68 results on '"Terao, T."'
Search Results
2. Black fingers and dark urine: cold agglutinin disease.
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Oda, N, Rokutanda, R, and Terao, T
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URINE ,FINGERS ,LEUCOCYTES - Abstract
Digital gangrene often occurs in autoimmune diseases, Buerger's disease, and arteriosclerosis obliterans.[1] In addition, cold agglutinin disease may also be a rare cause of digital gangrene.[2] In this case, the onset of the digital gangrene and dark urine after cold exposure led us to suspect a cold agglutinin disease. A previously healthy 55-year-old woman presented to the emergency department in winter because of painful discoloration of the distal tip of her right middle, ring and little fingers (Figure 1A). Google Scholar Crossref Search ADS PubMed WorldCat 2 Koike Y, Akiyama Y, Utani A. Cold agglutinin disease-associated digital gangrene treated with plasmapheresis. [Extracted from the article]
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- 2022
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3. 339P A comparison of survival of patients with relapsed or refractory diffuse large B cell lymphoma undergoing allogeneic stem cell transplantation or receiving CAR-T therapy.
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Hayashino, K., Nishimori, H., Fujiwara, K., Kondo, K., Matsubara, C., Terao, T., Kitamura, W., Kamoi, C., Seike, K., Fujiwara, H., Asada, N., Ennishi, D., Fujii, K., Fujii, N., Matsuoka, K-I., and Maeda, Y.
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STEM cell transplantation , *B cell lymphoma , *OVERALL survival - Published
- 2023
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4. Association between irritable temperament and glucose metabolism in the left insula and the right cerebellum.
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Muronaga M, Hirakawa H, Terao T, Izumi T, Satoh M, and Kohno K
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- Humans, Male, Female, Adult, Young Adult, Middle Aged, Cerebral Cortex diagnostic imaging, Cerebral Cortex metabolism, Temperament physiology, Positron-Emission Tomography, Fluorodeoxyglucose F18, Cerebellum diagnostic imaging, Cerebellum metabolism, Glucose metabolism, Insular Cortex diagnostic imaging, Insular Cortex metabolism
- Abstract
Introduction: Affective temperaments are assumed to have biological and neural bases. In the present study, we analyzed
18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) images of healthy participants to explore the neural basis of affective temperaments., Method: We utilized data of affective temperament measured by the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire and18 F-FDG PET images of healthy participants from two of our previous studies. A multiple regression analysis was performed to assess the association between18 F-FDG uptake and temperament scores using Statistical Parametric Mapping 12., Results: The final sample included 62 healthy participants. Whole-brain analysis revealed a cluster of18 F-FDG uptake that was significantly and positively associated with irritable temperament scores in the right cerebellum (Crus II, VIII, and IX). After further adjustment for the other four temperament scores, whole-brain analysis revealed a cluster of18 F-FDG uptake significantly and positively associated with irritable temperament scores in the left insula and right cerebellum (Crus II, VIII, and IX). However, no significant association was found between18 F-FDG uptake and the other four temperaments (depressive, cyclothymic, hyperthymic, and anxious)., Conclusions: The left insula and right cerebellum of the cerebrocerebellar circuit may be one of the neural bases of irritable temperament., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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5. Remission of hypersensitivity pneumonitis after allogeneic hematopoietic stem cell transplantation.
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Inukai Motokura Y, Higo H, Matsumoto C, Uno M, Fujiwara K, Terao T, Makimoto S, Higaki F, Matsuoka KI, Tokioka F, Maeda Y, and Miyahara N
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- Humans, Male, Middle Aged, Remission Induction, Tomography, X-Ray Computed, Prednisolone administration & dosage, Hematopoietic Stem Cell Transplantation adverse effects, Alveolitis, Extrinsic Allergic etiology, Alveolitis, Extrinsic Allergic diagnosis, Alveolitis, Extrinsic Allergic therapy, Myelodysplastic Syndromes therapy, Transplantation, Homologous
- Abstract
A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT., Competing Interests: Declaration of competing interest The authors have no conflicts of interest., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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6. Association between human herpesvirus-6 encephalitis and antiviral prophylaxis after allogeneic hematopoietic stem cell transplantation in the letermovir era.
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Terao T, Matsuoka KI, Fuji S, Kawamura S, Toya T, Doki N, Uchida N, Tanaka M, Fukuda T, Sawa M, Ishikawa J, Nishida T, Ohigashi H, Maruyama Y, Fujiwara SI, Kanda Y, Ota S, Ishimaru F, Atsuta Y, Kanda J, Ogata M, Yakushijin K, and Nakasone H
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- Humans, Male, Adult, Female, Middle Aged, Quinazolines therapeutic use, Triazoles therapeutic use, Transplantation, Homologous, Acetates, Hematopoietic Stem Cell Transplantation adverse effects, Antiviral Agents therapeutic use, Encephalitis, Viral prevention & control, Encephalitis, Viral etiology, Roseolovirus Infections prevention & control, Roseolovirus Infections etiology, Herpesvirus 6, Human
- Abstract
The impact of letermovir (LTV)-an anti-cytomegalovirus (CMV) drug-on human herpesvirus-6 (HHV-6) encephalitis is unclear. We hypothesized that LTV prophylaxis may increase the incidence of HHV-6 encephalitis by reducing anti-CMV therapies after allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the association between HHV-6 encephalitis and antiviral prophylaxis, 7985 adult patients from a nationwide registry who underwent their first HSCT between January 2019 and December 2021 were analyzed. The incidence of HHV-6 encephalitis on day 100 after HSCT was 3.6%; 11.5% for the broad-spectrum antiviral group (foscarnet, ganciclovir, or valganciclovir); 2.8% for the LTV group, and 3.8% for the other antiviral group (p < 0.001). These differences persisted when cord blood transplantation (CBT) was analyzed separately (14.1%, 5.9%, and 7.4%, p < 0.001). In the multivariate analysis, CBT (hazard ratio [HR]: 2.90), broad-spectrum antiviral prophylaxis (HR: 1.91), and grade II-IV acute graft-versus-host disease requiring systemic corticosteroids (HR: 2.42) were independent risk factors for encephalitis (all p < 0.001). The findings of this large modern database study indicate that broad-spectrum antiviral prophylaxis, rather than LTV prophylaxis, is paradoxically associated with HHV-6 encephalitis in the LTV era. This paradoxical finding needs to be further explored in future studies., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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- 2024
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7. The genetic association between bipolar disorder and dementia: a qualitative review.
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Hirakawa H and Terao T
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Bipolar disorder is a chronic disorder characterized by fluctuations in mood state and energy and recurrent episodes of mania/hypomania and depression. Bipolar disorder may be regarded as a neuro-progressive disorder in which repeated mood episodes may lead to cognitive decline and dementia development. In the current review, we employed genome-wide association studies to comprehensively investigate the genetic variants associated with bipolar disorder and dementia. Thirty-nine published manuscripts were identified: 20 on bipolar disorder and 19 on dementia. The results showed that the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A were overlapping between patients with bipolar disorder and dementia. In conclusion, the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A may be associated with the neuro-progression of bipolar disorder to dementia. Further genetic studies are needed to comprehensively clarify the role of genes in cognitive decline and the development of dementia in patients with bipolar disorder., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision The reviewer HH is currently organizing a Research Topic with the authors., (Copyright © 2024 Hirakawa and Terao.)
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- 2024
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8. Hearing intervention and cognitive decline: the ACHIEVE trial.
