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In this study investigation of accumulations of critical raw materials (cobalt (Co), antimony (Sb), vanadium (V), lanthanum (La) and tungsten (W)) from wastewater by using C. fracta were aimed. Besides, assessment of the potential health risks in terms of the use of organic fertilizer obtained from the macroalga to be harvested from the treatment were also aimed. Highest Co, Sb, V, La and W accumulations by algae in reactor were 125±6.2%, 201.25±10%, 318.18±15%, 357.97±18%, and 500±25%, respectively. When compared with control, Co, Sb, V, La and W in algae increased 2.25, 3.01, 4.18, 4.58, and 6 times, respectively. The algae was very high bioaccumulative for Co and La. Highest MPI was calculated as 3.94. Non-carcinogenic risk of CRMs according to different exposure types (ingestion, inhalation, and dermal) were calculated for man, woman and child. There is not any non-carcinogenic risk from the investigated exposure ways of algae as organic fertilizer. [ABSTRACT FROM AUTHOR]

In this study, phycoremediation of thallium toxic metal present in galery water of an abandoned mine area was investigated by using Cladophora fracta. Within the scope of the study, a reactor containing Cladophora fracta was used and it was determined whether the Cladophora fracta accumulated thallium depending on time. Additionally, the bioconcentration factor was calculated. According to research findings; the accumulations of thallium by Cladophora fracta, compared with uncontaminated alga, were 225% at 5 min, 450% at 10 min, 550% at 20 min, 575% at 40 min, 700% at 60 min, and 900% at 120 min, respectively. BCF values were between 1000-5000. This indicated that Cladophora fracta had bioaccumulation potential. As a result, this research carried out in mining area has documented the phycoremediation of thallium in gallery water of an abandoned mine area. [ABSTRACT FROM AUTHOR]

Aim of our study was the determination and monitoring of tetracycline (TC) and degradation products (DEP) in livestock slaughterhouse wastewater treatment plant (SWWTP) effluent. For this purpose, TC and DEP values in SWWTP were investigated. The concentrations of TC and DEP were monitored for 12 months. TC, 4-epitetracycline (ETC), 4-epianhydrotetracycline (EATC), anhydrotetracycline (ATC), and physicochemical parameters of pH, suspended solids (SS), BOD5, COD, and TP were calculated. The maximum TC concentration was determined as 1.68±0.08 µg/L in March and the minimum TC was 1.08±0.05 µg/L in January. The maximum ETC was 2.93±0.14 µg/L in March and April. The minimum ETC was 1.98±0.1 µg/L in January. EATC was 10.82±0.5 µg/L in September, and minimum EATC value was determined as 9.14±0.4 µg/L in March. The maximum ATC value was 8.62±0.4 µg/L in June and the lowest ATC value was 6.61±0.3 µg/L in September. Concentrations of TC and DEP detected in SWWTP effluent were listed in descending order as EATC> ATC> ETC> TC. [ABSTRACT FROM AUTHOR]

The potential human health risks of some toxic/harmful elements related to the consumption of Pseudevernia furfuracea (L.) Zopf. were investigated. The toxic/harmful elements (cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn)) were determined in P. furfuracea. According to the analysis result, the maximum (max.) toxic/harmful element value was 62 ± 3.1 mg/kg for Mn and minimum (min.) value was 0.19 ± 0.01 mg/kg for Cd. The estimated daily exposure doses (EDEXDs) for men, women and children were dietary (bread) > dietary (tea) > dermal. For dietary (bread) and dietary (tea) non-carcinogenic (HQ) risk was children > women > men. For dermal, HQ risk was women > children > men. Hazard index (HI) value for men was >1 for Cr. HI value for men was 1.36 for Cr. HI value for women was >1 for Cr and Mn. HI values for women were 1.54 for Cr and 1.01 for Mn. Also, the HI value for children was >1 for Cr, Mn, and Pb. HI values for children were 3.44 for Cr, 2.24 for Mn, and 1.66 for Pb. This situation showed that there was a non-carcinogenic risk. Carcinogenic risk values were dietary (bread) > dietary (tea) > dermal. The total max. carcinogenic value was 1.97E-03 for Cr while the total min. carcinogenic value was 1.31E-05 for Pb. As a result, it has been determined that there may be a risk of cancer due to the consumption of lichen as bread and this situation may adversely affect human health. [ABSTRACT FROM AUTHOR]

