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5. Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization: CREDO-Kyoto PCI/CABG Registry

Author

Kimura, Takeshi, Shiomi, Hiroki, Matsuda, Mitsuo, Takeuchi, Yuzo, Mitsuoka, Hirokazu, Uegaito, Takashi, Nakagawa, Yoshihisa, Tamura, Toshihiro, Konishi, Takashi, Ootani, Seiji, Fujiwara, Hisayoshi, Takatsu, Yoshiki, Sato, Yukihito, Taniguchi, Ryoji, Kataoka, Kazuaki, Inoko, Moriaki, Nohara, Ryuji, Nakano, Kimisato, Miyamoto, Syoichi, Kunihiko, Nagai, Murakami, Tomoyuki, Takeda, Teruki, Ishida, Katsuya, Nobuyoshi, Masakiyo, Yamaji, Kyohei, Yasumoto, Hitoshi, Iwabuchi, Masashi, Ando, Kenji, Domei, Takenori, Kato, Masayuki, Tatami, Ryozo, Shirotani, Manabu, Hattori, Ryuichi, Kita, Toru, Furukawa, Yutaka, Ehara, Natsuhiko, Kihara, Yasuki, Eizawa, Hiroshi, Kato, Hiroshi, Ishii, Katsuhisa, Aoyama, Takeshi, Sakurai, Takahiro, Kawanami, Masaki, Suyama, Tamaki, Tada, Eiji, Tanaka, Masaru, Inada, Tsukasa, Uzui, Hiroyasu, Nakano, Akira, Lee, Jong-Dae, Onodera, Tomoya, Takizawa, Akinori, Ryuzo, Nawada, Shinoda, Eiji, Takahashi, Masaaki, Yamada, Miho, Horie, Minoru, Yamamoto, Takashi, Takashima, Hiroyuki, Sakai, Hiroshi, Tamura, Takashi, Toyofuku, Mamoru, Kotoura, Hajime, Miura, Akira, Takahashi, Mamoru, Matoba, Yoshiki, Takumi, Takuro, Tei, Chuwa, Hamasaki, Shuichi, Doi, Osamu, Kambara, Hirofumi, Kaburagi, Satoshi, Sakamoto, Hiroki, Tada, Tomohisa, Mitsudo, Kazuaki, Kadota, Kazushige, Tada, Takeshi, Miki, Shinji, Mizoguchi, Tetsu, Akira, Yoshida, Kaneda, Kazuhisa, Ogawa, Hisao, Sugamura, Koichi, Sugiyama, Seigo, Doyama, Kiyoshi, Araki, Makoto, Suwa, Satoru, Sakata, Ryuzo, Ikeda, Tadashi, Marui, Akira, Minatoya, Kenji, Yamazaki, Kazuhiro, Onoe, Masahiko, Ogawa, Tatsuya, Yamanaka, Kazuo, Iwakura, Atsushi, Ohno, Nobuhisa, Fujiwara, Keiichi, Hanyu, Michiya, Soga, Kinji, Matsushita, Tsutomu, Nishiwaki, Noboru, Yoshida, Yuichi, Tamura, Nobushige, Okada, Yukikatsu, Nasu, Michihiro, Koyama, Tadaaki, Nakayama, Shogo, Tanaka, Kuniyoshi, Koshiji, Takaaki, Morioka, Koichi, Shimamoto, Mitsuomi, Yamazaki, Fumio, Terai, Yasuhiko, Nishizawa, Junichiro, Aota, Masaki, Kanemitsu, Naoki, Hara, Hiroyuki, Tabata, Takafumi, Imoto, Yutaka, Yamamoto, Hiroyuki, Matsuda, Katsuhiko, Nara, Masafumi, Tsuneyoshi, Hiroshi, Komiya, Tatsuhiko, Nakajima, Hiroyuki, Esaki, Jiro, Kawasuji, Michio, Moriyama, Syuji, Tambara, Keiichi, Arimura, Sakiko, Fujino, Yumika, Hanazawa, Miya, Hibi, Chikako, Kato, Risa, Kinoshita, Yui, Kitagawa, Kumiko, Kitamura, Masayo, Kuwahara, Takahiro, Sachiko, Maeda, Miki, Izumi, Minematsu, Saeko, Nishida, Satoko, Okamoto, Naoko, Saeki, Asuka, Sasae, Hitomi, Sato, Yuki, Takahashi, Asuka, Takinami, Emi, Tezuka, Saori, Tsuda, Marina, Tsumori, Miyuki, Uchida, Yuriko, Yamamoto, Yuko, Yamauchi, Misato, Yamazaki, Itsuki, Yoshimoto, Mai, Abe, Mitsuru, Fuki, Masayuki, Hayano, Mamoru, Kato, Eri, Kato, Yoshihiro, Matsumura-Nakano, Yukiko, Nakajima, Tetsu, Nakatsuma, Kenji, Natsuaki, Masahiro, Takeji, Yasuaki, Tazaki, Junichi, Tokushige, Akihiro, Watanabe, Hiroki, Yaku, Hidenori, Yamamoto, Erika, Yamamoto, Ko, Yamashita, Yugo, Yoshikawa, Yusuke, Morimoto, Takeshi, Kato, Eri T., Imada, Kazuaki, Nishikawa, Ryusuke, Mabuchi, Hiroshi, and Soga, Yoshiharu

