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302 results on '"Soucy, Jean-Paul"'

1. Cryo-EM structure of Alzheimers disease tau filaments with PET ligand MK-6240.

Author

Kunach, Peter, Vaquer-Alicea, Jaime, Smith, Matthew, Monistrol, Jim, Hopewell, Robert, Moquin, Luc, Therriault, Joseph, Tissot, Cecile, Rahmouni, Nesrine, Massarweh, Gassan, Soucy, Jean-Paul, Guiot, Marie-Christine, Shoichet, Brian, Rosa-Neto, Pedro, Diamond, Marc, and Shahmoradian, Sarah

Subjects
Alzheimer Disease, tau Proteins, Positron-Emission Tomography, Humans, Cryoelectron Microscopy, Ligands, Brain, Autoradiography, Female, Male, Carbolines
Abstract

Positron Emission Tomography (PET) ligands have advanced Alzheimers disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD brain tissue with elevated tau burden, purify filaments, and determine the structure of second-generation high avidity PET ligand MK-6240 at 2.31 Å resolution, which bound at a 1:1 ratio within the cleft of tau paired-helical filament (PHF), engaging with glutamine 351, lysine 353, and isoleucine 360. This information elucidates the basis of MK-6240 PET in quantifying PHF deposits in AD and may facilitate the structure-based design of superior ligands against tau amyloids.

Published
2024

3. Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Author

Aguzzoli, Cristiano Schaffer, Ferreira, Pâmela CL, Povala, Guilherme, Ferrari-Souza, João Pedro, Bellaver, Bruna, Katz, Carolina Soares, Zalzale, Hussein, Lussier, Firoza Z, Rohden, Francieli, Abbas, Sarah, Leffa, Douglas T, Medeiros, Marina Scop, Therriault, Joseph, Benedet, Andréa L, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Macedo, Arthur Cassa, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Pallen, Vanessa, Cohen, Ann, Lopez, Oscar L, Tudorascu, Dana L, Klunk, William E, Villemagne, Victor L, Soucy, Jean Paul, Zimmer, Eduardo R, Schilling, Lucas P, Karikari, Thomas K, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, Valcour, Victor, Miller, Bruce L, Rosa-Neto, Pedro, and Pascoal, Tharick A

Subjects
Health Services and Systems, Health Sciences, Aging, Alzheimer's Disease, Brain Disorders, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Biomedical Imaging, Neurodegenerative, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Male, Humans, Female, Aged, Alzheimer Disease, Microglia, tau Proteins, Cross-Sectional Studies, Amyloid beta-Peptides, Biomarkers, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceNeuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms.ObjectiveTo evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum.Design, setting, and participantsThis cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada. Recruitment was based on referrals of individuals from the community or from outpatient clinics. Exclusion criteria included active substance abuse, major surgery, recent head trauma, safety contraindications for positron emission tomography (PET) or magnetic resonance imaging, being currently enrolled in other studies, and having inadequately treated systemic conditions.Main outcomes and measuresAll individuals underwent assessment for neuropsychiatric symptoms (Neuropsychiatry Inventory Questionnaire [NPI-Q]), and imaging for microglial activation ([11C]PBR28 PET), amyloid-β ([18F]AZD4694 PET), and tau tangles ([18F]MK6240 PET).ResultsOf the 109 participants, 72 (66%) were women and 37 (34%) were men; the median age was 71.8 years (range, 38.0-86.5 years). Overall, 70 had no cognitive impairment and 39 had cognitive impairment (25 mild; 14 Alzheimer disease dementia). Amyloid-β PET positivity was present in 21 cognitively unimpaired individuals (30%) and in 31 cognitively impaired individuals (79%). The NPI-Q severity score was associated with microglial activation in the frontal, temporal, and parietal cortices (β = 7.37; 95% CI, 1.34-13.41; P = .01). A leave-one-out approach revealed that irritability was the NPI-Q domain most closely associated with the presence of brain microglial activation (β = 6.86; 95% CI, 1.77-11.95; P = .008). Furthermore, we found that microglia-associated irritability was associated with study partner burden measured by NPI-Q distress score (β = 5.72; 95% CI, 0.33-11.10; P = .03).Conclusions and relevanceIn this cross-sectional study of 109 individuals across the AD continuum, microglial activation was associated with and a potential biomarker of neuropsychiatric symptoms in Alzheimer disease. Moreover, our findings suggest that the combination of amyloid-β- and microglia-targeted therapies could have an impact on relieving these symptoms.