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Terao T
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- Humans, Aged, Hearing Loss prevention & control, Hearing Aids, Randomized Controlled Trials as Topic, Cognitive Dysfunction prevention & control, Cognitive Dysfunction etiology
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- 2024
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9. Combination of reduced post-transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft-versus-host disease in human leukocyte antigen-haploidentical peripheral blood stem-cell transplantation.
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Terao T, Kondo T, Nakamura M, Takasuka H, Fujiwara H, Asada N, Ennishi D, Nishimori H, Fujii K, Fujii N, Maeda Y, and Matsuoka KI
- Abstract
We evaluated the clinical impacts of the concurrent modification of post-transplant cyclophosphamide (PTCy) dose and tacrolimus (Tac)-initiation timing in 61 patients with human leukocyte antigen-haploidentical transplantation. Reduced-dose PTCy (80 mg/kg) was associated with a higher incidence of moderate-to-severe chronic graft-versus-host disease (GVHD) than standard-dose PTCy (100 mg/kg) (35.0% vs. 26.6%, p = 0.053). Notably, early-initiation Tac (day -1) increased moderate-to-severe chronic GVHD than standard-initiation Tac (day 5) in the reduced-dose PTCy group ( p = 0.032), whereas Tac-initiation timing did not impact chronic GVHD in the standard-dose PTCy group. These data indicate that the combination of reduced-dose PTCy and early-initiation Tac can amplify chronic GVHD., Competing Interests: The authors have no competing interests., (© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
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- 2024
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10. Antidepressant monotherapy in treatment-refractory bipolar II depression.
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Terao T
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- Humans, Bipolar Disorder drug therapy, Antidepressive Agents therapeutic use, Depressive Disorder, Treatment-Resistant drug therapy
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- 2024
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11. Chimeric antigen receptor T-cell therapy after COVID-19 in refractory high-grade B-cell lymphoma.
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Hayashino K, Seike K, Fujiwara K, Kondo K, Matsubara C, Terao T, Kitamura W, Kamoi C, Fujiwara H, Asada N, Nishimori H, Ennishi D, Fujii K, Fujii N, Matsuoka KI, and Maeda Y
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- Humans, Female, Aged, Antiviral Agents, Immunotherapy, Adoptive, Cell- and Tissue-Based Therapy, Antigens, CD19, Receptors, Chimeric Antigen, COVID-19, Hepatitis C, Chronic, Lymphoma, Large B-Cell, Diffuse
- Abstract
Although chimeric antigen receptor T-cell (CAR-T) therapies have dramatically improved the outcomes of relapsed/refractory B-cell malignancies, recipients suffer from severe humoral immunodeficiencies. Furthermore, patients with coronavirus disease 2019 (COVID-19) have a poor prognosis, as noted in several case reports of recipients who had COVID-19 before the infusion. We report the case of a 70-year-old woman who developed COVID-19 immediately before CAR-T therapy for high-grade B-cell lymphoma. She received Tixagevimab-Cilgavimab chemotherapy and radiation therapy but never achieved remission. She was transferred to our hospital for CAR-T therapy, but developed COVID-19. Her symptoms were mild and she was treated with long-term molnupiravir. On day 28 post-infection, lymphodepleting chemotherapy was restarted after a negative polymerase chain reaction (PCR) test was confirmed. The patient did not experience recurrence of COVID-19 symptoms or severe cytokine release syndrome. Based on the analysis and comparison of the previous reports with this case, we believe that CAR-T therapy should be postponed until a negative PCR test is confirmed. In addition, Tixagevimab-Cilgavimab and long term direct-acting antiviral agent treatment can be effective prophylaxis for severe COVID-19 and shortening the duration of infection., (© 2024. The Author(s).)
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- 2024
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12. 3D CNN-based Deep Learning Model-based Explanatory Prognostication in Patients with Multiple Myeloma using Whole-body MRI.
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Morita K, Karashima S, Terao T, Yoshida K, Yamashita T, Yoroidaka T, Tanabe M, Imi T, Zaimoku Y, Yoshida A, Maruyama H, Iwaki N, Aoki G, Kotani T, Murata R, Miyamoto T, Machida Y, Matsue K, Nambo H, and Takamatsu H
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- Humans, Artificial Intelligence, Retrospective Studies, Magnetic Resonance Imaging methods, Deep Learning, Multiple Myeloma diagnostic imaging
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Although magnetic resonance imaging (MRI) data of patients with multiple myeloma (MM) are used to predict prognosis, few reports have applied artificial intelligence (AI) techniques for this purpose. We aimed to analyze whole-body diffusion-weighted MRI data using three-dimensional (3D) convolutional neural networks (CNNs) and Gradient-weighted Class Activation Mapping (Grad-CAM), an explainable AI, to predict prognosis and explore the factors involved in prediction. We retrospectively analyzed the MRI data of a total of 142 patients with MM obtained from two medical centers. We defined the occurrence of progressive disease after MRI evaluation within 12 months as a poor prognosis and constructed a 3D CNN-based deep learning model to predict prognosis. Images from 111 cases were used as the training and internal validation data; images from 31 cases were used as the external validation data. Internal validation of the AI model with stratified 5-fold cross-validation resulted in a significant difference in progression-free survival (PFS) between good and poor prognostic cases (2-year PFS, 91.2% versus [vs.] 61.1%, P = 0.0002). The AI model clearly stratified good and poor prognostic cases in the external validation cohort (2-year PFS, 92.9% vs. 55.6%, P = 0.004), with an area under the receiver operating characteristic curve of 0.804. According to Grad-CAM, the MRI signals of the spleen and bones of the vertebrae and pelvis contributed to prognosis prediction. This study is the first to show that image analysis of whole-body MRI using a 3D CNN without any other clinical data is effective in predicting the prognosis of patients with MM., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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13. Bile cast nephropathy after sinusoidal obstruction syndrome.
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Terao T, Horikawa K, and Matsuoka KI
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- Humans, Bile, Hepatic Veno-Occlusive Disease diagnosis, Hepatic Veno-Occlusive Disease etiology, Hepatic Veno-Occlusive Disease therapy, Acute Kidney Injury
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- 2024
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14. Suicide attempt during ramelteon addition to flunitrazepam: A case report.
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Terao T
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Background: Benzodiazepines, such as flunitrazepam, may be at risk of disinhibition, leading to aggressiveness, impulsivity, self-harm, and possibly suicide attempts, whereas ramelteon may be far from disinhibition., Case Presentation: In a 43-year-old female with primary insomnia, flunitrazepam alone did not induce any type of disinhibition, but the addition of ramelteon to flunitrazepam brought about disinhibition, leading to aggressiveness and finally to her suicide attempt. Her disinhibition rapidly subsided as soon as ramelteon alone was discontinued., Conclusion: These findings suggest that a suicide attempt may occur during ramelteon and flunitrazepam combination in a susceptible patient., Competing Interests: The author declares no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)
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- 2024
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15. Analysis of baseline circulating tumor cells integrated with PET/CT findings in transplant-ineligible multiple myeloma.
