Search

This paper provides an overview of the application of social networks in Serbian entrepreneurship and the entrepreneurial ecosystem. Social networks have become a necessary marketing tool in business since their inception for scientific and social purposes. There is almost no business branch that operates without the use of social networks, as an auxiliary or basic marketing tool. In Serbia, social networks have experienced significant expansion in recent years, and everyday life is almost unimaginable without platforms like Instagram, Facebook, and Twitter. Entrepreneurship in Serbia heavily relies on social networks for marketing and operational purposes. On the other hand, the entrepreneurial ecosystem is a term that has attracted a lot of attention from scientists and researchers in the last ten years. The main goal of entrepreneurship is to create an economic and social system that enables business growth and development, which will also contribute to the economic prosperity of the country. Entrepreneurial ecosystems encompass a broader concept, intertwining entrepreneurs, organizations, individuals, and institutions at the national level to support and catalyze entrepreneurship development collectively or systemically. The aim of this paper is to elucidate the concept of the entrepreneurial ecosystem in Serbia and demonstrate the use of social networks for its growth and development in the modern business environment.

This paper presents the onomastic material from Korman, a village located in the northwestern part of Pomoravlje of Aleksinac. After some remarks about the village itself, the paper contains a list of microtoponyms as well as a list of anthroponyms, including surnames, male personal names, female personal names, male nicknames, female nicknames, male hypocoristics and female hypocoristics. The main reason for extracting the onomastic material from Korman is that it has not yet been presented to the scientific public and the material presented in this paper will serve for future broader onomastic research.

The application of innovative technologies that foster smart production resources’ interconnectivity alongside the virtual space that facilities to support process simulation makes the technology factor become the center of Industry 4.0. The production process modeling and simulation can be used to facilitate flexibility and automation of a shop floor. In our previous research, we have created a Domain-Specific Modeling Language (DSML) named MultiProLan, aiming to create production process models suitable for the automatic generation of executable code that enables the automatic execution of production processes. As the next step, we have proposed research on a DSML language aimed at Industry 4.0 human worker modeling. Industry 4.0 still considers workers as a cost, while favoring technological aspects over the workers’ wellbeing. Industry 5.0 complements Industry 4.0, focusing on a human-centric approach that puts core human needs and interests at the top of production processes. Based on our research proposal, here we present a blueprint of the HResModLan DSML prototype aimed at the formal specification of a human worker within Industry 5.0. Presented abstract and concrete syntaxes of the language are tested on a case study of a furniture factory to demonstrate whether they are a good base for the further development of the HResModLan language.

This paper examines physical activity and exercise as used for the health of the ancient Greeks. Records and testimonies from philosophers, trainers, physicians, athletes... guided people toward improving vitality through exercise. These sources contain historical facts relating to the maintenance of individual physical, psychological, social and affective health through movement and exercise. Conclusions about the continuous relationship between direct physical activity and exercise (PAE) and physical exercise and health (PEH) were reached through multifaceted analysis (historical, comparative, causal, semantic) and synthesis, as well as inductive and deductive reasoning. The subject of this paper is the common-sense recognition and deliberation on the significance of PAE for human health during the paleo society, its problematisation and application in practice leading to PEH. The starting premise is cognitively provocative, referring to the origins and utility of paleo science and practice in today's understanding and practice of PAE and PEH. Paleo philosophers believed that PAE, only in optimal amounts, i.e., the "measure of common-sense moderation, " can have a beneficial, positive effect on a healthy lifestyle for humans/athletes. Their frequent critical views on deviations from the common-sense essence of PEH were directed towards preserving the benefits of a healthy lifestyle-PEH. They believed that common sense (bon sens) represents the fundamental axiom for the development of "practical science, " through which the problems of the life of an individual, society and nature were understood, solved, and guided. Philosophers, physicians, and trainers were the most knowledgeable about the importance of PAE for a healthy lifestyle of an individual in ancient Greece! The second premise, although sporadically considered in this paper, contains meaning and expression for provoking modern science and practice of PAE and PEH, pointing out that there is a current tendency of individuals to relinquish the common-sense nature of exercise in favour of personal prophylaxis. The conclusion is that despite sometimes "aggressive" efforts of the society to institutionalise PAE to PEH, individuals continue to seek the factors of health, sustainability and survival (conditio humana). Although direct and simple life activity, PEH appears to be an unknown determinant of the quality of life, as if theories on nature and nurture in human development through PAE are not truthful.

