter, Paolini, Eduardo, Malagón, Andrés A. Plazas, Stefanazzi, Leandro, Tiffenberg, Javier, Treptou, Ken, Uemura, Sho, and Wilcer, Neal

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

We present the first on-sky results from an ultra-low-readout-noise Skipper CCD focal plane prototype for the SOAR Integral Field Spectrograph (SIFS). The Skipper CCD focal plane consists of four 6k x 1k, 15 $\mu$m pixel, fully-depleted, p-channel devices that have been thinned to ~250 $\mu$m, backside processed, and treated with an anti-reflective coating. These Skipper CCDs were configured for astronomical spectroscopy, i.e., single-sample readout noise < 4.3 e- rms/pixel, the ability to achieve multi-sample readout noise $\ll$ 1 e- rms/pixel, full-well capacities ~40,000-65,000 e-, low dark current and charge transfer inefficiency (~2 x 10$^{-4}$ e-/pixel/s and 3.44 x 10$^{-7}$, respectively), and an absolute quantum efficiency of $\gtrsim$ 80% between 450 nm and 980 nm ($\gtrsim$ 90% between 600 nm and 900 nm). We optimized the readout sequence timing to achieve sub-electron noise (~0.5 e- rms/pixel) in a region of 2k x 4k pixels and photon-counting noise (~0.22 e- rms/pixel) in a region of 220 x 4k pixels, each with a readout time of $\lesssim$ 17 min. We observed two quasars (HB89 1159+123 and QSO J1621-0042) at redshift z ~ 3.5, two high-redshift galaxy clusters (CL J1001+0220 and SPT-CL J2040-4451), an emission line galaxy at z = 0.3239, a candidate member star of the Bo\"{o}tes II ultra-faint dwarf galaxy, and five CALSPEC spectrophotometric standard stars (HD074000, HD60753, HD106252, HD101452, HD200654). We present charge-quantized, photon-counting observations of the quasar HB89 1159+123 and show the detector sensitivity increase for faint spectral features. We demonstrate signal-to-noise performance improvements for SIFS observations in the low-background, readout-noise-dominated regime. We outline scientific studies that will leverage the SIFS-Skipper CCD data and new detector architectures that utilize the Skipper floating gate amplifier with faster readout times., Comment: 20 pages, 13 figures, 1 table; Proc. SPIE

Published
2024
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3. Searches for CE{\nu}NS and Physics beyond the Standard Model using Skipper-CCDs at CONNIE

Author

Aguilar-Arevalo, Alexis A., Avalos, Nicolas, Bertou, Xavier, Bonifazi, Carla, Cancelo, Gustavo, Cervantes-Vergara, Brenda A., Chavez, Claudio, Chierchie, Fernando, Corrêa, Gustavo Coelho, D'Olivo, Juan Carlos, Anjos, João dos, Estrada, Juan, Moroni, Guillermo Fernandez, Neto, Aldo R. Fernandes, Ford, Richard, Kilminster, Ben, Kuk, Kevin, Lathrop, Andrew, Lemos, Patrick, Lima Jr., Herman P., Makler, Martin, Maslova, Katherine, Marinho, Franciole, Molina, Jorge, Nasteva, Irina, Oliveira, Ana Carolina, Paulucci, Laura, Rodrigues, Dario, Sarkis, Y., Sofo-Haro, Miguel, Stalder, Diego, Tiffenberg, Javier, Uemura, Sho, and Ventura, Pedro

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Coherent Neutrino-Nucleus Interaction Experiment (CONNIE) aims to detect the coherent scattering (CE$\nu$NS) of reactor antineutrinos off silicon nuclei using thick fully-depleted high-resistivity silicon CCDs. Two Skipper-CCD sensors with sub-electron readout noise capability were installed at the experiment next to the Angra-2 reactor in 2021, making CONNIE the first experiment to employ Skipper-CCDs for reactor neutrino detection. We report on the performance of the Skipper-CCDs, the new data processing and data quality selection techniques and the event selection for CE$\nu$NS interactions, which enable CONNIE to reach a record low detection threshold of 15 eV. The data were collected over 300 days in 2021-2022 and correspond to exposures of 14.9 g-days with the reactor-on and 3.5 g-days with the reactor-off. The difference between the reactor-on and off event rates shows no excess and yields upper limits at 95% confidence level for the neutrino interaction rates comparable with previous CONNIE limits from standard CCDs and higher exposures. Searches for new neutrino interactions beyond the Standard Model were performed, yielding an improvement on the previous CONNIE limit on a simplified model with light vector mediators. A first dark matter (DM) search by diurnal modulation was performed by CONNIE and the results represent the best limits on the DM-electron scattering cross-section, obtained by a surface-level experiment. These promising results, obtained using a very small-mass sensor, illustrate the potential of Skipper-CCDs to probe rare neutrino interactions and motivate the plans to increase the detector mass in the near future.

Published
2024

4. SENSEI: First Direct-Detection Results on sub-GeV Dark Matter from SENSEI at SNOLAB

Author

SENSEI Collaboration, Adari, Prakruth, Bloch, Itay M., Botti, Ana M., Cababie, Mariano, Cancelo, Gustavo, Cervantes-Vergara, Brenda A., Crisler, Michael, Daal, Miguel, Desai, Ansh, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Juan, Etzion, Erez, Moroni, Guillermo Fernandez, Holland, Stephen E., Kehat, Yonatan, Korn, Yaron, Lawson, Ian, Luoma, Steffon, Orly, Aviv, Perez, Santiago E., Rodrigues, Dario, Saffold, Nathan A., Scorza, Silvia, Singal, Aman, Sofo-Haro, Miguel, Stefanazzi, Leandro, Stifter, Kelly, Tiffenberg, Javier, Uemura, Sho, Villalpando, Edgar Marrufo, Volansky, Tomer, Wu, Yikai, Yu, Tien-Tien, Emken, Timon, and Xu, Hailin

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We present the first results from a dark matter search using six Skipper-CCDs in the SENSEI detector operating at SNOLAB. With an exposure of 534.9 gram-days from well-performing sensors, we select events containing 2 to 10 electron-hole pairs. After aggressively masking images to remove backgrounds, we observe 55 two-electron events, 4 three-electron events, and no events containing 4 to 10 electrons. The two-electron events are consistent with pileup from one-electron events. Among the 4 three-electron events, 2 appear in pixels that are likely impacted by detector defects, although not strongly enough to trigger our "hot-pixel" mask. We use these data to set world-leading constraints on sub-GeV dark matter interacting with electrons and nuclei., Comment: 5 pages, 2 figures, + Supplemental Materials (5 pages, 5 figures) + References

