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Introduction: In India, diabetes is turning into an epidemic as currently, more than 62 million individuals suffer from the disease. To our knowledge, very few studies have evaluated the correlation between lipid profiles and glycated hemoglobin (HbA1c) in newly diagnosed type II diabetes patients with hypertension. The early detection of lipid abnormalities in these patients will help prevent the cardiovascular outcomes. Material and Methods: The study was conducted in the Department of General Medicine, Sapthagiri Institute of Medical Sciences & Research Center, Bangalore. In our study 70 patients of Type 2 diabetes mellitus were taken for the study after applying inclusion and exclusion criteria. Biochemical data such as fasting plasma glucose (FPG), HbA1c and lipid profile, along with the patient's age, BMI and gender, were also taken from the electronic file system. The inclusion criteria allowed for only patients who were regularly seeing their physician and whose electronic file was up to date. Results: In our study, among 80 Type 2 diabetic individuals included in this study, 47 were male and 33 were female. Distribution of Glucose Triad results of FBS, PPBS and HbA1c levels of patients presented as Mean±SD, mean FBS was 201.49±41.84, mean PPBS was 273.39±91.48 and mean HbA1c was 8.83±0.83. Mean total cholesterol was 201.38 ± 11.48, mean total triglyceride was 198.48 ± 12.39, Mean HDL was 36.48 ± 4.62, mean LDL was 140.09 ± 9.63 and VLDL was 24.81 ± 2.47. HbA1c positively and significantly correlated with total cholesterol (r=0.223), LDL (r=0.243), HbA1c negatively and significantly correlated with HDL (r= - 0.126), and did not show any show correlation with VLDL (r=0.039) and total triglycerides (r=0.17). Conclusion: This study showed a significant correlation between levels of glycosylated hemoglobin (HbA1c) and lipid profile. This may help in predicting the lipid profile levels from the degree of glycemic control and therefore, identifying the patients with increased risk of diabetic complications. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the interaction between Thyroid hormones and Glucose homeostasis in post menopausal Diabetic and Non-Diabetic women. Materials and Methods: The study was conducted in the Department of General Medicine, Sapthagiri Institute of Medical Sciences & Research Center, Bangalore. 40 Post menopausal Non-diabetic women attending OPD, Department of Medicine. Anthropometric & Physiological parameters were taken. Complete blood picture count, Fasting blood glucose(FBS), Glycosylated haemoglobin(HbA1C), Oestradiol, progesterone, Follicle stimulating hormone(FSH), Luteinizing hormone(LH) levels were analyzed. Unpaired "t" test, is used for the analysis of data between Diabetic and Non-Diabetic group. P < 0.05 considered statistically significant. Results: The present hospital - based cross sectional study was conducted on sample size of 160 subjects of age more than 40 years. These subjects were divided into two groups-80 known Type 2 Diabetes Mellitus constituting study group and 80 healthy age and gender matched individuals constituting control group. The thyroid hormones were analyzed with the ELISA method and HbA1C was analyzed using Ion Exchange Resin Method. The results of the present study showed a positive correlation between TSH and FPG, HbA1C with TSH, a negative correlation of HbA1C with T3 and there was a negative correlation between FPG and T3. Discussion: In our study we found, there is significant increase in weight, BSA, BMI, where as significant decrease in DBP of diabetic group compared to Non-Diabetics & there is significant increase in FBS, HbA1C levels of Diabetic group significant decrease in LH levels of Diabetics compared to Non-Diabetics. However T3 levels of Diabetic and Non-Diabetic group were almost same, where as T4, Oestradiol and progesterone levels of diabetic group non-significantly increased and FSH and TSH levels non-significantly decreased in Diabetics. There is frequent co-existence of thyroid dysfunction and diabetes mellitus among post menopausal diabetic women. Conclusion: Screening of all post menopausal diabetic women for thyroid disorders should be included in routine investigation for better diagnosis and prognosis of the patients. [ABSTRACT FROM AUTHOR]