Published
2023

5. APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Author

Ferrari-Souza, João Pedro, Bellaver, Bruna, Ferreira, Pâmela C. L., Benedet, Andréa L., Povala, Guilherme, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Soares, Carolina, Wang, Yi-Ting, Chamoun, Mira, Servaes, Stijn, Macedo, Arthur C., Vermeiren, Marie, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Cohen, Ann, Lopez, Oscar L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Triana-Baltzer, Gallen, Saad, Ziad S., Kolb, Hartmuth C., Karikari, Thomas K., Villemagne, Victor L., Tudorascu, Dana L., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
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6. The neurophysiological brain-fingerprint of Parkinson’s disease

Author

Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav

Published
2024
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12. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Author

Hansen, Justine Y., Shafiei, Golia, Markello, Ross D., Smart, Kelly, Cox, Sylvia M. L., Nørgaard, Martin, Beliveau, Vincent, Wu, Yanjun, Gallezot, Jean-Dominique, Aumont, Étienne, Servaes, Stijn, Scala, Stephanie G., DuBois, Jonathan M., Wainstein, Gabriel, Bezgin, Gleb, Funck, Thomas, Schmitz, Taylor W., Spreng, R. Nathan, Galovic, Marian, Koepp, Matthias J., Duncan, John S., Coles, Jonathan P., Fryer, Tim D., Aigbirhio, Franklin I., McGinnity, Colm J., Hammers, Alexander, Soucy, Jean-Paul, Baillet, Sylvain, Guimond, Synthia, Hietala, Jarmo, Bedard, Marc-André, Leyton, Marco, Kobayashi, Eliane, Rosa-Neto, Pedro, Ganz, Melanie, Knudsen, Gitte M., Palomero-Gallagher, Nicola, Shine, James M., Carson, Richard E., Tuominen, Lauri, Dagher, Alain, and Misic, Bratislav

Published
2022
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13. Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Author

Ottoy, Julie, primary, Kang, Min Su, additional, Tan, Jazlynn Xiu Min, additional, Boone, Lyndon, additional, Vos de Wael, Reinder, additional, Park, Bo-yong, additional, Bezgin, Gleb, additional, Lussier, Firoza Z., additional, Pascoal, Tharick A., additional, Rahmouni, Nesrine, additional, Stevenson, Jenna, additional, Fernandez Arias, Jaime, additional, Therriault, Joseph, additional, Hong, Seok-Jun, additional, Stefanovic, Bojana, additional, McLaurin, JoAnne, additional, Soucy, Jean-Paul, additional, Gauthier, Serge, additional, Bernhardt, Boris C., additional, Black, Sandra E., additional, Rosa-Neto, Pedro, additional, and Goubran, Maged, additional

Published
2024
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14. Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

Author

Therriault, Joseph, Pascoal, Tharick A., Lussier, Firoza Z., Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2022
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15. Intra-individual comparison of 18F-sodium fluoride PET–CT and 99mTc bone scintigraphy with SPECT in patients with prostate cancer or breast cancer at high risk for skeletal metastases (MITNEC-A1): a multicentre, phase 3 trial