Published
2023

5. Fast Single-Quantum Measurement with a Multi-Amplifier Sensing Charge-Coupled Device

Author

Botti, Ana M., Cervantes-Vergara, Brenda A., Chavez, Claudio R., Chierchie, Fernando, Drlica-Wagner, Alex, Estrada, Juan, Moroni, Guillermo Fernandez, Holland, Stephen E., Gimenez, Blas J. Irigoyen, Lapi, Agustin J., Villalpando, Edgar Marrufo, Haro, Miguel Sofo, Tiffenberg, Javier, and Uemura, Sho

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A novel readout architecture that uses multiple non-destructive floating-gate amplifiers to achieve sub-electron readout noise in a thick, fully-depleted silicon detector is presented. This Multi-Amplifier Sensing Charge-Coupled Device (MAS-CCD) can perform multiple independent charge measurements with each amplifier; measurements with multiple amplifiers can then be combined to further reduce the readout noise. The readout speed of this detector scales roughly linearly with the number of amplifiers without requiring segmentation of the active area. The performance of this detector is demonstrated, emphasizing the ability to resolve individual quanta and the ability to combine measurements across amplifiers to reduce readout noise. The unprecedented low noise and fast readout of the MAS-CCD make it a unique technology for astronomical observations, quantum imaging, and low-energy interacting particles.

Published
2023
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6. Dual-sided Charge-Coupled Devices

Author

Tiffenberg, Javier, Egaña-Ugrinovic, Daniel, Haro, Miguel Sofo, Du, Peizhi, Essig, Rouven, Fernandez-Moroni, Guillermo, and Uemura, Sho

Subjects
Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Existing Charge-Coupled Devices (CCDs) operate by detecting either the electrons or holes created in an ionization event. We propose a new type of imager, the Dual-Sided CCD, which collects and measures both charge carriers on opposite sides of the device via a novel dual-buried channel architecture. We show that this dual detection strategy provides exceptional dark-count rejection and enhanced timing capabilities. These advancements have wide-ranging implications for dark-matter searches, near-IR/optical spectroscopy, and time-domain X-ray astrophysics., Comment: 12 pages, 12 figures. v2: matches published version. Merged appendices into the main text, added dark matter projected reach plot

Published
2023

7. Unraveling Fano noise and partial charge collection effect in X-ray spectra below 1 keV

Author

Rodrigues, Dario, Cababie, Mariano, Florenciano, Ignacio Gomez, Botti, Ana, Estrada, Juan, Fernandez-Moroni, Guillermo, Magnoni, Agustina, Tiffenberg, Javier, and Uemura, Sho

Subjects
Physics - Instrumentation and Detectors
Abstract

Fano noise, readout noise, and the partial charge collection (PCC) effect collectively contribute to the degradation of energy spectra in Charge Coupled Devices (CCD) measurements, especially at low energies. In this work, the X-ray produced by the fluorescence of fluorine (677 eV) and aluminum (1486 eV) were recorded using a Skipper-CCD, which enabled the reading noise to be reduced to 0.2 e-. Based on an analytical description of photopeak shapes resulting from the convolution of the PCC effect and Fano noise, we achieved a precise characterization of the energy spectra. This description enabled us to disentangle and quantify the contributions from both Fano noise and the PCC effect. As a result, we determined the Fano factor and the electron-hole pair creation energy. Additionally, we estimated the PCC-region of the sensor and, for the first time, experimentally observed the expected skewness of photopeaks at low energies., Comment: 8 pages, 5 figures

Published
2023

8. SENSEI: Search for Millicharged Particles produced in the NuMI Beam

Author

Barak, Liron, Bloch, Itay M., Botti, Ana M., Cababie, Mariano, Cancelo, Gustavo, Chaplinsky, Luke, Crisler, Michael, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Juan, Etzion, Erez, Moroni, Guillermo Fernandez, Harnik, Roni, Holland, Stephen E., Korn, Yaron, Liu, Zhen, Munagavalasa, Sravan, Orly, Aviv, Perez, Santiago E., Plestid, Ryan, Rodrigues, Dario, Saffold, Nathan A., Scorza, Silvia, Singal, Aman, Haro, Miguel Sofo, Stefanazzi, Leandro, Stifter, Kelly, Tiffenberg, Javier, Uemura, Sho, Volansky, Tomer, and Yu, Tien-Tien

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Millicharged particles appear in several extensions of the Standard Model, but have not yet been detected. These hypothetical particles could be produced by an intense proton beam striking a fixed target. We use data collected in 2020 by the SENSEI experiment in the MINOS cavern at the Fermi National Accelerator Laboratory to search for ultra-relativistic millicharged particles produced in collisions of protons in the NuMI beam with a fixed graphite target. The absence of any ionization events with 3 to 6 electrons in the SENSEI data allow us to place world-leading constraints on millicharged particles for masses between 30 MeV to 380 MeV. This work also demonstrates the potential of utilizing low-threshold detectors to investigate new particles in beam-dump experiments, and motivates a future experiment designed specifically for this purpose., Comment: 7 pages, 5 figures

Published
2023

9. Searching for millicharged particles with 1 kg of Skipper-CCDs using the NuMI beam at Fermilab

Author

Perez, Santiago, Rodrigues, Dario, Estrada, Juan, Harnik, Roni, Liu, Zhen, Cervantes-Vergara, Brenda A., D'Olivo, Juan Carlos, Plestid, Ryan D., Tiffenberg, Javier, Yu, Tien-Tien, Aguilar-Arevalo, Alexis, Alcalde-Bessia, Fabricio, Avalos, Nicolas, Baez, Oscar, Baxter, Daniel, Bertou, Xavier, Bonifazi, Carla, Botti, Ana, Cancelo, Gustavo, Castelló-Mor, Nuria, Chavarria, Alvaro E., Chavez, Claudio R., Chierchie, Fernando, De Egea, Juan Manuel, Dreyer, Cyrus, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Ezequiel, Etzion, Erez, Grylls, Paul, Fernandez-Moroni, Guillermo, Fernández-Serra, Marivi, Ferreyra, Santiago, Holland, Stephen, Barreda, Agustín Lantero, Lathrop, Andrew, Lawson, Ian, Loer, Ben, Luoma, Steffon, Villalpando, Edgar Marrufo, Montero, Mauricio Martinez, McGuire, Kellie, Molina, Jorge, Munagavalasa, Sravan, Norcini, Danielle, Piers, Alexander, Privitera, Paolo, Saffold, Nathan, Saldanha, Richard, Singal, Aman, Smida, Radomir, Sofo-Haro, Miguel, Stalder, Diego, Stefanazzi, Leandro, Traina, Michelangelo, Tsai, Yu-Dai, Uemura, Sho, Ventura, Pedro, Cortabitarte, Rocío Vilar, and Yajur, Rachana