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Ikeda D, Terao T, Oura M, Uehara A, Tabata R, Narita K, Takeuchi M, Machida Y, and Matsue K
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- Humans, Positron Emission Tomography Computed Tomography, Retrospective Studies, Multiple Myeloma diagnostic imaging, Multiple Myeloma therapy, Neoplastic Cells, Circulating, Transplants
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Abstract: We aimed to improve prognostic predictors in patients with transplant-ineligible multiple myeloma (TIE-MM) by combining baseline circulating clonal tumor cells (CTCs) and positron emission tomography/computed tomography (PET/CT) findings. The factors associated with prognosis were retrospectively investigated in 126 patients with TIE-MM who underwent CTC quantification by multiparameter flow cytometry and PET/CT at the initial presentation. The total lesion glycolysis (TLG) level was calculated using the Metavol software. The median percentage of CTC was 0.06% (range, 0%-4.82%), and 54 patients (42.9%) demonstrated high CTC levels. High CTC levels were associated with significantly poorer progression-free survival (PFS, 2-year 43.4% vs 68.1%; P < .001) and overall survival (OS, 5-year 39.0% vs 68.3%; P < .001). Similarly, high TLG levels significantly worsened the PFS (2-year, 41.2% vs 67.6%; P = .038) and OS (5-year, 37.7% vs 63.1%; P = .019). The multivariate analyses showed that Revised International Staging System (R-ISS) III, high CTC and TLG levels, and complete response were significant prognostic factors for PFS and OS. A novel predictive model was constructed using CTCs, TLG, and R-ISS III. The patients were stratified into 3 groups according to the number of risk factors, revealing an extremely high-risk group with a 2-year PFS of 0% and a 5-year OS of 20%. Patients without any high-risk features had better prognosis, with a 2-year PFS of 78.6% and a 5-year OS of 79.5%. The combination of CTCs and volumetric assessment of PET/CT at diagnosis augments the existing stratification systems and may pave the way for a risk-adapted treatment approach., (© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
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- 2024
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16. [Relapsed primary central nervous system lymphoma treated with CD19 chimeric antigen receptor T-cell therapy and allogeneic hematopoietic stem cell transplantation].
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Fujii F, Terao T, Nishimori H, Fujii K, Matsuo T, Yoshino T, Ueda H, Oyama T, Matsumura A, Kondo K, Matsubara C, Fujiwara K, Seike K, Fujiwara H, Asada N, Ennishi D, Fujii K, Fujii N, Matsuoka KI, and Maeda Y
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- Humans, Antigens, CD19 immunology, Middle Aged, Male, Lymphoma therapy, Receptors, Chimeric Antigen, Hematopoietic Stem Cell Transplantation, Central Nervous System Neoplasms therapy, Transplantation, Homologous, Recurrence
- Abstract
Relapsed and/or refractory (R/R) primary central nervous system lymphoma (PCNSL) has a poor prognosis. A 57-year-old man diagnosed with PCNSL achieved a complete response by high-dose methotrexate-based chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT). The disease was not cured, so he was treated with the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel after the third relapse. However, the disease relapsed again 28 days after CAR T-cell therapy. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was attempted as curative therapy after bridging with second ASCT and tirabrutinib monotherapy. Although a temporary response was achieved, the disease relapsed 98 days after allo-HSCT. While receiving tirabrutinib for relapse after allo-HSCT, the patient developed acute respiratory failure due to transplant-related toxicity and post-transplant thrombotic microangiopathy. He died 175 days after allo-HSCT. Although various treatments for PCNSL have been investigated in recent years, the treatment strategy for R/R PCNSL has not been established. Further studies are warranted to improve the outcomes of patients with R/R PCNSL.
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- 2024
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17. Increased volume of the left hippocampal dentate gyrus after 4 weeks of bright light exposure in patients with mood disorders: a randomized controlled study.
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Hirakawa H, Terao T, Hatano K, Shirahama M, Kugimiya T, Kohno K, Matsuta H, Shimomura T, and Fujiki M
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- Humans, Cognition, Magnetic Resonance Imaging, Mood Disorders diagnostic imaging, Mood Disorders pathology, Research Design, Dentate Gyrus diagnostic imaging, Dentate Gyrus pathology, Hippocampus pathology
- Abstract
Bright light exposure (BL) induces neurogenesis in the rat hippocampal dentate gyrus (DG). We had previously conducted a randomized controlled trial (RCT) in which a 4-week period of BL in healthy participants resulted in increased volume of the left DG-head. This study aimed to investigate the effects of BL on the DG in patients with mood disorders. A 4-week RCT was conducted in which patients with mood disorders were randomly assigned to either a BL group (10,000 lx) or dim light exposure group (DL group; 50 lx). All patients underwent clinical assessment and magnetic resonance imaging at baseline and after the intervention. The study registration number is UMIN000019220. Our final sample included 24 patients (BL group, n = 12; DL group, n = 12). A significant effect of time and group was detected in the volumes of the left DG-head (F (1, 22) = 11.6, partial η2 = 0.35, p = 0.003) and left DG-total (left DG-total = left DG-head + left DG-body; [F (1, 22) = 6.5, partial η2 = 0.23, p = 0.02]). Additionally, the BL group demonstrated a significant increase in the volume of the left DG-head (95% CI: -5.4 to -1.6, d = 1.2, p = 0.002) and left DG-total (95% CI: -6.3 to -1.5, d = 1.06, p = 0.005) as well as a positive correlation between the percentage change in the volume of the left DG-total and the percentage change in the scores of the mood visual analog scale (r = 0.58, p = 0.04). In conclusion, our study results suggest that compared to DL, BL leads to a significantly greater increase in the left DG volume in patients with mood disorders. This increase in the left DG volume may be associated with mood improvement in the patients., (© 2023. The Author(s).)
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- 2023
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18. Refractory Depression With Persistent Sore Throat and Hypochondriacal Delusion of SARS-CoV-2 Infection: A Case Study.
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Hayasaki G, Terao T, Hirakawa H, Muronaga M, and Kohno K
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- Female, Humans, Delusions etiology, SARS-CoV-2, Hallucinations, Pain, COVID-19 complications, Depressive Disorder, Treatment-Resistant, Pharyngitis
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Abstract: Herein, we present a case of a female patient with a persistent sore throat, which preceded a hypochondriacal delusion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Both the sore throat and hypochondriacal delusion persisted together, despite the repeatedly negative results of reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 and a moderate improvement in her depression. Four possibilities for the patient's sore throat were discussed: pain symptoms of somatic symptom disorder, pain symptoms of depression, delusion of pain in her throat, and somatic hallucination as a sore throat. Consequently, somatic hallucinations were considered the most likely. In any case, the present findings suggest that sore throat can precede hypochondriacal delusion of SARS-CoV-2 infection in some noninfected patients. When patients continue to complain of a sore throat despite the negative results of SARS-CoV-2 by the RT-PCR test, we should consider that it might be a somatic hallucination and soon hypochondriacal delusions may occur, leading to the manifestation of other symptoms of psychiatric disorders, such as depression, which may be refractory and/or suicidal., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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19. Safety, pharmacokinetics, and efficacy of belantamab mafodotin monotherapy in Japanese patients with relapsed or refractory multiple myeloma: DREAMM-11.