Published
2022
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7. Association of wound, ischemia, and foot infection clinical stage with frailty and malnutrition in chronic limb-threatening ischemia patients undergoing endovascular intervention.

Author

Otsuji, Hideaki, Kanda, Daisuke, Takumi, Takuro, Tokushige, Akihiro, Sonoda, Takeshi, Arikawa, Ryo, Anzaki, Kazuhiro, Ikeda, Yoshiyuki, and Ohishi, Mitsuru

Abstract

Objective: The Wound, Ischemia, and foot Infection (WIfI) clinical stage has been thought to have a prognostic value in Chronic limb-threatening ischemia (CLTI) patients, and frailty and nutritional status appear to represent pivotal factor affecting prognosis among CLTI patients. The purpose of this study was to examine clinical factors (including frailty and nutritional status) relevant to WIfI clinical stage. Methods: This retrospective study investigated 200 consecutive CLTI patients. We individually assessed WIfI clinical stage, frailty according to the Clinical Frailty Scale (CFS) score, and malnutrition according to Geriatric Nutritional Risk Index (GNRI). We then compared mortality after endovascular intervention between a WIfI stage 1, 2 group and a stage 3, 4 group, and investigated associations between baseline characteristics (including CFS and GNRI) and WIfI clinical stage. Results: Among 200 patients, 123 patients (62%) showed WIfI stage 1 or 2, and the remaining 77 patients (38%) had WIfI stage 3 or 4. CFS score was significantly higher in the WIfI stage 3, 4 group [median 6.0, interquartile range (IQR) 5.5–7.0] compared with the WIfI stage 1, 2 group (median 5.0, IQR 4.0–6.0, p < 0.001), and GNRI was significantly lower in the WIfI stage 3, 4 group (median 88, IQR 80–97) than in the WIfI stage 1, 2 (median 103, IQR 94–111, p < 0.001). Forty patients (20%) died after endovascular intervention. Incidences of all-cause and cardiac deaths were higher in the WIfI stage 3, 4 group than in the WIfI stage 1, 2 group (27% vs. 15%, p = 0.047 and 12% vs. 3%, p = 0.040, respectively). Kaplan–Meier analysis showed a significantly lower survival rate in the WIfI stage 3, 4 group than in the WIfI stage 1, 2 group (p = 0.002 by log-rank test). Multivariate logistic regression analysis using relevant factors from univariate analysis showed CFS score [odds ratio (OR) 2.06, 95% confidence interval (CI) 1.41–3.13, p < 0.001), diabetes mellitus (OR 3.17, 95%CI 1.17–8.61, p = 0.023) and GNRI (OR 0.93, 95%CI 0.89–0.97, p = 0.002) significantly associated with WIfI stage 3 or 4. In addition, multivariate ordinal logistic regression analysis for WIfI clinical stage showed CFS score (OR 1.43, 95%CI 1.09–1.89, p = 0.011), diabetes mellitus (OR 1.77, 95%CI 1.26–2.54, p < 0.001), and high-sensitivity C-reactive protein (OR 1.14, 95%CI 1.02–1.28, p = 0.041) were positively associated with WIfI clinical stage, and GNRI correlated negatively with WIfI clinical stage (OR 0.95, 95%CI 0.91–0.97, p < 0.001). Conclusions: These results indicate that CLTI patients with high WIfI clinical stage may be more frail and malnourished, and be associated with poor prognosis after endovascular intervention. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization