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Oscura is a planned light-dark matter search experiment using Skipper-CCDs with a total active mass of 10 kg. As part of the detector development, the collaboration plans to build the Oscura Integration Test (OIT), an engineering test with 10% of the total mass. Here we discuss the early science opportunities with the OIT to search for millicharged particles (mCPs) using the NuMI beam at Fermilab. mCPs would be produced at low energies through photon-mediated processes from decays of scalar, pseudoscalar, and vector mesons, or direct Drell-Yan productions. Estimates show that the OIT would be a world-leading probe for mCPs in the MeV mass range., Comment: 13 pages, 10 figures

Published
2023

10. Skipper-CCD Sensors for the Oscura Experiment: Requirements and Preliminary Tests

Author

Cervantes-Vergara, Brenda A., Perez, Santiago, Estrada, Juan, Botti, Ana, Chavez, Claudio R., Chierchie, Fernando, Saffold, Nathan, Aguilar-Arevalo, Alexis, Alcalde-Bessia, Fabricio, Avalos, Nicolás, Baez, Oscar, Baxter, Daniel, Bertou, Xavier, Bonifazi, Carla, Cancelo, Gustavo, Castelló-Mor, Nuria, Chavarria, Alvaro E., De Egea, Juan Manuel, D'Olivo, Juan Carlos, Dreyer, Cyrus, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Ezequiel, Etzion, Erez, Grylls, Paul, Fernandez-Moroni, Guillermo, Fernández-Serra, Marivi, Ferreyra, Santiago, Holland, Stephen, Barreda, Agustín Lantero, Lathrop, Andrew, Lawson, Ian, Loer, Ben, Luoma, Steffon, Villalpando, Edgar Marrufo, Montero, Mauricio Martinez, McGuire, Kellie, Molina, Jorge, Munagavalasa, Sravan, Norcini, Danielle, Piers, Alexander, Privitera, Paolo, Rodrigues, Dario, Saldanha, Richard, Singal, Aman, Smida, Radomir, Sofo-Haro, Miguel, Stalder, Diego, Stefanazzi, Leandro, Tiffenberg, Javier, Traina, Michelangelo, Uemura, Sho, Ventura, Pedro, Cortabitarte, Rocío Vilar, and Yajur, Rachana

Subjects
Physics - Instrumentation and Detectors
Abstract

Oscura is a proposed multi-kg skipper-CCD experiment designed for a dark matter (DM) direct detection search that will reach unprecedented sensitivity to sub-GeV DM-electron interactions with its 10 kg detector array. Oscura is planning to operate at SNOLAB with 2070 m overburden, and aims to reach a background goal of less than one event in each electron bin in the 2-10 electron ionization-signal region for the full 30 kg-year exposure, with a radiation background rate of 0.01 dru. In order to achieve this goal, Oscura must address each potential source of background events, including instrumental backgrounds. In this work, we discuss the main instrumental background sources and the strategy to control them, establishing a set of constraints on the sensors' performance parameters. We present results from the tests of the first fabricated Oscura prototype sensors, evaluate their performance in the context of the established constraints and estimate the Oscura instrumental background based on these results.

Published
2023
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11. The Oscura Experiment

Author

Aguilar-Arevalo, Alexis, Bessia, Fabricio Alcalde, Avalos, Nicolas, Baxter, Daniel, Bertou, Xavier, Bonifazi, Carla, Botti, Ana, Cababie, Mariano, Cancelo, Gustavo, Cervantes-Vergara, Brenda Aurea, Castello-Mor, Nuria, Chavarria, Alvaro, Chavez, Claudio R., Chierchie, Fernando, De Egea, Juan Manuel, D`Olivo, Juan Carlos, Dreyer, Cyrus E., Drlica-Wagner, Alex, Essig, Rouven, Estrada, Juan, Estrada, Ezequiel, Etzion, Erez, Fernandez-Moroni, Guillermo, Fernandez-Serra, Marivi, Holland, Steve, Barreda, Agustin Lantero, Lathrop, Andrew, Lipovetzky, Jose, Loer, Ben, Villalpando, Edgar Marrufo, Molina, Jorge, Perez, Santiago, Privitera, Paolo, Rodrigues, Dario, Saldanha, Richard, Cruz, Diego Santa, Singal, Aman, Saffold, Nathan, Stefanazzi, Leandro, Sofo-Haro, Miguel, Tiffenberg, Javier, Torres, Christian, Uemura, Sho, and Vilar, Rocio

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Oscura experiment will lead the search for low-mass dark matter particles using a very large array of novel silicon Charge Coupled Devices (CCDs) with a threshold of two electrons and with a total exposure of 30 kg-yr. The R&D effort, which began in FY20, is currently entering the design phase with the goal of being ready to start construction in late 2024. Oscura will have unprecedented sensitivity to sub-GeV dark matter particles that interact with electrons, probing dark matter-electron scattering for masses down to 500 keV and dark matter being absorbed by electrons for masses down to 1 eV. The Oscura R&D effort has made some significant progress on the main technical challenges of the experiment, of which the most significant are engaging new foundries for the fabrication of the CCD sensors, developing a cold readout solution, and understanding the experimental backgrounds.

Published
2022

12. Searching for millicharged particles with 1 kg of Skipper-CCDs using the NuMI beam at Fermilab

Author

Perez, Santiago, Rodrigues, Dario, Estrada, Juan, Harnik, Roni, Liu, Zhen, Cervantes-Vergara, Brenda A., D’Olivo, Juan Carlos, Plestid, Ryan D., Tiffenberg, Javier, Yu, Tien-Tien, Aguilar-Arevalo, Alexis, Alcalde-Bessia, Fabricio, Avalos, Nicolás, Baez, Oscar, Baxter, Daniel, Bertou, Xavier, Bonifazi, Carla, Botti, Ana, Cancelo, Gustavo, Castelló-Mor, Nuria, Chavarria, Alvaro E., Chavez, Claudio R., Chierchie, Fernando, De Egea, Juan Manuel, Dreyer, Cyrus, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Ezequiel, Etzion, Erez, Grylls, Paul, Fernandez-Moroni, Guillermo, Fernández-Serra, Marivi, Ferreyra, Santiago, Holland, Stephen, Barreda, Agustín Lantero, Lathrop, Andrew, Lawson, Ian, Loer, Ben, Luoma, Steffon, Villalpando, Edgar Marrufo, Montero, Mauricio Martinez, McGuire, Kellie, Molina, Jorge, Munagavalasa, Sravan, Norcini, Danielle, Piers, Alexander, Privitera, Paolo, Saffold, Nathan, Saldanha, Richard, Singal, Aman, Smida, Radomir, Sofo-Haro, Miguel, Stalder, Diego, Stefanazzi, Leandro, Traina, Michelangelo, Tsai, Yu-Dai, Uemura, Sho, Ventura, Pedro, Cortabitarte, Rocío Vilar, and Yajur, Rachana