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Iida S, Sunami K, Mishima Y, Fujii T, Kato H, Terao T, Matsuzawa Y, Matsubara M, Crossman T, Kremer BE, and Gupta I
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- Humans, East Asian People, Antibodies, Monoclonal, Humanized therapeutic use, Proteasome Inhibitors, Multiple Myeloma drug therapy
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Belantamab mafodotin, a B-cell maturation antigen-targeting antibody-drug conjugate (ADC), was investigated in Japanese patients with relapsed/refractory multiple myeloma in Part 1 of the phase I DREAMM-11 study. Patients who had received ≥ 2 prior lines of therapy including a proteasome inhibitor and immunomodulatory agent were eligible. Eight patients received belantamab mafodotin monotherapy at 2.5 mg/kg (n = 4) or 3.4 mg/kg (n = 4) by intravenous infusion every 3 weeks on day 1 of each cycle until disease progression or unacceptable toxicity. Primary objectives were tolerability and safety, and secondary objectives included pharmacokinetics (PK) and efficacy. The most common Grade ≥ 3 adverse event was thrombocytopenia/platelet count decreased (2.5 mg/kg cohort, 100% [4/4]; 3.4 mg/kg cohort, 75% [3/4]), and no dose-limiting toxicities were observed. Ocular events, including keratopathy findings, were observed in most patients (2.5 mg/kg cohort, 100% [4/4]; 3.4 mg/kg cohort, 75% [3/4]) and were managed with dose modifications. All resolved within the study period. Overall response rates were 50% (2/4) in the 2.5 mg/kg cohort and 25% (1/4) in the 3.4 mg/kg cohort. Although PK profiles in Japanese patients varied, individual exposures overlapped with previous results in Western populations. Belantamab mafodotin monotherapy was generally well-tolerated and demonstrated clinical activity at both doses., (© 2023. The Author(s).)
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- 2023
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20. Increasing the uptake of 18 F-fluorodeoxyglucose in the left hippocampus after 4 weeks of bright light exposure in healthy participants: A randomized controlled study.
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Hirakawa H, Terao T, Hatano K, Shirahama M, and Kohno K
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- 2023
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21. Negative Prognostic Impact of High-Dose or Long-Term Corticosteroid Use in Patients with Relapsed or Refractory B-Cell Lymphoma Who Received Tisagenlecleucel.
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Terao T, Kitamura W, Fujii N, Asada N, Kamoi C, Fujiwara K, Kondo K, Matsubara C, Hayashino K, Seike K, Fujiwara H, Ennishi D, Nishimori H, Fujii K, Matsuoka KI, and Maeda Y
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- Humans, Prognosis, Retrospective Studies, Neoplasm Recurrence, Local, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse drug therapy
- Abstract
The prognostic impact of corticosteroid therapy in patients receiving tisagenlecleucel (tisa-cel) treatment who are more likely to develop cytokine release syndrome (CRS) remains unclear. This study aimed to evaluate the clinical impact and lymphocyte kinetics of corticosteroid administration for CRS in 45 patients with relapsed and/or refractory B-cell lymphoma treated with tisa-cel. This was a retrospective evaluation of all consecutive patients diagnosed with relapsed and/or refractory diffuse large B-cell lymphoma, follicular lymphoma with histologic transformation to large B-cell lymphoma, or follicular lymphoma who received commercial-based tisa-cel treatment. The best overall response rate, complete response rate, median progression-free survival (PFS), and median overall survival (OS) were 72.7%, 45.5%, 6.6 months, and 15.3 months, respectively. CRS (predominantly grade 1/2) occurred in 40 patients (88.9%), and immune effector cell-associated neurotoxicity syndrome (ICANS) of all grades occurred in 3 patients (6.7%). No grade ≥3 ICANS occurred. Patients with high-dose (≥524 mg, methylprednisolone equivalent; n = 12) or long-term (≥8 days; n = 9) corticosteroid use had inferior PFS and OS to patients with low-dose or no corticosteroid use (both P < .05). The prognostic impact remained even in 23 patients with stable disease (SD) or progressive disease (PD) before tisa-cel infusion (P = .015). but not in patients with better disease status (P = .71). The timing of corticosteroid initiation did not have a prognostic impact. Multivariate analysis identified high-dose corticosteroid use and long-term corticosteroid use as independent prognostic factors for PFS and OS, respectively, after adjusting for elevated lactate dehydrogenase level before lymphodepletion chemotherapy and disease status (SD or PD). Lymphocyte kinetics analysis demonstrated that after methylprednisolone administration, the proportions of regulatory T cells (Tregs), CD4
+ central memory T (TCM ) cells, and natural killer (NK) cells were decreased, whereas the proportion of CD4+ effector memory T (TEM ) cells was increased. Patients with a higher proportion of Tregs at day 7 had a lower incidence of CRS, but this did not affect prognosis, indicating that early elevation of Tregs may serve as a biomarker for CRS development. Furthermore, patients with higher numbers of CD4+ TCM cells and NK cells at various time points had significantly better PFS and OS, whereas the number of CD4+ TEM cells did not impact prognostic outcomes. This study suggests that high-dose or long-term corticosteroid use attenuates the efficacy of tisa-cel, especially in patients with SD or PD. Additionally, patients with high levels of CD4+ TCM cells and NK cells after tisa-cel infusion had longer PFS and OS., (Copyright © 2023 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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22. Self-reported low self-esteem due to poor maternal care improves with the existential approach in bipolar disorder: a case report.
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Hirakawa H, Terao T, and Kawano N
- Abstract
Parental nurturing attitudes influence children and are linked to the establishment of self-esteem. Females who have experienced poor maternal care during their childhood may have low self-esteem, and this factor may significantly augment the likelihood of depression. Particularly, childhood maltreatment among individuals with bipolar disorder is associated with unfavorable clinical features, such as a heightened risk of severe manic, depressive, or psychotic symptoms, as well as suicide attempts. Here, we report a case of a woman with bipolar disorder who had self-reported low self-esteem due to poor maternal care, which subsequently improved via an existential approach. This existential approach confers meaning to the lives of every individual, even in the face of adversity. Our findings suggest that the existential approach may enable the discovery of more positive life values during times of hardship and could improve self-reported low self-esteem due to poor maternal and change the way of life in patients with bipolar disorder., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Hirakawa, Terao and Kawano.)
- Published
- 2023
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23. Clinical Characteristics and Outcomes of Cyclin D1-Positive AL Amyloidosis.
- Author
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Tsushima T, Terao T, Narita K, Fukumoto A, Ikeda D, Kamura Y, Kuzume A, Tabata R, Miura D, Takeuchi M, and Matsue K
- Subjects
- Humans, Male, Aged, Female, Cyclin D1 genetics, Cyclin D1 metabolism, In Situ Hybridization, Fluorescence, Immunoglobulin Light-chain Amyloidosis, Multiple Myeloma diagnosis, Paraproteinemias
- Abstract
Objectives: To demonstrate the clinical features and prognostic impact of cyclin D1 positivity in patients with amyloid light chain amyloidosis (AL)., Methods: We consecutively included 71 patients diagnosed with AL with cyclin D1 positivity between February 2008 and January 2022. t(11;14) was examined through interphase fluorescence in situ hybridization using bone marrow cells., Results: The median age of the patients was 73 years, and 53.5% were male. The underlying diseases included symptomatic multiple myeloma, smoldering multiple myeloma, Waldenström macroglobulinemia, and monoclonal gammopathy of undetermined significance, representing 33.8%, 26.8%, 2.8%, and 36.6%, respectively. The prevalence of cyclin D1 and t(11;14) was 38.0% and 34.7%, respectively. Higher frequency of light chain paraprotein type was seen in cyclin D1-positive patients with AL than in cyclin D1-negative patients (70.4% vs 18.2%). The median overall survival (OS) of patients with AL with and without cyclin D1 expression was 18.9 months and 73.1 months, respectively (P = .019). Early death occurred in 44.4% of cyclin D1-positive patients and 31.8% of cyclin D1-negative patients. Moreover, 83.3% of cyclin D1-positive patients and 21.4% of cyclin D1-negative patients died of cardiac causes., Conclusions: Cyclin D1 immunohistochemistry accurately identified patients with t(11;14). Cyclin D1-positive patients had significantly inferior OS compared with cyclin D1-negative patients., (© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
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- View/download PDF
24. Treatments for major depression.
- Author
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Terao T
- Subjects
- Humans, Depression therapy, Depressive Disorder, Major drug therapy
- Published
- 2023
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25. Deep brain stimulation for patients with dystonia in Machado-Joseph disease: three case reports.
