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2. Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial

Author

Rodgers, Anthony, Salam, Abdul, Schutte, Aletta E, Cushman, William C, de Silva, H Asita, Di Tanna, Gian Luca, Grobbee, Diederick E, Narkiewicz, Krzysztof, Ojji, Dike B, Poulter, Neil R, Schlaich, Markus P, Oparil, Suzanne, Spiering, Wilko, Williams, Bryan, Wright, Jackson T, Jr, Lakshman, P, Uluwattage, W, Hay, P, Pereira, T, Amarasena, N, Ranasinghe, G, Gianacas, Chris, Shanthakumar, Mathangi, Liu, Xiaoqiu, Wang, Nelson, Gnanenthiran, Sonali R, and Whelton, Paul K

Published
2024
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9. Plasma lipids in Pseudoxanthoma Elasticum (PXE) patients: A comparative study with population-based reference values and Non-PXE controls

Author

Interne Geneeskunde Vasculaire, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M, Visseren, Frank L J, Kok, Madeleine, de Jong, Pim A, Spiering, Wilko, Interne Geneeskunde Vasculaire, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M, Visseren, Frank L J, Kok, Madeleine, de Jong, Pim A, and Spiering, Wilko

Published
2024

10. Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study

Author

Researchgr. Systems Radiology, MS Interne Geneeskunde, Circulatory Health, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, van den Beukel, Tim C., Wolters, Frank J., Siebert, Uwe, Spiering, Wilko, Ikram, M. Arfan, Vernooij, Meike W., de Jong, Pim A., Bos, Daniel, Researchgr. Systems Radiology, MS Interne Geneeskunde, Circulatory Health, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, van den Beukel, Tim C., Wolters, Frank J., Siebert, Uwe, Spiering, Wilko, Ikram, M. Arfan, Vernooij, Meike W., de Jong, Pim A., and Bos, Daniel

Published
2024

11. Do pseudoxanthoma elasticum patients have higher prevalence of kidney stones on computed tomography compared to hospital controls?

Author

Interne Geneeskunde Vasculaire, MS Radiologie, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., Kok, Madeleine, Bartstra, Jonas W., de Jong, Pim A., Spiering, Wilko, Foppen, Wouter, Interne Geneeskunde Vasculaire, MS Radiologie, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., Kok, Madeleine, Bartstra, Jonas W., de Jong, Pim A., Spiering, Wilko, and Foppen, Wouter

Published
2024

14. Cyclical Etidronate Reduces the Progression of Arterial Calcifications in Patients with Pseudoxanthoma Elasticum: A 6-Year Prospective Observational Study.

Author

Harmsen, Iris M., van den Beukel, Tim, Kok, Madeleine, Visseren, Frank L. J., de Jong, Pim A., Papapoulos, Socrates E., and Spiering, Wilko

Subjects
ARTERIAL calcification, GENETIC disorders, COMPUTED tomography, CALCIFICATION, GENETIC mutation
Abstract

Background: Pseudoxanthoma elasticum (PXE), a rare genetic disorder presenting with slowly progressing calcification of various tissues, including the arteries, is caused by mutations in the ABCC6 gene that lead to the reduction of pyrophosphate, a natural inhibitor of calcification. We showed that, compared to a placebo, the cyclical administration of etidronate, a stable pyrophosphate analog, significantly reduced arterial calcification assessed by low-dose CT scans after one year. The aim of the present prospective, single center, observational cohort study was the assessment of the efficacy and safety of cyclical etidronate in patients treated for periods longer than one year. Methods: Seventy-three patients were followed for a median of 3.6 years without etidronate and 2.8 years with etidronate, and each patient served as their own control. Results: The median absolute yearly progression of total calcification volume during the period with etidronate (388 [83–838] µL) was significantly lower than that without etidronate (761 [362–1415] µL; p < 0.001). The rates of the relative progression of arterial calcification were 11.7% (95% CI: 9.6–13.9) without etidronate compared to 5.3% (95% CI: 3.7–7.0) with etidronate, after adjustment for confounders. Conclusions: The cyclical administration of etidronate for nearly 3 years significantly reduced the progression rate of arterial calcification in patients with PXE with pre-existing calcifications without any serious adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The effects of etidronate on brain calcifications in Fahr’s disease or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial

