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Cell homing, a process that leverages the body's natural ability to recruit cells and repair damaged tissues, presents a promising alternative to cell transplantation methods. Central to this approach is the recruitment of endogenous stem/progenitor cells—such as those from the apical papilla, bone marrow, and periapical tissues—facilitated by chemotactic biological cues. Moreover, biomaterial scaffolds embedded with signaling molecules create supportive environments, promoting cell migration, adhesion, and differentiation for the regeneration of the pulp–dentin complex. By analyzing in vivo animal studies using cell homing strategies, this review explores how biomolecules and scaffold materials enhance the recruitment of endogenous stem cells to the site of damaged dental pulp tissue, thereby promoting repair and regeneration. It also examines the key principles, recent advancements, and current limitations linked to cell homing-based regenerative endodontic therapy, highlighting the interplay of biomaterials, signaling molecules, and their broader clinical implications. [ABSTRACT FROM AUTHOR]

Urban public spaces hold significant importance in societal life, playing crucial roles in the development and sustainability of urban environments. These spaces face numerous challenges in the contemporary era. This study examines how sustainable public space design should be structured within the framework of the United Nations Sustainable Development Goals (SDGs), specifically Goal 11, and the parameters set forth by Project for Public Spaces Inc. (PPS), a highly influential non-profit organization based in the United States that provides research, training, technical assistance, planning, and design recommendations. Qualitative data collection methods, including literature review, expert interviews, and the Analytic Hierarchy Process (AHP), are employed to evaluate various sustainability criteria. AHP is used to prioritize the criteria and sub-criteria derived from SDG and PPS frameworks. Through this method, the necessary parameters for a sustainable public space design model are identified based on expert opinions. The findings indicate that physical structure is the top priority criterion for public space sustainability. Historical value, green infrastructure, and ecological efficiency emerge as the highest priority parameters. Among social criteria, security and control, comfort, active and passive interaction, continuity, detectability, and meaning are significant. Economic vitality criteria include contributions to the local and urban economy, increasing local employment, contributions to tourism, and service diversity. Administrative coordination criteria encompass protection, investment incentives, and effective coordination. The study proposes a comprehensive model for sustainable public space design that integrates physical, social, economic, and administrative dimensions. The model emphasizes the importance of multidisciplinary approaches and stakeholder involvement in ensuring urban areas are resilient, inclusive, and sustainable. Key priorities include the protection of historical values, the development of green infrastructure, and the enhancement of ecological efficiency. Future research should explore the application of this model in different urban contexts to validate and refine its effectiveness. [ABSTRACT FROM AUTHOR]

Simple Summary: In recent decades, numerous studies have investigated the cognitive abilities of fish, primarily focusing on species commonly used in neuroscience laboratories. In this study, we examined the learning abilities of a neglected species in the field of cognitive ethology, the red-bellied piranha. We assessed whether these fish could learn a colour discrimination task in an automated operant conditioning chamber. In the first experiment, fish were presented with a red vs. green discrimination task, followed by a yellow vs. white discrimination task in the second experiment. In both cases, the fish did not learn the task. We then simplified the task by presenting achromatic stimuli differing in brightness, always on the same side of the tank. This time, the fish successfully learned how to discriminate between the colours. Our findings suggest that red-bellied piranhas may have limitations in their learning abilities. This study also highlights some limitations of the current procedure. We propose that the automated operant conditioning setup needs adjustments to more effectively investigate the learning capabilities of this species. Most studies on the cognitive abilities of fish have focused on model organisms adopted in behavioural neuroscience. To date, little attention has been devoted to characiformes fish and we record a lack of cognitive investigation on the piranha. In this study, we conducted a preliminary set of experiments to assess whether red-bellied piranhas (Pygocentrus nattereri) can solve an automated operant conditioning task, specifically, a reversal learning task. In Experiment 1, the fish were required to discriminate between red and green, while in Experiment 2, they had to discriminate between white and yellow. In either case, we found no evidence of learning capacities with our protocol after extensive training exceeding one thousand trials overall. In Experiment 3, we simplified the learning task by using achromatic stimuli (black and white discrimination) and always presenting the reinforced stimulus on the same side of the tank (a combination of response learning and place learning). Subjects did learn how to discriminate between the colours, although no subject was able to reach the criterion in the subsequent reversal learning task, suggesting that piranhas may be limited in their cognitive flexibility. However, our training procedure may have been inefficient in addressing this issue. We outline some potential limitations of the current methodology to help to establish a more effective approach for investigating operant conditioning in this species. [ABSTRACT FROM AUTHOR]

Urban development and population growth present new challenges for developing urban public spaces (UPS) in cities. The significance of cities as centers of integration of different socio-cultural groups is growing. Taking into account the diversity of needs and expectations of sensory-sensitive groups (women) as residents and users of urban public spaces is a key task facing modern city managers. Women's public participation is relevant and important, because recognizing their needs and taking them into account in urban spatial policy contributes to creating cities tailored to the needs and expectations of residents and users, according to the principle of "everyone-important". This article has goals for the identification of factors that reduce the safety and comfort of women's activities and the most important architectural features UPS. The results of the research indicate that the determinants that reduce the friendliness of safety and comfort in UPS are a lack of lighting, lack of esthetics of space development, lack of benches and toilets, and street noise. A space tailored to women's needs and expectations should be well-lit with a level walking and sidewalk surface and include architectural infrastructure elements such as adequate municipal sanitation (toilets), benches and urban furniture, with landscaped green space (squares, flowerbeds, trees), which is in line with the principles of universal design. This study's results found that such factors can help create safe, egalitarian, and inclusive cities. They complete the research gap in the field of sustainable urban development and are key to developing gender-equitable urban planning and urban development policy practices. [ABSTRACT FROM AUTHOR]

Garden buildings not only enhance the aesthetics of gardens but also affect the visual and psychological experience of visitors. However, existing studies lack a systematic analysis of the shape types and combination patterns of buildings, which indirectly affects the overall experience of visitors. This study explores the attractiveness of different forms, styles, and combinations of buildings to visitors through oculometry and psychological analysis. The results of the study show that buildings are always the main focus of visitors' sight in the garden, and traditional buildings can stimulate visitors' excitement and curiosity. When observed at close range, visitors' attention to simple-shaped buildings was mainly focused on the overall shape, while details of complex-shaped buildings, such as decorations, doors, windows, and columns, can significantly attract the eye. In contrast, when viewed from a distance, simple and regular combinations of building shapes were more effective in attracting visitors' attention, while the appeal of the historic features of complex buildings declined, possibly due to reduced clarity of detail. Visually striking elements such as buildings with acute angles or curved eaves attracted more visual attention when viewed from a distance. This study not only provides a scientific basis for the design of shapes and historical characteristics of garden buildings but also provides practical guidance for the layout and spatial remodeling of garden buildings. [ABSTRACT FROM AUTHOR]