Author

Yamaji, Kyohei, primary, Shiomi, Hiroki, additional, Morimoto, Takeshi, additional, Matsumura-Nakano, Yukiko, additional, Ehara, Natsuhiko, additional, Sakamoto, Hiroki, additional, Takeji, Yasuaki, additional, Yoshikawa, Yusuke, additional, Yamamoto, Ko, additional, Kato, Eri T., additional, Imada, Kazuaki, additional, Tada, Takeshi, additional, Taniguchi, Ryoji, additional, Nishikawa, Ryusuke, additional, Tada, Tomohisa, additional, Uegaito, Takashi, additional, Ogawa, Tatsuya, additional, Yamada, Miho, additional, Takeda, Teruki, additional, Eizawa, Hiroshi, additional, Tamura, Nobushige, additional, Tambara, Keiichi, additional, Suwa, Satoru, additional, Shirotani, Manabu, additional, Tamura, Toshihiro, additional, Inoko, Moriaki, additional, Nishizawa, Junichiro, additional, Natsuaki, Masahiro, additional, Sakai, Hiroshi, additional, Yamamoto, Takashi, additional, Kanemitsu, Naoki, additional, Ohno, Nobuhisa, additional, Ishii, Katsuhisa, additional, Marui, Akira, additional, Tsuneyoshi, Hiroshi, additional, Terai, Yasuhiko, additional, Nakayama, Shogo, additional, Yamazaki, Kazuhiro, additional, Takahashi, Mamoru, additional, Tamura, Takashi, additional, Esaki, Jiro, additional, Miki, Shinji, additional, Onodera, Tomoya, additional, Mabuchi, Hiroshi, additional, Furukawa, Yutaka, additional, Tanaka, Masaru, additional, Komiya, Tatsuhiko, additional, Soga, Yoshiharu, additional, Hanyu, Michiya, additional, Domei, Takenori, additional, Ando, Kenji, additional, Kadota, Kazushige, additional, Minatoya, Kenji, additional, Nakagawa, Yoshihisa, additional, Kimura, Takeshi, additional, Matsuda, Mitsuo, additional, Takeuchi, Yuzo, additional, Mitsuoka, Hirokazu, additional, Konishi, Takashi, additional, Ootani, Seiji, additional, Fujiwara, Hisayoshi, additional, Takatsu, Yoshiki, additional, Sato, Yukihito, additional, Kataoka, Kazuaki, additional, Nohara, Ryuji, additional, Nakano, Kimisato, additional, Miyamoto, Syoichi, additional, Kunihiko, Nagai, additional, Murakami, Tomoyuki, additional, Ishida, Katsuya, additional, Nobuyoshi, Masakiyo, additional, Yamaji, Kyohei, additional, Yasumoto, Hitoshi, additional, Iwabuchi, Masashi, additional, Kato, Masayuki, additional, Tatami, Ryozo, additional, Hattori, Ryuichi, additional, Kita, Toru, additional, Kihara, Yasuki, additional, Kato, Hiroshi, additional, Aoyama, Takeshi, additional, Sakurai, Takahiro, additional, Kawanami, Masaki, additional, Suyama, Tamaki, additional, Tada, Eiji, additional, Inada, Tsukasa, additional, Uzui, Hiroyasu, additional, Nakano, Akira, additional, Lee, Jong-Dae, additional, Takizawa, Akinori, additional, Ryuzo, Nawada, additional, Shinoda, Eiji, additional, Takahashi, Masaaki, additional, Horie, Minoru, additional, Takashima, Hiroyuki, additional, Toyofuku, Mamoru, additional, Kotoura, Hajime, additional, Miura, Akira, additional, Matoba, Yoshiki, additional, Takumi, Takuro, additional, Tei, Chuwa, additional, Hamasaki, Shuichi, additional, Doi, Osamu, additional, Kambara, Hirofumi, additional, Kaburagi, Satoshi, additional, Mitsudo, Kazuaki, additional, Mizoguchi, Tetsu, additional, Akira, Yoshida, additional, Kaneda, Kazuhisa, additional, Ogawa, Hisao, additional, Sugamura, Koichi, additional, Sugiyama, Seigo, additional, Doyama, Kiyoshi, additional, Araki, Makoto, additional, Sakata, Ryuzo, additional, Ikeda, Tadashi, additional, Onoe, Masahiko, additional, Yamanaka, Kazuo, additional, Iwakura, Atsushi, additional, Fujiwara, Keiichi, additional, Soga, Kinji, additional, Matsushita, Tsutomu, additional, Nishiwaki, Noboru, additional, Yoshida, Yuichi, additional, Okada, Yukikatsu, additional, Nasu, Michihiro, additional, Koyama, Tadaaki, additional, Tanaka, Kuniyoshi, additional, Koshiji, Takaaki, additional, Morioka, Koichi, additional, Shimamoto, Mitsuomi, additional, Yamazaki, Fumio, additional, Aota, Masaki, additional, Hara, Hiroyuki, additional, Tabata, Takafumi, additional, Imoto, Yutaka, additional, Yamamoto, Hiroyuki, additional, Matsuda, Katsuhiko, additional, Nara, Masafumi, additional, Nakajima, Hiroyuki, additional, Kawasuji, Michio, additional, Moriyama, Syuji, additional, Arimura, Sakiko, additional, Fujino, Yumika, additional, Hanazawa, Miya, additional, Hibi, Chikako, additional, Kato, Risa, additional, Kinoshita, Yui, additional, Kitagawa, Kumiko, additional, Kitamura, Masayo, additional, Kuwahara, Takahiro, additional, Sachiko, Maeda, additional, Miki, Izumi, additional, Minematsu, Saeko, additional, Nishida, Satoko, additional, Okamoto, Naoko, additional, Saeki, Asuka, additional, Sasae, Hitomi, additional, Sato, Yuki, additional, Takahashi, Asuka, additional, Takinami, Emi, additional, Tezuka, Saori, additional, Tsuda, Marina, additional, Tsumori, Miyuki, additional, Uchida, Yuriko, additional, Yamamoto, Yuko, additional, Yamauchi, Misato, additional, Yamazaki, Itsuki, additional, Yoshimoto, Mai, additional, Abe, Mitsuru, additional, Fuki, Masayuki, additional, Hayano, Mamoru, additional, Kato, Eri, additional, Kato, Yoshihiro, additional, Nakajima, Tetsu, additional, Nakatsuma, Kenji, additional, Tazaki, Junichi, additional, Tokushige, Akihiro, additional, Watanabe, Hiroki, additional, Yaku, Hidenori, additional, Yamamoto, Erika, additional, and Yamashita, Yugo, additional