Author

Snijders, Birgitta MG, primary, Mathijssen, Gini, additional, Peters, Mike JL, additional, Emmelot-Vonk, Marielle H, additional, de Jong, Pim A, additional, Bakker, Susan, additional, Crommelin, Heleen A, additional, Ruigrok, Ynte M, additional, Brilstra, Eva H, additional, Schepers, Vera PM, additional, Spiering, Wilko, additional, van Valen, Evelien, additional, and Koek, Huiberdina L, additional

Published
2024
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16. Rationale for a New Low-Dose Triple Single Pill Combination for the Treatment of Hypertension

Author

Rodgers, Anthony, primary, Salam, Abdul, additional, Cushman, William, additional, de Silva, Asita, additional, Di Tanna, Gian Luca, additional, Gnanenthiran, Sonali R., additional, Grobbee, Diederick, additional, Narkiewicz, Krzysztof, additional, Ojji, Dike, additional, Oparil, Suzanne, additional, Poulter, Neil, additional, Schlaich, Markus P., additional, Schutte, Aletta E., additional, Spiering, Wilko, additional, Williams, Bryan, additional, Wright, Jackson T., additional, and Whelton, Paul, additional

Published
2024
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21. Bruch´s membrane calcification in pseudoxanthoma elasticum: comparing histopathology and clinical imaging

Author

Risseeuw, Sara, primary, Pilgrim, Matthew G., additional, Bertazzo, Sergio, additional, Brown, Connor N., additional, Csincsik, Lajos, additional, Fearn, Sarah, additional, Thompson, Richard B., additional, Bergen, Arthur A., additional, ten Brink, Jacoline B., additional, Kortvely, Elod, additional, Spiering, Wilko, additional, Ossewaarde – van Norel, Jeannette, additional, van Leeuwen, Redmer, additional, and Lengyel, Imre, additional

Published
2023
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22. Intracranial arteriosclerosis and the risk of dementia: A population‐based cohort study.

Author

van den Beukel, Tim C., Wolters, Frank J., Siebert, Uwe, Spiering, Wilko, Ikram, M. Arfan, Vernooij, Meike W., de Jong, Pim A., and Bos, Daniel

Abstract

BACKGROUND: The impact of intracranial arteriosclerosis on dementia remains largely unclear. METHODS: In 2339 stroke‐free and dementia‐free participants (52.2% women, mean age 69.5 years) from the general population, we assessed intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC) as proxy for arteriosclerosis. Associations with dementia were assessed using Cox models. In addition, indirect effects through cerebral small vessel disease (cSVD) and subcortical brain structure volumes were assessed using causal mediation analyses. RESULTS: During a median of 13.4 years (25th–75th percentiles 9.9–14.5) of follow‐up, 282 participants developed dementia. Both ICAC presence (hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 1.00–2.32]) and volume (HR per standard deviation: 1.19, 95% CI: 1.01–1.40) increased dementia risk. For VBAC, severe calcifications increased dementia risk (HR for third vs first volume tertile: 1.89, 95% CI: 1.00–3.59). These effects were mediated partly through increased cSVD (percentage mediated for ICAC: 13% and VBAC: 24%). DISCUSSION: Intracranial arteriosclerosis increases the risk of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Validation of spot urine in estimating 24-h urinary sodium, potassium and sodium-to-potassium ratio during three different sodium diets in healthy adults.

Author

Groenland, Eline H., Vendeville, Jean-Paul A. C., Bots, Michiel L., Visseren, Frank L. J., Musson, Ruben E. A., and Spiering, Wilko

Subjects
DIETARY sodium, HIGH-salt diet, SALT-free diet, POTASSIUM, SODIUM, THIRST
Abstract