Public places play a central role in shaping positive and negative human experiences. They have a profound impact on people's lives, affecting their sense of place, well-being, and overall quality of life. While public spaces have such an impact, little is known about their effects on the overall experiences of people in Saudi cities. Particularly, in Saudi Arabia, the form of public spaces has rapidly evolved and changed in recent years. Therefore, this study examined the impact of urban public spaces on people's experiences, aiming to assess satisfaction levels within the broader context of urban life in Saudi Arabia. Specifically, it investigated the correlation between the public spaces and individuals' perceptions and feelings toward the environment of Taif city. Taif is one of the key cities in Saudi Arabia targeted for significant improvements in quality of life as part of the 2030 vision. Therefore, it is important to study the effects on the residents there. The method used in the study involved quantitative data collected through a survey of 384 participants from Taif, which included questions measuring multiple aspects of the quality of urban public life, including the safety, walkability, social interaction, and functionality of public spaces. The results indicate that people in Taif would face a jeopardised level of satisfaction, as not all elements of the public spaces meet the desired standards. Therefore, their experiences would be impacted negatively if the noted concerns are not addressed. By identifying key urban design elements that impact people's experiences and overall well-being, this research provides a foundation for planners and policymakers to work towards achieving the Saudi vision of creating more liveable and enduring urban environments in Saudi Arabian cities. [ABSTRACT FROM AUTHOR]

This article critically examines how ideology permeates the politics of diversity today and is forcing us to clarify political positions towards a much more intercultural approach to diversity. At a time when the demographic argument is gaining momentum in the US, Europe, and other continents, with neo-colonial beliefs of white supremacy and irrational fears of the 'Great replacement' movement, the diversity politics debate is becoming strongly polarized. In this 'ideological turn' diversity emerges as a political option rather than a by-product of the globalization processes. Going beyond the multicultural/intercultural debate, this article represents a step forward by highlighting the specificities of interculturalism and how these distinctive features can be considered today as strategic resources for revitalizing the left's position on diversity politics. As a normative and political ideology, interculturalism may have the potential to shape diversity as a new public culture and implement the scale shift of citizenship from a state to a more urban intercultural citizenship. Theorizing these features from the left would certainly help to reduce right-wing ideologies that foster a strong reluctance to diversity. [ABSTRACT FROM AUTHOR]

Social sustainability has emerged as a critical factor in evaluating societal welfare and well-being. Consequently, researchers have initiated the development of a theoretical framework to delineate the components of social sustainability, achieving notable progress in this endeavor. However, the interplay between the social dimension and the environmental and economic dimensions remains insufficiently explored in user experiences, posing challenges in integrating social sustainability into preliminary design parameters in the built environment and resulting in socially inefficient spaces. This study seeks to elucidate the relationship between social sustainability and the environment while devising a measurement methodology that encompasses the physical environment. Concentrating on public spaces, pivotal in daily experiences and reflective of individual interactions, the research was conducted across five distinct public spaces in the Seyhan district of Adana. Methodologically, the study employed field research, preliminary examination, and statistical analysis. Data collection techniques, including surveys, observations, and measurements, were utilized to unveil statistically significant correlations between social sustainability and the physical environment of public spaces. Consequently, this study delineates the dimensions of these relationships and translates them into actionable design data. [ABSTRACT FROM AUTHOR]

In the upcoming period, city squares' urban redesign will be crucial in achieving sustainable development goals. This study presents a systematic review of OTC-related studies for the urban design of city squares using the PRISMA 2020 methodology. A review included a total of 173 papers from 2001 to 2023. The results identified five study types—clusters based on four pre-defined criteria: study approach, data collection methods, time duration, and primary objectives. The clusters indicate that more than half of all studies are related to the comparison of thermal comfort and heat mitigation measures. Most of the case studies were located in one of three climate zones: temperate oceanic (Cfb) (58 studies), hot summer Mediterranean (Csa) (40 studies), or humid subtropical (Cfa) (28 studies). The most common geometry of the analyzed urban square is medium-sized, is rectangular, and has dominant axel orientation south–north. Also, based on all five clusters, several research gaps were identified, appropriate for future research: the majority of studies related to the traditionally considered climate areas, no typology of urban square geometry configuration based on OTC assessment, and the lack of a local design model for assessing and improving the thermal comfort of city squares. [ABSTRACT FROM AUTHOR]

(1) Background: Public space is an important carrier for maintaining the cultural values of a village and the production and living customs of the villagers, but the use rights and boundaries are in an unstable and ambiguous state, and it is not a completely open and inclusive public space. The study aims to deepen the understanding of the publicness of public space in traditional villages from the perspective of subjective and objective combination, which reveals the relationship between the space and villagers' behavior. (2) Methods: The research established an evaluation framework for assessing the "publicness" of public spaces in traditional villages by integrating space syntax and cognitive surveys. This framework facilitates the analysis of the extent and dimensions of publicness, along with corresponding behavioral patterns, and explores the underlying mechanisms influencing publicness. (3) Results: The study reveals significant variations in the publicness of traditional village spaces. High-publicness areas tend to cluster, whereas low-publicness areas are more scattered, and riverfront regions exhibit greater publicness compared to mountain-adjacent ones. Villagers exhibit notable differences in their evaluations of public spaces, and individuals aged 14–18 and those over 66 rate the highest. The utilization rate of high-publicness spaces is significantly high, catering to a diverse array of activities. In spaces with lower publicness, the duration and variety of activities tend to be more constrained, often limited to rapid exchanges or brief respites, exhibiting a narrower scope of activities. (4) Conclusions: The study underscores the variability and complexity of publicness in traditional village spaces, which manifest not only in spatial layouts and types but also in villagers' usage patterns and behavioral preferences. This may be influenced by objective factors such as spatial accessibility, social interaction, and richness of cultural activities. [ABSTRACT FROM AUTHOR]

