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Surgery is the mainstay of lung cancer treatment options. Traditionally, lobectomy has held its place as the gold standard for treating localized lung cancer, while sublobar resection, including wedge resection and segmentectomy, was primarily considered as an alternative, often reserved for patient ineligible to sustain a radical intervention. However, with the widespread application of computed tomography (CT) to clinical practice, the increasing detection rate of pulmonary ground glass nodules (GGNs) has reshaped this landscape. Ground glass opacity (GGO) in persistent lung nodules is an indicative factor of a favorable prognosis, typically corresponding to pathological changes such as atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), or adenocarcinomas predominantly featuring a lepidic growth pattern. A large number of retrospective studies have shown that sublobar resection can achieve satisfactory therapeutic outcomes for such lesions. A series of prospective studies from Japan have confirmed that for early-stage lung cancers dominated by GGOs, sublobar resection is also a viable curative surgical option. The follow-up data showed that there was no statistical difference in the survival status of these patients compared with that of pulmonary lobectomy. This article aims to delve into the role of limited lung resection in the context of lung adenocarcinoma presenting with GGO features.

Manganese dioxide has been significantly utilized in zinc ion batteries (ZIBs). However, in the rechargeable battery system, the manganese dioxide cathode suffers from poor conductivity, volume expansion, and substance dissolution, resulting in low capacity and poor stability. Herein, a 3D frame structure MnO2@CNTs cathode is proposed. In this system, the electrodeposited spherical MnO2 is anchored and interlinked via the in‐situ growth carbon nanotubes (CNTs) onto the carbon cloth. Benefiting the unique 3D frame structure, the MnO2 structure crush problem and the pathway of the electrons and ions are dramatically improved. The optimized MnO2@CNTs cathode demonstrate a high capacity of 256.35 mAh g−1 at 0.1 A g−1 and exceptional cycling stability. Furthermore, in‐situ Raman spectroscopy elucidates the energy storage mechanism of aqueous ZIBs (AZIBs). Moreover, COMSOL finite elements analysis demonstrates that the petal edge‐rich nanostructures of MnO2@CNTs generate a localized high electric field under constant current, accelerating ion/electron transfer. This work explains the rationale for CNTs to improve the properties of MnO2 cathodes, providing a new perspective for the design of high‐performance batteries. [ABSTRACT FROM AUTHOR]

In deep carbonate reservoirs, testing and production with open-hole completion can help release the maximum production capacity. However, because the reservoir is subjected to high in situ stress, if the test pressure differential is too large, the wellbore collapse and instability will occur easily, causing downhole accidents. Therefore, it is necessary to determine the state of the borehole during the open-hole test in the carbonate reservoir and analyze the ultimate test pressure differential accordingly to ensure test safety. Considering the characteristics of open-hole completion, based on the mechanical properties of the carbonate reservoir and the stress distribution around the borehole during testing, a calculation method of the elastic zone, plastic zone, and residual failure zone around the open-hole wellbore was proposed. Regarding actual engineering data, a criterion for the overall stability of the open-hole section had been established from three aspects: the volume ratio of the plastic zone; the failure zone around the wellbore; and the failure angle on the borehole wall. According to this criterion, it is possible to determine the ultimate pressure differential during the open-hole test process and provide theoretical support for designing the open-hole completion test and production parameters for deep carbonate reservoirs. [ABSTRACT FROM AUTHOR]

Background: Subclinical hypothyroidism (SH) increases the risk of cardiovascular events, however the influence of SH on prognosis of ejection fraction preserved heart failure (HFpEF) is not fully understood. Methods: In this prospective observational study, patients with HFpEF were divided into euthyroidism group (n = 413) and SH group (n = 79). Patients were followed up for at least 30 months to examine the association between SH and cardiovascular events in patients with HFpEF. The primary end point was composite cardiovascular events (cardiovascular death and re-hospitalization). The patients underwent flow-mediated dilation (FMD) measurement by ultrasound in order to value endothelial function. Results: The rate of composite cardiovascular events was higher in SH group than in euthyroidism group (54.49% and 26.36%, respectively; p < 0.001). The higher risk of cardiovascular events in SH group was primarily due to a higher risk of re-hospitalization compared to euthyroidism group (45.56% and 20.58%, respectively; p < 0.001). The rate of cardiovascular death was higher in SH group than in euthyroidism group (13.92% and 5.81%, respectively; p = 0.017). Cox proportional hazards regression showed that SH (hazard ratios [HR] 1.921, 95% confidence interval [CI] 1.139– 3.240), level of TSH (HR 1.025, 95% CI 1.010– 1.054), age (HR 1.017, 95% CI 1.002– 1.034), LVEF (HR 0.975, 95% CI 0.953– 0.996), atrial fibrillation (HR 1.581, 95% CI 1.083– 2.307), eGFR (HR 0.987, 95% CI 0.978– 0.997), and NYHA cardiac function (HR 2.342, 95% CI 1.649– 3.326) were independent predictors of cardiovascular events in patients with HFpEF (all P < 0.05). Conclusion: Subclinical hypothyroidism was associated with increased cardiovascular events and death in patients with HFpEF. [ABSTRACT FROM AUTHOR]

The vapor–solid reaction technique holds potential for producing large‐scale organic–inorganic perovskite films, using a two‐step deposition process. The sucess of perovskite formation heavily relies on the crystallization of lead iodide (PbI2) precursor films. However, the high crystallinity of PbI2 can hinder organic vapors' diffusion and negatively affecting the solar cells by increasing charge recombination and accelerating degradation. To address this, pyridinium trifluoromethanesulfonate (PTFS) is introduced into the PbI2 precursor solution to control the nucleation and growth of PbI2 films. PTFS has been found to effectively suppresses PbI2 crystallization and enhance the integration of formamidinium ion (FA+) through hydrogen bonding, facilitating the full transformation of PbI2 into perovskite. It also minimizes defect formation by interacting with uncoordinated Pb2+ and FA+ ions. These modifications have significantly enhanced power conversion efficiency (PCE), reaching up to 21.19%, and the devices have maintained 93% of their initial performance after 1580 h of exposure to air. [ABSTRACT FROM AUTHOR]