Published
2022
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12. The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins.

Author

Kanda D, Miyata M, Ikeda Y, Tokushige A, Sonoda T, Arikawa R, Anzaki K, Kosedo I, Yoshino S, Takumi T, and Ohishi M

Subjects
Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Humans, Lipoproteins, Angina, Stable drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods
Abstract

Aim: In this study, we aim to examine the clinical meaning of low-density lipoprotein cholesterol (LDL-C) ＜70 mg/dL as assessed by Friedewald equation [LDL-C (F)] and Martin method [LDL-C (M)] and non-high-density lipoprotein cholesterol (HDL-C) ＜100 mg/dL on the occurrence of new lesions among Japanese patients with stable angina who underwent percutaneous coronary intervention (PCI) and were prescribed with strong statins., Methods: Among the 537 consecutive stable angina patients who had underwent PCI and had been prescribed with strong statins, the association between the occurrence of new lesions with myocardial ischemia at the 9-month follow-up coronary angiography and ≤ 2 years after PCI and baseline characteristics were assessed., Results: New lesions appeared 9 months and ≤ 2 years after PCI in 31 and 90 patients, respectively. Multivariate logistic regression analysis revealed diabetes mellitus (DM) was significantly associated with the occurrence of new lesions ≤ 2 years after PCI [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.06-2.83, p=0.031], and only non-HDL-C ≥ 100 mg/dL was associated with the occurrence of new lesions both at 9 months and ≤ 2 years after PCI [OR 1.80, 95 % CI 1.10-3.00, p=0.021 and OR 1.85, 95 % CI 1.13-3.07, p=0.016]., Conclusions: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.

Published
2022
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