Author

Bénard, François, Harsini, Sara, Wilson, Don, Zukotynski, Katherine, Abikhzer, Gad, Turcotte, Eric, Cossette, Mariève, Metser, Ur, Romsa, Jonathan, Martin, Montgomery, Mar, Colin, Saad, Fred, Soucy, Jean-Paul, Eigl, Bernhard J, Black, Peter, Krauze, Andra, Burrell, Steven, Nichol, Alan, and Tardif, Jean-Claude

Published
2022
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16. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Published
2023
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18. Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Author

Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., and Rosa-Neto, Pedro

Published
2022
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19. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Author

Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., and Rosa-Neto, Pedro

Published
2022
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22. Evaluation of an automated feedback intervention to improve antibiotic prescribing among primary care physicians (OPEN Stewardship): a multinational controlled interrupted time-series study

Author

Soucy, Jean-Paul R., primary, Low, Marcelo, additional, Acharya, Kamal R., additional, Ellen, Moriah, additional, Hulth, Anette, additional, Löfmark, Sonja, additional, Garber, Gary E., additional, Watson, William, additional, Moran-Gilad, Jacob, additional, Davidovitch, Nadav, additional, Amar, Tamar, additional, McCready, Janine, additional, Orava, Matthew, additional, Brownstein, John S., additional, Brown, Kevin A., additional, Fisman, David N., additional, and MacFadden, Derek R., additional

Published
2024
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24. An Evaluation of the Impact of an OPEN Stewardship Generated Feedback Intervention on Antibiotic Prescribing among Primary Care Veterinarians in Canada and Israel

Author

Acharya, Kamal R., primary, Cohen, Adar, additional, Brankston, Gabrielle, additional, Soucy, Jean-Paul R., additional, Hulth, Anette, additional, Löfmark, Sonja, additional, Brownstein, John S., additional, Davidovich, Nadav, additional, Ellen, Moriah E., additional, Fisman, David N., additional, Moran-Gilad, Jacob, additional, Steinman, Amir, additional, MacFadden, Derek R., additional, and Greer, Amy L., additional

Published
2024
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25. Quantification of [11C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations

Author

Milella, Michele Stanislaw, primary, minuzzi, luciano, additional, benkelfat, chawki, additional, soucy, jean-paul, additional, kirlow, alexandre, additional, Schirrmacher, esther, additional, angle, mark, additional, Verhaeghe, Jeroen, additional, massarweh, gassan, additional, reader, andrew j, additional, aliaga, antonio, additional, Peixoto-Santos, Jose Eduardo, additional, guiot, Marie-Christine, additional, kobayashi, eliane, additional, rosa-neto, pedro, additional, and Leyton, Marco, additional

Published
2024
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26. Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Author

Therriault, Joseph, primary, Woo, Marcel S., additional, Salvadó, Gemma, additional, Gobom, Johan, additional, Karikari, Thomas K., additional, Janelidze, Shorena, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Tissot, Cécile, additional, Ashton, Nicholas J., additional, Benedet, Andréa Lessa, additional, Montoliu-Gaya, Laia, additional, Macedo, Arthur C., additional, Lussier, Firoza Z., additional, Stevenson, Jenna, additional, Vitali, Paolo, additional, Friese, Manuel A., additional, Massarweh, Gassan, additional, Soucy, Jean-Paul, additional, Pascoal, Tharick A., additional, Stomrud, Erik, additional, Palmqvist, Sebastian, additional, Mattsson-Carlgren, Niklas, additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Hansson, Oskar, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2024
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27. Synaptic dysfunction, Tau pathology and Neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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29. CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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30. Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer’s disease

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Benedet, Andrea Lessa, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Souza, Diogo O., additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Pascoal, Tharick A., additional, and Zimmer, Eduardo R, additional

Published
2023
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31. Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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32. Mapping the effects of functional and structural network reorganization on the tau‐cognition relationship in Alzheimer’s disease

