Search

Based on the geological condition of Luohe Formation sandstone aquifer above the deep working face of 4# coal in Gaojiapu Mine, Binchang Mining area, the relationship between aquifer and dynamic disaster breeding is discussed. Firstly, the formation and its setting condition of the aquifer above 4# coal seam are introduced. Based on field water inflow monitoring data, we examined the relationship between the resistance of the support and the change of water inflow. The temporal and spatial correlation between micro seismicity and water movement is analyzed and identified, which will offer significant value for the early-warning of the dynamic hazards and water inrush. We expound the dynamic and static load of confined water movement on the working face after the increase of water inrush, and point out that it is important to pay more attention to the dynamic disaster risk of the working face after the water surge.

Purpose: Autostereoscopic displays have become increasingly common, but their impact on ocular dimensions remains unknown. We sought to identify changes in the crystalline lens dimensions induced by autostereoscopic three‐dimensional (3D) viewing. Methods: Forty young adults (age: 22.6 ± 2.0 years, male/female: 15/25) were consecutively enrolled and randomly divided into two groups (3D and two‐dimensional [2D] viewing groups) to watch a 30‐min movie clip displayed in 3D or 2D mode on a tablet computer. The lens thickness (LT), diameter, curvature, decentration and tilt were measured with anterior segment optical coherence tomography under both non‐accommodating (static) and accommodating conditions. Results: In the static condition, the LT decreased by 0.03 ± 0.03 mm (p < 0.001) and the anterior radius of curvature (ARC) increased by 0.49 ± 0.59 mm (p = 0.001) post‐3D viewing. In contrast, following 2D viewing, the ARC decreased by 0.23 ± 0.25 mm (p = 0.001). Additionally, the increase in the steep ARC post‐3D viewing was greater in high‐myopic eyes than low to moderate myopic eyes (p = 0.04). When comparing the accommodative with the static (non‐accommodative) condition, for 3D viewing the lens decentration decreased (−0.03 ± 0.05 mm, p = 0.02); while for 2D viewing, the posterior curvature radius (−0.14 ± 0.20 mm, p = 0.006) and diameter (−0.13 ± 0.20 mm, p = 0.01) decreased. Conclusions: Viewing with the autostereoscopic 3D tablet could temporally decrease the thickness and curvature of the lens under non‐accommodating conditions. However, its long‐term effect requires further exploration. [ABSTRACT FROM AUTHOR]

In this study, the microstructural evolution of a Ti-15Mo medical alloy was investigated, when the in situ cyclic tensile strain had 2% amplitude and the tension–compression cyclic deformation had 1%, 2%, and 3% amplitude. The Vickers hardness and wear resistance of the alloy were also optimized due to the grain-refining effect after cyclic deformation and annealing. The twinning-induced plasticity (TWIP) was considered the main deformation mechanism of the Ti-15Mo alloy during the tensile–compressive cycle deformation with suitable strain amplitude. The {332}<113> twins and boundaries were the main contributors to the grain refinement. The optimal microstructure, hardness, and wear resistance were obtained in the alloy deformed by tension–compression cyclic strain with a 3% strain amplitude. The wear resistance of the annealed alloy in Hank's solution was excellent in contrast to the original Ti-15Mo alloy due to its reasonable microstructure and hardness. It is clear that abundant twins were formed and retained in the coarse grains of the original alloy after cyclic deformation and annealing, which provided the expected refined grains and performance. [ABSTRACT FROM AUTHOR]