To evaluate the validity of spot urine assay methods in estimating the 24-h urinary sodium, potassium and sodium-to-potassium ratio during three different sodium diets. Twelve healthy volunteers were asked to adhere to 3 dietary sodium targets (3.3–5.0g/day,<3.3 g/day and >5.0 g/day) for three consecutive weeks and to measure salt excretion daily in spot urine samples using a self-monitoring device. On day 7 of each week, 24-h urine was collected to compare measured with estimated 24-h salt excretion (by the Kawasaki, Tanaka and INTERSALT equations). Correlation coefficients relating measured and estimated 24-h sodium excretion were low and not significant for Kawasaki and INTERSALT and moderate for the Tanaka equation (τ 0.56–0.64,p<.05). Bland–Altman plots showed considerable differences between estimated and measured sodium excretion across all salt diets. Over 40% of the participants showed an absolute difference between measured and estimated 24-h sodium of more than 1000 mg/day. The correlation coefficients between 24-h and spot Na/K ratio were 0.67, 0.94 and 0.85(p<.05), and mean differences were 0.59, 0.06 and 0.48 for the intermediate, low and high sodium diets, respectively. These findings do not support estimation of individual 24-h salt excretion from spot urine by the Kawasaki, Tanaka, or INTERSALT formula. Accurate monitoring of salt intake is essential to improve BP control. At present, measurement of sodium and potassium excretion in multiple non-consecutive 24-h urinary collections is considered the gold standard for measuring dietary sodium intake. However, this method is burdensome, time-consuming and error prone. Therefore, we assessed and compared the validity of three formula-based approaches to estimate 24-h urinary sodium and potassium excretion and the Na/K ratio from spot urine samples measured by a self-monitoring device under three different sodium diets using 24-h urine collections as the reference. We conclude that use of three commonly used equations that estimate 24-h urinary sodium and potassium excretion result in substantial bias, poor precision and poor accuracy and are therefore not recommended. The Na/K ratio based on multiple casual urine samples may be a useful, low-burden, low-cost alternative method to 24-h urine collection for monitoring daily salt intake. [ABSTRACT FROM AUTHOR]

Published
2023
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24. The effects of etidronate on brain CALCIfications in FAhr’s DiseasE or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial

Author

Snijders, Birgitta MG, primary, Mathijssen, Gini, additional, Peters, Mike JL, additional, Emmelot-Vonk, Marielle H, additional, de Jong, Pim A, additional, Bakker, Susan, additional, Crommelin, Heleen A, additional, Ruigrok, Ynte M, additional, Brilstra, Eva H, additional, Schepers, Vera PM, additional, Spiering, Wilko, additional, Valen, Evelien van, additional, and Koek, Huiberdina L, additional

Published
2023
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25. Validation of spot urine in estimating 24-h urinary sodium, potassium and sodium-to-potassium ratio during three different sodium diets in healthy adults

Author

Interne Geneeskunde Vasculaire, Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Cluster 24/7 centraal laboratorium, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul A.C., Bots, Michiel L., Visseren, Frank L.J., Musson, Ruben E.A., Spiering, Wilko, Interne Geneeskunde Vasculaire, Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Cluster 24/7 centraal laboratorium, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul A.C., Bots, Michiel L., Visseren, Frank L.J., Musson, Ruben E.A., and Spiering, Wilko

Published
2023

26. Plasma Level of Pyrophosphate Is Low in Pseudoxanthoma Elasticum Owing to Mutations in the ABCC6 Gene, but It Does Not Correlate with ABCC6 Genotype

Author

Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Radiologie, Brain, MS Oogheelkunde, MS Interne Geneeskunde, Kozák, Eszter, Bartstra, Jonas W., de Jong, Pim A., Mali, Willem P.T.M., Fülöp, Krisztina, Tőkési, Natália, Pomozi, Viola, Risseeuw, Sara, Norel, Jeannette Ossewaarde van, van Leeuwen, Redmer, Váradi, András, Spiering, Wilko, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Radiologie, Brain, MS Oogheelkunde, MS Interne Geneeskunde, Kozák, Eszter, Bartstra, Jonas W., de Jong, Pim A., Mali, Willem P.T.M., Fülöp, Krisztina, Tőkési, Natália, Pomozi, Viola, Risseeuw, Sara, Norel, Jeannette Ossewaarde van, van Leeuwen, Redmer, Váradi, András, and Spiering, Wilko

Published
2023

27. Stepwise treatment of uncontrolled HyperTensioN (Stepwise-HTN): Study design of a cluster randomised controlled trial in primary care

Author

Cardiovasculaire Epi Team 5, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Kiliç, Birsen, Biermans, Marion C.J., Rutten, Frans H., Deinum, Jaap, Spiering, Wilko, van der Wel, Mark C., de Grauw, Wim J.C., Bots, Michiel L., Hollander, Monika, Cardiovasculaire Epi Team 5, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Kiliç, Birsen, Biermans, Marion C.J., Rutten, Frans H., Deinum, Jaap, Spiering, Wilko, van der Wel, Mark C., de Grauw, Wim J.C., Bots, Michiel L., and Hollander, Monika