Published
2024
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13. Skipper Charge-Coupled Device for Low-Energy-Threshold Particle Experiments above Ground

Author

Moroni, Guillermo Fernandez, Chierchie, Fernando, Tiffenberg, Javier, Botti, Ana, Cababie, Mariano, Cancelo, Gustavo, Depaoli, Eliana L, Estrada, Juan, Holland, Stephen E, Rodrigues, Dario, Sidelnik, Iván, Haro, Miguel Sofo, Stefanazzi, Leandro, and Uemura, Sho

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Engineering, Physical sciences
Abstract

We present experimental results using a single-electron resolution skipper CCD running above ground level to demonstrate the potential of this technology for its use in reactor neutrino observations and other low-energy particle-interaction experiments. Operating conditions and event-selection criteria are provided to decouple most of the background rate at low energies. The majority of this background comes from interactions in the inactive silicon surrounding the active detector volume that ends up in the readout register of the sensor. Our final results are compared with other low-threshold technologies showing a good control of the background for low ionization energies down to five electron-hole pairs. This demonstrates that the skipper CCD proves to be among the best options to measure low-energy and weakly interacting particles at ground level.

Published
2022

14. SENSEI: Characterization of Single-Electron Events Using a Skipper Charge-Coupled Device

Author

Barak, Liron, Bloch, Itay M, Botti, Ana, Cababie, Mariano, Cancelo, Gustavo, Chaplinsky, Luke, Chierchie, Fernando, Crisler, Michael, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Juan, Etzion, Erez, Moroni, Guillermo Fernandez, Gift, Daniel, Holland, Stephen E, Munagavalasa, Sravan, Orly, Aviv, Rodrigues, Dario, Singal, Aman, Haro, Miguel Sofo, Stefanazzi, Leandro, Tiffenberg, Javier, Uemura, Sho, Volansky, Tomer, and Yu, Tien-Tien

Subjects
Nuclear and Plasma Physics, Physical Sciences, Engineering, Physical sciences
Abstract

We use a science-grade skipper charge-coupled device (skipper CCD) operating in a low-radiation background environment to develop a semiempirical model that characterizes the origin of single-electron events in CCDs. We identify, separate, and quantify three independent contributions to the single-electron events, which were previously bundled together and classified as "dark counts": dark current, amplifier light, and spurious charge. We measure a dark current, which depends on exposure, of (5.89±0.77)×10-4e-/pix/day, and an unprecedentedly low spurious charge contribution of (1.52±0.07)×10-4e-/pix, which is exposure independent. In addition, we provide a technique to study events produced by light emitted from the amplifier, which allows the detector's operation to be optimized to minimize this effect to a level below the dark-current contribution. Our accurate characterization of the single-electron events allows one to greatly extend the sensitivity of experiments searching for dark matter or coherent neutrino scattering. Moreover, an accurate understanding of the origin of single-electron events is critical to further progress in ongoing research and development efforts of skipper and conventional CCDs.

Published
2022

15. Prognosis prediction of PDAC via detection of O‐glycan altered extracellular vesicles in perioperative sera.

Author

Uemura, Sho, Kabe, Yasuaki, Kitago, Minoru, Matsuda, Sachiko, Abe, Yuta, Hasegawa, Yasushi, Hori, Shutaro, Tanaka, Masayuki, Nakano, Yutaka, Sato, Yasunori, Itonaga, Makoto, Ono, Masayuki, Kawakami, Tatsuya, Suematsu, Makoto, and Kitagawa, Yuko

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy due to the difficulty in diagnosis and poor prognosis because of the high recurrence rate, necessitating reliable biomarkers to improve the diagnosis and prognosis. However, the existing markers have limitations. We previously identified extracellular vesicles (EVs) recognized by O‐glycan‐binding lectins (Amaranthus caudatus agglutinin [ACA]) as a novel diagnostic biomarker for PDAC using an EV‐counting system (ExoCounter). This retrospective study analyzed changes in ACA‐positive EVs in perioperative PDAC serum and its association with prognosis using ExoCounter. Absolute EV levels in the pre‐ and postoperative sera of 44 patients who underwent curative pancreatectomy for PDAC were quantified using ExoCounter. The carbohydrate antigen 19‐9 levels declined in most samples postoperatively, and presented no correlation with poor prognosis. In contrast, ACA‐positive EVs increased in serum at 7 days postoperatively in 27 of 44 patients (61.4%). We therefore divided participants with ACA‐positive EVs before and after surgery into elevation and decline groups. The overall survival (OS) and recurrence‐free survival (RFS) of patients with higher ACA‐positive EVs were significantly shorter than those with lower ACA‐positive EVs (26.1 months vs. not reached, P = 0.018; 11.9 vs. 38.6 months, P = 0.013). Multivariable analysis revealed that ACA‐positive EV elevation in postoperative serum was an independent prognostic factor for poor OS (hazard ratio [HR] = 3.891, P = 0.023) and RFS (HR = 2.650, P = 0.024). The detection of ACA‐positive EVs in perioperative serum may be used to predict the prognosis of PDAC in the early postoperative period. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Risk factor analysis of postoperative pancreatic fistula after distal pancreatectomy with a focus on the peritoneum to portal vein distance on computed tomography.