The combined use of lasmiditan and triptan is unexplored in medical literature. This study aimed to investigate whether the intake of lasmiditan following triptan improves migraine pain. Following triptan intake, if headache relief was less than 50% at 1 h, patients took 50 mg of lasmiditan within 2 h of migraine onset. Patients recorded headache intensity and adverse events (AEs) caused by lasmiditan at 1, 2, and 4 h after the intake of an additional 50 mg of lasmiditan. A significant reduction in pain scale was observed post 50 mg lasmiditan intake (p < 0.001, t-test). Pain relief was reported for 32 migraine attacks (80%) at 1 h after additional lasmiditan intake. Although AEs were observed in 63% of the patients who took an additional lasmiditan, most were mild and resolved 1 h after lasmiditan intake. Our study revealed the significant headache relief provided by an additional lasmiditan for patients who did not achieve satisfactory results following initial triptan intake for treating migraine. The AEs associated with this treatment strategy were mild and lasted for a short time. This study suggested that the combination of triptan and lasmiditan is promising for the treatment of migraine and should be studied in a randomized placebo-controlled trial. [ABSTRACT FROM AUTHOR]

As the quality of public space has become significant for urban development, the creation of high-quality public spaces is becoming increasingly important. Since the implementation of urban renewal policies, an increasing number of buildings have emerged, creating new types of public spaces. Compared to original public spaces, new public spaces are more open, flexible, and diverse. The design of public spaces is closely related to users and the flâneur can precisely serve as a user and observer to conduct in-depth research. So, our study was conducted under the identity of the flâneur, focusing on two cases in Guangzhou. The flâneur completes the data collection through two methods. Static research involves observing and taking photos, whereas dynamic research involves interviews and questionnaires. This study analysed three aspects: the group category, behavioural diversity, and activity time and evaluated the public space using the NPS scale. The study found that the recommendation rate of new urban public spaces is higher than that of original public spaces. The study also found that original public spaces need to be improved in four ways: equipping furniture facilities, improving traffic congestion, increasing blue-green spaces, and establishing artistic spaces. New urban public spaces need to make efforts to create more interactive spaces and increase stagnation points. [ABSTRACT FROM AUTHOR]

A smarter city should be a safer city. Nighttime safety in metropolitan areas has long been a global concern, particularly for large cities with diverse demographics and intricate urban forms, whose citizens are often threatened by higher street-level crime rates. However, due to the lack of night-time urban appearance data, prior studies based on street view imagery (SVI) rarely addressed the perceived night-time safety issue, which can generate important implications for crime prevention. This study hypothesizes that night-time SVI can be effectively generated from widely existing daytime SVIs using generative AI (GenAI). To test the hypothesis, this study first collects pairwise day-and-night SVIs across four cities diverged in urban landscapes to construct a comprehensive day-and-night SVI dataset. It then trains and validates a day-to-night (D2N) model with fine-tuned brightness adjustment, effectively transforming daytime SVIs to nighttime ones for distinct urban forms tailored for urban scene perception studies. Our findings indicate that: (1) the performance of D2N transformation varies significantly by urban-scape variations related to urban density; (2) the proportion of building and sky views are important determinants of transformation accuracy; (3) within prevailed models, CycleGAN maintains the consistency of D2N scene conversion, but requires abundant data. Pix2Pix achieves considerable accuracy when pairwise day–and–night-night SVIs are available and are sensitive to data quality. StableDiffusion yields high-quality images with expensive training costs. Therefore, CycleGAN is most effective in balancing the accuracy, data requirement, and cost. This study contributes to urban scene studies by constructing a first-of-its-kind D2N dataset consisting of pairwise day-and-night SVIs across various urban forms. The D2N generator will provide a cornerstone for future urban studies that heavily utilize SVIs to audit urban environments. [ABSTRACT FROM AUTHOR]

Simple Summary: This study presents evidence that the introduction of a cognitively challenging computerized system for US Navy California sea lions during positive-reinforcement training sessions was related to an increase in session participation, measured through the consumption of the offered diet each day. Additionally, a reduction in the number of days animals were clinically ill was observed, suggesting an increase in sea lion welfare following the implementation of computerized enrichment. Cognitive enrichment is becoming more prevalent in professional marine mammal facilities. Research with dolphins has suggested that such enrichment provides more welfare benefits than enrichment that does not incorporate cognitive challenge. However, there is little research supporting the use of cognitive enrichment as a means to improve the welfare of sea lions. Recently, a novel form of technological cognitive enrichment, the Enclosure Video Enrichment (EVE) system, was introduced to a population of California sea lions at the US Navy's Marine Mammal Program as a means to enhance welfare. Two of the initial focal animals introduced to EVE were selected based on their health history and the possible benefits of cognitive enrichment in improving health measures. To evaluate this, information regarding the animals' consumption of their offered diet was compared to other animals in the population of similar age and the absence of a similar health history. Subsequently, the total diet consumption of the targeted animals was evaluated in the two years prior to the introduction to EVE and compared to the total diet consumption during the initial 2 years of regular EVE sessions. There was a significant decrease in the number of days in which the sea lions did not consume their entire offered diet in the two years after implementing regular EVE sessions, an increase in participation and performance of voluntary husbandry behaviors, and a reduction in the number of days animals were clinically ill. This study provides evidence of cognitive enrichment as a management tool to improve animal health and welfare as well as performance in training sessions. [ABSTRACT FROM AUTHOR]

Simple Summary: This review summarizes the history and current clinical applications of antiangiogenic treatment. It specifically discusses current challenges of the treatment and opportunities for optimization, including normalization of the tumor vasculature, modulation of milieu-dependent heterogeneity of the vasculature, and targeting of angiocrine protein functions. The vasculature is a key player and regulatory component in the multicellular microenvironment of solid tumors and, consequently, a therapeutic target. In colorectal carcinoma (CRC), antiangiogenic treatment was approved almost 20 years ago, but there are still no valid predictors of response. In addition, treatment resistance has become a problem. Vascular heterogeneity and plasticity due to species-, organ-, and milieu-dependent phenotypic and functional differences of blood vascular cells reduced the hope of being able to apply a standard approach of antiangiogenic therapy to all patients. In addition, the pathological vasculature in CRC is characterized by heterogeneous perfusion, impaired barrier function, immunosuppressive endothelial cell anergy, and metabolic competition-induced microenvironmental stress. Only recently, angiocrine proteins have been identified that are specifically released from vascular cells and can regulate tumor initiation and progression in an autocrine and paracrine manner. In this review, we summarize the history and current strategies for applying antiangiogenic treatment and discuss the associated challenges and opportunities, including normalizing the tumor vasculature, modulating milieu-dependent vascular heterogeneity, and targeting functions of angiocrine proteins. These new strategies could open perspectives for future vascular-targeted and patient-tailored therapy selection in CRC. [ABSTRACT FROM AUTHOR]