Published
2023

28. Plasma Level of Pyrophosphate Is Low in Pseudoxanthoma Elasticum Owing to Mutations in the ABCC6 Gene, but It Does Not Correlate with ABCC6 Genotype

Author

Kozák, Eszter, primary, Bartstra, Jonas W., additional, de Jong, Pim A., additional, Mali, Willem P. T. M., additional, Fülöp, Krisztina, additional, Tőkési, Natália, additional, Pomozi, Viola, additional, Risseeuw, Sara, additional, Norel, Jeannette Ossewaarde-van, additional, van Leeuwen, Redmer, additional, Váradi, András, additional, and Spiering, Wilko, additional

Published
2023
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30. Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)

Author

Zoet, Gerbrand A., Paauw, Nina D., Veerbeek, Jan H.W., Groenhof, T. Katrien J., Spiering, Wilko, Verhaar, Marianne C., Franx, A., Titia Lely, A., and Obstetrics & Gynecology

Subjects
Adult, Cross-Over Studies, Dietary Approaches To Stop Hypertension, Postpartum Period, Imidazoles, Obstetrics and Gynecology, Blood Pressure, Gestational Age, Losartan, Renin-Angiotensin System, SDG 3 - Good Health and Well-being, Double-Blind Method, Pre-Eclampsia, Cardiovascular Diseases, Pregnancy, Internal Medicine, Humans, Female, Angiotensin II Type 1 Receptor Blockers
Abstract

Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure. However, nocturnal dipping was significantly higher on RAAS inhibition and low sodium diet compared to placebo and sympathoinhibition. Optimal cardiovascular prevention after preeclampsia should be further explored.

Published
2022

33. Reply

Author

van Kleef, Monique E.A.M., primary and Spiering, Wilko, additional

Published
2022
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34. Nonadherence in Hypertension: How to Develop and Implement Chemical Adherence Testing.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Lane, Dan, Lawson, Alexander, Burns, Angela, Azizi, Michel, Burnier, Michel, Jones, Donald J L, Kably, Benjamin, Khunti, Kamlesh, Kreutz, Reinhold, Patel, Prashanth, Persu, Alexandre, Spiering, Wilko, Toennes, Stefan W, Tomaszewski, Maciej, Williams, Bryan, Gupta, Pankaj, Dasgupta, Indranil, Endorsed by the European Society of Hypertension (ESH) Working Group on Cardiovascular Pharmacotherapy and Adherence, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Lane, Dan, Lawson, Alexander, Burns, Angela, Azizi, Michel, Burnier, Michel, Jones, Donald J L, Kably, Benjamin, Khunti, Kamlesh, Kreutz, Reinhold, Patel, Prashanth, Persu, Alexandre, Spiering, Wilko, Toennes, Stefan W, Tomaszewski, Maciej, Williams, Bryan, Gupta, Pankaj, Dasgupta, Indranil, and Endorsed by the European Society of Hypertension (ESH) Working Group on Cardiovascular Pharmacotherapy and Adherence

Abstract

Nonadherence to antihypertensive medication is common, especially in those with apparent treatment-resistant hypertension (true treatment-resistant hypertension requires exclusion of nonadherence), and its routine detection is supported by clinical guidelines. Chemical adherence testing is a reliable and valid method to detect adherence, yet methods are unstandardized and are not ubiquitous. This article describes the principles of chemical adherence testing for hypertensive patients and provides a set of recommendations for centers wishing to develop the test. We recommend testing should be done in either of two instances: (1) in those who have resistant hypertension or (2) in those on 2 antihypertensives who have a less than 10 mm Hg drop in systolic blood pressure on addition of the second antihypertensive medication. Furthermore, we recommend that verbal consent is secured before undertaking the test, and the results should be discussed with the patient. Based on medications prescribed in United Kingdom, European Union, and United States, we list top 20 to 24 drugs that cover >95% of hypertension prescriptions which may be included in the testing panel. Information required to identify these medications on mass spectrometry platforms is likewise provided. We discuss issues related to ethics, sample collection, transport, stability, urine versus blood samples, qualitative versus quantitative testing, pharmacokinetics, instrumentation, validation, quality assurance, and gaps in knowledge. We consider how to best present, interpret, and discuss chemical adherence test results with the patient. In summary, this guidance should help clinicians and their laboratories in the development of chemical adherence testing of prescribed antihypertensive drugs.

