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10 results on '"T, Salerno"'

1. The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support

Author

Alexander M. Bernhardt, Hannah Copeland, Anita Deswal, Jason Gluck, Michael M. Givertz, Arthur Reshad Garan, Shelley Hall, Awori Hayanga, Ivan Knezevic, Federico Pappalardo, Joyce Wald, Cristiano Amarelli, William L. Baker, David Baran, Daniel Dilling, Airlie Hogan, Anna L. Meyer, Ivan Netuka, Minoru Ono, Gustavo Parrilla, Duc Thin Pham, Scott Silvestry, Christy Smith, Koji Takeda, Sunu S. Thomas, Esther Vorovich, Jo Ellen Rodgers, Nana Aburjania, Jean M. Connors, Jasmin S. Hanke, Elrina Joubert-Huebner, Gal Levy, Ann E. Woolley, David L.S. Morales, Amanda Vest, Francisco A. Arabia, Michael Carrier, Christopher T. Salerno, Benedikt Schrage, Savitri Fedson, Larry A. Allen, Cynthia J. Bither, Shannon Dunlay, Paola Morejon, Kay Kendall, Michael Kiernan, Sean Pinney, Stephan Schueler, Peter Macdonald, Diyar Saeed, Evgenij Potapov, and Tien M.H. Ng

Subjects
Pulmonary and Respiratory Medicine, Transplantation, Surgery, Cardiology and Cardiovascular Medicine
Published
2023
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5. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)

