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Abstract Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians have found that some of the most frequently cited barriers to clozapine prescribing are related to the blood-monitoring requirements. However, these surveys tend to explore general perspectives and may not reflect the true impact of different barriers in real-world outpatient settings. This study aimed to explore this issue. First, by surveying the clinicians responsible for the treatment of 39 clozapine-eligible, yet clozapine-naive, outpatients with schizophrenia. Then, based on the survey results, explanatory interviews with the participating psychiatrists were conducted and analyzed thematically. The most frequently cited reason for non-prescribing of clozapine was the expected non-compliance with blood-monitoring requirements; however, overall stability and/or severe mental illness was chosen as the most important reason in most patient-cases. The qualitative analysis highlighted the combined impact of standard clinical practice, personal experiences, and organizational constraints on clozapine utility.

Introduction Personal recovery is an important aspect for many individuals diagnosed with schizophrenia, as people can live rich, fulfilling lives despite ongoing symptoms. Prior reviews have found several factors to be associated with personal recovery, but a comprehensive overview of the psychosocial interventions aimed at improving personal recovery in schizophrenia is needed.Methods and analysis Key terms relating to personal recovery and psychosocial interventions to promote personal recovery will be searched for in the following databases: PubMed, EMBASE, PsycINFO, CINAHL, MEDLINE, Google Scholar, Web of Science Core Collection and Cochrane. Additionally, a simple search for grey literature will be conducted in The Networked Digital Library of Theses and Dissertations. Two reviewers will individually screen and extract the data, and the selection of sources will be documented in a Preferred Reporting Items for Systematic reviews and Meta-Analyses flow chart. A content analysis will be conducted on the data, and the findings will be presented in tables, and narratively synthesised. Lastly, research gaps will be identified, and recommendations for future research will be proposed.Ethics and dissemination Ethics approval was not required for the development or publishing of this protocol. Findings will be disseminated through conferences, meeting with patient organisations and consumers, and published in a peer-reviewed scientific journal.

Measurement(s) RNA viral genome Technology Type(s) quantitative reverse transcription polymerase chain reaction assay Factor Type(s) Geographical coordinate - Lat • Geographical coordinate - Long • Flow rate • Human population • Ammonia concentration • Sample collection date Sample Characteristic - Organism SARS Coronavirus 2 Sample Characteristic - Environment wastewater treatment plant • sewage Sample Characteristic - Location Scotland

Different forms of childhood maltreatment are known to be significant risk factors for psychosis. However, the strength of this relationship is frequently contested due to different findings between studies, partly because of variations in the conceptualizations and assessments of childhood trauma. The objective of the current study was to explore the convergent validity of two childhood trauma instruments, the Brief Betrayal Trauma Survey (BBTS) and the Childhood Trauma Questionnaire short-form (CTQ-SF), in a sample of first-episode psychosis (FEP) participants. This was a cross-sectional study where participants from a Danish early psychosis service (OPUS) were recruited over a 2-year period. Ninety-nine participants were assessed with both instruments, and reports of childhood emotional, physical, and sexual abuse were compared. There were significantly differing reports of childhood trauma in all domains, with higher reports of childhood abuse in the CTQ than in the BBTS. Findings suggest previous heterogeneous results in studies exploring the association between childhood trauma and psychosis could partly be due to different assessments of trauma. Future studies wishing to explore this association should aim to use a common conceptualization of childhood trauma in their assessments.

