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Case Report: Hemophilia A is a hereditary bleeding disorder due to factor VIII deficiency. With the advances in the treatment of hemophilia in recent years, the average life expectancy of patients has reached the healthy population. Along with prolonged life, additional diseases and intervention requirements are developing in this patient group. Due to the developments, management of patients going under interventions are more clear and easier. In this case, a patient who underwent an intervention with extended half-life factor therapy was presented.Forty-three-year-old male patient with severe hemophilia A was evaluated on request for circumcision surgery while using prophylactically extended half-life factor therapy 2 × 1000 Units / week. Tranexamic acid was started one day preoperatively to the patient whose basal factor level was below 1% and whose inhibitory level was negative. Body weight of the patient was 63 kg. Extended half-life factor VIII preparation (efmorogtocog alfa) loading dose of 3000 units was administered befrore half an hour of the procedure. aPtt was detected for 30 seconds and factor VIII level was 55% 30 minutes after loading dose. The patient was given appropriate sedative treatment to prevent pre-perioperative erection. The operation was carried out without any problems. 1500 Units 12 hours after the loading dose, and 24 hours after this dose was performed. The patient was discharged without complications without bleeding. Factor therapy was continued with prophylaxis dosing. Tranexamic acid was continued for 7 days. No complications were observed.Interventional procedures of hemophilia patients can be performed without complications with a multidisciplinary approach under appropriate dose and scheme factor therapy. In the case, an interventinal procedure was made by giving an extended half-life factor to a severe hemophilia patient who could not have a circumcision operation for many years due to previous hesitations of both patient and surgeons.

OBJECTIVE: Our aim in this study was to investigate the effect of Gallic acid (GA) on gingival tissue injury. MATERIALS AND METHODS: Twenty rats were categorized into two groups. In the burn group, an excisional wound area was created by removing a 4 mm diameter flap from the left molar region in the mucoperiosteal region of the gingiva. In the Burn+gallic acid group, 1.2 mg/ml GA was administered as irrigation for 1 week. Animals were sacrificed under anesthesia at the end of experiment. Malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) levels were measured. Hematoxylin Eosin, fibroblast growth factor (FGF) and epidermal growth factor (EGF) immunostaining were applied to tissues. RESULTS: MDA and MPO levels increased, and GSH, epithelization, FGF and EGF expression levels were decreased. Gallic acid treatment improved these scores. Degenerated gingival epithelium, disintegrity in epithelial and connective tissue fibers, edema and inflammatory cells were observed in the burn group. Gallic acid treatment after burn improved the pathologies. After burn injury, FGF and EGF activity was increased in Gallic acid-treated groups. CONCLUSIONS: We suggest that GA has the potential for better healing outcomes in oral wounds. GA seems to have promising therapeutic efficacy in enhancing oral wound healing. [ABSTRACT FROM AUTHOR]

Abstract Background/Aims: In this study, the results of patients who had orthotopic heart transplantation (OHT) in acute rejection who admitted to our clinic with decompensated heart failure and who could not undergo endomyocardial biopsy (EMB) were evaluated. Methods: The study included 27 patients who underwent OHT in our clinic between December 1998 and November 2021, who admitted with acute rejection causing decompensated heart failure during follow-up, and who could not undergo EMB and administered IV pulse steroid plus plasmapheresis. Demographics of patients, peri-treatment left ventricular functions, survival rates and causes of mortality were analyzed. Results: 19 (70.4%) were male and mean age was 28.7 ± 14.7 (range: 3-54). After OHT, overall survival rates were 92.6%, 77.6%, and 69.4% at 1st, 3rd and 5th year respectively. During the follow-up, the survival rates of patients who presented with decompensated heart failure and given pulse steroid plus plasmapheresis were 70.4%, 58.8%, and 53.4% at 1st, 3rd and 5th year respectively after plasmapheresis. Median rejection time after transplant was 19 months (range 0-113 months). Pre-, and post-treatment left ventricle ejection fractions were 25.11% ± 11.1%, and 52.14% ± 13.4% respectively (p

