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6 results on '"Takehara, Kazuhiko"'

2. Efficacy and safety of tocilizumab in Japanese patients with systemic sclerosis and associated interstitial lung disease: A subgroup analysis of a global, randomised, controlled Phase 3 trial.

Author

Kuwana, Masataka, Takehara, Kazuhiko, Tanaka, Yoshiya, Yamashita, Katsuhisa, Katsumata, Kyoko, Takata, Mai, and Shima, Yoshihito

Subjects
*INTERSTITIAL lung diseases, *CLINICAL trials, *SYSTEMIC scleroderma, *JAPANESE people, *TOCILIZUMAB, *VITAL capacity (Respiration)
Abstract

Objectives: The aim of this article is to investigate the efficacy and safety of tocilizumab in Japanese patients with systemic sclerosis. Methods: Post hoc subgroup analysis of a global, randomised, controlled trial in patients treated with weekly tocilizumab 162 mg or placebo subcutaneously in a 48-week double-blind period (tocilizumab and placebo groups) followed by tocilizumab for 48 weeks in an open-label extension (continuous-tocilizumab and placebo-tocilizumab groups). Results: Among 20 patients, 12 were randomised to tocilizumab (all had interstitial lung disease) and eight were randomised to placebo (six had interstitial lung disease). The modified Rodnan skin score improved in both treatment groups. The mean change in percent-predicted forced vital capacity was 3.3% [95% confidence interval (CI), −2.5 to 9.0] for tocilizumab and −3.8% (95% CI, −9.9 to 2.2) for placebo in the double-blind period and 2.0% (95% CI, −0.7 to 4.6) for continuous-tocilizumab and −1.4% (95% CI, −6.7 to 4.0) for placebo-tocilizumab in the open-label extension. Rates of serious adverse events per 100 patient-years were 19.3 for tocilizumab and 26.8 for placebo in the double-blind period and 0.0 for continuous-tocilizumab and 13.6 for placebo-tocilizumab in the open-label period. Conclusions: The efficacy and safety of tocilizumab in patients with systemic sclerosis were consistent between the Japanese subpopulation and the global trial population. [ABSTRACT FROM AUTHOR]

Published
2024
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3. GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Author

Ishikawa, Yuki, primary, Tanaka, Nao, additional, Asano, Yoshihide, additional, Kodera, Masanari, additional, Shirai, Yuichiro, additional, Akahoshi, Mitsuteru, additional, Hasegawa, Minoru, additional, Matsushita, Takashi, additional, Saito, Kazuyoshi, additional, Motegi, Sei-ichiro, additional, Yoshifuji, Hajime, additional, Yoshizaki, Ayumi, additional, Kohmoto, Tomohiro, additional, Takagi, Kae, additional, Oka, Akira, additional, Kanda, Miho, additional, Tanaka, Yoshihito, additional, Ito, Yumi, additional, Nakano, Kazuhisa, additional, Kasamatsu, Hiroshi, additional, Utsunomiya, Akira, additional, Sekiguchi, Akiko, additional, Niiro, Hiroaki, additional, Jinnin, Masatoshi, additional, Makino, Katsunari, additional, Makino, Takamitsu, additional, Ihn, Hironobu, additional, Yamamoto, Motohisa, additional, Suzuki, Chisako, additional, Takahashi, Hiroki, additional, Nishida, Emi, additional, Morita, Akimichi, additional, Yamamoto, Toshiyuki, additional, Fujimoto, Manabu, additional, Kondo, Yuya, additional, Goto, Daisuke, additional, Sumida, Takayuki, additional, Ayuzawa, Naho, additional, Yanagida, Hidetoshi, additional, Horita, Tetsuya, additional, Atsumi, Tatsuya, additional, Endo, Hirahito, additional, Shima, Yoshihito, additional, Kumanogoh, Atsushi, additional, Hirata, Jun, additional, Otomo, Nao, additional, Suetsugu, Hiroyuki, additional, Koike, Yoshinao, additional, Tomizuka, Kohei, additional, Yoshino, Soichiro, additional, Liu, Xiaoxi, additional, Ito, Shuji, additional, Hikino, Keiko, additional, Suzuki, Akari, additional, Momozawa, Yukihide, additional, Ikegawa, Shiro, additional, Tanaka, Yoshiya, additional, Ishikawa, Osamu, additional, Takehara, Kazuhiko, additional, Torii, Takeshi, additional, Sato, Shinichi, additional, Okada, Yukinori, additional, Mimori, Tsuneyo, additional, Matsuda, Fumihiko, additional, Matsuda, Koichi, additional, Amariuta, Tiffany, additional, Imoto, Issei, additional, Matsuo, Keitaro, additional, Kuwana, Masataka, additional, Kawaguchi, Yasushi, additional, Ohmura, Koichiro, additional, and Terao, Chikashi, additional