Forest management decisions affect carbon stock and rates of sequestration. One subject of debate is the rotation age that will optimize sequestration over extended periods. Some argue that shorter rotations facilitate greater sequestration rates due to the accelerated growth rates of younger trees compared to mature or old-growth trees. Others maintain that frequent harvesting will not allow forest carbon to rebound after each subsequent rotation, and thus more extended periods between clearcutting is the superior choice. These contrasting viewpoints are mirrored regarding the impact of thinning treatments, in that either thinning will enhance forest carbon uptake by facilitating improved and sustained r growth of residual trees or removing any above-ground biomass will outweigh the yields. This study aims to compare the different suites of management decisions and identify practical combinations of rotation ages and thinning applications that will optimize carbon sequestration while meeting other objectives over a 240-year projection timeframe. Stand development under different harvest rotations and thinning specifications was modeled using a Forest Vegetation Simulator (FVS). We found that site productivity was the primary determinant in stand-above-ground carbon dynamics under various management scenarios. Thus, the optimal rotation age/thinning treatment combinations differed between site classes. High productivity stands were estimated to sequester the most above-ground live carbon with 60-year rotations with a low-intensity thin at age 40. Moderately productive stands performed the best with 80-year rotations when two low-intensity thinning treatments were applied between harvests. For high and moderate productivity stands, estimates of gross carbon increased when two low or moderate-intensity thinning treatments were applied within 80- or 120-year rotations. High-intensity thinning treatments reduced total carbon sequestered over the 240-year projection timeframe for all productivity levels and rotation ages, except for low productivity stands under 120-year rotations.

Based on a large cohort of dual diagnosis patients, the aim of this study was to quantify the patient-perceived problems and advantages of their substance use and relate the quantity of problems to the substance type and psychiatric diagnosis. Data comes from a naturalistic cohort admitted to an in-patient facility in Denmark specialized in integrated dual diagnosis treatment. We included 1076 patients at their first admission to the facility from 2010 to 2017. Participants completed 607 DrugCheck and 130 DUDIT-E questionnaires. we analyzed the questionnaires and included admission diagnosis by use of t-test and ANOVA to depict the patterns in substance use in relation to psychiatric diagnosis. The three most common substance related problems according to the DrugCheck questionnaire were: feeling depressed, financial problems, and losing interest in daily activities. From DUDIT-E, the highest-ranking negative substance related effects were financial ruin, deterioration of health, and problems at work. Effects on social life relationships were also evident with more than 40% of participants. The top three positive substance related effects reported were relaxation, improved sleep, and control over negative emotions. The number of problems listed varied significantly with the type of preferred substance. Patients using pain medication, sedatives, central stimulants, and alcohol reported most problems. Diagnosis did not differentiate the problems experienced. Results partially support the broad self-medication hypothesis for patients with severe mental illness, but also points out that patients are well aware of negative effects. [ABSTRACT FROM AUTHOR]

Objective: Posttraumatic stress disorder (PTSD) has long been recognized as a debilitating psychiatric disorder. The definition of Criterion A has been a topic of controversy, and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and International Classification of Diseases, 11th version have opted for a narrow and a broad approach to the gatekeeper criterion, respectively. The aim of this study was to test the implications of a narrow ( DSM-5 ) versus broad (including psychologically threatening events) Criterion A for endorsement of a probable PTSD diagnosis and symptom severity., Method: The study was based on a cross-sectional survey conducted in March 2021 among the general population of adult Danish residents in Denmark, ranging in age between 18 and 79 years ( n = 1,033)., Results: Psychologically threatening events did not lead to a statistically significant increase in probable PTSD diagnoses, but psychologically threatening events were independently related to probable PTSD risk and severity. Controlling for other potentially traumatizing events and demographic factors, psychologically threatening events were the strongest risk factor for higher symptom severity. We found probable PTSD rates higher but comparable to other Scandinavian countries such as Norway and Sweden., Conclusion: Exposure to psychologically threatening events is an important factor in explaining probable PTSD risk and severity although not independently leading to a significant increase in probable PTSD rates. Probable rates of DSM-5 PTSD are higher than Danish official estimates in a random sample of the Danish adult population (6.8%-6.9% compared to 1%). The generalizability of study findings is limited by nonrepresentativity, the use of self-report measures, and assessment during the COVID-19 lockdown. (PsycInfo Database Record (c) 2023 APA, all rights reserved).