Objective: There is limited data in the literature on the mental health of newly diagnosed hematological cancer (HC) patients in COVID-19 pandemic. This study evaluates the mental health statuses of HC inpatients diagnosed during the COVID-19 pandemic in comparison to the statuses of patients diagnosed with HC before the pandemic. Methodology: A cross-sectional survey collected the mental health measurements of 77 inpatients with HC between March and May 2021. The levels of depression, generalized anxiety, distress, sleep disorder, health anxiety, trait anxiety, coronaphobia, and resilience in HC patients newly diagnosed during the pandemic (NDHC) (n=38) and HC patients diagnosed before the pandemic (BPHC) (n=39) were compared. The relationships between predictive factors and cancer patients’ mental health statuses were evaluated. Results: Depression (63.2% vs. 35.9%, p=0.017) and sleep disorder (67.8% vs. 38.5, p=0.016) were significantly higher, while generalized anxiety (57.9% vs. 38.5%, p=0.088) and distress (52.6% vs. 33.3%, p=0.087) were higher in NDHC.Health anxiety was more common in BPHC (53.8% vs. 31.6%, p=0.048).Among NDHC, women had more anxiety symptoms than men (76.5% vs. 42.9%, p=0.037).Diagnosing newly increased the risk of severity of depression and sleep disorders, bu decreased the risk of health anxiety. Conclusion: Our data indicate that patients with HC are vulnerable to mental health problems in the COVID-19 pandemic. This vulnerability is higher in newly diagnosed HC patients than in patients diagnosed before the pandemic. These findings may help develop interventions that reduce the vulnerability to adverse psychological effects by identifying risk factors for HC patients under pandemic conditions.

Background: The aim of the study was to investigate the changes occurring in the mandibular condyle by using mentoplate together with rapid maxillary expansion (MP-RME) treatment in the correction of skeletal class III relationship, using fractal analysis (FA)., Methods: The sample consisted of 30 individuals (8-11 years) diagnosed with skeletal Class III malocclusion who underwent MP-RME treatment. Archival records provided cone-beam computed tomography (CBCT) images taken at two intervals: before MP-RME treatment (T0) and after treatment (T1). The CBCT images were obtained using standardized settings to ensure consistency in image quality and resolution. The trabecular structures in the bilateral condyles at both T0 and T1 were analyzed using FA. The FA was performed on these condylar images using the Image J software. The region of interest (ROI) was carefully selected in the condyle to avoid overlapping with cortical bone, and the box-counting method was employed to calculate the fractal dimension (FD). Statistical analysis was conducted to compare the FD values between T0 and T1 and to evaluate gender differences. The statistical significance was determined using paired t-tests for intra-group comparisons and independent t-tests for inter-group comparisons, with a significance level set at p < 0.05., Results: The analysis revealed no statistically significant differences in the trabecular structures of the condyles between T0 and T1 (p > 0.05). However, a significant gender difference was observed in FA values, with males exhibiting higher FA values in the left condyle compared to females at both T0 and T1 (p < 0.05). Specifically, the FA values in the left condyle increased from a mean of 1.09 ± 0.09 at T0 to 1.13 ± 0.08 at T1 in males, whereas in females, the FA values remained relatively stable with a mean of 1 ± 0.09 at T0 and 1.03 ± 0.11 at T1., Conclusion: The findings indicate that MP-RME therapy does not induce significant alterations in the trabecular structure of the mandibular condyle. These results suggest the treatment's safety concerning the structural integrity of the condyle, although the observed gender differences in FA values warrant further investigation., (© 2024. The Author(s).)

Objective: This study aimed to investigate the effect of a home exercise program on pain and quality of life (QoL) in TMD., Methods: Twenty patients were included in the study. The Group A received both a home exercise program and a physiotherapy program, while only a physiotherapy program was given to the Group B. Pain was measured using the Visual Analogue Scale (VAS) and QoL using the Short-Form 36 (SF-36)., Results: Pain decreased in both groups (p < 0.05). Among the SF-36 domains, bodily pain, vitality and social functioning scores improved in the Group A, while only the bodily pain parameter improved in the Group B (p < 0.05). On between-group comparison, the positive effect on pain and quality of life was greater in the Group A (p < 0.05)., Conclusion: The addition of a home exercise program to the conventional physiotherapy program provided greater improvement in pain and QoL in patients with TMD.