Modern diagnostics of athlete preparation involves the acquisition ofalargenumberof data,whichrequiressuperiorknowledge,serious logistics, protocols, staff, time, etc. Technological breakthroughs in surface electromyography (sEMG) in measuring the activities of respiratory muscles in vivo opened new possibilities in this direction. The correlation between physical preparedness and the ability to maintain breath has been a theoretical phenomenon for over a century.The result at the duration of the breath holding time (BHT) is generally considered a positive indicator of the volume of respiratory capacity during physical activity. Experimental research determined involuntary activities of auxiliary respiratory musculature at the end of the quiet retention of breath and are determined as a physiological break point of breath holding. The time from the start of the breath holding to the first involuntary breathing movement (IBM) is called the control pause (CP). Since this time is not the physiological maximum of breath holding, it is very important to determine the exact moment of reaching the first IBM and the time-frequency characteristics of sEMG signals during the IBM phase (work problem). Using Wavelet methodology, the analysis of sEMG signals is performed on three skeletal muscles, two inhaling (M. Scalenus - Anterior et Medium - SC, and M. Parasternal Intercostales-IC) and one exhalatory (M. Rectus abdominis - Ra), that in addition to others, have auxiliary role and function in the respiratory cycle, and that are sensitive to physiological changes due to apnea, so in their neuromotor response are a possible indicator of metabolic processes that are detected as involuntary breathing movements. Multiple growths in the electrical activity of these muscles during IBM in certain frequency ranges have enabled precise IBM measurement, thus determining the physiologically acceptable duration of the CP. Observation and analysis of the specific respiratory and muscular response indicate dominations of hypoxic or hypercapnic metabolic condition (subject of research). Based on monitoring these changes in 12 subjects classified in the group categorized amateur athletes, it was determined that better-trained subjects have longer CP and react hypercapnically. The conclusions of this non-experimental case study correspond to the practice of training preparation but open the space for new research, primarily those who should develop an affordable method for non-invasive realtime physical preparation.

This paper considers direct mobile-to-mobile (M2M) communications with a dual antenna selection (AS) system at a destination mobile node (DMN) in interference limited, dissimilar composite fading environments. In particular, we model dissimilar interference limited signals at the inputs of the dual branch AS system as (i) the ratio of two Nakagami-m (N) random variables (RVs) at the first branch and (ii) the ratio of two Rice RVs at the second branch, in order to account for non line-of-sight (NLOS) and line-of-sight (LOS) communications, respectively. Moreover, we assume variable powers of the desired as well as interference signals at the output of the DMN in order to account for the impact of shadowing. For the proposed model, we derive probability density functions, cumulative distribution functions, outage probabilities and average level crossing rates. The derived statistical results are evaluated for all the statistical measures considered and are graphically presented in order to provide insight into the impact of composite fading severities and LOS factors for the desired signal, as well as for the interference, on the system performances.

This paper discusses the body of an athlete (sport), ancient Greek sculpture (history of art), digital environment (digital devices - new technologies) and sports marketing (new information systems in business) thus enabling support to different approaches to the system of knowledge in each of the given disciplines. The interdisciplinary (pluralistic) approach opens a possibility to expand not only knowledge, but the scientific awareness as well. The subject of the paper focuses on the phenomenon of the 'permanent record' of sculptures whose theme refers to the events related to an athlete's body in the period of Ancient Greece. Owing to its values, the contents of these masterpieces have had a beneficial effect as they influenced the art of each subsequent period of civilization and are preserved for the future. In the course of a more detailed research and analysis of the history of heritage, new knowledge has been gained that can contribute to the general benefit of the society that we live in. In the digital world, 3D computer animation takes up a very important place within the mass and popular media thus becoming not only the guardian of the heritage of ancient Greece sculptural art depicting the bodies of athletes, but also one of the integral parts of today's general culture, which is mostly used in the promotion of marketing in sports. It is thought that this paper can be inspiring for others in generating new original ideas towards further research.

This research study focuses on the male and female nicknames recorded in the village Donji Ljubeš, located near Aleksinac. The nicknames are analysed from the aspect of motivation and classified into twelve groups. Criteria to determine the motivation were received from local residents. In this field research, 160 personal nicknames were collected. There are 139 male and 21 female nicknames. As a contribution to the work, a dictionary of nicknames was compiled. The collected material was accentually and semantically processed. Considering that the research of this kind in the area of Aleksinačko Pomoravlje is in deficit, this study can significantly contribute to the onomastics of the given area.

