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Your search keyword '"Takahashi, Masahide"' showing total 129 results
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129 results on '"Takahashi, Masahide"'

2. Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade

Author

Owaki, Takayuki, Iida, Tadashi, Miyai, Yuki, Kato, Katsuhiro, Hase, Tetsunari, Ishii, Makoto, Ando, Ryota, Hinohara, Kunihiko, Akashi, Tomohiro, Mizutani, Yasuyuki, Ishikawa, Takuya, Mii, Shinji, Shiraki, Yukihiro, Esaki, Nobutoshi, Yamamoto, Masami, Tsukamoto, Tetsuya, Nomura, Sachiyo, Murakami, Takashi, Takahashi, Masahide, Yuguchi, Yuri, Maeda, Motohiro, Sano, Tomoyasu, Sassa, Naoto, Matsukawa, Yoshihisa, Kawashima, Hiroki, Akamatsu, Shusuke, and Enomoto, Atsushi

Published
2024
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6. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics

Author

Iida, Tadashi, Mizutani, Yasuyuki, Esaki, Nobutoshi, Ponik, Suzanne M., Burkel, Brian M., Weng, Liang, Kuwata, Keiko, Masamune, Atsushi, Ishihara, Seiichiro, Haga, Hisashi, Kataoka, Kunio, Mii, Shinji, Shiraki, Yukihiro, Ishikawa, Takuya, Ohno, Eizaburo, Kawashima, Hiroki, Hirooka, Yoshiki, Fujishiro, Mitsuhiro, Takahashi, Masahide, and Enomoto, Atsushi

Published
2022
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8. The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis

Author

Kobayashi, Hiroki, Gieniec, Krystyna A., Lannagan, Tamsin R.M., Wang, Tongtong, Asai, Naoya, Mizutani, Yasuyuki, Iida, Tadashi, Ando, Ryota, Thomas, Elaine M., Sakai, Akihiro, Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A., Vrbanac, Laura, Ng, Jia Q., Goyne, Jarrad, Radford, Georgette, Lawrence, Matthew J., Sammour, Tarik, Hayakawa, Yoku, Klebe, Sonja, Shin, Alice E., Asfaha, Samuel, Bettington, Mark L., Rieder, Florian, Arpaia, Nicholas, Danino, Tal, Butler, Lisa M., Burt, Alastair D., Leedham, Simon J., Rustgi, Anil K., Mukherjee, Siddhartha, Takahashi, Masahide, Wang, Timothy C., Enomoto, Atsushi, Woods, Susan L., and Worthley, Daniel L.

Published
2022
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10. Machine learning-assisted chemical design of highly efficient deicers.

Author

Ito, Kai, Fukatsu, Arisa, Okada, Kenji, and Takahashi, Masahide

Subjects
DEICING chemicals, CHEMICAL milling, SUSTAINABILITY, ORGANIC solvents, ICE crystals, PROPYLENE glycols
Abstract

The use of deicers in urban areas, on runways and aircrafts has raised concerns about their environmental impact. Understanding the ice-melting mechanism is crucial for developing environmentally friendly deicers, yet it remains challenging. This study employs machine learning to investigate the ice penetration capacity (IPC) of 21 salts and 16 organic solvents as deicers. Relationships between their IPC and various physical properties were analysed using extreme gradient boosting (XGBoost) and Shapley additive explanation (SHAP). Three key ice-melting mechanisms were identified: (1) freezing-point depression, (2) interactions between deicers and H2O molecules and (3) infiltration of ions into ice crystals. SHAP analysis revealed different ice-melting factors and mechanisms for salts and organic solvents, suggesting a potential advantage in combining the two. A mixture of propylene glycol (PG) and sodium formate demonstrated superior environmental impact and IPC. The PG and sodium formate mixture exhibited higher IPC when compared to six commercially available deicers, offering promise for sustainable deicing applications. This study provides valuable insights into the ice-melting process and proposes an effective, environmentally friendly deicer that combines the strengths of organic solvents and salts, paving the way for more sustainable practices in deicing. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Correction: Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics

Author

Iida, Tadashi, Mizutani, Yasuyuki, Esaki, Nobutoshi, Ponik, Suzanne M., Burkel, Brian M., Weng, Liang, Kuwata, Keiko, Masamune, Atsushi, Ishihara, Seiichiro, Haga, Hisashi, Kataoka, Kunio, Mii, Shinji, Shiraki, Yukihiro, Ishikawa, Takuya, Ohno, Eizaburo, Kawashima, Hiroki, Hirooka, Yoshiki, Fujishiro, Mitsuhiro, Takahashi, Masahide, and Enomoto, Atsushi

Published
2022
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17. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas

Author

Ando, Ryota, primary, Shiraki, Yukihiro, additional, Miyai, Yuki, additional, Shimizu, Hiroki, additional, Furuhashi, Kazuhiro, additional, Minatoguchi, Shun, additional, Kato, Katsuhiro, additional, Kato, Akira, additional, Iida, Tadashi, additional, Mizutani, Yasuyuki, additional, Ito, Kisuke, additional, Asai, Naoya, additional, Mii, Shinji, additional, Esaki, Nobutoshi, additional, Takahashi, Masahide, additional, and Enomoto, Atsushi, additional

Published
2023
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20. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.

Author

Ando, Ryota, Shiraki, Yukihiro, Miyai, Yuki, Shimizu, Hiroki, Furuhashi, Kazuhiro, Minatoguchi, Shun, Kato, Katsuhiro, Kato, Akira, Iida, Tadashi, Mizutani, Yasuyuki, Ito, Kisuke, Asai, Naoya, Mii, Shinji, Esaki, Nobutoshi, Takahashi, Masahide, and Enomoto, Atsushi

Subjects
PANCREAS, PANCREATIC intraepithelial neoplasia, PANCREATIC duct, CHRONIC pancreatitis, FIBROSIS, PANCREATIC tumors, REGENERATION (Biology), PANCREATIC enzymes
Abstract

Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblasts or cancer‐associated fibroblasts (CAFs) that promote stromal fibroinflammatory reactions. However, previous studies on PSCs were mainly based on the findings obtained using ex vivo expanded PSCs, with few studies that addressed the significance of in situ tissue‐resident PSCs using animal models. Their contributions to fibrotic reactions in CP and PDAC are also lesser‐known. These limitations in our understanding of PSC biology have been attributed to the lack of specific molecular markers of PSCs. Herein, we established Meflin (Islr), a glycosylphosphatidylinositol‐anchored membrane protein, as a PSC‐specific marker in both mouse and human by using human pancreatic tissue samples and Meflin reporter mice. Meflin‐positive (Meflin+) cells contain lipid droplets and express the conventional PSC marker Desmin in normal mouse pancreas, with some cells also positive for Gli1, the marker of pancreatic tissue‐resident fibroblasts. Three‐dimensional analysis of the cleared pancreas of Meflin reporter mice showed that Meflin+ PSCs have long and thin cytoplasmic protrusions, and are localised on the abluminal side of vessels in the normal pancreas. Lineage tracing experiments revealed that Meflin+ PSCs constitute one of the origins of fibroblasts and CAFs in CP and PDAC, respectively. In these diseases, Meflin+ PSC‐derived fibroblasts showed a distinctive morphology and distribution from Meflin+ PSCs in the normal pancreas. Furthermore, we showed that the genetic depletion of Meflin+ PSCs accelerated fibrosis and attenuated epithelial regeneration and stromal R‐spondin 3 expression, thereby implying that Meflin+ PSCs and their lineage cells may support tissue recovery and Wnt/R‐spondin signalling after pancreatic injury and PDAC development. Together, these data indicate that Meflin may be a marker specific to tissue‐resident PSCs and useful for studying their biology in both health and disease. © 2023 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Supplementary Data from Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis

Author

Mizutani, Yasuyuki, primary, Kobayashi, Hiroki, primary, Iida, Tadashi, primary, Asai, Naoya, primary, Masamune, Atsushi, primary, Hara, Akitoshi, primary, Esaki, Nobutoshi, primary, Ushida, Kaori, primary, Mii, Shinji, primary, Shiraki, Yukihiro, primary, Ando, Kenju, primary, Weng, Liang, primary, Ishihara, Seiichiro, primary, Ponik, Suzanne M., primary, Conklin, Matthew W., primary, Haga, Hisashi, primary, Nagasaka, Arata, primary, Miyata, Takaki, primary, Matsuyama, Makoto, primary, Kobayashi, Tomoe, primary, Fujii, Tsutomu, primary, Yamada, Suguru, primary, Yamaguchi, Junpei, primary, Wang, Tongtong, primary, Woods, Susan L., primary, Worthley, Daniel, primary, Shimamura, Teppei, primary, Fujishiro, Mitsuhiro, primary, Hirooka, Yoshiki, primary, Enomoto, Atsushi, primary, and Takahashi, Masahide, primary

Published
2023
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23. Supplemental Table S1 from Akt–Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

Author

Yamamura, Yumiko, primary, Asai, Naoya, primary, Enomoto, Atsushi, primary, Kato, Takuya, primary, Mii, Shinji, primary, Kondo, Yuji, primary, Ushida, Kaori, primary, Niimi, Kaoru, primary, Tsunoda, Nobuyuki, primary, Nagino, Masato, primary, Ichihara, Shu, primary, Furukawa, Koichi, primary, Maeda, Kengo, primary, Murohara, Toyoaki, primary, and Takahashi, Masahide, primary

Published
2023
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25. Supplemental Figure S1 from Akt–Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

Author

Yamamura, Yumiko, primary, Asai, Naoya, primary, Enomoto, Atsushi, primary, Kato, Takuya, primary, Mii, Shinji, primary, Kondo, Yuji, primary, Ushida, Kaori, primary, Niimi, Kaoru, primary, Tsunoda, Nobuyuki, primary, Nagino, Masato, primary, Ichihara, Shu, primary, Furukawa, Koichi, primary, Maeda, Kengo, primary, Murohara, Toyoaki, primary, and Takahashi, Masahide, primary

Published
2023
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33. Data from A Novel Mouse Model for De novo Melanoma

Author

Kumasaka, Mayuko Y., primary, Yajima, Ichiro, primary, Hossain, Khaled, primary, Iida, Machiko, primary, Tsuzuki, Toyonori, primary, Ohno, Tamio, primary, Takahashi, Masahide, primary, Yanagisawa, Masashi, primary, and Kato, Masashi, primary

Published
2023
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36. Data from Akt–Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

Author

Yamamura, Yumiko, primary, Asai, Naoya, primary, Enomoto, Atsushi, primary, Kato, Takuya, primary, Mii, Shinji, primary, Kondo, Yuji, primary, Ushida, Kaori, primary, Niimi, Kaoru, primary, Tsunoda, Nobuyuki, primary, Nagino, Masato, primary, Ichihara, Shu, primary, Furukawa, Koichi, primary, Maeda, Kengo, primary, Murohara, Toyoaki, primary, and Takahashi, Masahide, primary

Published
2023
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48. Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

Author

Miyai, Yuki, primary, Sugiyama, Daisuke, additional, Hase, Tetsunari, additional, Asai, Naoya, additional, Taki, Tetsuro, additional, Nishida, Kazuki, additional, Fukui, Takayuki, additional, Chen-Yoshikawa, Toyofumi Fengshi, additional, Kobayashi, Hiroki, additional, Mii, Shinji, additional, Shiraki, Yukihiro, additional, Hasegawa, Yoshinori, additional, Nishikawa, Hiroyoshi, additional, Ando, Yuichi, additional, Takahashi, Masahide, additional, and Enomoto, Atsushi, additional

Published
2022
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50. Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer

Author

Ichihara, Ryosuke, primary, Shiraki, Yukihiro, additional, Mizutani, Yasuyuki, additional, Iida, Tadashi, additional, Miyai, Yuki, additional, Esaki, Nobutoshi, additional, Kato, Akira, additional, Mii, Shinji, additional, Ando, Ryota, additional, Hayashi, Masamichi, additional, Takami, Hideki, additional, Fujii, Tsutomu, additional, Takahashi, Masahide, additional, and Enomoto, Atsushi, additional

Published
2022
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