Published
2024
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4. Perspective to precision medicine in scleroderma

Author

Komura, Kazuhiro, primary, Yanaba, Koichi, additional, Bouaziz, Jean-David, additional, Yoshizaki, Ayumi, additional, Hasegawa, Minoru, additional, Varga, John, additional, Takehara, Kazuhiko, additional, and Matsushita, Takashi, additional

Published
2024
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5. GWAS for Systemic Sclerosis Identified six novel susceptibility loci including penetrating Fcγ-Receptor Region

Author

Ishikawa, Yuki, primary, Tanaka, Nao, additional, Asano, Yoshihide, additional, Kodera, Masanari, additional, Shirai, Yuichiro, additional, Akahoshi, Mitsuteru, additional, Hasegawa, Minoru, additional, Matsushita, Takashi, additional, Saito, Kazuyoshi, additional, Motegi, Sei-ishiro, additional, Yoshifuji, Hajime, additional, Yoshizaki, Ayumi, additional, Komoto, Tomohiro, additional, Takagi, Kae, additional, Oka, Akira, additional, Kanda, Miho, additional, Tanak, Yoshihito, additional, Ito, Yumi, additional, Nakano, Kazuhisa, additional, Kasamatsu, Hiroshi, additional, Utsunomiya, Akira, additional, Sekiguchi, Akiko, additional, Niro, Hiroaki, additional, Jinnin, Masatoshi, additional, Makino, Katsunari, additional, Makino, Takamitsu, additional, Ihn, Hironobu, additional, Yamamoto, Motohisa, additional, Suzuki, Chisako, additional, Takahashi, Hiroki, additional, Nishida, Emi, additional, Morita, Akimichi, additional, Yamamoto, Toshiyuki, additional, Fujimoto, Manabu, additional, Kondo, Yuya, additional, Goto, Daisuke, additional, Sumida, Takayuki, additional, Ayuzawa, Naho, additional, Yanagida, Hidetashi, additional, Horita, Tetsuya, additional, Atsumi, Tatsuya, additional, Endo, Hirahito, additional, Shima, Yoshihito, additional, Kumanogoh, Atsushi, additional, Hirata, Jun, additional, Otomo, Nao, additional, Suetsugu, Hiroyuki, additional, Koike, Yoshinao, additional, Tomizuka, Kohei, additional, Yoshino, Soichiro, additional, Liu, Xiaoxi, additional, Ito, Shuji, additional, Hikino, Keiko, additional, Suzuki, Akari, additional, Momozawa, Yukihide, additional, Ikegawa, Shiro, additional, Tanaka, Yoshiya, additional, Ishikawa, Osamu, additional, Takehara, Kazuhiko, additional, Torii, Takeshi, additional, Sato, Shinichi, additional, Okada, Yukinori, additional, Mimori, Tsuneyo, additional, Matsuda, Fumihiko, additional, Matsuda, Koichi, additional, Amariuta, Tiffany, additional, Imoto, Issei, additional, Matsuo, Keitaro, additional, Kuwana, Masataka, additional, Kawaguchi, Yasushi, additional, Ohmura, Koichiro, additional, and Terao, Chikashi, additional

Published
2023
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6. ESDR028 - A role for FcγRIIB in systemic sclerosis

Author

Sawada, Kaori, primary, Hamaguchi, Yasuhito, primary, Numata, Natsuki, primary, Mizumaki, Kie, primary, Oishi, Kyosuke, primary, Maeda, Shintaro, primary, Ikawa, Yuka, primary, Komuro, Akito, primary, Takehara, Kazuhiko, primary, and Matsushita, Takashi, primary

Published
2022
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