In recent years, advancements in microfluidic and sensor technologies have led to the development of new methods for monitoring cell growth both in macro- and micro-systems. In this paper, a microfluidic (MF) platform with a microbioreactor and integrated impedimetric sensor is proposed for cell growth monitoring during the cell cultivation process in a scaled-down simulator. The impedimetric sensor with an interdigitated electrode (IDE) design was realized with inkjet printing and integrated into the custom-made MF platform, i.e., the scaled-down simulator. The proposed method, which was integrated into a simple and rapid fabrication MF system, presents an excellent candidate for the scaled-down analyses of cell growths that can be of use in, e.g., optimization of the cultivated meat bioprocess. When applied to MRC-5 cells as a model of adherent mammalian cells, the proposed sensor was able to precisely detect all phases of cell growth (the lag, exponential, stationary, and dying phases) during a 96-h cultivation period with limited available nutrients. By combining the impedimetric approach with image processing, the platform enables the real-time monitoring of biomasses and advanced control of cell growth progress in microbioreactors and scaled-down simulator systems.

Cardiovascular diseases (CVD) are the leading cause of death worldwide. Since the establishment of the "lipid hypothesis", according to which, cholesterol level is directly correlated to the risk of CVD, many different lipid-lowering agents have been introduced in clinical practice. A majority of these drugs, in addition to their lipid-lowering properties, may also exhibit some anti-inflammatory and immunomodulatory activities. This hypothesis was based on the observation that a decrease in lipid levels occurs along with a decrease in inflammation. Insufficient reduction in the inflammation during treatment with lipid-lowering drugs could be one of the explanations for treatment failure and recurrent CVD events. Thus, the aim of this narrative review was to evaluate the anti-inflammatory properties of currently available lipid-lowering medications including statins, ezetimibe, bile acid sequestrants (BAS), proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, fibrates, omega-3 fatty acids, and niacin, as well as dietary supplements and novel drugs used in modern times.

Biointegrative information processing systems offer a great advantage to autonomous biodevices, as their capacity for biological computation provides the ability to sense the state of more complex environments and better integrate with downstream biological regulation systems. Deoxyribozymes (DNAzymes) and aptamers are of interest to such computational biosensing systems due to the enzymatic properties of DNAzymes and the ligand-inducible conformational structures of aptamers. Herein, we describe a novel method for providing ligand-responsive allosteric control to a DNAzyme using an RNA aptamer. We designed a NOT-logic-compliant E6 DNAzyme to be complementary to an RNA aptamer targeting theophylline, such that the aptamer competitively interacted with either theophylline or the DNAzyme, and disabled the DNAzyme only when theophylline concentration was below a given threshold. Out of our seven designed "complexing aptazymes," three demonstrated effective theophylline-responsive allosteric regulation (2.84 ± 3.75%, 4.97 ± 2.92%, and 8.91 ± 4.19% activity in the absence of theophylline; 46.29 ± 3.36%, 50.70 ± 10.15%, and 61.26 ± 6.18% activity in the presence of theophylline). Moreover, the same three complexing aptazymes also demonstrated the ability to semi-quantitatively determine the concentration of theophylline present in solution, successfully discriminating between therapeutically ineffective (<20 μM), safe (20-100 μM), and toxic (>100 μM) theophylline concentrations. Our method of using an RNA aptamer for ligand-responsive allosteric control of a DNAzyme expands the way aptamers can be configured for biosensing, and suggests a pathway for embedding DNAzymes to provide enhanced information processing and control of biological systems., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Employing concepts from physics, chemistry and bioengineering, 'learning-by-building' approaches are becoming increasingly popular in the life sciences, especially with researchers who are attempting to engineer cellular life from scratch. The SynCell2020/21 conference brought together researchers from different disciplines to highlight progress in this field, including areas where synthetic cells are having socioeconomic and technological impact. Conference participants also identified the challenges involved in designing, manipulating and creating synthetic cells with hierarchical organization and function. A key conclusion is the need to build an international and interdisciplinary research community through enhanced communication, resource-sharing, and educational initiatives., Competing Interests: OS, JD, EB, AB, AB, KJ, ZM, LO, TD, JS, JS, KA, BJ, MD, KG, DS, SA, MG, ML, AS, JS, GL No competing interests declared, (© 2021, Staufer et al.)