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Your search keyword '"Stephanie Schwartz"' showing total 6 results
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6 results on '"Stephanie Schwartz"'

1. Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C

Author

Aline B. Maddux, Cameron C. Young, Suden Kucukak, Laura D. Zambrano, Margaret M. Newhams, Caitlin K. Rollins, Natasha B. Halasa, Shira J. Gertz, Elizabeth H. Mack, Stephanie Schwartz, Michele Kong, Laura L. Loftis, Katherine Irby, Courtney M. Rowan, Keiko M. Tarquinio, Matt S. Zinter, Hillary Crandall, Natalie Z. Cvijanovich, Jennifer E. Schuster, Julie C. Fitzgerald, Mary A. Staat, Charlotte V. Hobbs, Ryan A. Nofziger, Steven Shein, Heidi Flori, Melissa L. Cullimore, Brandon M. Chatani, Emily R. Levy, Katri V. Typpo, Janet R. Hume, Angela P. Campbell, Adrienne G. Randolph, the Overcoming COVID-19 Investigators, Meghan Murdock, Heather Kelley, Candice Colston, Mary Glas Gaspers, Ronald C. Sanders, Emily Port, Rachel Mansour, Sara Shankman, Kaitlin Jones, Caitlin Rollins, Tanya Novak, Janet Chou, Mary Beth Son, Julia Clarke, Brooke Sens, Eve Listerud, Sabrina Chen, Kasey Stewart, Heidi R. Flori, Mary K. Dahmer, Supriya Behl, Noelle M. Drapeau, Lora Martin, Lacy Malloch, Maygan Martin, Kayla Patterson, Cameron Sanders, Kengo Inagaki, Sarah McGraw, Anita Dhanrajani, Abigail Kietzman, Shannon Hill, Russell J. McCulloh, Stephanie P. Schwartz, Tracie C. Walker, Mary Allen Staat, Rajashri Rasal, Ryan Burnett, Jenny Bush, Meena Golcha, Laura Stewart, Krow Ampofo, Manish M. Patel, Leora R. Feldstein, Mark W. Tenforde, Ashley M. Jackson, and Angela Campbell

Subjects
post-acute COVID-19 syndrome, COVID-19 post-intensive care syndrome, critical care outcomes, SARS-CoV-2, multisystem inflammatory syndrome in children, MIS-C, Pediatrics, RJ1-570
Abstract

ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients

Published
2023
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2. Synchronization of kinetic and kinematic hand tasks with electrocorticography and cortical stimulation during awake craniotomies.

Author

Léon Taquet, Brian J Conway, Timothy F Boerger, Sarah C Young, Stephanie Schwartz, Brian D Schmit, and Max O Krucoff

Subjects
Medicine, Science
Abstract

Awake craniotomies provide unique and invaluable scientific opportunities for neurophysiological experimentation in consenting human subjects. While such experimentation carries a long history, rigorous reporting of methodologies focusing on synchronizing data across multiple platforms is not universally reported and often not translatable to across operating rooms, facilities, or behavioral tasks. Therefore, here we detail an intraoperative data synchronization methodology designed to work across multiple commercially available platforms to collect behavioral and surgical field videos, electrocorticography, brain stimulation timing, continuous finger joint angles, and continuous finger force production. Our technique was developed to be nonobstructive to operating room (OR) staff and generalizable to a variety of hand-based tasks. We hope that the detailed reporting of our methods will support the scientific rigor and reproducibility of future studies, as well as aid other groups interested in performing related experiments.

Published
2023
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3. NLRP3 regulates microglial metabolic function in Alzheimer’s disease

Author

Roisin M. McManus, Max P Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michelle‐Amirah Khalil, Mario Lauterbach, David Gomez‐Cabrero, Jesper Tegner, Karsten Hiller, Eicke Latz, and Michael T. Heneka

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022
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4. NLRP3-Mediated Glutaminolysis Regulates Microglia in Alzheimer's Disease

Author

Roisin McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramon Perea, Michelle-Amirah Khalil, Mario Lauterbach, Lea Heinemann, Titus Schlüter, Juan F. Rodriguez Alcazar, Susanne F. Schmidt, Jasper Spitzer, Peri Noori, Alberto Maillo, David Gomez-Cabrero, Jesper Tegnér, Karsten Hiller, Eicke Latz, and Michael T. Heneka

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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5. Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor

Author

Stephanie Schwartz, Nidhi Patel, Tyler Longmire, Pushpa Jayaraman, Xiaomo Jiang, Hongbo Lu, Lisa Baker, Janelle Velez, Radha Ramesh, Anne-Sophie Wavreille, Melanie Verneret, Hong Fan, Tiancen Hu, Fangmin Xu, John Taraszka, Marc Pelletier, Joy Miyashiro, Mikael Rinne, Glenn Dranoff, Catherine Sabatos-Peyton, and Viviana Cremasco

Subjects
General Medicine
Abstract

Objectives Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Herein, we describe the development and characterization of sabatolimab. Methods Sabatolimab was tested for binding to its target TIM-3 and blocking properties. The functional effects of sabatolimab were tested in T-cell killing and myeloid cell cytokine assays. Antibody-mediated cell phagocytosis (ADCP) by sabatolimab was also assessed. Results Sabatolimab was shown to (i) enhance T-cell killing and inflammatory cytokine production by dendritic cells (DCs); (ii) facilitate the phagocytic uptake of TIM-3-expressing target cells; and (iii) block the interaction between TIM-3 and its ligands PtdSer/galectin-9. Conclusion Taken together, our results support both direct anti-leukemic effects and immune-mediated modulation by sabatolimab, reinforcing the notion that sabatolimab represents a novel immunotherapy with immuno-myeloid activity, holding promise for the treatment of myeloid cell neoplasms.

Published
2022
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6. Walker Evans : No Politics

Author

Stephanie Schwartz and Stephanie Schwartz

Subjects
Photography, Artistic, Documentary photography
Abstract

“NO POLITICS whatever.” Walker Evans made this emphatic declaration in 1935, the year he began work for FDR's Resettlement Administration. Evans insisted that his photographs of tenant farmers and their homes, breadlines, and the unemployed should be treated as “pure record.” The American photographer's statements have often been dismissed. In Walker Evans: No Politics, Stephanie Schwartz challenges us to engage with what it might mean, in the 1930s and at the height of the Great Depression, to refuse to work politically. Offering close readings of Evans's numerous commissions, including his contribution to Carleton Beals's anti-imperialist tract, The Crime of Cuba (1933), this book is a major departure from the standard accounts of Evans's work and American documentary. Documentary, Schwartz reveals, is not a means of being present—or being “political.” It is a practice of record making designed to distance its maker from the “scene of the crime.” That crime, Schwartz argues, is not just the Depression; it is the processes of Americanization reshaping both photography and politics in the 1930s. Historicizing documentary, this book reimagines Evans and his legacy—the complexities of claiming “no politics.”

Published
2023

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