Urban parks play a crucial role in enhancing the social interactions of older adults. However, despite the broad recognition of urban parks' benefits, there is a notable gap in research focusing on their role in promoting social interactions, particularly in Asia. This study explores the effects of personal, social, and physical factors and park use patterns on older adults' social interactions. Survey data from 589 older adults aged 50 years or older were collected through face-to-face and online questionnaires and were analyzed using a hierarchical multiple regression model. The results showed that personal factors, social factors, physical factors, and park use patterns explained 10.8%, 8.2%, 9.4%, and 2.3% of the total variance in park social interactions, respectively. Key factors like gender, health status, social cohesion, features, conditions, accessibility, and park use patterns were found to significantly influence these interactions. This study provides empirical evidence to support the important role of urban parks in facilitating social interactions among older adults and contributes to a deeper understanding of the complex factors affecting these interactions. To meet the needs of older adults and maximize the social health benefits, these prominent factors should be emphasized in policy development and interventions, integrating older adults' perceptions and personal experiences. [ABSTRACT FROM AUTHOR]

The human knee is a complex joint that comprises several ligaments, including the medial collateral ligament (MCL). The MCL provides stability to the knee and helps prevent its excessive inward movement. The MCL also has a thin layer of connective tissue known as the epiligament (EL), which adheres to the ligament. This unique feature has drawn attention in the field of ligament healing research, as it may have implications for the recovery process of MCL injuries. According to the EL theory, ligament regeneration relies heavily on the provision of cells, blood vessels, and molecules. The present study sought to compare the expression of vascular endothelial growth factor (VEGF), CD34, and α-smooth muscle actin (α-SMA) in healthy knees' proximal and distal MCL segments to better understand how these proteins affect ligament healing. By improving the EL theory, the current results could lead to more effective treatments for ligament injury. To conduct the present analysis, monoclonal antibodies were used against CD34, α-SMA, and VEGF to examine samples from 12 fresh knee joints' midsubstance MCLs. We identified a higher cell density in the EL than in the ligament connective tissue, with higher cell counts in the distal than in the proximal EL part. CD34 immunostaining was weak or absent in blood vessels and the EL, while α-SMA immunostaining was strongest in smooth muscle cells and the EL superficial layer. VEGF expression was mainly in the blood vessels' tunica media. The distal part showed more SMA-positive microscopy fields and higher cell density than the proximal part (4735 vs. 2680 cells/mm2). Our study identified CD34, α-SMA, and VEGF expression in the MCL EL, highlighting their critical role in ligament healing. Differences in α-SMA expression and cell numbers between the ligament's proximal and distal parts may explain different healing capacities, supporting the validity of the EL theory in ligament recovery. [ABSTRACT FROM AUTHOR]

The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 expression. Four mRNA libraries of oral squamous carcinoma H413 cell lines were sequenced, and 599 candidate genes exhibited differential expression between DSG3-overexpressing and matched control lines, with 12 genes highly significantly differentially expressed, including 9 upregulated and 3 downregulated. Genes with known implications in cancer, such as MMP-13, KRT84, OLFM4, GJA1, AMOT and ADAMTS1, were strongly linked to DSG3 overexpression. Gene ontology analysis indicated that the DSG3-associated candidate gene products participate in crucial cellular processes such as junction assembly, focal adhesion, extracellular matrix formation, intermediate filament organisation and keratinocyte differentiation. Validation of RNA-Seq was performed through RT-qPCR, Western blotting and immunofluorescence analyses. Furthermore, using transmission electron microscopy, we meticulously examined desmosome morphology and revealed a slightly immature desmosome structure in DSG3-overexpressing cells compared to controls. No changes in desmosome frequency and diameter were observed between the two conditions. This study underscores intricate and multifaceted alterations associated with DSG3 in oral squamous carcinoma cells, implying a potential oncogenic role of this gene in biological processes that enable cell communication, motility and survival. [ABSTRACT FROM AUTHOR]

In Saudi Arabia, community pharmacies offer healthcare services for different conditions. However, clarity of the competence of pharmacists in managing migraines is lacking. This study aimed to explore the current knowledge, attitude, and practice patterns of community pharmacists concerning migraine management in the northwestern part of Saudi Arabia. A cross-sectional study was carried out between June and September 2022 among 215 Saudi community pharmacists. Data analysis was performed by descriptive and inferential statistics using SPSS version 27. Most community pharmacists (87.9%) feel that migraine management is essential to their practice, and 83.3% suggest between one and five over-the-counter (OTC) migraine products daily. Among the study pharmacists, 83.7% feel migraine patients should try OTC before prescription medications. Only 9.3% of the community pharmacists do not believe that migraine is a neurological disorder. The medications most prescribed for migraine were triptans, representing 52.1% of prescriptions. There were significant differences between the gender of the pharmacists and their knowledge, attitude, and practice overall score (p-value = 0.04). Male pharmacists exhibited higher knowledge, attitude, and practice scores than female pharmacists. Although many community pharmacists acknowledge their expertise and involvement in managing migraines, there is a requirement for further education and training to enhance their capacity to offer complete care to migraine patients. Pharmacists should also consider non-pharmacological interventions and complementary therapies when treating migraine symptoms. [ABSTRACT FROM AUTHOR]

This article investigates ufaFabrik's practice within Berlin's urban context, which emerged from an occupation of an abandoned site and evolved into a long-term experiment in radical place-making. Through this case study analysis, it explores the role of radical place-making in shaping urban policy, focusing on the dimensions of decision, place and policy. Drawing on an expanded conceptualisation of place-making that embraces a radical perspective, the study is based on a Ph.D. programme and on extensive field research. ufaFabrik has given place-making a political meaning, challenging conventional urban planning in relation to 'undecided' spaces. This paradigm of place-making represents grassroots activism and insurgent action and it can catalyse both local and urban transformations. Through a critical analysis of the limits and possibilities of radical place-making practice, the article argues that the ufaFabrik offers valuable insights into the potential of participatory and community-led approaches to reshape urban spaces and promote more inclusive and sustainable forms of urban governance. The study highlights how the re-politicisation of urban issues emerges from conflict and challenges established power dynamics. It highlights the interconnection between 'place' and 'making', weaving experiential and generative elements into the urban discourse, highlighting its transformative potential and reconfiguration of decision-making dynamics. [ABSTRACT FROM AUTHOR]