- Author
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Ikezawa J, Yokochi F, Okiyama R, Isoo A, Agari T, Sunami Y, Terao T, and Takahashi K
- Subjects
- Humans, Brain, Machado-Joseph Disease complications, Machado-Joseph Disease therapy, Dystonia etiology, Dystonia therapy, Deep Brain Stimulation, Dystonic Disorders therapy
- Published
- 2023
- Full Text
- View/download PDF
26. A strange smell and visions in a 45-year-old man with focal epilepsy.
- Author
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Hirakawa H and Terao T
- Subjects
- Male, Humans, Middle Aged, Smell, Epilepsies, Partial etiology
- Abstract
Competing Interests: Declaration of interests We declare no competing interests.
- Published
- 2023
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27. Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML.
- Author
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Terao T, Matsuoka KI, Ueda H, Matsumura A, Matsubara C, Kondo K, Kondo T, Fujiwara H, Asada N, Ennishi D, Nishimori H, Fujii K, Fujii N, and Maeda Y
- Subjects
- Humans, Aniline Compounds adverse effects, Pyrazines adverse effects, Neoplasm Recurrence, Local, Leukemia, Myeloid, Acute chemically induced
- Published
- 2023
- Full Text
- View/download PDF
28. Antibody status following booster vaccination against SARS-CoV-2 virus in patients with haematologic malignancies.
- Author
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Ikeda D, Terao T, Fukumoto A, Uesugi Y, Tabata R, Kuzume A, Tsushima T, Miura D, Narita K, Takeuchi M, Yamashita T, Takamatsu H, and Matsue K
- Subjects
- Humans, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Vaccination, Antibodies, Viral, COVID-19 prevention & control, Hematologic Neoplasms therapy
- Abstract
Antibody titres in 462 patients with haematological malignancies after the second (D2) and third (D3) SARS-CoV-2 vaccine were compared with those of healthy controls (HCs). Significant decay of antibody titre was observed pre D3, but titre surged post D3. The number of seronegative patients decreased from 79 (17.1%) to 44 (9.5%) from post D2 to post D3, and patients with adequate antibody titre increased from 204 (44.2%) to 358 (77.5%). Of the patients who received B-cell-targeted therapy, 80% were seronegative and 71% remained seronegative after D3. CD19+, CD4+, CD8+ cell counts, and immunoglobulin G (IgG) levels were identified as independent predictors for adequate serologic response., (© 2022 British Society for Haematology and John Wiley & Sons Ltd.)
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- 2023
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29. Latent bipolar depression.
- Author
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Terao T
- Subjects
- Humans, Depression, Bipolar Disorder
- Published
- 2023
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30. Encephalo-Arterio-Synangiosis with Cranioplasty after Treatment of Acute Subdural Hematoma Associated with Subcortical Hemorrhage Due to Unilateral Moyamoya Disease.
- Author
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Kato N, Kakizaki S, Hirokawa Y, Michishita S, Ishii T, Terao T, and Murayama Y
- Abstract
Moyamoya disease is often diagnosed after intracranial hemorrhage in adult patients. Here, we report a case of unilateral moyamoya disease treated with indirect revascularization combined with cranioplasty after treatment for acute subdural hematoma and subcortical hemorrhage. A middle-aged woman with disturbed consciousness was transferred to our hospital. Computed tomography (CT) revealed an acute subdural hematoma with left temporoparietal subcortical hemorrhage. Three-dimensional CT angiography indicated a scarcely enhanced left middle cerebral artery (MCA) that was suspected to be delayed or nonfilling due to increased intracranial pressure. Subsequently, hematoma evacuation and external decompression were performed. Postoperative digital subtraction angiography (DSA) revealed stenosis of the left MCA and moyamoya vessels, indicating unilateral moyamoya disease. Forty-five days after the initial procedure, we performed encephalo-arterio-synangiosis (EAS) using the superficial temporal artery simultaneously with cranioplasty for the skull defect. The modified Rankin Scale score of the patient one year after discharge was 1, and the repeat DSA showed good patency of the EAS. Revascularization using EAS in the second step can be an option for revascularization for hemorrhagic moyamoya disease if the patient required cranioplasty for postoperative skull defect after decompressive craniotomy., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this article., (Copyright © 2023 Naoki Kato et al.)
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- 2023
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31. Patients with Chronic Liver Disease under Surveillance for Hepatocellular Carcinoma Have a Favorable Long-Term Outcome for Pancreatic Cancer Due to Early Diagnosis and High Resection Rate.
- Author
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Kumagi T, Terao T, Kuroda T, Koizumi M, Imamura Y, Ohno Y, Yokota T, Azemoto N, Uesugi K, Kisaka Y, Tanaka Y, Shibata N, Miyata H, Miyake T, and Hiasa Y
- Abstract
Patients with viral hepatitis-related chronic liver disease (CLD) under surveillance for hepatocellular carcinoma (HCC) are often diagnosed with pancreatic cancer (PC) at an early stage. However, the long-term outcomes of these patients are unclear. We aimed to clarify the long-term outcomes of patients with PC with viral hepatitis-related CLD using a chart review. Data collection included the Union for International Cancer Control (UICC) stage at PC diagnosis, hepatitis B virus and hepatitis C virus status, and long-term outcomes. The distribution of the entire cohort ( N = 552) was as follows: early stage (UICC 0-IB; n = 52, 9.5%) and non-early stages (UICC IIA-IV; n = 500, 90.5%). At diagnosis, the HCC surveillance group ( n = 18) had more patients in the early stages than the non-surveillance group ( n = 534) (50% vs. 8.0%), leading to a higher indication rate for surgical resection (72.2% vs. 29.8%) and a longer median survival time (19.0 months vs. 9.9 months). We confirmed that patients with viral hepatitis-related CLD under HCC surveillance were diagnosed with PC at an early stage. Because of the higher indication rate for surgical resection in these patients, they had favorable long-term outcomes for PC.
- Published
- 2023
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32. Naturally absorbed lithium may prevent suicide attempts and deliberate self-harm while eicosapentaenoic acid may prevent deliberate self-harm and arachidonic acid may be a risk factor for deliberate self-harm: The updated different findings in new analyses.
- Author
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Izumi T, Kanehisa M, Terao T, Shiotsuki I, Shirahama M, Satoh M, Muronaga M, Kohno K, Hirakawa H, Etoh M, and Matsukawa T
- Abstract
Background: Since our previous investigation on the effects of trace lithium, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) on deliberate self-harm and suicide attempts in 2018, to our knowledge, no replication study has been conducted on this topic., Subjects and Methods: We increased 37 new patients and totally 234 patients were re-analyzed to further investigate the association of suicide-related behaviors with levels of trace lithium, EPA, DHA, and AA in a different way to avoid multicollinearity., Results: Higher lithium levels were significantly associated with fewer suicide attempts and deliberate self-harm, higher EPA levels were significantly associated with fewer deliberate self-harm, and higher AA levels were significantly associated with more deliberate self-harm., Discussion: Although the sample size was only slightly larger than the previous study, the present results were clearly different from the previous ones due to the use of different statistical analyses to avoid multicollinearity., Conclusion: The present findings suggest that naturally absorbed lithium may protect against suicide and deliberate self-harm, while naturally absorbed EPA may protect against deliberate self-harm. However, naturally absorbed AA may be a risk factor for deliberate self-harm., Competing Interests: TT was received lecture fees from Mochida, Takeda, Eisai, Meiji, Otsuka, Sumitomo Pharma, and Shionogi Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Izumi, Kanehisa, Terao, Shiotsuki, Shirahama, Satoh, Muronaga, Kohno, Hirakawa, Etoh and Matsukawa.)