Author

Yahya Shehabi, Ary Serpa Neto, Rinaldo Bellomo, Belinda D. Howe, Yaseen M. Arabi, Michael Bailey, Frances E. Bass, Suhaini Bin Kadiman, Colin J. McArthur, Michael C. Reade, Ian M. Seppelt, Jukka Takala, Matt P. Wise, Steve A. Webb, C. Mashonganyika, H. McKee, A. Tonks, A. Donnelly, N. Hemmings, S. O’Kane, A. Blakemore, M. Butler, K. Cowdrey, J. Dalton, E. Gilder, S. Long, L. McCarthy, S. McGuinness, R. Parke, Y. Chen, C. McArthur, R. McConnochie, L. Newby, R. Bellomo, G. Eastwood, L. Peck, H. Young, C. Boschert, J. Edington, J. Fletcher, J. Smith, K. Nand, A. Raza, T. Sara, J. Bennett-Britton, J. Bewley, V. Bodenham, L. Cole, K. Driver, L. Grimmer, L. Howie, C. Searles, K. Sweet, D. Webster, A. van Berkel, H. Connor, J. Dennett, M. van Der Graaff, S. Henderson, J. Mehrtens, K. Miller, E. Minto, A. Morris, S. Noble, K. Parker, L. Bulfin, N. Hart, K. Shepherd, S. Vij, S. Dickson, E. Elloway, C. Ferguson, R. Jackson, P. MacNaughton, M. Marner, R. Squire, S. Waddy, P. Wafer, J. Welbourne, P. Ashcroft, D. Chambler, S. Dukes, A. Harris, S. Horton, S. Sharpe, P. Williams, S. Williams, M. Bailey, E. Blazquez, D. France, R. Hutchison, A. O’Connor, G. Comadira, M. Gough, M. Tallott, M. Bastick, R. Cameron, S. Donovan, K. Ellis, A. Gaur, R. Gregory, J. Naumoff, E. Turner, M. White, K. F. J. Au, J. Fratzia, S. Treloar, C. H. Lim, Y. Maseeda, A. P. Tan, C. L. Tang, C. Y. Yong, M. Akaltan, S. Berger, D. Blaser, L. Fazlija, M. L. Jong, M. Lensch, R. Ludwig, T. Merz, K. Nettelbeck, M. Roth, M. Schafer, J. Takala, A. Wehr, D. Zacharias, R. Amran, H. N. Ashraf, N. Azmi, N. Basri, H. Burhanuddin, Y. Hadinata, A. Hamdan, S. Kadiman, A. I. Y. M. Rashid, I. N. Sabran, S. Sulaiman, I. N. Zabidi, A. Al-Dawood, M. Aljuaid, H. Al Anizi, A. Al Saeedi, Y. Arabi, M. Dbsawy, A. Deeb, M. Hegazy, I. Magdi, E. Clarey, E. Corcoran, C. Finney, C. Harris, P. Hopkins, H. Noble, L. Thompson, T. Williams, L. A. Dumlao, R. Bassam, M. A. Hassan, N. Naseem, M. H. Al-Kurdi, A. M. Al-Harthy, S. Bernard, L. Sebafundi, C. Serban, S. K. Lim, N. Mazidah, N. Saidin, N. Sjamsuddin, I. T. A. Tan, N. Zabidi, M. Brain, S. Mineall, M. Kanhere, N. Soar, N. Abd Kadir, N. H. Abdullah, R. Awang, Z. Emperan, N. S. Husin, N. I. Ismail, S. Z. Ismail, F. N. A. Mohd Khadzali, M. F. Norddin, J. Aguila, C. Bold, B. Clatworthy, A. Dias, C. Hogan, A. Kazemi, V. Lai, R. Song, A. Williams, D. Bhatia, S. Elliot, P. Galt, K. Lavrans, P. Ritchie, A. Wang, R. Gresham, J. Lowrey, K. Masters, P. Palejs, I. Seppelt, F. Symonds, L. Weisbrodt, C. Whitehead, M. Babio-Galan, V. Calder, I. Clement, A. Harrison, I. McCullagh, C. Scott, R. Bevan, S. Caniba, D. Hacking, L. Maher, M. L. Azzolini, P. Beccaria, S. Colombo, G. Landoni, C. Leggieri, C. Luca, D. Mamo, E. Moizo, G. Monti, M. Mucci, A. Zangrillo, M. Albania, S. Arora, Y. Shi, A. Abudayah, G. Almekhlafi, E. Al Amodi, S. Al Samarrai, M. Badawi, R. Cubio Caba, O. Elffaki, Y. Mandourah, J. Valerio, C. Joyce, J. Meyer, E. Saylor, B. Venkatesh, E. Venz, J. Walsham, K. Wetzig, T. M. Khoo, J. E. S. Liew, A. N. Sakthi, A. Zulkurnain, A. Bamford, C. Bergin, R. Carrera, L. Cooper, L. Despy, S. Harkett, L. Mee, E. Reeves, C. Snelson, E. Spruce, G. Cooper, R. Hodgson, D. Pearson, M. Rosbergen, M. N. Ali, N. I. Bahar, A. Ismail, W. N. W. Ismail, N. M. Samat, N. S. M. Piah, R. Abd Rahman, M. Duroux, M. Ratcliffe, T. Warhurst, U. Buehner, E. Williams, N. Jacques, L. Keating, S. Macgill, K. L. Tamang, N. Tolan, A. Walden, R. Bower, J. Cranshaw, K. Molloy, S. Pitts, J. Butler, R. Dunlop, C. Fourie, P. Jarrett, M. Lassig-Smith, A. Livermore, S. O’Donoghue, M. Reade, T. Starr, J. Stuart, L. Campbell, M. Phillips, D. Stephens, J. Thomas, D. Cooper, R. McAllister, G. Andrew, L. Barclay, H. Dawson, D. M. Griffith, D. Hope, G. Wojcik, C. McCulloch, R. Paterson, L. Ascough, C. Paisley, J. Patrick-Heselton, D. Shaw, V. Waugh, K. Williams, I. Welters, D. Barge, A. Jordan, C. MacIsaac, T. Rechnitzer, F. Bass, J. Gatward, N. Hammond, P. Janin, W. Stedman, E. Yarad, N. A. Razak, N. Dzulkipli, S. L. Jong, K. Asen, W. L. Voon, S. Liew, J. Ball, V. Barnes, C. Dalton, S. Farnell-Ward, H. Farrah, K. Maher, J. Mellinghoff, C. Ryan, P. Shirley, L. Conlon, A. Glover, I. Martin-Loeches, E. O’Toole, J. Ewan, J. Ferrier, E. Litton, S. A. Webb, W. Berry, U. Blanco Alonso, A. Bociek, S. Campos, S. Jawara, F. Hanks, A. Kelly, K. Lei, C. McKenzie, M. Ostermann, R. Wan, S. Al-Soufi, S. Leow, K. McCann, C. Reynolds, K. Brickell, C. Fahey, L. Hays, N. Hyde, A. Nichol, D. Ryan, J. Brailsford, A. Buckley, L. Forbes, T. Maguire, J. Moore, L. Murray, A. Ghosh, M. Park, S. Said, A. Visser, H. Z. Abidin, S. Ali, M. H. Hassan, S. C. Omar, W. F. W. Shukeri, D. Brealey, G. Bercades, E. Blackburn, N. Macallum, A. Macklin, J. H. Ryu, K. Tam, D. Smyth, A. Arif, C. Bassford, C. Morgan, C. Swann, G. Ward, L. Wild, A. Bone, T. Elderkin, D. Green, D. Sach, T. Salerno, N. Simpson, F. Brohi, M. Clark, L. Williams, J. Brooks, E. Cocks, J. Cole, J. Curtin, R. Davies, H. Hill, M. Morgan, N. Palmer, C. Whitton, M. Wise, P. Baskaran, M. S. Hasan, L. Y. Tham, R. Sol Cruz, D. Dinsdale, S. Edney, C. Firkin, F. FitzJohn, G. Hill, A. Hunt, S. Hurford, G. Jones, H. Judd, C. Latimer-Bell, C. Lawrence, E. Lesona, L. Navarra, Y. Robertson, H. Smellie, A. M. Vucago, P. Young, P. Clark, J. Kong, J. Ho, V. Nayyar, and C. Skelly

