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Introduction: Platelet-rich fibrin (PRF) has been shown to accelerate bone regeneration in artificial defects. Postextraction alveolar resorption is significantly more on the buccal surfaces, and PRF has been shown to decrease the resorption rate. Materials and Methods: The study included 30 medically fit subjects of an age group of 20–50 years irrespective of gender for bilateral extraction of nonrestorable teeth in CMDC, Lucknow. Subjects were randomly divided into Groups A and B. In Group A (controls), the extraction sockets were closed without any intra-socket medicaments. In Group B (cases), PRF was placed in extraction socket before the closure of the socket. The pain and radiographic changes were evaluated. Discussion: Intragroup comparison showed significant differences in bone density, bone width, and bone height at 1, 3, and 6 months in both control group and PRF group. Intergroup comparison also showed significant differences in terms of swelling between control group and PRF group. Conclusion: PRF shows excellent biocompatibility and bone regeneration potential. The use of PRF can reduce long time needed for new bone formation, as well as the morbidity risk related to harvesting autogenous bone graft. [ABSTRACT FROM AUTHOR]