- Published
- 2022
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33. Limited efficacy of high-dose methotrexate to prevent the central nervous system relapse in patients with IVLBCL.
- Author
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Terao T, Tsushima T, Ikeda D, Fukumoto A, Kamura Y, Kuzume A, Tabata R, Miura D, Narita K, Takeuchi M, and Matsue K
- Subjects
- Humans, Methotrexate adverse effects, Neoplasm Recurrence, Local drug therapy, Central Nervous System pathology, Chronic Disease, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lymphoma, Large B-Cell, Diffuse drug therapy, Central Nervous System Neoplasms diagnosis
- Abstract
To evaluate the efficacy of high-dose methotrexate (HD-MTX, ≥1 g/m
2 ) for the prevention of central nervous system (CNS) recurrence in patients with intravascular large B-cell lymphoma (IVLBCL), we reviewed 51 patients with pathologically diagnosed untreated IVLBCL. In total, there were five cases of CNS relapse (9.8%), and the 12-month CNS relapse rate was 9.2%. No statistical difference in CNS relapse rate ( p = 0.86) was observed between patients with and without HD-MTX ( n = 20 and 31, respectively). Furthermore, the composite endpoint defined as either CNS and/or neurolymphomatosis relapse was not significant in terms of the administration of HD-MTX ( p = 0.25). No significant predictor of CNS relapse was found. In conclusion, patients with IVLBCL are at high risk of CNS recurrence; however, HD-MTX administration may not be effective for CNS recurrence prophylaxis. Key pointsThe administration of HD-MTX for patients with untreated IVLBCL may not be effective for preventing CNS relapse.- Published
- 2022
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34. Lithium in drinking water and Alzheimer's dementia: Epidemiological Findings from National Data Base of Japan.
- Author
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Muronaga M, Terao T, Kohno K, Hirakawa H, Izumi T, and Etoh M
- Subjects
- Humans, Female, Aged, Lithium, Japan epidemiology, Alzheimer Disease epidemiology, Drinking Water, Bipolar Disorder
- Abstract
Objectives: The aim of this study was to investigate the association between lithium levels in drinking water and prevalence of Alzheimer's dementia (AD)., Methods: Lithium levels in the drinking water of 808 cities and wards (i.e., 785 Japanese cities of 46 prefectures and 23 wards of Tokyo) in Japan were examined in relation to the prevalence of AD during the 5 years from 2010 to 2014, which was calculated on the basis of the national data base of Ministry of Health, Labor, and Welfare of Japan. Multiple regression analyses were used to investigate the association of lithium levels with the prevalence of AD with adjustment for relevant factors (proportions of one-person households as a family factor and people in primary industry employment as a job factor, annual total sunshine hours as a meteorological factor, and total number of beds of psychiatric hospitals as a medical factor) in total, male, and female elderly populations., Results: The adjusted model showed a significant inverse association of lithium levels with female, but not with male, or total prevalence of AD., Conclusions: These findings suggest that higher lithium levels in drinking water may be associated with lower prevalence of AD in female, but not male, populations., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
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35. A Highly Conductive n-Type Coordination Complex with Thieno[3,2- b ]thiophene Units: Facile Synthesis, Orientation, and Thermoelectric Properties.
- Author
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Ueda K, Fukuzaki R, Ito T, Toyama N, Muraoka M, Terao T, Manabe K, Hirai T, Wu CJ, Chuang SC, Kawano S, and Murata M
- Abstract
An organometallic nickel complex containing thieno[3,2- b ]thiophene units was designed and synthesized. Composite films of the resulting nickel complex and polyvinylidene difluoride, which can be fabricated via a simple solution process under atmospheric conditions, exhibit remarkably high n-type conductivity (>200 S cm
-1 ). Moreover, the thermoelectric power factor of the n-type composite film was proven to be air stable. A grazing-incidence wide-angle X-ray diffraction analysis indicated a significant impact of introducing the thieno[3,2- b ]thiophene core into the backbone of the nickel complex on the orientation within the composite films.- Published
- 2022
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36. Successful treatment using combined monthly maintenance electroconvulsive therapy and monthly long-acting injection paliperidone for treatment-resistant schizophrenia with vulnerability to clozapine: A case report.
- Author
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Hirakawa H, Terao T, and Muronaga M
- Subjects
- Humans, Paliperidone Palmitate pharmacology, Paliperidone Palmitate therapeutic use, Schizophrenia, Treatment-Resistant, Antipsychotic Agents, Clozapine, Electroconvulsive Therapy, Schizophrenia drug therapy
- Published
- 2022
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37. Management of lymphoma-associated chylothorax by interventional radiology and chemotherapy: a report of five cases.
- Author
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Fukumoto A, Terao T, Kuzume A, Tabata R, Tsushima T, Miura D, Ikeda D, Kamura Y, Narita K, Takeuchi M, and Matsue K
- Subjects
- Humans, Radiology, Interventional, Thoracic Duct pathology, Chylothorax diagnostic imaging, Chylothorax etiology, Chylothorax therapy, Embolization, Therapeutic methods, Lymphoma complications, Lymphoma pathology, Lymphoma therapy
- Abstract
Chylous effusion is associated with lymphatic obstruction or leakage in mediastinal or abdominal lymph nodes, and is a rare but troublesome complication in patients with malignant lymphomas. Although there is no standard of care, it is often treated with simultaneous chemotherapeutic and non-chemotherapeutic interventions. Here, we describe the cases of five patients with lymphoma-associated chylothorax with the aim of clarifying an effective treatment strategy. All patients achieved a partial response or better for lymphoma. All patients underwent interventional radiology (IVR) procedures, including lymphangiography (LAG) and thoracic duct embolization (TDE). Complete resolution of chylothorax was eventually achieved by IVR procedures or pleurodesis in all patients. No patients experienced serious adverse events related to LAG/TDE. Treatment of chylous effusion required months for most patients (range: 0.2-4.8 months). Our data suggest that a combination of chemotherapy and LAG/TDE is effective for refractory lymphoma-related chylous effusion., (© 2022. Japanese Society of Hematology.)
- Published
- 2022
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38. Effects of a rework program in a university hospital and predictors of work restoration and maintenance in the participants.