Published
2022

35. The effect of endovascular baroreflex amplification on central sympathetic nerve circuits and cerebral blood flow in patients with resistant hypertension: A functional MRI study

Author

Groenland, Eline H, van Kleef, Monique E A M, Hendrikse, Jeroen, Spiering, Wilko, Siero, Jeroen C W, Groenland, Eline H, van Kleef, Monique E A M, Hendrikse, Jeroen, Spiering, Wilko, and Siero, Jeroen C W

Abstract

BACKGROUND: Endovascular baroreflex amplification (EVBA) by implantation of the MobiusHD is hypothesized to lower blood pressure by decreasing sympathetic activity through the mechanism of the baroreflex. In the present exploratory study we investigated the impact of MobiusHD implantation on central sympathetic nerve circuits and cerebral blood flow (CBF) in patients with resistant hypertension.MATERIALS AND METHODS: In thirteen patients, we performed blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) at rest and during Valsalva maneuvers, before and 3 months after EVBA. Data were analyzed using a whole-brain approach and a brainstem-specific analysis. CBF was assessed using arterial spin labeling MRI.RESULTS: Resting-state fMRI analysis did not reveal significant differences in functional connectivity at 3 months after EVBA. For the Valsalva maneuver data, the whole-brain fMRI analysis revealed significantly increased activation in the posterior and anterior cingulate, the insular cortex, the precuneus, the left thalamus and the anterior cerebellum. The brainstem-specific fMRI analysis showed a significant increase in BOLD activity in the right midbrain 3 months after EVBA. Mean gray matter CBF (partial volume corrected) decreased significantly from 48.9 (9.9) ml/100 gr/min at baseline to 43.4 (13.0) ml/100 gr/min (p = 0.02) at 3 months.CONCLUSIONS: This first fMRI pilot study in patients with resistant hypertension treated with EVBA showed a significant increase in BOLD activity during the Valsalva maneuver in brain regions related to sympathetic activity. No notable signal intensity changes were observed in brain areas involved in the baroreflex circuit. Future randomized controlled studies are needed to investigate whether the observed changes are directly caused by EVBA.CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov, identifier: NCT02827032.

Published
2022

36. Intracranial atherosclerosis in pseudoxanthoma elasticum:A case-control study

Author

Lucci, Carlo, van den Beukel, Tim C., Bartstra, Jonas W., Zwanenburg, Jaco, van der Kolk, Anja, Takx, Richard, Hendrikse, Jeroen, Geerlings, Mirjam I., Bos, Daniel, Spiering, Wilko, de Jong, Pim A., Lucci, Carlo, van den Beukel, Tim C., Bartstra, Jonas W., Zwanenburg, Jaco, van der Kolk, Anja, Takx, Richard, Hendrikse, Jeroen, Geerlings, Mirjam I., Bos, Daniel, Spiering, Wilko, and de Jong, Pim A.

Abstract

Background and aims: Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by systemic calcification of elastin fibers. Additionally, PXE is associated with an increased risk of stroke. It has been hypothesized that this may be caused by accelerated (intracranial) atherogenesis, as a consequence of specific genetic mutations underlying PXE. Hence, we compared the distribution and burden of intracranial atherosclerosis between PXE patients and healthy controls. Methods: Fifty PXE patients and 40 age-and-sex-matched healthy controls (without previous ischemic cerebrovascular disease) underwent 3T MRI to visualize atherosclerotic intracranial vessel wall lesions (VWLs). We compared the presence and burden of VWLs (total and for the anterior cerebral, middle cerebral, intracranial internal carotid, posterior cerebral, and basilar arteries separately) between PXE patients and healthy controls using logistic (presence versus absence) and negative binomial regression models (VWL count) adjusted for relevant confounders. All regressions included group (PXE patients vs. healthy controls) as independent variable. Results: We found that 34 (68.0%) PXE patients and 28 (70.0%) healthy controls had a VWL (odds ratio for presence 1.06 [95%CI 0.38-2.91]). In addition, the total burden of VWLs was similar between PXE patients (68 VWLs) and healthy controls (73 VWLs, incidence rate ratio for count 0.81 [95%CI 0.55-1.20]). Findings were similar when analyses were stratified for artery. Conclusions: The distribution and burden of intracranial atherosclerosis were similar between PXE patients and healthy controls. This implies PXE and its underlying mutations do not involve increased (intracranial) atherogenesis and that vascular calcification or other mechanisms explains the increased stroke risk in PXE.