Background: Nasal septum osteotomy is used for separating the nasal septum and maxilla during a Le Fort I osteotomy. If this osteotomy is applied too high or is tilted into the nasal cavity, the sphenoid sinus and various adjacent vital structures may be damaged, and serious bleeding, neurological complications, blindness or even death may occur. The aim of this study is to determine the safety margin of the nasal septum osteotomy for sphenoid sinus during the Le Fort I surgery in cleft lip and palate (CLP) patients., Methods: Twenty cleft lip and palate (the CLP group) and 20 healthy individuals (the control group) were included in this study. Three values (two lines and an angle) were measured by cone beam computed tomography (CBCT). The first line is the line passing through the junction of the spina nasalis anterior point and the lower point of the perpendicular lamina of the palatine bone. The undersired line is the line passing through the junction of the spina nasalis anterior point and the lower anterior border of the base of the sphenoid sinus. The osteotomy angle is the angle between these two lines., Results: In the control group; a surgical line of 44.11-61.14 mm (mean 51.91 ± 4.32), an undesired line of 52.48-69.58 mm (mean 59.14 ± 5.08) and an angle of 18.22-27.270 (mean 22.66 ± 2.55) were found, while in the CLP group, a surgical line of 34.53-51.16 mm (mean 43.38 ± 4.79), an undesired line of 46.86-61.35 mm (mean 55.02 ± 3.24) and an angle of 17.60-28.810 (mean 22.60 ± 2.81) were found., Conclusions: Although the angle to the sphenoid sinus was not significantly affected by CLP, careful planning and consideration of these anatomical differences are crucial to prevent complications and ensure the safety of Le Fort I surgery in CLP patients. Further research with larger sample sizes and subgroup analysis of unilateral and bilateral CLP cases is needed to improve our understanding of these anatomical variations and improve surgical approaches to individuals with CLP undergoing orthognathic procedures., (© 2024. The Author(s).)

Purpose: The anatomical position of the lingula is clinically very important to prevent injuries during sagittal split ramus osteotomy. Our study aims to evaluate the localisation of the lingula by cone beam computed tomography (CBCT) and to compare the localisation of the lingula between malocclusion, gender, and lingula types., Methods: A retrospective study was conducted to evaluate the shape and location of the lingula using CBCT. A total of 250 CBCT images were included in this study. The lingula was classified as nodular, assimilated, truncated, or triangular type. Six defined distances from the top of the lingula were measured: anterior border of the ramus (L-A), posterior border of the ramus (L-P), internal oblique ridge (L-IOR), mandibular notch (L-N), and distal surface of the mandibular second molar (L-M2) and occlusal plane (L-OP). The measured distances were compared between gender, malocclusion, and lingula types., Results: The most common type of lingula was nodular (32.4%). The L-N, L-P, L-M2, and L-OP distances between genders were statistically higher in male patients than in female patients. The L-IOR, L-M2, and L-OP distances exhibited statistically significant differences found between malocclusions. No statistically significant difference was found when the distances of the lingula to the anatomical points were compared between the lingula types., Conclusion: These variations in positioning of the lingula depending on the dysmorphoses are developing towards a systematic 3D examination before any mandibular osteotomy to precisely visualize the position and shape of the lingula., (© 2024. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.)

Background: The aim of our study is to evaluate the postoperative complications after the extraction of impacted third molar teeth and to investigate the effects of these complications on the quality of life of patients., Methods: Demographic, clinical, and radiological evaluations were conducted, covering factors like age, gender, and tooth position. Clinical measurements, pain and edema assessments, and quality of life evaluations through OHIP-14 scores were performed. Preoperative and postoperative mouth opening, trismus, alveolitis and dehiscence were evaluated., Results: A total of 100 patients were included in our study. No significant gender-based differences were found in measurements, pain, or swelling. There was no statistically significant difference between the preoperative and postoperative results of difference A-C, difference B-E, difference A-D, and difference mouth opening. Procedure duration correlated positively with age, alveolar osteitis, trismus, and swelling. Postoperative quality of life, assessed by OHIP-14, demonstrated a negative correlation with age and trismus. It was observed that the gender and the tooth positions of the patients had no effect on the severity of postoperative pain and edema., Conclusions: As the age of the patients increases and the duration of the procedure increases, the rate of postoperative complications increases and it is concluded that the quality of life decreases significantly., (© 2024. The Author(s).)