- Author
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Yamashita H, Sakai A, and Terao T
- Abstract
During sickness absence, it appears necessary for psychiatric patients suffering from depression or bipolar disorder to undergo a psychiatric rehabilitation called the rework program that aids in work restoration and maintenance. However, few studies have investigated the effects of such a program and predictors of work restoration and maintenance in the participants. Here, we aimed to investigate the effects of a rework program as well as to examine whether cognitive function and mental state at the end of the rework program predict the probability of work restoration and maintenance and whether the frequency of rework program participation predicts successful work restoration and maintenance. The rework program included both patients absent from work and unemployed patients. Patients completed assessments including Trail Making Test Type B (TMT-B), the Wisconsin Card Sorting Test, and the Social Adaptation Self-Evaluation Scale just before graduating from the rework program. Simultaneously, their depressive state was assessed using the Hamilton Depression Rating scale. The patients were divided into the job group, comprising 94 patients who were able to restore their work or get a new job, and the non-job group, comprising 34 patients who were not able to do so. We found that the program was more effective in patients absent from work than in unemployed patients, TMT-B could predict work restoration and maintenance, and the frequency of rework program participation could predict work restoration but not work maintenance. Based on the findings, we propose "Yamashita's criterion" where a TMT-B completion time of 70 s is the cut-off point for work restoration. The present findings may provide useful evidence that could aid in the further development of rework program(s)., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Yamashita, Sakai and Terao.)
- Published
- 2022
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39. Black fingers and dark urine: cold agglutinin disease.
- Author
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Oda N, Rokutanda R, and Terao T
- Subjects
- Fingers, Humans, Anemia, Hemolytic, Autoimmune diagnosis, Kidney Diseases
- Published
- 2022
- Full Text
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40. Rapid liver atrophy and refractory ascites due to hepatoportal sclerosis in a patient after haploidentical stem cell transplantation.
- Author
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Ikeda D, Tsushima T, Fukumoto A, Kuzume A, Tabata R, Terao T, Miura D, Narita K, Takeuchi M, Honma K, and Matsue K
- Subjects
- Ascites diagnosis, Ascites etiology, Ascites therapy, Atrophy, Humans, Sclerosis, Gastrointestinal Diseases, Hematopoietic Stem Cell Transplantation adverse effects, Liver Diseases
- Published
- 2022
- Full Text
- View/download PDF
41. Progress of modern imaging modalities in multiple myeloma.
- Author
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Terao T and Matsue K
- Subjects
- Fluorodeoxyglucose F18, Humans, Magnetic Resonance Imaging methods, Neoplasm, Residual, Positron Emission Tomography Computed Tomography methods, Positron-Emission Tomography methods, Tomography, X-Ray Computed methods, Multiple Myeloma diagnostic imaging, Multiple Myeloma therapy
- Abstract
Multiple myeloma (MM) is an incurable hematological malignancy, but treatment advances made in the last two decades have markedly improved its prognosis. Imaging has played a particularly important role in the management of myeloma. Whole-body low-dose computed tomography (WBLDCT) is replacing conventional skeletal survey by whole-body X-rays. In addition, magnetic resonance imaging (MRI) and positron-emission tomography/computed tomography (PET/CT) have become important imaging modalities not only for MM diagnosis but also for assessment of myeloma cell infiltration, extramedullary disease, treatment efficacy, and prognosis. However, there is room to improve their accuracy and specificity for assessment of treatment response, tumor volume, and residual disease. This review introduces novel diagnostic techniques, such as WBLDCT, MRI, and PET/CT, discusses their contribution to MM care, and lists areas for future research., (© 2022. Japanese Society of Hematology.)
- Published
- 2022
- Full Text
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42. Low clinical protective response to SARS-CoV-2 mRNA COVID-19 vaccine in patients with multiple myeloma.
- Author
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Terao T, Yamashita T, Fukumoto A, Kamura Y, Ikeda D, Kuzume A, Tabata R, Tsushima T, Miura D, Narita K, Takeuchi M, Doi M, Umezawa Y, Otsuka Y, Takamatsu H, and Matsue K
- Subjects
- Antibodies, Viral, BNT162 Vaccine, COVID-19 Vaccines, Humans, Prospective Studies, RNA, Messenger, SARS-CoV-2, COVID-19 prevention & control, Multiple Myeloma therapy, Vaccines
- Abstract
We conducted a prospective, three-center, observational study in Japan to evaluate the prevalence of seropositivity and clinically protective titer after coronavirus disease 2019 vaccination in patients with plasma cell dyscrasia(PCD). Two-hundred sixty-nine patients with PCD [206 symptomatic multiple myeloma (MM)] were evaluated. Seropositivity was observed in 88.7% and a clinically protective titer in 38.3% of MM patients, both of which were significantly lower than those of healthy controls. Patients receiving anti-CD38 antibodies had much lower antibody titers, but antibody titers recovered in those who underwent a wash-out period before vaccine administration. Older age (≥65), anti-CD38 antibody administration, immunomodulatory drugs use, lymphopenia (<1000/μL), and lower polyclonal IgG (<550 mg/dL) had a negative impact for the sufficient antibody production according to multivariate analysis. Patients with clinically protective titer had a significantly higher number of CD19+ lymphocytes than those with lower antibody responses (114 vs. 35/μL, p = 0.016). Our results suggested that patients with PCD should be vaccinated, and that the ideal protocol is to temporarily interrupt anti-CD38 antibody therapy for a "wash-out" period of a few months, followed by a (booster) vaccine after the B-cells have recovery., (© 2022. Japanese Society of Hematology.)
- Published
- 2022
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43. Antibody response to COVID-19 vaccination in patients with lymphoma.
- Author
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Narita K, Nakaji S, Tabata R, Terao T, Kuzume A, Tsushima T, Ikeda D, Fukumoto A, Miura D, Takeuchi M, Doi M, Umezawa Y, Otsuka Y, Takamatsu H, and Matsue K
- Subjects
- Antibodies, Viral, Antibody Formation, COVID-19 Vaccines, Humans, SARS-CoV-2, Vaccination, COVID-19 prevention & control, Lymphoma therapy, Vaccines
- Abstract
Patients with lymphoma are at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, evaluation of SARS-CoV-2 vaccination efficacy is essential. We conducted a prospective observational study to monitor the antibody response in 500 patients with lymphoma after SARS-CoV-2 vaccination. Antibody levels increased in a stepwise manner after the first and second dose of the vaccine. After completion of the two-dose series, anti-S antibody was negative in 109 patients (21.8%), and below clinically protective levels (anti-S ≥ 264 U/mL) in 236 patients (47.2%). The median anti-S titers at 0-6 months, 7-12 months, 13-24 months, and 24 months after treatment completion were 0.4 U/mL, 3.8 U/mL, 270 U/mL, and 650 U/mL, respectively. Multivariate analysis showed that receiving the vaccine < 6 months since completing treatment, white blood cell count < 5050/μL, percentage of CD19 + cells < 10%, CD4 + cells < 27%, immunoglobulin (Ig) A < 195 mg/dL, IgM < 50 mg/dL, serum soluble interleukin 2 receptor > 600 U/mL, and presence of lymphoma cells in the peripheral blood were significantly correlated with anti-S < 264 U/mL. Lymphoma patients had variably impaired antibody response to the SARS-CoV-2 vaccine. We identified various factors to predict COVID-19 vaccine effectiveness in lymphoma patients that may help tailoring possible vaccine boosters., (© 2022. Japanese Society of Hematology.)
- Published
- 2022
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44. Depletion of CD38-positive regulatory T cells by anti-CD38 monoclonal antibodies induces a durable response to SARS-CoV-2 vaccination in patients with plasma cell dyscrasia.