Author

Ottoy, Julie, primary, Kang, Min Su, additional, de Wael, Reinder Vos, additional, Park, Bo‐Yong, additional, Bezgin, Gleb, additional, Lussier, Firoza Z, additional, Rahmouni, Nesrine, additional, Stevenson, Jenna, additional, Arias, Jaime Fernandez, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Bernhardt, Boris, additional, Black, Sandra E., additional, Rosa‐Neto, Pedro, additional, and Goubran, Maged, additional

Published
2023
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33. APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Benedet, Andrea Lessa, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Klunk, William E, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Karikari, Thomas K, additional, Villemagne, Victor L, additional, Tudorascu, Dana, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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34. The role of biofluid markers in predicting near‐term cognitive impairment

Author

Yakoub, Yara, primary, Ashton, Nicholas J., additional, Karikari, Thomas K, additional, Montoliu‐Gaya, Laia, additional, Schöll, Michael, additional, Spreng, R. Nathan, additional, Rosa‐Neto, Pedro, additional, Soucy, Jean‐Paul, additional, Breitner, John C.S., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Poirier, Judes, additional, and Villeneuve, Sylvia, additional

Published
2023
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35. Plasma p‐tau 181 outperforms FDG‐PET and plasma‐NfL in the diagnosis of biological AD

Author

Socualaya, Kely Quispialaya, primary, Therriault, Joseph, additional, Aliaga, Antonio, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Arias, Jaime Fernandez, additional, Hosseini, Seyyed Ali, additional, Vitali, Paolo, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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36. Plasma p-tau 181 outperforms FDG-PET in the early diagnosis of biological AD

Author

Quispialaya, Kely, primary, Therriault, Joseph, additional, Aliaga, Antonio, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Karikari, Tomas, additional, Benedet, Andrea, additional, Ashton, Nicholas, additional, Macedo, Arthur C., additional, Firoza, Lussier, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Hosseini, Seyyed Ali, additional, Nazneen, Tahnia, additional, Jean-Claude, Bertrand, additional, Zimmer, Eduardo R., additional, Soucy, Jean-Paul, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
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38. Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies

Author

Ferrari‐Souza, João Pedro, primary, Ferreira, Pamela C.L., additional, Bellaver, Bruna, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Benedet, Andrea Lessa, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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39. Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Poltronetti, Nina Margherita, additional, Soucy, Jean‐Paul, additional, Wang, Yi‐Ting, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Ashton, Nicholas J., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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40. [18F]MK6240 and [18F]PI2620 autoradiography on postmortem human brain tissue in AD

Author

Aliaga, Antonio, primary, Therriault, Joseph, additional, Socualaya, Kely Quispialaya, additional, Aliaga, Arturo Aliaga, additional, Hopewell, Robert, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Massarweh, Gassan, additional, Pascoal, Tharick A., additional, Soucy, Jean‐Paul, additional, Rosa‐Neto, Pedro, additional, and Zimmer, Eduardo R, additional

Published
2023
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42. Plasma p‐tau181 and nfl as surrogates biomarkers in clinical trials targeting preclinical stage of Alzheimer’s disease

Author

Ferreira, Pamela C.L., primary, Ferrari‐Souza, João Pedro, additional, Tissot, Cécile, additional, Bellaver, Bruna, additional, Leffa, Douglas Teixeira, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Ashton, Nicholas J., additional, Cohen, Ann D., additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Villemagne, Victor L, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R., additional, Karikari, Thomas K, additional, and Pascoal, Tharick A., additional

Published
2023
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43. Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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44. The evolution of randomized controlled trials in Alzheimer's disease: A systematic review and meta-analysis

Author

Kwan, Angela, primary, Therriault, Joseph, additional, Aumont, Etienne, additional, Woo, Marcel, additional, Arfaie, Saman, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Vitali, Paolo, additional, Soucy, Jean-Paul, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2023
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47. Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Author

Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, and Tardif, Jean‐Claude

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS: Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Structural white matter properties and cognitive resilience to tau pathology.