Objective: To investigate the differential expression of genes and microRNAs (miRNAs) in patients with lung adenocarcinoma and the relationship between such changes and patient prognosis. Methods: We analyzed the expression levels of genes and miRNAs in lung adenocarcinoma tissues and adjacent normal tissues using The Cancer Genome Atlas database (TCGA). We analyzed the function of the differentially expressed genes and miRNAs in a co-expression network. Finally, we performed survival analysis of differential genes and miRNAs in the co-expression network using clinical data from the TCGA database. Results: We successfully identified 6064 differentially expressed genes: 5324 upregulated genes and 740 downregulated genes. And we identified 161 differentially expressed miRNAs: 126 upregulated miRNAs and 35 downregulated miRNAs. We identified several genes that were related to each other in the co-expression network. Further analysis revealed that the high expression levels of G6PC, APOB, F2, PAQR9, and PAQR9-AS1 genes were associated with poor prognosis. However, there was no significant correlation between the expression of hsa-mir-122 with regards to patient prognosis. Conclusions: Our data showed that hsa-mir-122 and a number of related genes may affect the prognosis of patients with lung adenocarcinoma by regulating the cytoskeleton, thus promoting tumor angiogenesis and the metastasis of tumor cells. The high expression levels of some differentially expressed genes was associated with the low survival rate in patients with lung adenocarcinoma. However, the levels of hsa-mir-122 were not correlated with patient prognosis. [ABSTRACT FROM AUTHOR]

Xingbei antitussive granules (XB) is a classic Chinese Medicine prescription for treating post-infectious cough(PIC), based on the Sanao Decoction from Formularies of the Bureau of People's Welfare Pharmacies in the Song Dynasty and Jiegeng decoction from Essentials of the Golden Chamber in the Han Dynasty. However, the therapeutic effects and pharmacological mechanisms are still ambiguous. In the present study, we endeavored to elucidate these underlying mechanisms. This study aimed to explore the potential impact and mechanism of XB on PIC, and provide a scientific basis for its clinical application. Cigarette smoking (CS) combined with lipopolysaccharide (LPS) nasal drops were administered to induce the PIC guinea pig with cough hypersensitivity status. Subsequently, the model guinea pigs were treated with XB and the cough frequency was observed by the capsaicin cough provocation test. The pathological changes of lung tissue were assessed by HE staining, and the levels of inflammatory mediators, mast cell degranulating substances, and neuropeptides were detected. The protein and mRNA expression of transient receptor potential vanilloid type 1(TRPV1), proteinase-activated receptor2(PAR2), and protein kinase C (PKC) were measured by Immunohistochemical staining, Western blot, and RT-qPCR. Changes in the abundance and composition of respiratory bacterial microbiota were determined by 16S rRNA sequencing. After XB treatment, the model guinea pigs showed a dose-dependent decrease in cough frequency, along with a significant alleviation in inflammatory infiltration of lung tissue and a reduction in inflammatory mediators. In addition, XB high-dose treatment significantly decreased the levels of mast cell Tryptase as well as β-hexosaminidase (β-Hex) and downregulated the expression of TRPV1, PAR2, and p-PKC. Simultaneously, levels of neuropeptides like substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and nerve growth factor (NGF) were improved. Besides, XB also can modulate the structure of respiratory bacterial microbiota and restore homeostasis. XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs whose mechanism may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota. [Display omitted] • Xingbei Zhike Granules ameliorated cough symptoms and inflammatory responses in guinea pigs. • Xingbei Zhike Granules exerted the ameliorative effect on guinea pigs by inhibiting tryptase/PAR2/TRPV1. • Xingbei Zhike Granules down-regulated the expressions of neuroinflammatory mediators in vivo. • Respiratory bacterial microbiota homeostasis may be exploited as a novel therapeutic target for post-infectious cough. [ABSTRACT FROM AUTHOR]

Sensor X is a turn-on sensor, which is applied in the fluorescence detection of Zn 2+ ions. Its photophysical process is comprehensively investigated to clarify its weak fluorescence. With the aid of density functional theory (DFT) and time-dependent density functional theory (TDDFT), the potential energy surfaces (PES) of X on both ground and first excited states are studied. Excited-state intramolecular proton transfer (EPT) processes as well as molecule twisting motion are observed, which induces several minima on the excited-state PES. Transition states as well as rate constants for these dynamic processes are obtained to evaluate their occurrences. The twisting motion of the sensor is an ultrafast process, which is initiated by a specific EPT process and leads to a nonemissive twisted intramolecular charge transfer (TICT) state. The fluorescence of the sensor is barely observable because of the easily attainable TICT state on the excited PES. This mechanism is trustworthy and intrinsically different from the previously proposed mechanism. After clarifying the photophysical process of the sensor, the Zn 2+ sensing mechanism is uncovered. Also, the selectivity against Cd 2+ and Hg 2+ is fully discussed.