Published
2022

37. Smartphone Application-Assisted Home Blood Pressure Monitoring Compared With Office and Ambulatory Blood Pressure Monitoring in Patients With Hypertension: the AMUSE-BP Study

Author

Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul A.C., Bemelmans, Remy H.H., Monajemi, Houshang, Bots, Michiel L., Visseren, Frank L.J., Spiering, Wilko, Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul A.C., Bemelmans, Remy H.H., Monajemi, Houshang, Bots, Michiel L., Visseren, Frank L.J., and Spiering, Wilko

Published
2022

38. Clinical characteristics do not reliably identify non-adherence in patients with uncontrolled hypertension

Author

Interne Geneeskunde Vasculaire, Circulatory Health, Apotheek Klinische Farmacie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Dasgupta, Indranil, Visseren, Frank L.J., van der Elst, Kim C.M., Lorde, Nathan, Lawson, Alexander J., Bots, Michiel L., Spiering, Wilko, Interne Geneeskunde Vasculaire, Circulatory Health, Apotheek Klinische Farmacie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Dasgupta, Indranil, Visseren, Frank L.J., van der Elst, Kim C.M., Lorde, Nathan, Lawson, Alexander J., Bots, Michiel L., and Spiering, Wilko

Published
2022

39. Assessing Outcomes After Adrenalectomy for Primary Aldosteronism - Early is Accurate: Retrospective Cohort Study

Author

Cancer, MS CGO, Heelkunde Opleiding, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Circulatory Health, MS Endocriene Oncologie, Suurd, Diederik P D, Vorselaars, Wessel M C M, Van Beek, Dirk-Jan, Borel Rinkes, Inne H M, Spiering, Wilko, Valk, Gerlof D, Vriens, Menno R, Cancer, MS CGO, Heelkunde Opleiding, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Circulatory Health, MS Endocriene Oncologie, Suurd, Diederik P D, Vorselaars, Wessel M C M, Van Beek, Dirk-Jan, Borel Rinkes, Inne H M, Spiering, Wilko, Valk, Gerlof D, and Vriens, Menno R

Published
2022

40. Is vaginal delivery harmful to patients with pseudoxanthoma elasticum?

Author

MS Oogheelkunde, MS Interne Geneeskunde, Circulatory Health, Cancer, Infection & Immunity, Risseeuw, Sara, Yildirim, Hilin, Spiering, Wilko, Imhof, Saskia M., Van Leeuwen, Redmer, Ossewaarde-Van Norel, Jeannette, MS Oogheelkunde, MS Interne Geneeskunde, Circulatory Health, Cancer, Infection & Immunity, Risseeuw, Sara, Yildirim, Hilin, Spiering, Wilko, Imhof, Saskia M., Van Leeuwen, Redmer, and Ossewaarde-Van Norel, Jeannette

Published
2022

41. Number of measurement days needed for obtaining a reliable estimate of home blood pressure and hypertension status

Author

Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Bots, Michiel L., Visseren, Frank L.J., McManus, Richard J., Spiering, Wilko, Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Groenland, Eline H., Bots, Michiel L., Visseren, Frank L.J., McManus, Richard J., and Spiering, Wilko

Published
2022

42. The relation between urinary sodium and potassium excretion and risk of cardiovascular events and mortality in patients with cardiovascular disease

Author

Interne Geneeskunde Vasculaire, Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, CCU Cardiologie, Team Medisch, Neurologen, MS Nefrologie, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul, Bots, Michiel L., de Borst, Gert Jan, Nathoe, Hendrik M., Ruigrok, Ynte M., Blankestijn, Peter J., Visseren, Frank L.J., Spiering, Wilko, Interne Geneeskunde Vasculaire, Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, CCU Cardiologie, Team Medisch, Neurologen, MS Nefrologie, MS Interne Geneeskunde, Groenland, Eline H., Vendeville, Jean Paul, Bots, Michiel L., de Borst, Gert Jan, Nathoe, Hendrik M., Ruigrok, Ynte M., Blankestijn, Peter J., Visseren, Frank L.J., and Spiering, Wilko