Simple Summary: This manuscript details seven different types of behavioral metrics utilized at Chimp Haven to monitor the welfare of the chimpanzees. Each metric focuses on a different aspect of chimpanzee behavior and well-being. Chimp Haven monitors the chimpanzees' social behavior via wounding reports, Nearest Night Neighbor proximities, behavioral time budgets, and shifting logs. Individual chimpanzee welfare is monitored via hair loss and wellness surveys as well as targeted individual assessments for abnormal behavior and individual logs on a chimpanzee's progress in our positive reinforcement training program. The metrics provided here may provide a framework for various types of objective and simple data collection for other animal organizations. Chimp Haven is a sanctuary for chimpanzees retired from biomedical research, rescued from the pet trade, or re-homed after other organizations could no longer care for them. To provide optimal care for over 300 chimpanzees, Chimp Haven's animal care team includes experts in behavioral science, veterinary treatment, and husbandry practices. To aid these teams in making routine welfare management decisions, a system of behavioral metrics provides objective data to guide decisions and track outcomes. Chimp Haven has built and piloted seven behavioral metric protocols over the past 5 years to provide staff with an objective and comprehensive picture of the chimpanzees' behavioral welfare. The data from behavioral observations, staff surveys, and routine staff documentation are analyzed and processed through Google Forms, ZooMonitor, Microsoft Power Bi, Microsoft Excel, and R. Each metric assists staff in making data-based decisions regarding the management of captive chimpanzees related to abnormal behavior, hair loss, wounding, social relationships, positive reinforcement training and overall wellness. In this article, we explore examples of each metric and how they have been utilized to monitor and make decisions for both social groups of chimpanzees as well as individuals. These metrics can be collected and shared easily in an understandable format, which may provide an important framework for others to follow to enable the tracking of welfare for other sanctuaries, non-human primates, as well as other species. [ABSTRACT FROM AUTHOR]

Simple Summary: Over the past century, the field of animal care and management has changed in many ways. Changes to animal care strategies are a reflection of our increased knowledge and understanding of the capacity of animals to experience suffering and positive well-being states and a growing awareness of the need to respect all animals we work with. This includes the way animals are handled, trained, and interacted with in all contexts, and includes all taxa from the smallest invertebrates to the largest mammals. It is pertinent to review the methods of handling and training animals, including wild and exotic animals living in zoos and aquariums, on a regular basis with respect to current knowledge, understanding, and best practice. There is an ethical responsibility to provide all animals living in human care with optimal and positive well-being. As animals living in zoos and aquariums frequently interact with their human caregivers as part of their daily care routines, it is both relevant and essential to consider the impact of these interactions on animal well-being. Allowing animals to have choice and control in multiple areas of their lives, such as by providing opportunities for them to voluntarily participate in their own care through, for example, positive reinforcement training, is an essential component of good animal well-being programs. This review aims to describe evidence-based approaches, ethics, and best practices in the handling and training of the many taxa held in zoos and aquariums worldwide, drawing from work in related animal care fields such as laboratories, farms, rescue, and sanctuaries. The importance of ongoing animal well-being assessments is discussed, with a particular focus on the need for continued review and refinement of processes and procedures pertaining to animal training and handling specifically. Review, enquiry, assessment, evaluation, and refinement will aim to dynamically support positive well-being for all animals. [ABSTRACT FROM AUTHOR]

Simple Summary: Adult children in midlife often become their aging parent's caregiver after a blood cancer diagnosis. Navigating this role reversal during midlife is an additional challenge. Adult children juggle multiple roles (as spouse, parent, and professional). Blood cancer caregiving also involves unpredictable challenges. These challenges can make communicating even more complex. We explored what adult-child caregivers do to enhance their family's communication and what they struggle with when talking to diagnosed parents. A total of 124 adult-child caregivers participated in an online survey. Results showed that caregivers perceive that family communication is enhanced when they communicate openly and frequently. They use technology to maintain contact, facilitate connectedness, share information, and encourage involvement. Diagnosed parents and their adult children struggle with being open. Yet, when they communicate more openly about cancer with family, they have more support. Interventions could help caregivers take the lead in facilitating openness and support after their parent's blood cancer diagnosis. Adult-child caregivers of an aging parent living with a blood cancer describe struggling to communicate with one another and within the family system. They may avoid critical care conversations, which may impede care and their ability to receive social support. We examined what approaches adult-child caregivers of a parent diagnosed with a blood cancer use to enhance their family communication, the topics they find most challenging to discuss, and the roles of openness and support. We used qualitative and quantitative approaches to analyze data from a larger online survey study. In partnership with the Leukemia & Lymphoma Society, we recruited 121 adult-child caregivers. Responses to one open-ended item were analyzed to capture strategies used to enhance communication with their parent and family. They reported utilizing digital communication modalities, prioritizing frequent communication, engaging in openness, establishing boundaries, kinkeeping, and enacting support. Within the quantitative data, we further explored two of these themes (openness and support) and their relationships to other variables using t-tests and regression analysis. Adult-child caregivers and diagnosed parents avoid talking about mortality and negative feelings. Openness in the family about cancer was linked to caregivers' perceptions of receiving social support. Findings demonstrate that cultivating openness between midlife adult children and diagnosed parents may enhance opportunities to receive support. [ABSTRACT FROM AUTHOR]

Differential diagnosis of hypoglycemia in the non-diabetic adult patient is complex and comprises various diseases, including endogenous hyperinsulinism caused by functional β-cell disorders. The latter is also designated as nesidioblastosis or non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS). Clinically, this rare disease presents with unspecific adrenergic and neuroglycopenic symptoms and is, therefore, often overlooked. A combination of careful clinical assessment, oral glucose tolerance testing, 72 h fasting, sectional and functional imaging, and invasive insulin measurements can lead to the correct diagnosis. Due to a lack of a pathophysiological understanding of the condition, conservative treatment options are limited and mostly ineffective. Therefore, nearly all patients currently undergo surgical resection of parts or the entire pancreas. Consequently, apart from faster diagnosis, more elaborate and less invasive treatment options are needed to relieve the patients from the dangerous and devastating symptoms. Based on a case of a 23-year-old man presenting with this disease in our department, we performed an extensive review of the medical literature dealing with this condition and herein presented a comprehensive discussion of this interesting disease, including all aspects from epidemiology to therapy. [ABSTRACT FROM AUTHOR]