Author

Uemura, Sho, Ban, Daisuke, Esaki, Minoru, Nara, Satoshi, Takamoto, Takeshi, Mizui, Takahiro, and Shimada, Kazuaki

Subjects
*DISEASE risk factors, *RECEIVER operating characteristic curves, *PANCREATIC fistula, *PREOPERATIVE risk factors, *PORTAL vein, *PANCREATECTOMY
Abstract

Background: Postoperative pancreatic fistula (POPF) is a major complication of distal pancreatectomy (DP). Although the visceral fat area (VFA) is a risk factor for POPF in DP, its measurement is complicated. This study aimed to identify a simple marker as a predictive indicator of POPF. Methods: We included 210 patients who underwent resection at our institution between 2020 and 2023. The patients' characteristics, preoperative laboratory data, and radiographic findings (e.g., portal vein distance and VFA) and their association with pancreatic fistula after DP were analyzed. POPF was defined as Grade B or C pancreatic fistula on the basis of the International Study Group of Pancreatic Surgery 2016 consensus. Results: POPF developed in 82 (39.0%) patients. Univariate analysis showed that female sex, pancreatic thickness of the cutting line, operative time, blood loss, C‐reactive protein (CRP) level on postoperative day (POD) 3, drain amylase level on POD 3, VFA, and the peritoneum to portal vein distance (PPD) were associated with POPF. Receiver operating characteristic curve analysis of PPD showed a higher area under the curve than VFA (cutoff for PPD: 68 mm). Multivariate analysis showed that CRP (odds ratio [OR]: 2.214), drain amylase (OR: 2.875), and PPD (OR: 15.538) were independent risk factors. When we compared the DP fistula risk score and PPD, receiver operating characteristic analysis showed areas under the curve of 0.650 and 0.803, respectively. Conclusions: A PPD of ≥68 mm is a useful risk predictor of POPF. Determining this distance is simple and easily applicable in the clinical setting. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Experimental advances with the QICK (Quantum Instrumentation Control Kit) for superconducting quantum hardware

Author

Ding, Chunyang, primary, Di Federico, Martin, additional, Hatridge, Michael, additional, Houck, Andrew, additional, Leger, Sebastien, additional, Martinez, Jeronimo, additional, Miao, Connie, additional, I, David Schuster, additional, Stefanazzi, Leandro, additional, Stoughton, Chris, additional, Sussman, Sara, additional, Treptow, Ken, additional, Uemura, Sho, additional, Wilcer, Neal, additional, Zhang, Helin, additional, Zhou, Chao, additional, and Cancelo, Gustavo, additional

Published
2024
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18. Single-Quantum Measurement With a Multiple-Amplifier Sensing Charge-Coupled Device

Author

Botti, Ana M., primary, Cervantes-Vergara, Brenda A., additional, Chavez, Claudio R., additional, Chierchie, Fernando, additional, Drlica-Wagner, Alex, additional, Estrada, Juan, additional, Moroni, Guillermo Fernandez, additional, Holland, Stephen E., additional, Gimenez, Blas Irigoyen, additional, Lapi, Agustin J., additional, Villalpando, Edgar Marrufo, additional, Haro, Miguel Sofo, additional, Tiffenberg, Javier, additional, and Uemura, Sho, additional

Published
2024
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19. Astronomical spectroscopy with Skipper CCDs: first results from a Skipper CCD focal plane prototype at SIFS

Author

Holland, Andrew D., Minoglou, Kyriaki, Marrufo Villalpando, Edgar, Drlica-Wagner, Alex, Roach, Brandon, Bonati, Marco, Bakshi, Abhishek, Campa, Julia, Cancelo, Gustavo, Cancino, Braulio, Chavez, Claudio R., Chierchie, Fernando, Estrada, Jaun, Fernandez Moroni, Guillermo, Fraga, Luciano, Gaido, Manuel E., Holland, Stephen E., Hur, Rachel, Jonas, Michelle, Moore, Peter, Paolini, Eduardo, Plazas Malagón, Andrés A., Stefanazzi, Leandro, Tiffenberg, Javier, Treptou, Ken, Uemura, Sho, and Wilcer, Neal

Published
2024
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21. Skipper-CCD sensors for the Oscura experiment: requirements and preliminary tests

Author

Cervantes-Vergara, Brenda A., primary, Perez, Santiago, additional, Estrada, Juan, additional, Botti, Ana, additional, Chavez, Claudio R., additional, Chierchie, Fernando, additional, Saffold, Nathan, additional, Aguilar-Arevalo, Alexis, additional, Alcalde-Bessia, Fabricio, additional, Avalos, Nicolás, additional, Baez, Oscar, additional, Baxter, Daniel, additional, Bertou, Xavier, additional, Bonifazi, Carla, additional, Cancelo, Gustavo, additional, Castelló-Mor, Nuria, additional, Chavarria, Alvaro E., additional, De Egea, Juan Manuel, additional, D'Olivo, Juan Carlos, additional, Dreyer, Cyrus, additional, Drlica-Wagner, Alex, additional, Essig, Rouven, additional, Estrada, Ezequiel, additional, Etzion, Erez, additional, Grylls, Paul, additional, Fernandez-Moroni, Guillermo, additional, Fernández-Serra, Marivi, additional, Ferreyra, Santiago, additional, Holland, Stephen, additional, Lantero Barreda, Agustín, additional, Lathrop, Andrew, additional, Lawson, Ian, additional, Loer, Ben, additional, Luoma, Steffon, additional, Marrufo Villalpando, Edgar, additional, Martinez Montero, Mauricio, additional, McGuire, Kellie, additional, Molina, Jorge, additional, Munagavalasa, Sravan, additional, Norcini, Danielle, additional, Piers, Alexander, additional, Privitera, Paolo, additional, Rodrigues, Dario, additional, Saldanha, Richard, additional, Singal, Aman, additional, Smida, Radomir, additional, Sofo-Haro, Miguel, additional, Stalder, Diego, additional, Stefanazzi, Leandro, additional, Tiffenberg, Javier, additional, Traina, Michelangelo, additional, Uemura, Sho, additional, Ventura, Pedro, additional, Vilar Cortabitarte, Rocío, additional, and Yajur, Rachana, additional

Published
2023
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22. Post‐operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression.

Author

Masugi, Yohei, Takamatsu, Manabu, Tanaka, Mariko, Hara, Kensuke, Inoue, Yosuke, Hamada, Tsuyoshi, Suzuki, Tatsunori, Arita, Junichi, Hirose, Yuki, Kawaguchi, Yoshikuni, Nakai, Yousuke, Oba, Atsushi, Sasahira, Naoki, Shimane, Gaku, Takeda, Tsuyoshi, Tateishi, Keisuke, Uemura, Sho, Fujishiro, Mitsuhiro, Hasegawa, Kiyoshi, and Kitago, Minoru

Subjects
SMAD proteins, PANCREATIC cancer, RAS oncogenes, CANCER prognosis, POLYMERASE chain reaction, P16 gene
Abstract

Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course of patients with pancreatic cancer in relation to these driver alterations has not been fully characterised in large populations. We hypothesised that pancreatic carcinomas with different combinations of KRAS mutation and aberrant expression of CDKN2A, p53, and SMAD4 might show distinctive recurrence patterns and post‐operative survival outcomes. To test this hypothesis, we utilised a multi‐institutional cohort of 1,146 resected pancreatic carcinomas and assessed KRAS mutations by droplet digital polymerase chain reaction and CDKN2A, p53, and SMAD4 expression by immunohistochemistry. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for disease‐free survival (DFS) and overall survival (OS) were computed according to each molecular alteration and the number of altered genes using the Cox regression models. Multivariable competing risks regression analyses were conducted to assess the associations of the number of altered genes with specific patterns of recurrence. Loss of SMAD4 expression was associated with short DFS (multivariable HR, 1.24; 95% CI, 1.09–1.43) and OS times (multivariable HR, 1.27; 95% CI, 1.10–1.46). Compared to cases with 0–2 altered genes, cases with three and four altered genes had multivariable HRs for OS of 1.28 (95% CI, 1.09–1.51) and 1.47 (95% CI, 1.22–1.78), respectively (ptrend < 0.001). Patients with an increasing number of altered genes were more likely to have short DFS time (ptrend = 0.003) and to develop liver metastasis (ptrend = 0.006) rather than recurrence at local or other distant sites. In conclusion, loss of SMAD4 expression and an increasing number of altered genes were associated with unfavourable outcomes in pancreatic cancer patients. This study suggests that the accumulation of the four major driver alterations can confer a high metastatic potential to the liver, thereby impairing post‐operative survival among patients with pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Early Science with the Oscura Integration Test

Author

Perez, Santiago, Rodrigues, Dario, Estrada, Juan, Harnik, Roni, Liu, Zhen, Cervantes-Vergara, Brenda A., DOlivo, Juan Carlos, Plestid, Ryan D., Tiffenberg, Javier, Yu, Tien-Tien, Aguilar-Arevalo, Alexis, Alcalde-Bessia, Fabricio, Avalos, Nicolas, Baez, Oscar, Baxter, Daniel, Bertou, Xavier, Bonifazi, Carla, Botti, Ana, Cancelo, Gustavo, Castello-Mor, Nuria, Chavarria, Alvaro E., Chavez, Claudio R., Chierchie, Fernando, De Egea, Juan Manuel, Dreyer, Cyrus, Drlica-Wagner, Alex, Essig, Rouven, Estrada, Ezequiel, Etzion, Erez, Grylls, Paul, Fernandez-Moroni, Guillermo, Fernandez-Serra, Marivi, Ferreyra, Santiago, Holland, Stephen, Barreda, Agustin Lantero, Lathrop, Andrew, Lawson, Ian, Loer, Ben, Luoma, Steffon, Villalpando, Edgar Marrufo, Montero, Mauricio Martinez, McGuire, Kellie, Molina, Jorge, Munagavalasa, Sravan, Norcini, Danielle, Piers, Alexander, Privitera, Paolo, Saffold, Nathan, Saldanha, Richard, Singal, Aman, Smida, Radomir, Sofo-Haro, Miguel, Stalder, Diego, Stefanazzi, Leandro, Traina, Michelangelo, Tsai, Yu-Dai, Uemura, Sho, Ventura, Pedro, Cortabitarte, Rocio Vilar, and Yajur, Rachana

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Experiment
Abstract

Oscura is a planned light-dark matter search experiment using Skipper-CCDs with a total active mass of 10 kg. As part of the detector development, the collaboration plans to build the Oscura Integration Test (OIT), an engineering test experiment with 10% of the Oscura's total mass. Here we discuss the early science opportunities with the OIT to search for millicharged particles (mCPs) using the NuMI beam at Fermilab. mCPs would be produced at low energies through photon-mediated processes from decays of scalar, pseudoscalar, and vector mesons, or direct Drell-Yan productions. Estimates show that the OIT would be a world-leading probe for low-mass mCPs., Comment: 21 pages, 13 figures

Published
2023
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24. EXCESS workshop: Descriptions of rising low-energy spectra