Published
2022

43. Intracranial atherosclerosis in pseudoxanthoma elasticum: A case-control study

Author

Arts-assistenten Radiologie, Researchgr. Systems Radiology, Highfield Research Group, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Computational Imaging, Onderzoek Beeld, Divisie Beeld, Brain, Cardiovasculaire Epi Team 7a, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Researchgr. Hart-brein as., Infection & Immunity, Lucci, Carlo, van den Beukel, Tim C, Bartstra, Jonas W, Zwanenburg, Jaco, van der Kolk, Anja, Takx, Richard, Hendrikse, Jeroen, Geerlings, Mirjam I, Bos, Daniel, Spiering, Wilko, de Jong, Pim A, Arts-assistenten Radiologie, Researchgr. Systems Radiology, Highfield Research Group, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Computational Imaging, Onderzoek Beeld, Divisie Beeld, Brain, Cardiovasculaire Epi Team 7a, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Researchgr. Hart-brein as., Infection & Immunity, Lucci, Carlo, van den Beukel, Tim C, Bartstra, Jonas W, Zwanenburg, Jaco, van der Kolk, Anja, Takx, Richard, Hendrikse, Jeroen, Geerlings, Mirjam I, Bos, Daniel, Spiering, Wilko, and de Jong, Pim A

Published
2022

44. Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)

Author

Arts-assistenten DV&B, Circulatory Health, Cardiovasculaire Epi Team 5, MS Interne Geneeskunde, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Verloskunde, Child Health, Zoet, Gerbrand A, Paauw, Nina D, Veerbeek, Jan H W, Groenhof, T Katrien J, Spiering, Wilko, Verhaar, Marianne C, Franx, A, Titia Lely, A, Arts-assistenten DV&B, Circulatory Health, Cardiovasculaire Epi Team 5, MS Interne Geneeskunde, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Verloskunde, Child Health, Zoet, Gerbrand A, Paauw, Nina D, Veerbeek, Jan H W, Groenhof, T Katrien J, Spiering, Wilko, Verhaar, Marianne C, Franx, A, and Titia Lely, A

Published
2022

45. Hypertensive response to exercise in adult patients with repaired aortic coarctation

Author

R&D Onderzoek, Onderzoek Precision medicine, Biostatistiek Onderzoek, Other research (not in main researchprogram), Cardiologie, Cardiologie patientenzorg, Cluster A, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Meijs, Timion A, Muller, Steven A, Minderhoud, Savine C S, de Winter, Robbert J, Mulder, Barbara J M, van Melle, Joost P, Hoendermis, Elke S, van Dijk, Arie P J, Zuithoff, Nicolaas P A, Krings, Gregor J, Doevendans, Pieter A, Spiering, Wilko, Witsenburg, Maarten, Roos-Hesselink, Jolien W, van den Bosch, Annemien E, Bouma, Berto J, Voskuil, Michiel, R&D Onderzoek, Onderzoek Precision medicine, Biostatistiek Onderzoek, Other research (not in main researchprogram), Cardiologie, Cardiologie patientenzorg, Cluster A, Circulatory Health, Team Medisch, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Meijs, Timion A, Muller, Steven A, Minderhoud, Savine C S, de Winter, Robbert J, Mulder, Barbara J M, van Melle, Joost P, Hoendermis, Elke S, van Dijk, Arie P J, Zuithoff, Nicolaas P A, Krings, Gregor J, Doevendans, Pieter A, Spiering, Wilko, Witsenburg, Maarten, Roos-Hesselink, Jolien W, van den Bosch, Annemien E, Bouma, Berto J, and Voskuil, Michiel

Published
2022

48. Hypertensive response to exercise in adult patients with repaired aortic coarctation

Author

Meijs, Timion A, primary, Muller, Steven A, additional, Minderhoud, Savine C S, additional, de Winter, Robbert J, additional, Mulder, Barbara J M, additional, van Melle, Joost P, additional, Hoendermis, Elke S, additional, van Dijk, Arie P J, additional, Zuithoff, Nicolaas P A, additional, Krings, Gregor J, additional, Doevendans, Pieter A, additional, Spiering, Wilko, additional, Witsenburg, Maarten, additional, Roos-Hesselink, Jolien W, additional, van den Bosch, Annemien E, additional, Bouma, Berto J, additional, and Voskuil, Michiel, additional

Published
2022
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