Wastewater management has become crucial for sustaining biological life in the near future. One of the key aspects is integration of treatment processes aiming reuse of treated water for many purposes instead of water discharge. This study focused on combining two different methods, photo-Fenton-like oxidation, and adsorption, for treatment of real textile wastewater to improve water quality to be reused for irrigation. The real textile wastewater was collected from a local plant and subjected to photo-Fenton-like oxidation and adsorption as hybrid process. The operational parameters were optimized for each step by assessing the water quality according to the domestic regulations for irrigation water. The photo-Fenton-like oxidation itself was not successful to achieve the targeted water quality for reuse whereas adsorption as an additional step made the treated water reusable in terms of organic content. But the treated water still contained a certain amount of salinity due to extreme salt usage in textile processing. It was concluded that the treated water at the end of hybrid process could be used for salinity resistant plants such as sugar beet, barley, and cotton which demonstrates a promising contribution to the circular economy for biomass., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Background: COVID-19 is known to be transmitted by direct contact, droplets or feces/orally. There are many factors which determines the clinical progression of the disease. Aminoacid disturbance in viral disease is shown in many studies. İn this study we aimed to evaluate the change of aminoacid metabolism especially the aspartate, glutamine and glycine levels which have been associated with an immune defence effect in viral disease., Methods: Blood samples from 35 volunteer patients with COVID-19, concretized diagnosis was made by oropharyngeal from nazofaringeal swab specimens and reverse transcriptase-polymerase chain reaction, and 35 control group were analyzed. The amino acid levels were measured with liquid chromatography-mass spectrometry technology. Two groups were compared by Kolmogorov-Smirnov analysis, Kruskal-Wallis and the Mann-Whitney U . The square test was used to evaluate the tests obtained by counting, and the error level was taken as 0.05., Results: The average age of the patient and control group were 48.5 ± 14.9 and 48.8 ± 14.6 years respectively. The decrease in aspartate (p = 5.5 × 10 -9 ) and glutamine levels (p = 9.0 × 10 -17 ) were significiantly in COVID group, whereas Glycine (p = 0.243) increase was not significiant., Conclusions: Metabolic pathways, are affected in rapidly dividing cells in viral diseases which are important for immun defence. We determined that aspartate, glutamine and glycine levels in Covid 19 patients were affected by the warburg effect, malate aspartate shuttle, glutaminolysis and pentose phosphate pathway. Enteral or parenteral administration of these plasma amino acid levels will correct the duration and pathophysiology of the patients' stay in hospital and intensive care., Competing Interests: Conflict of interestThe authors declare that there are no potential conflicts of interest regarding the research, authorship and publication of this article., (© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022.)

The buckling behavior of sandwich shells with functionally graded (FG) coatings operating under different external pressures was generally investigated under simply supported boundary conditions. Since it is very difficult to determine the approximation functions satisfying clamped boundary conditions and to solve the basic equations analytically within the framework of first order shear deformation theory (FOST), the number of publications on this subject is very limited. An analytical solution to the buckling problem of FG-coated cylindrical shells under clamped boundary conditions subjected to uniform hydrostatic pressure within the FOST framework is presented for the first time. By mathematical modeling of the FG coatings, the constitutive relations and basic equations of sandwich cylindrical shells within the FOST framework are obtained. Analytical solutions of the basic equations in the framework of the Donnell shell theory, obtained using the Galerkin method, is carried out using new approximation functions that satisfy clamped boundary conditions. Finally, the influences of FG models and volume fractions on the hydrostatic buckling pressure within the FOST and classical shell theory (CT) frameworks are investigated in detail.