A number of studies address the spatial planning, architectural design, and management of public open spaces (POSs) to curb the overuse of spaces to create high-quality spaces. Little attention has been paid to the problem of underutilization of POSs. Therefore, this paper undertakes a comprehensive analysis of the literature on the factors that influence the vitality of POSs, proposing Bronfenbrenner's social–ecological model (SEM) as a conceptual framework. In this work, we conducted a systematic literature search using the PRISMA method to screen and select articles from three major databases (Science Web, Elsevier, and Scopus). Thirty-four journal articles from 2000 to 2022 were selected for the final review. This study systematically identifies and classifies a set of variables related to the vitality of POSs and develops an SEM-based framework of factors that influence the vitality of POSs. The framework examines the influence of individual user characteristics, the social environment, the physical environment, and the political environment on the vitality of POSs. Finally, strategies to improve the vitality of POSs are proposed: (1) POSs' optimization and promotion strategies should be developed gradually, starting from the most basic needs, stage by stage; (2) To improve the vitality of POSs, we should consider both the general public and special groups; (3) Through the synergistic effect between social, material, and policy environments, the comprehensive improvement of POSs' vitality is achieved. This study provides the latest insights into the vitality of POSs and makes a theoretical contribution by conceptualizing the SEM framework and summarizing the influencing factors at different levels. The study of these factors should also have practical implications, as the results will ultimately provide improvement strategies to help policy-makers and local communities to effectively and sustainably improve the vitality of POSs. [ABSTRACT FROM AUTHOR]

Background: A large proportion of people who sustain a whiplash injury will have persistent pain, disability, and participation problems. Several prognostic factors for functional recovery have been reported in the literature but these factors are often evaluated based on differing implementations in clinical practice. Additionally, physiotherapists also rely on their clinical intuition to estimate the functional prognosis of their patients, but this is seldom measured in experimental research. Furthermore, no study to date has explored the associations between clinical intuition, clinically estimated factors, and objectively measured factors for functional recovery of patients with Whiplash-Associated Disorders (WAD). Aim: The aim of this exploratory study is to evaluate associations between prognostic factors for functional recovery, based on routinely collected data in a specialized primary care physiotherapy practice in a consecutive sample of patients (n = 523) with WAD. Methods: Three sources of prognostic factors were selected: (1) physiotherapists' synthesis of clinical intuition in terms of high-risk, inconclusive risk, or low-risk for functional recovery, (2) patient-registered factors from history taking, and (3) patient-reported prognostic factors derived from questionnaires. Prognostic factors were selected based on the literature, recommendations in Dutch clinical practice guidelines, and consensus between experts. Spearman's rank correlation coefficients were calculated to explore the associations between sources of prognostic factors, using a cutoff ≥0.25 for acceptable association. Results: Associations between physiotherapists' intuitive synthesis and patient-registered variables were substantial (rs = 0.86), between patient-registered variables and patient-reported variables fair (ranging from 0.30 to 0.41) to substantial (ranging from 0.69 to 0.73), and between physiotherapists intuitive synthesis and patient-reported variables fair (ranging from 0.30 to 0.37). Conclusion: When estimating prognosis for functional recovery using clinical reasoning, physiotherapists should integrate patients' registered experience of their course of recovery, as well as the timeline after an accident, with their own synthesis of clinical intuition regarding prognostic factors in patients with WAD. [ABSTRACT FROM AUTHOR]

Community public service facilities have a primary supportive role in the health of the elderly. Under the background of global aging, it has become vital to evaluate the elderly-adaptability of their layouts. Based on the supply and demand interaction perspective, this study used the questionnaire-AHP-2SFCA method for this purpose. Firstly, taking the six main districts of Hangzhou as an example, we analyzed the spatial distribution characteristics of the elderly population, and a weight index table of the health importance of public service facilities was constructed using a questionnaire survey and the AHP method. Secondly, the improved 2SFCA was used to analyze the accessibility of public service facilities in Hangzhou, and combined with the weight index table, the elderly-adaptability of public service facilities in the community life circle was comprehensively evaluated. Finally, the demands of the elderly and the supply of public service facilities in the same region were superimposed to study the differential pattern of supply and demand. The results showed the following: (1) The communities with the largest elderly population are mainly concentrated in Shangcheng District, Xiacheng District, the north of Gongshu District, the west of Jianggan District, and the north of Binjiang District. (2) Green space facilities in parks are most important to the health of the elderly, with a weight of 0.46. (3) The overall evaluation results of the community life circle in the study area were good, and the proportion of areas above the medium level was more than 50%. This showed that the concepts of "neighborhood center" and "big community elderly care" in Hangzhou have achieved initial positive results. (4) Based on the interaction between supply and demand, the research area can be divided into four patterns: supply and demand balance, supply shortage, demand gap, and low supply and demand. The results of this study will help to improve the layout and aging-friendly status of community life circle facilities in Hangzhou, and provide information for other aging cities. [ABSTRACT FROM AUTHOR]

Baby chicks and other animals including human infants master simple arithmetic. They discriminate 2 vs. 3 (1 + 1 vs. 1 + 1 + 1) but fail with 3 vs. 4 (1 + 1 + 1 vs. 1 + 1 + 1 + 1). Performance is restored when elements are grouped as 2 + 1 vs. 2 + 2. Here, we address whether grouping could lead to asymmetric response bias. We recoded behavioural data from a previous study, in which separate groups of four-day-old domestic chicks underwent an arithmetic task: when the objects were presented one-by-one (1 + 1 + 1 vs. 1 + 1 + 1 + 1), chicks failed in locating the larger group irrespective of its position and did not show any side bias; Experiment 1. When the objects were presented as grouped (2 + 1 vs. 2 + 2), chicks succeeded, performing better when the larger set was on their left; Experiment 2. A similar leftward bias was also observed with harder discriminations (4 vs. 5: 3  +  1 vs. 3  +  2), with baby chicks succeeding in the task only when the larger set was on the left (Experiments 3 and 4). A previous study showed a rightward bias, with tasks enhancing individual processing. Despite a similar effect in boosting proto-arithmetic calculations, individual processing (eliciting a right bias) and grouping (eliciting a left bias) seem to depend on distinct cognitive mechanisms. [ABSTRACT FROM AUTHOR]