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Abstract

Sedation Practice in Intensive Care Evaluation (SPICE-III) trial reported significant heterogeneity in mortality with dexmedetomidine treatment. Supplemental propofol was commonly used to achieve desirable sedation.to quantify the association of different infusion rates of dexmedetomidine or propofol, given in combination, with mortality and if this is modified by age.We included 1177 patients randomized in SPICE-III to receive dexmedetomidine and given supplemental propofol, stratified by age (65 or ≤65 years). We used double stratification analysis to produce quartiles of steady infusion rates of dexmedetomidine, while escalating propofol dose and vice versa. We used Cox proportional hazard and multivariable regression, adjusted for relevant clinical variable to evaluate the association of sedative dose with 90-day mortality.Younger patients 598/1177(50.8%) received a significantly higher dose of both sedatives compared with older patients, to achieve comparable sedation depth. On double stratification analysis, escalating infusion rates of propofol to 1.27 mg/kg/h at a steady dexmedetomidine infusion rate (0.54 mcg/kg/h) was associated with reduced adjusted mortality in younger, but not older patients. This was consistent with multivariable regression modelling [hazard ratio: 0.59(95% Confidence Interval 0.43-0.78),P0.0001], adjusted for baseline risk and interaction with dexmedetomidine dose. In contrast, among younger patients using multivariable regression, escalating dexmedetomidine infusion rate was associated with increased adjusted mortality [HR:1.30(95%CI 1.03-1.65), P=0.029].In patients ≤ 65 years sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol was associated with decreased adjusted 90-day mortality. Conversely, increasing dexmedetomidine may be associated with increased mortality. Clinical trial registration available at www.gov, ID: NCT01728558.

Published
2022

7. Molecular identification and antimicrobial resistance pattern of Nocardia isolated from 14 diseased dogs and cats.

Author

Condas LAZ, de Farias MR, Siqueira AK, Salerno T, Chi KD, Werner J, de Vargas AC, Bond GB, Gonoi T, Matsuzawa T, and Ribeiro MG

Subjects
Cats, Animals, Dogs, Humans, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Cefuroxime pharmacology, Cefuroxime therapeutic use, RNA, Ribosomal, 16S genetics, Drug Resistance, Bacterial, Imipenem pharmacology, Imipenem therapeutic use, Gentamicins pharmacology, Microbial Sensitivity Tests, Nocardia, Cat Diseases drug therapy, Cat Diseases microbiology, Dog Diseases microbiology, Nocardia Infections drug therapy, Nocardia Infections veterinary, Nocardia Infections microbiology, Anti-Infective Agents pharmacology, Osteomyelitis drug therapy
Abstract