In this study, photo-Fenton-like oxidation method was evaluated for synthetic sugar industry wastewater using visible-light driven Cu-BiOI photocatalyst. Reaction conditions including initial pH, catalyst loading, initial hydrogen peroxide (H 2 O 2 ) concentration, and temperature, were optimized. At these optimized conditions, the total saccharide concentration (TSC) and total organic carbon (TOC) removals were 56.20% and 30.67%, respectively whereas the maximum TSC and TOC removal reached up to 93.35% and 74.72% respectively by decreasing initial sucrose concentration. The kinetic study showed that the reaction order for sucrose and TOC oxidation was determined as 2 for pseudo-homogeneous power law models with respect to sucrose concentration and TOC, respectively.For heterogeneous models, Langmuir-Hinshelwood model based on the mechanism of adsorbed pollutant and oxidant on different catalytic sites was the best fit for oxidation of sucrose and other organic intermediates. According to the catalyst characterization studies, incorporation of copper was successful and Cu-BiOI possesses high photocatalytic activity accomplished by acid-assisted synthesis method., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

This study aimed to psychometrically evaluate the Turkish version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) in women with MS. The study included 130 women with MS. The Turkish linguistic validation process of the original English MSISQ-15 was performed according to standardized guidelines. Reliability analysis was evaluated with test-retest analysis and intra-class correlation (ICC). Internal consistency between the items was analyzed using the Cronbach's alpha coefficient. Item analysis results were used to assess the contribution of the items to the scale. In evaluating the validity of the scale, the relationship between the MSISQ and the Female Sexual Function Index (FSFI), the Multiple Sclerosis Quality of Life Questionnaire-54 (MSQOL-54), and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PSIQ-12) was investigated. Psychometric properties were analyzed using internal consistency, test-rest reliability, construct validity, and floor-ceiling effect. The internal consistency of the Turkish MSISQ-15 was strong in terms of both sub-dimension score and the total score (Cronbach's a coefficient > 0.80). The test-retest reliability of the scale was very strong (ICC > 0.90). A medium-high correlation was found between the MSISQ-15 and the MSQOL-54, the FSFI, and the PSIQ-12 (between r = -0.448 and r = -0.798, p < 0.001, respectively). The MSISQ-15 is a comprehensive, reliable, and valid inventory to obtain information about the cause of sexual dysfunction in Turkish women with MS and to evaluate the level of sexual dysfunction. In future studies, it is recommended to examine the sensitivity of the Turkish MSISQ-15 to treatment-related changes., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Background: Eosinophils constitute 1%-5% of peripheral blood leukocytes, less in the presence of acute infections (referred to as eosinopenia). Studies indicate that eosinopenia can be used as a prognostic predictor for chronic obstructive pulmonary disease exacerbation, sepsis, or acute myocardial infarction disease. There are only a few studies about predicting mortality in emergency departments and intensive care units (ICUs). Prognostic studies about patients in ICUs are generally carried out using different scoring systems. We aimed to analyze if the eosinophil count can estimate the prognosis among non-traumatic patients who underwent cardiopulmonary resuscitation and were hospitalized in ICU thereafter., Methods: The data were evaluated of 865 non-traumatic adult patients (>18 years of age) who were admitted with cardiopulmonary arrest or developed cardiopulmonary arrest during clinical follow-ups. Admission venous blood sample tests, complete blood count, and biochemical laboratory results were recorded. Arterial blood gas results were also evaluated. The mean results of the recorded laboratory results were compared between the surviving and non-surviving patients groups., Results: There was a significant difference between the two groups in regard to platelet, eosinophil count, pH, PaO 2 , SaO 2 , and HCO 3 - (P<0.001 for all). In the multiple linear regression analysis, eosinophil counts were found to be an independent factor (odds ratio=0.03, 95% confidence interval 0.33-0.56, P<0.001) associated with the mortality after cardiopulmonary resuscitation., Conclusion: Because admission eosinophil counts can be measured easily, they are inexpensive biomarkers that can be used for predicting the prognosis among the patients who have return of spontaneous circulation and are treated in ICUs.