Author

Adari, Prakruth, primary, Aguilar-Arevalo, Alexis A., additional, Amidei, Dante, additional, Angloher, G., additional, Armengaud, Eric, additional, Augier, C., additional, Balogh, Levente, additional, Banik, S., additional, Baxter, David, additional, Beaufort, C., additional, Beaulieu, G., additional, Belov, V., additional, Ben Gal, Y., additional, Benato, Giovanni, additional, Benoît, Alain, additional, Bento, Antonio, additional, Bergé, Laurent, additional, Bertolini, Andrea, additional, Bhattacharyya, R., additional, Billard, J., additional, Bloch, Itay M., additional, Botti, A., additional, Breier, Robert, additional, Bres, G., additional, Bret, J-.L., additional, Broniatowski, A., additional, Brossard, Alexis, additional, Bucci, Carlo, additional, Bunker, Raymond, additional, Cababie, M., additional, Calvo, M., additional, Camus, P., additional, Cancelo, G., additional, Canonica, Lucia, additional, Cappella, Fabio, additional, Cardani, Laura, additional, Caron, Jean-François, additional, Casali, N., additional, del Castello, G., additional, Cazes, Aurélie, additional, Cerulli, Riccardo, additional, Cervantes Vergara, B.A., additional, Chaize, D., additional, Chapellier, M., additional, Chaplinsky, L., additional, Charlieux, F., additional, Chaudhuri, M., additional, Chavarria, Alvaro E., additional, Chemin, G., additional, Chen, Ran, additional, Chen, Hao, additional, Chierchie, F., additional, Colantoni, I., additional, Colas, J., additional, Cooley, Jodi, additional, Coquillat, Jean-Marie, additional, Corcoran, Emily, additional, Crawford, S., additional, Crisler, Michael, additional, Cruciani, Angelo, additional, Cushman, Priscilla, additional, D'Addabbo, Antonio, additional, D'Olivo, Juan Carlos, additional, Dastgheibi-Fard, A., additional, De Jésus, Maria, additional, Deng, Y., additional, Dent, James, additional, Depaoli, Eliana, additional, Dering, Koby, additional, Dharani, Sukeerthi, additional, Di Lorenzo, S., additional, Drlica-Wagner, Alex, additional, Dumoulin, Louis, additional, Durnford, Daniel, additional, Dutta, Bhaskar, additional, Einfalt, L., additional, Erb, Anna, additional, Erhart, A., additional, Essig, Rouven, additional, Estrada, Juan, additional, Etzion, Erez, additional, Exshaw, O., additional, Favela-Perez, F., additional, von Feilitzsch, F., additional, Fernandez Moroni, Guillermo, additional, Ferreiro Iachellini, Nahuel, additional, Ferriol, S., additional, Fichtinger, S., additional, Figueroa-Feliciano, Enectalí, additional, Filippini, J.-B., additional, Filosofov, Dmitry, additional, Formaggio, Joseph A., additional, Friedl, Markus, additional, Fuard, S., additional, Fuchs, Dominik, additional, Fuss, Alexander, additional, Gaïor, R., additional, Garai, Abhijit, additional, Garrah, Carter, additional, Gascon, J., additional, Gerbier, Gilles, additional, Ghaith, Muad, additional, Ghete, V. M., additional, Gift, Daniel, additional, Giomataris, I., additional, Giroux, Guillaume, additional, Giuliani, A., additional, Gorel, Pierre, additional, Gorla, Paolo, additional, Goupy, C., additional, Goupy, J., additional, Goy, C., additional, Gros, M., additional, Gros, Philippe, additional, Guardincerri, Yann, additional, Guerin, C., additional, Guidi, Vincenzo, additional, Guillaudin, O., additional, Gupta, S., additional, Guy, E., additional, Harrington, Patrick, additional, Hauff, D., additional, Heine, S. T., additional, Hertel, Scott A., additional, Holland, Stephen, additional, Hong, Z., additional, Hoppe, Eric W., additional, Hossbach, Todd W., additional, Ianigro, J.-C., additional, Iyer, Vivek, additional, Jastram, Andrew, additional, Ješkovský, Miroslav, additional, Jin, Y., additional, Jochum, Josef, additional, Johnston, J. P., additional, Juillard, A., additional, Karaivanov, Dimitar, additional, Kashyap, V., additional, Katsioulas, Ioannis, additional, Kazarcev, S., additional, Kaznacheeva, Margarita, additional, Kelly, Fiona, additional, Kilminster, B., additional, Kinast, Angelina, additional, Klinkenberg, L., additional, Kluck, Holger, additional, Knights, Patrick, additional, Korn, Yaron, additional, Kraus, Hans, additional, von Krosigk, Belina, additional, Kubik, Andrew, additional, Kurinsky, Noah, additional, Lamblin, Jacob, additional, Langenkämper, Alexander, additional, Langrock, S., additional, Lasserre, Thierry, additional, Lattaud, H., additional, Lautridou, P., additional, Lawson, Ian, additional, Lee, S.-J., additional, Lee, M., additional, Letessier-Selvon, Antoine, additional, Lhuillier, D., additional, Li, M., additional, Lin, Y.-T., additional, Lubashevskiy, Alexey, additional, Mahaparta, Rupak, additional, Maludze, Sandro, additional, Mancuso, Michele, additional, Manthos, Ioannis, additional, Marini, Laura, additional, Marnieros, S., additional, Martin, Ryan D., additional, Matalon, Ariel, additional, Matthews, J., additional, Mauri, B., additional, Mayer, D. W., additional, Mazzolari, Andrea, additional, Mazzucato, E., additional, Meyer zu Theenhausen, Hanno, additional, Michielin, E., additional, Minet, J., additional, Mirabolfathi, Nader, additional, v. Mirbach, K., additional, Misiak, Dimitri, additional, Mitra, P., additional, Mocellin, J.-L., additional, Mohanty, Bedangadas, additional, Mokina, Valentyna, additional, Mols, J.-P., additional, Monfardini, Alessandro, additional, Mounier, F., additional, Munagavalasa, Sravan, additional, Muraz, Jean-François, additional, Navick, X.-F., additional, Neep, Thomas, additional, Neog, Himangshu, additional, Neyrial, H., additional, Nikolopoulos, Kostas, additional, Nilima, Athoy, additional, Nones, C., additional, Novati, Valentina, additional, O'Brien, Paul, additional, Oberauer, L., additional, Olivieri, E., additional, Olmi, Alessandro, additional, Onillon, A., additional, Oriol, C., additional, Orly, A., additional, Orrell, John L., additional, Ortmann, T., additional, Overman, C. T., additional, Pagliarone, Carmine Elvezio, additional, Palušová, Veronika, additional, Pari, P., additional, Patel, P. K., additional, Pattavina, Luca, additional, Petricca, Federica, additional, Piers, Alexander, additional, Pinckney, Harold D., additional, Piro, Marie-Cécile, additional, Platt, Mark, additional, Poda, D., additional, Ponomarev, Dmitry, additional, Potzel, Walter, additional, Povinec, Pavel, additional, Pröbst, F., additional, Privitera, P., additional, Pucci, F., additional, Ramanathan, K., additional, Real, J.-S., additional, Redon, T., additional, Reindl, Florian, additional, Ren, R., additional, Robert, Adeline, additional, Da Rocha, Julia, additional, Rodrigues, D., additional, Rogly, R., additional, Rothe, Johannes, additional, Rowe, Noah, additional, Rozov, Sergey, additional, Rozova, I., additional, Saab, Tarek, additional, Saffold, Nathan, additional, Salagnac, T., additional, Sander, Joel, additional, Sanglard, Veronique, additional, Santos, D., additional, Sarkis, Youssef, additional, Savu, V., additional, Savvidis, G., additional, Savvidis, I., additional, Schönert, S., additional, Schäffner, Karoline, additional, Schermer, Nicole, additional, Schieck, Jochen, additional, Schmidt, Benjamin, additional, Schmiedmayer, D., additional, Schwertner, C., additional, Scola, L., additional, Settimo, Mariangela, additional, Shevchik, Ye., additional, Sibille, Valérian, additional, Sidelnik, Ivan, additional, Singal, Aman, additional, Smida, Radomir, additional, Sofo Haro, Miguel, additional, Soldner, Torsten, additional, Stachurska, Juliana, additional, Stahlberg, Martin, additional, Stefanazzi, Leandro, additional, Stodolsky, Leo, additional, Strandhagen, Christian, additional, Strauss, R., additional, Stutz, A., additional, Thomas, R., additional, Thompson, A., additional, Tiffenberg, Javier, additional, Tomei, Claudia, additional, Traina, M., additional, Uemura, Sho, additional, Usherov, I., additional, Vagneron, L., additional, Van De Pontseele, Wouter, additional, Vázquez de Sola Fernández, Francisco Andrés, additional, Vidal, M., additional, Vignati, M., additional, Virto, A. L., additional, Vivier, M., additional, Volansky, Tomer, additional, Wagner, V., additional, Wagner, Felix, additional, Walker, Joel, additional, Ward, R., additional, Watkins, Samuel L., additional, Wex, A., additional, Willers, Michael, additional, Wilson, M. J., additional, Winslow, Lindley, additional, Yakushev, Evgeny, additional, Yu, T.-T., additional, Zampaolo, M., additional, Zaytsev, Alexander, additional, Zema, Vanessa, additional, Zinatulina, Daniya, additional, and Zolotarova, A., additional

Published
2022
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25. The QICK (Quantum Instrumentation Control Kit): Readout and control for qubits and detectors