Author

Qiu, Ting, Liu, Zhen‐Qi, Rheault, François, Legarreta, Jon Haitz, Valcourt Caron, Alex, St‐Onge, Frédéric, Strikwerda‐Brown, Cherie, Metz, Amelie, Dadar, Mahsa, Soucy, Jean‐Paul, Pichet Binette, Alexa, Spreng, R. Nathan, Descoteaux, Maxime, and Villeneuve, Sylvia

Abstract

INTRODUCTION: We assessed whether macro‐ and/or micro‐structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid‐β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free‐water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years.White matter properties attenuated the impact of tau pathology on memory change.Health/risk factors were associated with white matter properties. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Public transit mobility as a leading indicator of COVID-19 transmission in 40 cities during the first wave of the pandemic.

Author

Soucy, Jean-Paul R., Sturrock, Shelby L., Berry, Isha, Westwood, Duncan J., Daneman, Nick, Fisman, David, MacFadden, Derek R., and Brown, Kevin A.

Subjects
PUBLIC transit, CITIES & towns, ECONOMIC indicators, COVID-19 pandemic, PANDEMICS, COVID-19, BASIC reproduction number
Abstract

Background: The rapid global emergence of the COVID-19 pandemic in early 2020 created urgent demand for leading indicators to track the spread of the virus and assess the consequences of public health measures designed to limit transmission. Public transit mobility, which has been shown to be responsive to previous societal disruptions such as disease outbreaks and terrorist attacks, emerged as an early candidate. Methods: We conducted a longitudinal ecological study of the association between public transit mobility reductions and COVID-19 transmission using publicly available data from a public transit app in 40 global cities from March 16 to April 12, 2020. Multilevel linear regression models were used to estimate the association between COVID-19 transmission and the value of the mobility index 2 weeks prior using two different outcome measures: weekly case ratio and effective reproduction number. Results: Over the course of March 2020, median public transit mobility, measured by the volume of trips planned in the app, dropped from 100% (first quartile (Q1)–third quartile (Q3) = 94–108%) of typical usage to 10% (Q1–Q3 = 6–15%). Mobility was strongly associated with COVID-19 transmission 2 weeks later: a 10% decline in mobility was associated with a 12.3% decrease in the weekly case ratio (exp(β) = 0.877; 95% confidence interval (CI): [0.859–0.896]) and a decrease in the effective reproduction number (β = −0.058; 95% CI: [−0.068 to −0.048]). The mobility-only models explained nearly 60% of variance in the data for both outcomes. The adjustment for epidemic timing attenuated the associations between mobility and subsequent COVID-19 transmission but only slightly increased the variance explained by the models. Discussion: Our analysis demonstrated the value of public transit mobility as a leading indicator of COVID-19 transmission during the first wave of the pandemic in 40 global cities, at a time when few such indicators were available. Factors such as persistently depressed demand for public transit since the onset of the pandemic limit the ongoing utility of a mobility index based on public transit usage. This study illustrates an innovative use of "big data" from industry to inform the response to a global pandemic, providing support for future collaborations aimed at important public health challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Author

Schaffer Aguzzoli, Cristiano, primary, Ferreira, Pâmela C. L., additional, Povala, Guilherme, additional, Ferrari-Souza, João Pedro, additional, Bellaver, Bruna, additional, Soares Katz, Carolina, additional, Zalzale, Hussein, additional, Lussier, Firoza Z., additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Leffa, Douglas T., additional, Scop Medeiros, Marina, additional, Therriault, Joseph, additional, Benedet, Andréa L., additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Cassa Macedo, Arthur, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Pallen, Vanessa, additional, Cohen, Ann, additional, Lopez, Oscar L., additional, Tudorascu, Dana L., additional, Klunk, William E., additional, Villemagne, Victor L., additional, Soucy, Jean Paul, additional, Zimmer, Eduardo R., additional, Schilling, Lucas P., additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Gauthier, Serge, additional, Valcour, Victor, additional, Miller, Bruce L., additional, Rosa-Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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