Copyright of Nigde Omer Halisdemir University Journal of Engineering Sciences / Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi is the property of Nigde Omer Halisdemir Universitesi (NOHU), Muhendislik Fakultesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Some heavy metals were detected in organs of the tomatoes grown in the discharge area of effluents of a municipal wastewater treatment plant. Also, the health risk potentials of heavy metals in the tomatoes consumed by human were investigated. The highest concentrations for Cu, Ni, Cr, Mn and Pb were followed the order of root>leaf>stem>fruit. When the bioconcentration factors values calculated for bioconcentration of metals from effluent to stem and root were examined, the highest values were determined for Cu. When translocation factors values are examined, the highest translocation from root to leaf was determined for Cd. The highest translocation from stem to leaf was determined for Pb. The estimated total exposure dose for male, female and children was listed as Zn>Mn>Cu>Cr>Ni>Pb>Cd. In terms of dietary, we can list the non-carcinogenic risks of heavy metals as children> female> male. The highest carcinogenic risk was calculated for Cr via dietary intake. [ABSTRACT FROM AUTHOR]

Background: The decline in pulmonary function is a predictor of disease progression in patients with cystic fibrosis (CF). This study aimed to determine the decline rate of percent predicted forced expiratory volume in 1 s (ppFEV1) based on the data of the CF Registry of Turkey. The secondary aim was to investigate the risk factors related to the decline in ppFEV1., Methods: A retrospective cohort study of CF patients over 6 years old, with pulmonary function data over at least 2 years of follow-up was extracted from the national CF registry for years 2017-2019. Patients were classified according to disease severity and age groups. Multivariate analysis was used to predict the decline in ppFEV1 and to investigate the associated risk factors., Results: A total of 1722 pulmonary function test results were available from 574 patients over the study period. Mean diagnostic age was older and weight for age, height for age, and body mass index z scores were significantly lower in the group of ppFEV1 < 40, while chronic Pseudomonas aeruginosa (p < .001) and mucoid P. aeruginosa colonization (p < .001) were significantly higher in this group (p < .001). Overall mean annual ppFEV1 decline was -0.97% (95% confidence interval [CI] = -0.02 to -1.92%). The mean change of ppFEV1 was significantly higher in the group with ppFEV1 ≥ 70 compared with the other (ppFEV1 < 40 and ppFEV1: 40-69) two groups (p = .004). Chronic P. aeruginosa colonization (odds ratio [OR] = 1.79 95% CI = 1.26-2.54; p = .01) and initial ppFEV1 ≥ 70 (OR = 2.98 95% CI = 1.06-8.36), p = .038) were associated with significant ppFEV1 decline in the whole cohort., Conclusions: This data analysis recommends close follow-up of patients with normal initial ppFEV1 levels at baseline; advocates for early interventions for P. aeruginosa; and underlines the importance of nutritional interventions to slow down lung disease progression., (© 2024 Wiley Periodicals LLC.)

Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs target the underlying defect and improve CFTR function. They are a part of standard care in many countries, but not all patients are eligible for these drugs due to age and genotype. Here, we aimed to determine the characteristics of non-eligible patients for CFTR modulators in the CF registry of Turkey (CFRT) to highlight their clinical needs., Methods: This retrospective cohort study included CF patient data from the CFRT in 2021. The decision of eligibility for the CFTR modulator was determined according to the 'Vertex treatment-Finder' on the Vertex® website. Demographic and clinical characteristics of patients were compared between eligible (group 1) and ineligible (group 2) groups for CFTR modulators., Results: Among the study population (N = 1527), 873 (57.2%) were in group 1 and 654 (42.8%) were in group 2. There was no statistical difference between groups regarding sex, meconium ileus history, diagnoses via newborn screening, FEV1 z-score, CF-associated complications, organ transplant history, and death. Patients in group 2 had a higher incidence of pancreatic insufficiency (87.7% vs. 83.2%, p = .010), lower median height z-scores (-0.87 vs. -0.55, p < .001), lower median body mass index z-scores (-0.65 vs. -0.50, p < .001), longer days receiving antibiotics due to pulmonary exacerbation (0 [interquartile range, IQR: 0-2] vs. 0 [IQR: 0-7], p = 0.001), and more non-invasive ventilation support (2.6% vs. 0.9%, p = 0.008) than patients in group 1., Conclusion: The ineligible group had worse clinical outcomes than the eligible group. This highlights their need for life-changing drugs to improve clinical outcomes., (© 2024 Wiley Periodicals LLC.)