Introduction: emotional exhaustion among trainee teachers is a relevant topic since it could have repercussions regarding the lives of their future pupils. Our objective was to determine the degree of trainee teachers' emotional exhaustion and associated variables during the COVID-19 pandemic. Methods: the design was cross-sectional and descriptive. Questionnaires with sociodemographic variables, perceptions of mental health, and the Emotional Exhaustion Scale (ECE) (α = 0.890; ω = 0.893) validated for the Chilean context were answered by 204 trainee teachers. The results were analyzed using SPSS software version 25 and the Emotional Exhaustion Interpretation Table (EES-Int). Results: the results show that 92.2% of the trainee teachers presented a worsening in their mental health, stress (66.2%), irritability (38.2%), anxiety (37.7%), and depressive symptoms (32.8%). Online classes (73.04%) and the pandemic (67.6%) were the main influencing factors. Education students who perceived their mental health had worsened became 6.63 times more likely to develop emotional exhaustion [AOR = 6.63; 95% CI: 1.78, 24.69]. In addition, education students with a high perception of academic stress were 7.45 more likely to develop emotional exhaustion [AOR = 7.45; 95% CI: 1.98, 28.09]. Conclusion: we can conclude that trainee teachers have high levels of emotional exhaustion and their perception of their mental health and the academic stress they are being subjected to during the COVID-19 pandemic may lead them to present symptoms of frequent or permanent problems with concentration, attention, recall of information, dissatisfaction with their performance, and frequent learning difficulties. From the affective dimension, they present frequent or permanent anxiety, restlessness, irritability, indifference, low mood, and psychomatization. From the socio-interactional dimension, they present frequent or permanent social withdrawal, interpersonal problems, problems at work or school, and family and relationship problems. Increasing the sample to delve into emotional exhaustion by subject area is necessary. For future studies, research should be conducted on the causes of emotional exhaustion by subject area and the coping strategies of trainee teachers to understand differences and provide input on emotional support in practice. [ABSTRACT FROM AUTHOR]

Apart from interactivity, representativeness (in the meaning of grandness) is the basic and required characteristic of public open spaces. The representativeness of public open spaces (POS) is understood in terms of their ability to portray cities and their inhabitants as a whole. This study considers the historical value of public spaces and determines their contemporary role as spaces for representing cities. Moreover, we explore the relationship between the natural value of such places and their representativeness function. It was necessary to define the criteria determining the representativeness of public spaces, including their physical, semiotic, and functional features. The study was carried out in the midtown zone of Szczecin. The subject of the study is urban landscape objects. The landscape, according to the definition presented by the European Landscape Convention, is part of the land, as perceived by local people and visitors, which evolves through time as a result of being acted upon by natural forces and human beings. The landscape approach used in this research enables an assessment that requires taking into account and comparing many aspects that build the layers of the landscape. Qualitative and quantitative research methods were used to assess the characteristics that distinguish POS in the symbolic, formal, location-related and functional layers and to examine their ecological value. The results of the study generally confirmed our hypothesis: i.e., embedding the studied POS within the city's tradition—with its strong semiotic connections and with the specific history of the place (genius loci)—increases the space's range of contemporary, representative functions. At the same time, an apparent decrease in the prestige of the studied POS was observed. Although they originally had high historical value, they either lost key artifacts constituting that identity or were excluded from the main functional and compositional axes of the city. Moreover, this study proves that the representativeness of POS, conditioned by historical value and contemporary functional, spatial, and location features, is generally inconsistent with their high natural value. Still, this inconsistency does not have to be a mean contradiction. [ABSTRACT FROM AUTHOR]

Heritage tourism-led urban renewal and regeneration has recently become a critical way of creating a city brand, designing tourism destinations, and attracting property developers and investors to cities. However, current practice points to a lack of proper understanding and consideration in preserving and interpreting elements of authentic identity in the Chinese historic urban landscape. In this study, we used the ancient city of Datong, China, under urban regeneration as a case study to explore how urban history and cultural resources are manifested in preserving and reconstructing historic urban landscapes. The methods included in-depth interviews with multiple stakeholders and groups, integrated with the analysis of planning documents and field observations. By categorising and evaluating the research data, we developed a new conceptual framework with applicable measures, contributing to heritage-tourism urban regeneration and shaping place identity in both theoretical and practical aspects. The conceptual framework and its corresponding concepts and measures developed from this research could provide guidelines for academics and practitioners to explore more potential aspects and concepts that focus on the research and development of Chinese cities with historic urban landscapes. [ABSTRACT FROM AUTHOR]

Simple Summary: Environmental enrichment for chimpanzees is important in order to minimize boredom and stress in captivity and to provide opportunities to engage in species-typical behaviors. However, few studies have investigated potential associations between enrichment objects, manipulation behaviors, and social contexts, nor have they examined if individual chimpanzees vary in their enrichment object preferences. In the current study, three ethograms were used to code the use of enrichment objects, engagement in manipulation behaviors, and social contexts of enrichment use of captive chimpanzees (Pan troglodytes). Data mining from a video archive consisting of 2054 videos collected over a decade allowed the ethograms to be applied to 732 min and 58 s of videos. Some enrichment objects were more often associated with specific manipulation behaviors and social contexts, indicating that enrichment objects might serve distinct social and behavioral purposes. The chimpanzees differed in their enrichment object preferences, suggesting that caregivers of captive chimpanzees should consider individual needs when providing enrichment in order to improve chimpanzees' experiences in captivity. Finally, the majority of enrichment object use and manipulation behaviors were able to be categorized, indicating that our ethograms were largely effective in coding enrichment use. Environmental enrichment provides mental stimulation and minimizes abnormal behaviors in captive animals. In captive chimpanzees, individual animals may vary in the ways in which they benefit from enrichment or use enrichment devices, so investigating nuances in enrichment use may improve the welfare of captive chimpanzees. In the current study, three ethograms measuring distinct features of enrichment use (i.e., enrichment object, manipulation behavior, and social context) were evaluated by coding videos of captive chimpanzees (Pan troglodytes) at Chimpanzee Sanctuary Northwest in Cle Elum, WA. A total of 732 min and 58 s of video footage was coded from a larger video archive (i.e., 2054 videos) of enrichment use that spanned a decade. A principal component analysis (PCA) revealed that different categories of enrichment objects were more often associated with specific manipulation behaviors and social contexts, suggesting that enrichment objects might fulfill different behavioral and social needs in captivity. Specifically, toy objects were associated with active tactile behaviors in affiliative contexts while oral behaviors were used with foraging objects in solitary contexts. Additionally, individual chimpanzees showed unique preferences for enrichment objects, indicating that caregivers of captive chimpanzees should consider individual needs instead of a "one size fits all" approach to enrichment provisions. [ABSTRACT FROM AUTHOR]