Author

Stefanazzi, Leandro, primary, Treptow, Kenneth, additional, Wilcer, Neal, additional, Stoughton, Chris, additional, Bradford, Collin, additional, Uemura, Sho, additional, Zorzetti, Silvia, additional, Montella, Salvatore, additional, Cancelo, Gustavo, additional, Sussman, Sara, additional, Houck, Andrew, additional, Saxena, Shefali, additional, Arnaldi, Horacio, additional, Agrawal, Ankur, additional, Zhang, Helin, additional, Ding, Chunyang, additional, and Schuster, David I., additional

Published
2022
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26. KRAS, CDKN2A, TP53, And SMAD4 Alterations in Relation to Postoperative Survival and Recurrence Patterns Among Patients with Pancreatic Cancer

Author

Masugi, Yohei, primary, Takamatsu, Manabu, additional, Tanaka, Mariko, additional, Hara, Kensuke, additional, Inoue, Yosuke, additional, Hamada, Tsuyoshi, additional, Suzuki, Tatsunori, additional, Arita, Junichi, additional, Hirose, Yuki, additional, Kawaguchi, Yoshikuni, additional, Nakai, Yousuke, additional, Oba, Atsushi, additional, Sasahira, Naoki, additional, Shimane, Gaku, additional, Takeda, Tsuyoshi, additional, Tateishi, Keisuke, additional, Uemura, Sho, additional, Fujishiro, Mitsuhiro, additional, Hasegawa, Kiyoshi, additional, Kitago, Minoru, additional, Takahashi, Yu, additional, Ushiku, Tetsuo, additional, Takeuchi, Kengo, additional, and Sakamoto, Michiie, additional

Published
2022
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28. KRAS variant allele frequency, but not mutation positivity, associates with survival of patients with pancreatic cancer.

Author

Suzuki, Tatsunori, Masugi, Yohei, Inoue, Yosuke, Hamada, Tsuyoshi, Tanaka, Mariko, Takamatsu, Manabu, Arita, Junichi, Kato, Tomotaka, Kawaguchi, Yoshikuni, Kunita, Akiko, Nakai, Yousuke, Nakano, Yutaka, Ono, Yoshihiro, Sasahira, Naoki, Takeda, Tsuyoshi, Tateishi, Keisuke, Uemura, Sho, Koike, Kazuhiko, Ushiku, Tetsuo, and Takeuchi, Kengo

Abstract

KRAS mutation is a major driver of pancreatic carcinogenesis and will likely be a therapeutic target. Due to lack of sensitive assays for clinical samples of pancreatic cancer with low cellularity, KRAS mutations and their prognostic association have not been fully examined in large populations. In a multi‐institutional cohort of 1162 pancreatic cancer patients with formalin‐fixed paraffin‐embedded tumor samples, we undertook droplet digital PCR (ddPCR) for KRAS codons 12/13/61. We examined detection rates of KRAS mutations by clinicopathological parameters and survival associations of KRAS mutation status. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for disease‐free survival (DFS) and overall survival (OS) were computed using the Cox regression model with adjustment for potential confounders. KRAS mutations were detected in 1139 (98%) patients. The detection rate did not differ by age of tissue blocks, tumor cellularity, or receipt of neoadjuvant chemotherapy. KRAS mutations were not associated with DFS or OS (multivariable HR comparing KRAS‐mutant to KRAS‐wild‐type tumors, 1.04 [95% CI, 0.62–1.75] and 1.05 [95% CI, 0.60–1.84], respectively). Among KRAS‐mutant tumors, KRAS variant allele frequency (VAF) was inversely associated with DFS and OS with HRs per 20% VAF increase of 1.27 (95% CI, 1.13–1.42; ptrend <0.001) and 1.31 (95% CI, 1.16–1.48; ptrend <0.001), respectively. In summary, ddPCR detected KRAS mutations in clinical specimens of pancreatic cancer with high sensitivity irrespective of parameters potentially affecting mutation detections. KRAS VAF, but not mutation positivity, was associated with survival of pancreatic cancer patients. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Readout optimization of multi-amplifier sensing charge-coupled devices for single-quantum measurement

Author

Holland, Andrew D., Minoglou, Kyriaki, Botti, Ana M., Cervantes-Vergara, Brenda A., Chavez, Claudio R., Chierchie, Fernando, Drlica-Wagner, Alex, Estrada, Juan, Fernandez Moroni, Guillermo, Holland, Stephen, Irigoyen Gimenez, Blas J., Lapi, Agustin J., Marrufo Villalpando, Edgar, Sofo Haro, Miguel, Tiffenberg, Javier, Uemura, Sho, Lin, Kenneth, Karcher, Armin, Guy, Julien, and Nugent, Peter E.

Published
2024
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30. Sub-electron noise multi-amplifier sensing CCDs for spectroscopy

Author

Holland, Andrew D., Minoglou, Kyriaki, Lin, Kenneth, Karcher, Armin, Guy, Julien, Holland, Stephen E., Kolbe, William F., Nugent, Peter E., Botti, Ana M., Cervantes-Vergara, Brenda A., Chavez, Claudio R., Chierchie, Fernando, Drlica-Wagner, Alex, Estrada, Juan, Fernandez Moroni, Guillermo, Irigoyen Gimenez, Blas J., Lapi, Agustin J., Sofo Haro, Miguel, Tiffenberg, Javier, and Uemura, Sho

Published
2024
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31. Search by the SENSEI Experiment for Millicharged Particles Produced in the NuMI Beam.

Author

Barak L, Bloch IM, Botti AM, Cababie M, Cancelo G, Cervantes-Vergara BA, Chaplinsky L, Crisler M, Drlica-Wagner A, Essig R, Estrada J, Etzion E, Moroni GF, Holland SE, Korn Y, Lawson I, Luoma S, Munagavalasa S, Orly A, Perez SE, Rodrigues D, Saffold NA, Scorza S, Singal A, Haro MS, Stefanazzi L, Stifter K, Tiffenberg J, Uemura S, Volansky T, Yu TT, Harnik R, Liu Z, and Plestid R

Abstract

Millicharged particles appear in several extensions of the standard model, but have not yet been detected. These hypothetical particles could be produced by an intense proton beam striking a fixed target. We use data collected in 2020 by the SENSEI experiment in the MINOS cavern at the Fermi National Accelerator Laboratory to search for ultrarelativistic millicharged particles produced in collisions of protons in the NuMI beam with a fixed graphite target. The absence of any ionization events with 3 to 6 electrons in the SENSEI data allow us to place world-leading constraints on millicharged particles for masses between 30 to 380 MeV. This work also demonstrates the potential of utilizing low-threshold detectors to investigate new particles in beam-dump experiments, and motivates a future experiment designed specifically for this purpose.

Published
2024
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