Patients with ITP have been reported to experience higher levels of depression and anxiety than their healthy counterparts. The limited research conducted on this subject in the pediatric age group has demonstrated that patients have psychosocial difficulties, and their quality of life is adversely affected. The correlation of depressive symptoms with disease characteristics of cITP has never been investigated. This was a cross-sectional study in patients being treated for cITP. Communication with participants was done during routine outpatient visits or by telephone or e-mail, and a survey about demographics and the Children's Depression Inventory (CDI) and the Social Anxiety Scale for Children-Revised (SAS-CR) was administered prospectively. A total of 56 children with cITP were recruited. The mean CDI score was 17 (SD: ± 9.44). Approximately half of the patients had higher CDI scores than healthy Turkish children. Older age, time since diagnosis, a number of hospitalizations (both total and within the last year) were positively correlated with CDI scores. There was no significant correlation between SAS-CR scores and disease characteristics. Depressive symptom scores were higher in children with cITP compared with healthy children in this study. Psychological needs may be overlooked in the medical management of children with cITP., (© 2024. Japanese Society of Hematology.)

Objectives: We aimed to assess first degree relatives (FDRs) of BD patients for the presence of clinical symptoms and signs of BD and evaluate common femoral vein (CFV) wall thickness measurement for the diagnosis., Methods: Patients with BD(n=129) and FDRs(n=230) of these patients were included. FDRs were questioned in terms of BD symptoms by phone. Pathergy test and CFV wall thickness measurement were performed among 111 FDRs who accepted the clinical assessment. Clinical assessment group were classified according to the criteria sets for BD. FDRs who did not meet the criteria sets and had at least one clinical finding in addition to oral aphthae(OA) were categorized as the "suspected BD"., Results: :We observed increased frequency of isolated BD manifestations in FDRs. Ten FDRs were diagnosed with BD during clinical evaluation. Significantly increased CFV wall thickness was observed in FDRs of BD patients fulfilling diagnostic BD criteria (p<0.001 for both sides) and also in those with suspected BD group (p<0.05 for both sides). Presence of OA, genital ulcer, folliculitis or erythema nodosum were associated with increased CFV wall thickness (p<0.05)., Conclusion: . Our results suggest that CFV wall thickness measurement can be used in diagnosis of familial BD., (© Japan College of Rheumatology 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.)

Several factors, including environmental degradation, air pollution, intense urbanization, excessive agriculture, and climate change, endanger the well-being of animals and plants. One of the major issues with an increasingly negative impact is agricultural contamination with pesticides and antibiotics. Seed coatings with neonicotinoid insecticides used as a protective layer against pests are shown to exceed the permissible limits in most cases. Neonicotinoid compounds bind to nicotinic acetylcholine receptors, therefore affecting the honey bees' brain. Heavy metals in higher concentrations are lethal for honey bees, and the residue in bee products might pose a threat to human health. Highly effective acaricides used to treat Varroa destructor infestations in honey bee colonies have negative effects on honey bee reproduction, olfaction, and honey production. Furthermore, amitraz and fluvalinate are mostly found in the highest amounts and lead to decreased honey production and reduced colony reproduction, along with decreased learning ability and memory. However, scientific studies have shown that honey bees act as a reliable bio-indicator of environmental pollution. In response to the growing demand for bee products, the effects of adulteration and improper storage conditions have gotten worse and represent a new risk factor. In light of the shifting global economy, it is important to analyze consumer expectations and adjust manufacturing accordingly. By ensuring the manufacture of high-quality, traceable products devoid of drug residues, consumers will be better protected from subsequent health problems. This review's objectives are based on the necessity of identifying the risks associated with honey bees and bee products., (© 2024. The Author(s).)