Nocardia are ubiquitous, saprophytic and opportunistic bacteria. They cause a set of pyogenic clinical infections in animals and humans, particularly immunocompromised patients, mostly affecting the skin and respiratory tract, with refractoriness to conventional therapy. The most descriptions of nocardial infections in companion animals involve case reports, and there are scarce case series studies focused on canine and feline nocardiosis in which diagnosis has been based on molecular techniques. We investigated epidemiological aspects, clinical findings, in vitro susceptibility profile, and molecular identification of Nocardia using PCR-based method targeted 16S rRNA gene in twelve dogs and two cats. Among dogs were observed cutaneous lesions (8/12 = 67%), pneumonia (3/12 = 25%), and encephalitis (2/12 = 17%), whereas cats developed cutaneous lesions and osteomyelitis. Nocardia and canine morbillivirus coinfection was described in six dogs (6/12 = 50%). A high mortality rate (6/8 = 75%) was seen among dogs. Three dogs (3/4 = 75%) and one cat (1/2 = 50%) with systemic signs (pneumonia, encephalitis, osteomyelitis), and 83% (5/6) of dogs with a history of concomitant morbillivirus infection died. N. nova (5/12 = 42%), N. cyriacigeorgica (3/12 = 25%), N. farcinica (2/12 = 17%), N. veterana (1/12 = 8%), and N. asteroides (1/12 = 8%) species were identified in dogs, whereas N. africana and N. veterana in cats. Among the isolates from dogs, cefuroxime (12/12 = 100%), amikacin (10/12 = 83%), gentamycin (10/12 = 83%), and imipenem (10/12 = 83%) were the most effective antimicrobials, whereas cefuroxime, cephalexin, amoxicillin/clavulanic acid, imipenem, and gentamycin were efficient against isolates from cats. Multidrug resistance was observed in 36% (5/14) of isolates. We describe a variety of Nocardia species infecting dogs and cats, multidrug-resistant ones, and a high mortality rate, highlighting a poor prognosis of nocardiosis in companion animals, particularly among animals systemically compromised or coinfected by canine morbillivirus. Our study contributes to species identification, in vitro antimicrobial susceptibility profile, clinical-epidemiological aspects, and outcome of natural Nocardia-acquired infections in dogs and cats., (© 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)

Published
2023
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8. Mitigation of Acrylamide Content in Biscuits through Combined Physical and Chemical Strategies.

Author

Lo Faro E, Salerno T, Montevecchi G, and Fava P

Abstract

Acrylamide in biscuits represents a major concern. This research work was aimed at modifying the current formulation of biscuits to reduce the acrylamide content while maintaining the chemical, physical, and sensory characteristics of the original product. A strategy based on the FoodDrinkEurope Acrylamide Toolbox was adopted. The content of the leavening agent ammonium bicarbonate, the baking temperature program, and the time duration of steam released during the baking process were the three factors evaluated through a factorial design of experiment. The partial replacement of ammonium bicarbonate (from 9.0 g to 1.5 g per 500 g of flour) with sodium bicarbonate (from 4.5 g to 12.48 g), lowering of the temperature in the central phase of the baking process (from 170 °C to 150 °C), and the release of steam for 3 min resulted in an 87.2% reduction in acrylamide concentration compared to biscuits of reference. CIELab color indices and a w were the parameters that showed the most significant correlation with acrylamide concentration in biscuits and could, therefore, become markers to predict the acrylamide content along production lines for an instant evaluation.

Published
2022
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9. Renal cell carcinoma with right atrium tumor thrombus treated with radical nephrectomy and tumor thrombectomy in a patient with previous coronary artery bypass graft: a case report.

Author

Ciancio G, Tabbara MM, Farag A, and Salerno T

Abstract

Renal cell carcinoma (RCC) with inferior vena cava (IVC) and right atrium (RA) tumor thrombus (TT) is a rare occurrence and its resection is surgical challenge. Management becomes even more difficult when the TT causes hepatic vein obstruction and leads to Budd-Chiari syndrome. We report a case of 68-year-old male with right RCC with IVC and RA TT with associated Budd-Chiari syndrome. Surgical management was performed without cardiopulmonary bypass (CPB) and re-sternotomy due to the patient's previous history of coronary artery bypass grafting (CABG) for 3 vessel coronary artery disease. Through a transabdominal approach, the diaphragm was dissected off the IVC and the RA was gently pulled into the abdomen and clamped under transesophageal echocardiogram (TEE) control. As use of CPB in these surgeries is associated with increased morbidity and mortality, this organ transplant-based approach is encouraged for patients requiring resection of RCC with supradiaphragmatic TT., Competing Interests: None., (AJCEU Copyright © 2022.)

Published
2022

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