Litewski Square is widely known as the place where the Lithuanian envoys camped to attend the Union Sejm in 1569. Today, Litewski Square represents a space of transformation. The urban public spaces of the square have been rebuilt several times, each instance delineating a distinct rendering of tradition and history. In this article, the evolution of the square is presented in order to analyse three main aspects. Over the years and under changing political conditions, its meaning, role, and function have shifted. Traditions and symbols that shape the space of the square have changed; these changing symbols have influenced how the meaning and functionality of the square have evolved over time. The research methodology of this paper is based on historical and interpretative studies. This form of analysis made it possible to identify the successive stages of the transformation of Litewski Square and, accordingly, in the context of changing political conditions, identify the elements that are important for the meaning of the square today. Litewski Square has evolved from an urban space with a clearly defined function to a multifunctional public space: from a memorial square into a modern space of leisure and entertainment. This paper argues that the accumulation of commemorative elements and directly adjacent recreational spaces give the impression of a lapidary, the constituent elements of which devalue each other. What this means is that, even as the number of commemorative symbolic elements have increased, their status is degraded, as well as that of Litewski Square as a whole. [ABSTRACT FROM AUTHOR]

Purpose: Issues pertaining to accessibility and inclusiveness of public spaces are not explicitly discussed in developing nations. Thus, this study aims to explore how ease of access and socio-economic status of residents influence the use of city-centre public spaces in Ibadan, Nigeria. Design/methodology/approach: A survey involving users (N = 427) of three different types of public spaces (shopping mall, park and recreational centre) was undertaken. Statistical analysis including Kruskal Wallis H-test and ordered logistic regression analysis were used in determining the differences in the public spaces attributes and predicting the determinants of use. Findings: The analysis revealed that the use of a private car, income and gender significantly predict the frequency of use. It was observed that the determinants of public space use differ across the three categories. In particular, accessibility better predicted the use of the park than it did for the shopping mall or the recreation club. Practical implications: It brings to fore ways through which city planning in developing countries can address social exclusion and spatial disparity within city-centres. Specifically, new proposals need to be sensitive to the walkability potentials when sitting parks whilst holistic efforts must be directed towards group-specific needs when planning shopping malls and recreation clubs. City management strategies, policies and incentives are required to encourage the use of public transportation systems within city-centre spaces as it presents a vital platform for improving access and inclusive use. Originality/value: The study fills the gap in the literature by extending knowledge on certain aspects of city-centre's public spaces in a unique cultural setting. The implications of socioeconomic disparity on public space use became apparent. [ABSTRACT FROM AUTHOR]

Retinopathy of prematurity (ROP) is a severe eye disease leading to blindness. Abnormal vessel formation is the pathological hallmark of neovascular ROP. In forming vessels, vascular endothelial growth factor (VEGF) is an important stimulator. The current anti-ROP therapy has focused on bevacizumab, a monoclonal antibody against VEGF, and pazopanib, a tyrosine kinase inhibitor on the VEGF receptor (VEGFR). Several lines of evidence have proposed that natural compounds may be more effective and safer for anti-VEGF function. Resveratrol, a common natural compound, binds to VEGF and blocks its interaction with VEGFR, thereafter suppressing angiogenesis. Here, we evaluate the efficacy of intravitreal injection, or topical instillation (eye drops), of resveratrol into the eyes of mice suffering from oxygen-induced retinopathy, i.e., developing ROP. The treatment of resveratrol significantly relieved the degree of vascular distortion, permeability and hyperplasia; the efficacy could be revealed by both methods of resveratrol application. In parallel, the treatments of resveratrol inhibited the retinal expressions of VEGF, VEGFR and CD31. Moreover, the applied resveratrol significantly relieved the damage caused by oxygen radicals through upregulating the level of superoxide dismutase (SOD) and downregulating the level of malondialdehyde (MDA) in the retina. Taken together, the potential therapeutic benefit of resveratrol in pro-angiogenic diseases, including retinopathy, can be considered. [ABSTRACT FROM AUTHOR]

Old community renovation is now gradually receiving attention in China's urban construction development, and how to make its public space sustainable has become a research topic. This paper conducts a study of the current situation of public space in old communities from the surface to the deep through field research methods. This paper has summarized four spatial characteristics of public space in old communities, including the increase of boundary space; spatial function is polarized between context-specific user groups and complex but sustainable symbiotic systems. Based on these findings, this paper proposes three sustainable renovation considerations and strategies, which include respecting the rationales of the original space, stimulating the cooperation of stakeholders, and recreating the daily life of residents. [ABSTRACT FROM AUTHOR]

Multiport magnetoinductive (MI) devices with directional filter properties are presented. Design equations are developed and solved using wave analysis and dispersion theory, and it is shown that high-performance directional filters can be realised for use both in MI systems with complex, frequency-dependent impedance and in conventional systems with real impedance. Wave analysis is used to reduce the complexity of circuit equations. High-performance MI structures combining directional and infinite rejection filtering are demonstrated, as well as multiple-passband high-rejection filtering. A new method for improving filtering performance through multipath loss compensation is described. Methods for constructing tuneable devices using toroidal ferrite-cored transformers are proposed and demonstrated, and experimental results for tuneable MI directional filters are shown to agree with theoretical models. Limitations are explored, and power handling sufficient for HF RFID applications is demonstrated, despite the use of ferrite materials. [ABSTRACT FROM AUTHOR]

Migraine is a hereditary disease, usually one-sided, sometimes bilateral. It is characterized by moderate to severe pain, which worsens with physical activity and may be associated with nausea and vomiting, may be accompanied by photophobia and phonophobia. The disorder can occur at any time of the day and can last from 4 to 72 h, with and without aura. The pathogenic mechanism is unclear, but extensive preclinical and clinical studies are ongoing. According to electrophysiology and imaging studies, many brain areas are involved, such as cerebral cortex, thalamus, hypothalamus, and brainstem. The activation of the trigeminovascular system has a key role in the headache phase. There also appears to be a genetic basis behind the development of migraine. Numerous alterations have been identified, and in addition to the genetic cause, there is also a close association with the surrounding environment, as if on the one hand, the genetic alterations may be responsible for the onset of migraine, on the other, the environmental factors seem to be more strongly associated with exacerbations. This review is an analysis of neurophysiological mechanisms, neuropeptide activity, and genetic alterations that play a fundamental role in choosing the best therapeutic strategy. To date, the goal is to create a therapy that is as personalized as possible, and for this reason, steps forward have been made in the pharmacological field in order to identify new therapeutic strategies for both acute treatment and prophylaxis. [ABSTRACT FROM AUTHOR]