Abstract: We present isolated bilateral adrenal metastases successfully treated with 177 Lu-PSMA in a 66-year-old man diagnosed with castration-resistant prostate cancer. The patient had progression under chemotherapy as depicted by 68 Ga-PSMA PET/CT showing intense bilateral PSMA uptake in the adrenal masses, and metastasis-directed therapies were considered as the first option for improving survival because the patient was oligometastatic. However, surgery and radiotherapy were not justifiable options due to the high risk of definitive adrenal insufficiency; therefore, the patient received 4 cycles of 177 Lu-PSMA treatment. 68 Ga-PSMA PET/CT showed near-complete response in bilateral adrenal metastases, and no sign of adrenal insufficiency was observed during follow-up., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Background: Cystic fibrosis (CF) is an autosomal recessive disorder caused by CF transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve pulmonary function and reduce respiratory infections in CF. This study investigated the clinical and laboratory follow-up parameters over 1 year in patients with CF who could not receive this treatment., Methods: This retrospective cohort study included 2018 and 2019 CF patient data from the CF registry of Turkey. Demographic and clinical characteristics of 294 patients were assessed, who had modulator treatment indications in 2018 but could not reach the treatment., Results: In 2019, patients younger than 18 years had significantly lower BMI z-scores than in 2018. During the 1-year follow-up, forced expiratory volumes (FEV1) and FEV1 z-scores a trend toward a decrease. In 2019, chronic Staphylococcus aureus colonization, inhaled antipseudomonal antibiotic use for more than 3 months, oral nutritional supplement requirements, and oxygen support need increased., Conclusions: Patients who had indications for modulator treatments but were unable to obtain them worsened even after a year of follow-up. This study emphasized the importance of using modulator treatments for patients with CF in our country, as well as in many countries worldwide., (© 2023 Wiley Periodicals LLC.)

Introduction: Cow's milk protein allergy (CMPA) is the most commonly encountered food allergy in the world, usually seen in infants under the age of 2 years. This study aims to determine the factors including COVID-19 affecting formula compliance of CMPA patients., Methods: This study is a prospective, observational study based on 10 different Paediatric Allergy-Immunology clinics in Turkey. Patients aged between 6 months and 2 years, who were followed up with IgE-mediated CMPA treatment or newly diagnosed and using breast milk and/or formula were included in the study. The sociodemographic characteristics of the patients, their symptoms, the treatments they received, and the effects of the COVID-19 pandemic on adherence to formula were evaluated with a questionnaire administered to the parents., Results: The compliance rate for formula-based treatment was 30.8% (IQR: 28.3, SD: 21.86). The number of patients with a single and multiple food allergy was 127 (51.6%) and 71 (28.9%), respectively. Breastfeeding duration, daily amount of prescribed formula and addition of sweetener to the formula were found to reduce compliance ( p  = 0.010, p  = 0.003, and p  = 0.004, respectively). However, it was determined that the patient's height, weight, age at diagnosis, and age of formula onset did not have a significant effect on compliance., Conclusion: It was found that the duration of breastfeeding, the increase in the daily amount of formula requirement, and the addition of sweeteners had adverse effects on formula compliance. There was no significant correlation between the formula adherence of CMPA patients and the pandemic., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Uygun, Karaatmaca, Topal, Arga, Sancakli, Ozcan, Igde, Cekic, Bingol, Buyuktiryaki, Sackesen, Sursal, Ozdener and Bingol.)

Background: We aimed to determine the number of cystic fibrosis (CF) patients recorded in the Cystic Fibrosis Registry of Türkiye (CFRT) who were in need of lung transplantation (LT) referral and examine clinical differences between patients who were LT candidates due to rapid forced expiratory volume in one second (FEV₁) decline and LT candidates without rapid FEV₁ decline in the last year to identify a preventable cause in patients with such rapid FEV₁ decline., Methods: All CF patients recorded in the CFRT in 2018 were evaluated in terms of LT. Patients were divided into those with FEV₁ below 50% and in need of LT due to a decrease of 20% or more in the previous year (Group 1) and those who did not have FEV₁ decline of more than 20% in the previous year but had other indications for LT (Group 2). Demographic and clinical features were compared between the two groups., Results: Of 1488 patients registered in CFRT, 58 had a need for LT. Twenty patients were included in Group 1 and others in Group 2. Our findings did not reveal any significant variations in treatment, chronic infection status, or complications between the two groups. The average weight z-score was significantly higher in Group 1. Positive correlations were detected between weight z-score and FEV₁ in 2017 in Group 1 and between FEV₁ values in 2017 and 2018 in Group 2., Conclusions: There appears to be a relationship between the nutritional status and weight z-scores of CF patients and pulmonary function, which may indirectly affect the need for lung transplantation referral.

