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1. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023
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2. SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

Author

Gioia, Ubaldo, Tavella, Sara, Martínez-Orellana, Pamela, Cicio, Giada, Colliva, Andrea, Ceccon, Marta, Cabrini, Matteo, Henriques, Ana C., Fumagalli, Valeria, Paldino, Alessia, Presot, Ettore, Rajasekharan, Sreejith, Iacomino, Nicola, Pisati, Federica, Matti, Valentina, Sepe, Sara, Conte, Matilde I., Barozzi, Sara, Lavagnino, Zeno, Carletti, Tea, Volpe, Maria Concetta, Cavalcante, Paola, Iannacone, Matteo, Rampazzo, Chiara, Bussani, Rossana, Tripodo, Claudio, Zacchigna, Serena, Marcello, Alessandro, and d’Adda di Fagagna, Fabrizio

Published
2023
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3. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Published
2024

4. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, Szewczyk, Nathaniel, Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, and Szewczyk, Nathaniel

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

5. Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis

Author

Masini, Maria Angela, Bonetto, Valentina, Manfredi, Marcello, Pastò, Anna, Barberis, Elettra, Timo, Sara, Vanella, Virginia Vita, Robotti, Elisa, Masetto, Francesca, Andreoli, Francesca, Fiore, Alessandra, Tavella, Sara, Sica, Antonio, Donadelli, Massimo, and Marengo, Emilio

Published
2022
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6. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-hahn, Juergen, Bottai, Daniele, Buchheim, Judith-irina, Calvaruso, Marco, Carnero-diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’innocenti, Andrea, Desaphy, Jean-francois, Frippiat, Jean-pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, Van Loon, Jack J.w.a., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, Monici, Monica, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-hahn, Juergen, Bottai, Daniele, Buchheim, Judith-irina, Calvaruso, Marco, Carnero-diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’innocenti, Andrea, Desaphy, Jean-francois, Frippiat, Jean-pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, Van Loon, Jack J.w.a., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Published
2024
Full Text
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7. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, Monici, Monica, Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024

8. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

9. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-hahn, Juergen, Bottai, Daniele, Buchheim, Judith-irina, Carnero-diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’innocenti, Andrea, Desaphy, Jean-francois, Frippiat, Jean-pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, Van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-hahn, Juergen, Bottai, Daniele, Buchheim, Judith-irina, Carnero-diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’innocenti, Andrea, Desaphy, Jean-francois, Frippiat, Jean-pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, Van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024
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10. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

Published
2023

12. P1327: INHIBITING TELOMERIC DNA DAMAGE RESPONSE AS A NEW THERAPEUTIC STRATEGY TO REJUVENATE THE AGEING HEMATOPOIETIC SYSTEM

Author

Oppezzo, Alessia, primary, Sepe, Sara, additional, Rossiello, Francesca, additional, Conti, Anastasia, additional, Marinelli, Eugenia, additional, Boggio, Sara, additional, Lillo, Alessia DI, additional, Rosso, Ilaria, additional, Tavella, Sara, additional, Matti, Valentina, additional, Cicio, Giada, additional, Cancila, Valeria, additional, Mancheno-Ferris, Alexandra, additional, Bertolazzi, Giorgio, additional, Iannelli, Fabio, additional, Micco, Raffaella DI, additional, Tripodo, Claudio, additional, and D’adda DI Fagagna, Fabrizio, additional

Published
2023
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14. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, Monici, Monica, Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, and Monici, Monica

Published
2023

15. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., Monici, Monica, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023

21. Traffic light at DSB–transit regulation between gene transcription and DNA repair.

Author

Modafferi, Stefania, Esposito, Francesca, Tavella, Sara, Gioia, Ubaldo, and Francia, Sofia

Subjects
*DOUBLE-strand DNA breaks, *RNA synthesis, *DNA damage, *GENETIC transcription, *GENETIC regulation, *DNA repair
Abstract

