1. Heritability of carotid intima-media thickness and inflammatory factors of atherosclerosis in a Chinese population
- Author
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Tsai-Chung Li, Cheng-Chieh Lin, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, and Chia-Ing Li
- Subjects
Intima-media thickness ,CRP ,Heritability ,Medicine ,Science - Abstract
Abstract Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h2 = 0.26, P
- Published
- 2024
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