Background: Myasthenia gravis is a chronic, autoimmune disease with muscle weakness. Acetylcholinesterase inhibitors are used in the symptomatic treatment of the disease. Allergic reaction to pyridostigmine bromide is rare. In the literature, no allergic reaction to pyridostigmine bromide has been reported in the pediatric population., Case: A 12-year-old female patient diagnosed with myasthenia gravis consulted our clinic with the complaint of urticaria due to pyridostigmine bromide. The oral challenge test performed with pyridostigmine bromide was positive. As the patient was required to be continue pyridostigmine bromide with no suitable alternatives, it was decided that the patient had to be desensitized to pyridostigmine. During and after the desensitization protocol, no reaction was observed., Conclusions: In this report, a successful desensitization protocol for pyridostigmine bromide in a child with myasthenia gravis is discussed.

Honey bee colonies are often subjected to diseases, nutrition quality, temperature and other stresses depending on environmental and climatic conditions. As a result of malnutrition, the level of Vg protein decreases, leading to overwintering losses. The Vg values must be high for a successful wintering, especially before wintering. If good nutrition is not reached, the long winter period may cause an increase in colony losses. Supplementary feeding is essential for colony sustainability when floral resources are insufficient, as in recent years with the emerging climate changes. Furthermore, quality food sources or nutrients are significant for maintaining honey bee health and longevity. This study examined the changes in HSP 70 and Vg proteins in 6 groups of 48 colonies fed with five different nutrients. The fatty acids that are present in the highest amount in Cistus creticus (Pink rock-rose), Papaver somniferum (Opium poppy) and mixed pollen samples were linoleic, palmitic and cis-9-oleic acids. The highest values in proline, lysine and glutamic acid were determined in C. creticus pollen. Regarding the P. somniferum pollen, the highest values were observed in lysine, proline, glutamic and aspartic acids. The highest values in lysine, proline, leucine and aspartic acid were noticed in mixed pollen. The effect of different feeding on Vg protein in nurse and forager bee samples was higher in the mixed pollen group in the fall period. In nurse bees, the mixed pollen group was followed by Cistus creticus pollen > Papaver somniferum pollen > sugar syrup > commercial bee cake > control group, respectively (p < 0.05). In forager bees, the order was mixed pollen, P. somniferum pollen, C. creticus pollen, commercial bee cake, sugar syrup and control. In the early spring period, the Vg levels were high in the mixed pollen group in the nurse bees and the commercial bee cake group in the forager bees. In the fall period, the HSP 70 value of the forager and nurse bees was the lowest in the C. creticus group (p < 0.05). In early spring, the active period of flora, a statistical difference was found between the treatment groups.

Climate change affects plant phenology and, as a result, can damage nectar and pollen sources, which are the basic needs of bees during flowering. This situation creates nutritional stress for bee colonies in the region. Changing climatic conditions, the use of agricultural lands adversely affects honeybees and beekeepers. The aim of this study is to determine the annual development performance of fixed honeybee colonies linked with the chemical and mineral profile of bee collected pollen. According to the research findings, in terms of colony development parameters, the number of bee frames (9.17) was found to be at the highest level in May, and in terms of brood area (4652.35 cm 2 ) in April (P<0.05). March, April, and May are the most abundant months in terms of pollen collection of the colonies (P<0.05). The pollen samples collected are rich in potassium, sodium, calcium, magnesium, silicon, and iron. There are differences between months in terms of pollen sources and mineral levels. Especially in stationary beekeeping, additional feeding is required during critical periods. The existing flora is insufficient for the future of the honey bee. In periods when the flora is weak, important plants for the honey bee should be grown in the region., (© 2022 Wiley-VHCA AG, Zurich, Switzerland.)