Transcription of actively expressed genes is dampened for kilobases around DNA lesions via chromatin modifications. This is believed to favour repair and prevent genome instability. Nonetheless, mounting evidence suggests that transcription may be induced by DNA breakage, resulting in the local de novo synthesis of non‐coding RNAs (ncRNAs). Such transcripts have been proposed to play important functions in both DNA damage signalling and repair. Here, we review the recently identified mechanistic details of transcriptional silencing at damaged chromatin, highlighting how post‐translational histone modifications can also be modulated by the local synthesis of DNA damage‐induced ncRNAs. Finally, we envision that these entangled transcriptional events at DNA breakages can be targeted to modulate DNA repair, with potential implications for locus‐specific therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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22. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis CRG, Calvaruso M, Angeloni D, Baatout S, Benchoua A, Bereiter-Hahn J, Bottai D, Buchheim JI, Carnero-Diaz E, Castiglioni S, Cavalieri D, Ceccarelli G, Chouker A, Cialdai F, Ciofani G, Coppola G, Cusella G, Degl'Innocenti A, Desaphy JF, Frippiat JP, Gelinsky M, Genchi G, Grano M, Grimm D, Guignandon A, Herranz R, Hellweg C, Iorio CS, Karapantsios T, van Loon J, Lulli M, Maier J, Malda J, Mamaca E, Morbidelli L, Osterman A, Ovsianikov A, Pampaloni F, Pavezlorie E, Pereda-Campos V, Przybyla C, Rettberg P, Rizzo AM, Robson-Brown K, Rossi L, Russo G, Salvetti A, Risaliti C, Santucci D, Sperl M, Tabury K, Tavella S, Thielemann C, Willaert R, Monici M, and Szewczyk NJ

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed., (© 2024. The Author(s).)

Published
2024
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23. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis T, Tabury K, Zhu S, Angeloni D, Baatout S, Benchoua A, Bereiter-Hahn J, Bottai D, Buchheim JI, Calvaruso M, Carnero-Diaz E, Castiglioni S, Cavalieri D, Ceccarelli G, Choukér A, Cialdai F, Ciofani G, Coppola G, Cusella G, Degl'Innocenti A, Desaphy JF, Frippiat JP, Gelinsky M, Genchi G, Grano M, Grimm D, Guignandon A, Hahn C, Hatton J, Herranz R, Hellweg CE, Iorio CS, Karapantsios T, van Loon JJWA, Lulli M, Maier J, Malda J, Mamaca E, Morbidelli L, van Ombergen A, Osterman A, Ovsianikov A, Pampaloni F, Pavezlorie E, Pereda-Campos V, Przybyla C, Puhl C, Rettberg P, Rizzo AM, Robson-Brown K, Rossi L, Russo G, Salvetti A, Santucci D, Sperl M, Tavella S, Thielemann C, Willaert R, Szewczyk N, and Monici M

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap "Biology in Space and Analogue Environments" focusing on "How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?" The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed., (© 2024. The Author(s).)

Published
2024
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24. Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.

Author

Pece R, Tavella S, Costa D, Varesano S, Camodeca C, Cuffaro D, Nuti E, Rossello A, Alfano M, D'Arrigo C, Galante D, Ravetti JL, Gobbi M, Tosetti F, Poggi A, and Zocchi MR

Subjects
Humans, Ki-1 Antigen, Membrane Proteins, Tumor Microenvironment, ADAM10 Protein antagonists & inhibitors, Brentuximab Vedotin therapeutic use, Hodgkin Disease drug therapy, Hodgkin Disease pathology, Immunoconjugates therapeutic use, Lymphoma drug therapy
Abstract

Shedding of ADAM10 substrates, like TNFa or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent such shedding in Hodgkin lymphoma (HL). Since tumor tissue architecture deeply influences the outcome of anti-cancer treatments, we set up a new threedimensional (3D) culture systems to verify whether ADAM10 inhibitors can contribute to, or enhance, the anti-lymphoma effects of the ADC brentuximab-vedotin (BtxVed). In order to recapitulate some aspects of lymphoma structure and architecture, we assembled two 3D culture models: mixed spheroids made of HL lymph node (LN) mesenchymal stromal cells (MSC) and Reed Sternberg/Hodgkin lymphoma cells (HL cells) or collagen scaffolds repopulated with LN-MSC and HL cells. In these 3D systems we found that: i) the ADAM10 inhibitors LT4 and MN8 reduce ATP content or glucose consumption, related to cell proliferation, increasing lactate dehydrogenase release as a cell damage hallmark; ii) these events are paralleled by mixed spheroids size reduction and inhibition of CD30 and TNFa shedding; iii) the effects observed can be reproduced in repopulated HL LN-derived matrix or collagen scaffolds; iv) ADAM10 inhibitors enhance the anti-lymphoma effect of the anti-CD30 ADC BtxVed both in conventional cultures and in repopulated scaffolds. Thus, we provide evidence for a direct and combined antilymphoma effect of ADAM10 inhibitors with BtxVed, leading to the improvement of ADC effects; this is documented in 3D models recapitulating features of the LN microenvironment, that can be proposed as a reliable tool for anti-lymphoma drug testing.

Published
2022
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