- Author
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Terao T, Naduka T, Ikeda D, Fukumoto A, Kamura Y, Kuzume A, Tabata R, Tsushima T, Miura D, Narita K, Takeuchi M, and Matsue K
- Subjects
- Antibodies, Monoclonal therapeutic use, Antibodies, Viral, COVID-19 Vaccines, Humans, RNA, Messenger, SARS-CoV-2, T-Lymphocytes, Regulatory, Vaccination, COVID-19 prevention & control, Neoplasms, Plasma Cell, Paraproteinemias
- Abstract
This study reports the relationship between CD38
+ regulatory T cells (Tregs) and messenger RNA coronavirus disease 2019 (mRNA-COVID-19) vaccination in 60 patients with plasma cell dyscrasia. Patients treated with anti-CD38 monoclonal antibodies (mAbs) had significantly lower CD38+ Tregs than those not treated (0.9 vs. 13.2/μl). Late-responders, whose antibody titres increased from weeks 4-12 after the second vaccination, had significantly lower CD38+ Treg counts than non-late-responders (2.5 vs. 10.3/μl). Antibody titres in patients with lower CD38+ Treg levels were maintained from weeks 4-12 but decreased in those with higher CD38+ Treg levels. Therefore, depletion of CD38+ Tregs by anti-CD38 mAbs may induce a durable response to mRNA-COVID-19 vaccination., (© 2022 British Society for Haematology and John Wiley & Sons Ltd.)- Published
- 2022
- Full Text
- View/download PDF
45. Antibody response to COVID-19 vaccine in 130 recipients of hematopoietic stem cell transplantation.
- Author
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Tsushima T, Terao T, Narita K, Fukumoto A, Ikeda D, Kamura Y, Kuzume A, Tabata R, Miura D, Takeuchi M, and Matsue K
- Subjects
- Antibody Formation, COVID-19 Vaccines, Humans, Retrospective Studies, Transplantation, Autologous, Transplantation, Homologous, COVID-19 prevention & control, Hematopoietic Stem Cell Transplantation
- Abstract
We evaluated anti-spike protein antibody (anti-S) production in 130 hematopoietic stem cell transplant (HSCT) recipients who received the coronavirus disease-2019 vaccine. Sixty-five received allo-HSCT and 65 received auto-HSCT. Disease-specific treatments were being administered to 43.1% of allo-HSCT and 69.2% of auto-HSCT patients. Seropositivity was observed in 87.7% of allo-HSCT and 89.2% in auto-HSCT patients. Anti-S antibody production was significantly impaired in auto-HSCT patients compared with controls (178U/mL [0.4-4990.0] vs. 669 U/mL [40.3-4377.0], p < 0.001), but not in allo-HSCT patients (900 U/mL [0.4-12,893.0] vs. 860 U/mL [40.3-8988.0], P = 0.659). Clinically relevant anti-S antibody levels (> 264 U/mL) were achieved in 59.2% of patients (76.9% in allo-HSCT and 41.5% in auto-HSCT). The main factors influencing the protective level of the antibody response were the CD19 + cell count and serum immunoglobulin G levels, and these were significant in both allo-HSCT and auto-HSCT patients. Other factors included time since HSCT, complete remission status, use of immunosuppressive drugs, and levels of lymphocyte subsets including CD4, CD8 and CD56 positive cells, but these were only significant in allo-HSCT patients. Allo-HSCT patients had a relatively favorable antibody response, while auto-HSCT patients had poorer results., (© 2022. Japanese Society of Hematology.)
- Published
- 2022
- Full Text
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46. Carfilzomib-induced thrombotic microangiopathy is underestimated in clinical practice: A report of five patients and literature review.
- Author
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Terao T, Tsushima T, Miura D, Ikeda D, Fukumoto A, Kuzume A, Tabata R, Narita K, Takeuchi M, and Matsue K
- Subjects
- Combined Modality Therapy, Humans, Male, Oligopeptides adverse effects, Multiple Myeloma complications, Thrombotic Microangiopathies chemically induced, Thrombotic Microangiopathies diagnosis, Thrombotic Microangiopathies epidemiology
- Abstract
Carfilzomib (Cfz) is widely used to treat multiple myeloma. However, real-world data of the incidence of thrombotic microangiopathy (TMA) caused by Cfz is inconsistent (<1-5%). We evaluated 96 consecutive patients who received Cfz to evaluate the incidence of TMA in clinical practice. TMA developed in five patients (5.2%) who were mainly receiving high-dose Cfz (≥56 mg/m
2 ). Based on a literature review, precaution should be taken for Cfz-induced TMA in male patients receiving high-dose Cfz irrespective of the combination therapy, Cfz administration period, and complement level. In conclusion, Cfz-induced TMA might be underestimated in clinical practice, and early intervention should be considered.- Published
- 2022
- Full Text
- View/download PDF
47. Impact of climate factors, especially temperature and relative humidity on mood fluctuations in bipolar spectrum disorder.
- Author
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Hirakawa H and Terao T
- Subjects
- Affect, Humans, Humidity, Temperature, Bipolar Disorder
- Published
- 2022
- Full Text
- View/download PDF
48. Editorial: Insights in Psychological Therapies: 2021.
- Author
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Terao T and Kumari V
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Published
- 2022
- Full Text
- View/download PDF
49. Fatal thrombotic microangiopathy with rhabdomyolysis as an initial symptom after the first dose of mRNA-1273 vaccine: A case report.
- Author
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Kamura Y, Terao T, Akao S, Kono Y, Honma K, and Matsue K
- Subjects
- 2019-nCoV Vaccine mRNA-1273, COVID-19 Vaccines adverse effects, Humans, Male, COVID-19, Rhabdomyolysis etiology, Thrombotic Microangiopathies etiology
- Abstract
We report a case of a Japanese man with severe rhabdomyolysis and multiple thrombosis of arterioles after the first dose of mRNA-1273 vaccine. He developed rapidly progressive rhabdomyolysis and infarctions of multiple organs. Antiplatelet factor 4 antibody test was negative. Despite the intensive supportive care, including aggressive fluid administration, hemodialysis, administration of anticoagulants, high-dose steroid, and eculizumab, the patient ultimately died of multiple organ failure. Autopsy revealed multiple thrombosis in the arterioles and organ necrosis. Low serum complements and C3 deposition in the renal glomeruli detected by immunofluorescence suggested a possible immune-mediated mechanism. To our knowledge, this is the first case report of rhabdomyolysis and multiple thrombosis of the arterioles as an adverse event following COVID-19 vaccination., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
50. A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling.
- Author
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Abe Y, Sakata-Yanagimoto M, Fujisawa M, Miyoshi H, Suehara Y, Hattori K, Kusakabe M, Sakamoto T, Nishikii H, Nguyen TB, Owada Y, Enomoto T, Sawa A, Bando H, Yoshida C, Tabata R, Terao T, Nakayama M, Ohshima K, Usuki K, Oda T, Matsue K, and Chiba S
- Subjects
- Humans, Lymph Nodes pathology, Lymphocytes, Transcriptome, Endothelial Cells, Lymphoma genetics, Lymphoma pathology
- Abstract
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our understanding of lymphoma NHCs has been hampered by unexplained NHC heterogeneity, even in normal human lymph nodes (LNs). Here we constructed a single-cell transcriptome atlas of more than 100,000 NHCs collected from 27 human samples, including LNs and various nodal lymphomas, and it revealed 30 distinct subclusters, including some that were previously unrecognized. Notably, this atlas was useful for comparative analyses with lymphoma NHCs, which revealed an unanticipated landscape of subcluster-specific changes in gene expression and interaction with malignant cells in follicular lymphoma NHCs. This facilitates our understanding of stromal remodelling in lymphoma and highlights potential clinical biomarkers. Our study largely updates NHC taxonomy in human LNs and analysis of disease status, and provides a rich resource and deeper insights into LN and lymphoma biology to advance lymphoma management and therapy., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
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