Introduction and Objective: The attitude and behaviors of parents are important in the management of children with food allergy (FA). The aim of this study is to evaluate the experiences and attitudes of parents of children with allergy to cow's milk and other FA., Materials and Methods: The parents of children with FA were asked to complete an 18-item questionnaire to evaluate the FA history and experiences during diagnosis, treatment, and follow up., Results: The data from 558 (91.2%) survey questionnaire that were filled completely were analyzed. The mean age of the parents was 33.4+4.9. It was found that most common food allergen was cow's milk (85.3%). The mean time to diagnosis from the onset of symptoms was 10.9±18.4 months. Around 229 parents (41.6%) admitted to at least four different physicians and 68 (12.3%) parents admitted to at least five different physicians before diagnosis. The median time to diagnosis from the onset of symptoms was five (1-108) months in the patients admitted to four or more physicians, but it was one (1-48) month in the patients that admitted to less physicians (p˂0.001). The most common symptoms were dermatitis and mucus-bloody stool, the least common ones were cardiovascular symptoms. Only 21.1% of the patients were able to use hypoallergenic formulas (HAF) in accordance with the recommendation of the physician., Conclusions: Delayed diagnosis of FA is a major concern, and during this period the patients admit many physicians. A majority of the patients with CMPA experience difficulties while using HAFs, and only one-fifth of them is able to use formula regularly.

The 3D morphology of hierarchically structured electrocatalytic systems is determined based on multi-scale X-ray computed tomography (XCT), and the crystalline structure of electrocatalyst nanoparticles is characterized using transmission electron microscopy (TEM), supported by X-ray diffraction (XRD) and spatially resolved near-edge X-ray absorption fine structure (NEXAFS) studies. The high electrocatalytic efficiency for hydrogen evolution reaction (HER) of a novel transition-metal-based material system - MoNi 4 electrocatalysts anchored on MoO 2 cuboids aligned on Ni foam (MoNi 4 /MoO 2 @Ni) - is based on advantageous crystalline structures and chemical bonding. High-resolution TEM images and selected-area electron diffraction patterns are used to determine the crystalline structures of MoO 2 and MoNi 4 . Multi-scale XCT provides 3D information of the hierarchical morphology of the MoNi 4 /MoO 2 @Ni material system nondestructively: Micro-XCT images clearly resolve the Ni foam and the attached needle-like MoO 2 micro cuboids. Laboratory nano-XCT shows that the MoO 2 micro cuboids with a rectangular cross-section of 0.5 × 1 µm 2 and a length of 10-20 µm are vertically arranged on the Ni foam. MoNi 4 nanoparticles with a size of 20-100 nm, positioned on single MoO 2 cuboids, were imaged using synchrotron radiation nano-XCT. The application of a deep convolutional neural network (CNN) significantly improves the reconstruction quality of the acquired data., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Honey bees need pollen and nectar sources to survive in nature. Particularly, having young bees in colonies is vital before wintering, and proper feeding is necessary to achieve this. In the present study, the effect of feeding with pollen sources of different protein content on colony performance, wintering ability and in-vitro longevity of colonies that weakened after feeding with pine honey in autumn, or that needed to enter the winter period, was investigated. The experiment was carried out in 48 colonies divided into six groups as follows: control, syrup, mixed pollen, Cistus creticus pollen (Pink rock-rose), Papaver somniferum pollen (Opium poppy), and commercial bee cake groups. In particular, the P. somniferum pollen group was different (p < 0.01) from the other experiment groups with the number of bee frames (3.44), the area with brood (1184.14 cm2) and the wintering ability of 92.19%. The effect of nutritional differences on survival was found to be statistically significant in vitro and this supports the colony results in the natural environment (p < 0.001). The P. somniferum group has the longest longevity with 23 days. Pollen preferences of honey bees were P. somniferum, C. creticus, and mixed pollen, respectively.

Background: Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease., Methods: Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data., Results: There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in  1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively)., Conclusions: The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF., (© 2022 Wiley Periodicals LLC.)

