Search

Background and Aims: Post-discharge nausea and vomiting (PDNV) is a pertinent problem in patients undergoing ambulatory surgery. The objective of this study was to assess the efficacy of the novel drug olanzapine, which has proved its efficiency in patients undergoing highly emetogenic chemotherapy for PDNV prevention. Methods: This randomised controlled trial recruited 106 adult patients (18-65 years) undergoing highly emetogenic daycare surgeries with propofol-based general anaesthesia (GA). Group O received preoperative oral olanzapine 10 mg, and Group C, acting as a control, received 8 mg of intravenous dexamethasone and 4 mg of ondansetron intraoperatively. The primary outcome was nausea (numeric rating scale >3) and/or vomiting 24 h after discharge. Secondary outcomes included nausea and vomiting in the post-anaesthesia care unit (PACU), severe nausea, vomiting and side effects. Normality was assessed using the Shapiro-Wilk test, and the independent samples t-test or the Mann-Whitney U test was used to compare continuous variables. Fisher's exact test was used to assess any non-random associations between the categorical variables. Results: The incidence and severity of postoperative nausea and vomiting were similar in both groups within PACU (four patients experienced nausea and vomiting, three had severe symptoms in Group O, P = 0.057) and in the post-discharge period (three patients in Group O had nausea and vomiting compared to five patients in Group C, of which four were severe, P = 0.484). The side effects (sedation, dizziness, and light-headedness) were comparable between the two groups. Conclusion: A single preoperative oral olanzapine can be an effective alternative to standard antiemetic prophylaxis involving dexamethasone and ondansetron for preventing PDNV in highly emetogenic daycare surgeries with propofol-based GA. Keywords: Ambulatory surgery, dexamethasone, emetogenic, general anaesthesia, olanzapine, ondansetron, postoperative nausea and vomiting, propofol, Author(s): Binayak Deb [1]; Kulbhushan Saini (corresponding author) [1]; Suman Arora [1]; Sanjay Kumar [1]; Shiv L. Soni [1]; Manu Saini [2] INTRODUCTION Post-discharge nausea and vomiting (PDNV) refers to [...]

Shelterbelts and windbreaks play a crucial role in enhancing agricultural productivity and environmental sustainability, particularly in arid regions where harsh climatic conditions pose significant challenges to land use. In India, where a substantial portion of the landscape is characterized by dry, arid and semi-arid conditions, the strategic implementation of windbreaks can mitigate soil erosion, reduce evaporation and enhance microclimatic conditions for crops. Globally, research in this area has gained momentum as the impacts of climate change intensify, further exacerbating the vulnerabilities of these fragile ecosystems. In India, the technology was practiced diligently to control movement of sand dunesand to stop desertification extending further from the Thar desert. By integrating native tree species and adopting region-specific management practices, studies have shown that shelterbelts/ windbreaks can significantly improve soil fertility and crop yield, while also providing habitats for biodiversity and other ecosystem services. Furthermore, the socio-economic benefits for local communities, such as improved livelihoods and resilience against climatic extremes, underline the importance of windbreak research in these regions. This review aims to synthesize existing knowledge on windbreak and shelterbelt practices in India's arid landscapes, highlighting successful cases, trends in research and potential pathways for future research. By examining the multifaceted benefits of these ecological structures, we aim to provide a comprehensive understanding of their role in promoting sustainable agricultural practices and enhancing resilience in vulnerable communities and opening vistas for future research. [ABSTRACT FROM AUTHOR]

Author(s): Ajay Singh [1]; Gautham Patel [1]; Venkata Ganesh (corresponding author) [1]; B. Naveen Naik [1]; Shiv L. Soni [1] Sir, With extensive vaccine outreach, the pandemic caused by the [...]