In this study, some persistent trace elements and critical raw materials were investigated in grapevines contaminated with Pb-Zn mining effluents. The persistent trace elements under certain conditions remain without any change in form in the environment over long periods. The critical raw materials are the ones that have economic importance and have the risks associated with their supply. The health risks of persistent trace elements and critical raw materials in the leaves of grapevine that are consumed by humans were determined. The highest persistent trace elements concentrations followed the order of root > stem > leaf for Mn, Cu, Cd, Ni, and Cr while root > leaf > stem for Zn and leaf > root > stem for Pb. The maximum critical raw material concentrations for Co and V followed the order of root > stem > leaf. For Sb and La, these were leaf > root > stem and root > stem > leaf, respectively. The maximum critical raw materials concentrations for W was leaf > stem = root. The total maximum carcinogenic value was 0.146 for Cd while the total minimum carcinogenic value was 0.0054 for Pb. In this study, potential carcinogenic risk values in terms of ingestion of contaminated soil (Cr, Cd, and Ni) and dietary take of grapevine leaves (Ni, Cr, Cd, and Pb) are higher than acceptable levels (1 × 10 -4  - 1 × 10 -6 ). Maximum cancer risk on human health was determined as dietary intake of grapevine leaves. When hazard quotient for dietary (HQ die ), hazard quotient for ingestion (HQ ing ), and hazard quotient for inhalation (HQ inh ) values ​​of critical raw materials were examined, the maximum values ​​were observed for children. Also, the highest hazard quotient for dermal (HQ der ) value was determined for men. The hazard index and total hazard index values were >1 for critical raw materials. As a result, values >1 indicated potential non-carcinogenic human health risk associated with the consumption of grapevines contaminated with mining effluents. Actual region-specific exposure estimates for consumption of grapevines, however, were not evaluated. Integr Environ Assess Manag 2022;18:517-527. © 2021 SETAC., (© 2021 SETAC.)

Background: Cystic fibrosis (CF) is a lethal recessive genetic disease caused by loss of function associated with mutations in the CF trans-membrane conductance regulator. It is highly prevalent (approximately 1 in 3,500) in Caucasians. The aim of this study was to compare demographic and clinical features, diagnostic tests, treatments, and complications of patients with CF whose newborn screening (NBS) with twice-repeated immune reactive trypsinogen testing was positive, normal, and not performed., Methods: In this study, 359 of all 1,488 CF patients recorded in the CF Registry of Turkey in 2018, who had been born through the process of NBS, were evaluated. Demographic and clinical features were compared in patients diagnosed with positive NBS (Group 1), normal (Group 2), or without NBS (Group 3)., Results: In Group 1, there were 299 patients, in Group 2, there were 40 patients, and in Group 3, there were 20 patients. Among all patients, the median age at diagnosis was 0.17 years. The median age at diagnosis was higher in Groups 2 and 3 than in Group 1 (P = 0.001). Fecal elastase results were higher in Group 2 (P = 0.033). The weight z-score was lower and chronic Staphylococcus aureus infection was more common in Group 3 (P = 0.017, P = 0.004, respectively)., Conclusions: Frequency of growth retardation and chronic S. aureus infection can be reduced with an early diagnosis using NBS. In the presence of clinical suspicion in patients with normal NBS, further analyses such as genetic testing should be performed, especially to prevent missing patients with severe mutations., (© 2021 Japan Pediatric Society.)

Objective: Piriform aperture, paranasal sinuses, and the cranium dimensions were compared with each other and we investigated the alterations depending on the age and gender in these structures. Before the endoscopic sinus surgery, anatomic variations in sinusoidal region and the occurring differences should be considered. The detection of these variations plays important roles in the prevention of complications which may happen in surgery or in obtaining a successful surgical result., Materials and Methods: Piriform aperture maximum width, frontal sinuses, sphenoidal sinuses, maxillary sinuses, and cranium widths and height length was measured from the regions that we were determined. Three hundred ninety three cases' computed tomography images were compared. The individuals without any head trauma, pathology, and surgical history in sinusoidal region were analyzed retrospectively. The detected measurements were studied among the paranasal sinuses, piriform aperture, and calvaria dimensions., Results: It was observed that the dimensions of paranasal sinuses were decreased and the dimension of piriform aperture was increased depending on age. In all individuals, a relationship in positive direction in a manner that piriform aperture width increases as the size of the cranium width increases. Morphologic alterations take place in the dimensions of paranasal sinuses as a result of bone deformations occurring in the bone structure depending age and gender in adult individuals., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 by Mutaz B. Habal, MD.)