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Inequalities play an important role in pure and applied mathematics. In particular, Jensen's inequality, one of the most famous inequalities, plays a main role in the study of the existence and uniqueness of initial and boundary value problems for differential equations. In this work we prove some new Jensen-type inequalities for m-convex functions, and apply them to generalized Riemann-Liouville-type integral operators. Furthermore, as a remarkable consequence, some new inequalities for convex functions are obtained. The research of Yamilet Quintana, José M. Rodríguez, and José M. Sigarreta is supported by a grant from Agencia Estatal de Investigación (PID2019-106433GB-I00/AEI/10.13039/501100011033), Spain. The research of Yamilet Quintana and José M. Rodríguez is supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M23) and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation).

In this work we obtain new lower and upper optimal bounds of general Sombor indices. Specifically, we get inequalities for these indices relating them with other indices: the first Zagreb index, the forgotten index and the first variable Zagreb index. Finally, we solve some extremal problems for general Sombor indices. We would like to thank the reviewers by their careful reading of the manuscript and their suggestions which have improved the presentation of this work. The research of José M. Rodríguez and José M. Sigarreta was supported by a grant from Agencia Estatal de Investigación (PID2019-106433GB-I00/AEI/10.13039/501100011033), Spain. The research of Jose M. Rodríguez is supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M23), and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation).

The concept of Gromov hyperbolicity grasps the essence of negatively curved spaces like the classical hyperbolic space and Riemannian manifolds of negative sectional curvature. It is remarkable that a simple concept leads to such a rich general theory. The study of hyperbolic graphs is an interesting topic since the hyperbolicity of any geodesic metric space is equivalent to the hyperbolicity of a graph related to it. In this Ph. D. Thesis we characterize the hyperbolicity constant of interval graphs and circular-arc graphs. Likewise, we provide relationships between dominant sets and the hyperbolicity constant. Finally, we study the invariance of the hyperbolicity constant when the graphs are transformed by several operators. Programa de Doctorado en Ingeniería Matemática por la Universidad Carlos III de Madrid Presidente: Domingo de Guzmán Pestana Galván.- Secretaria: Ana Portilla Ferreira.- Vocal: Eva Tourís Lojo

Topological indices have been widely used in different fields associated with scientific research. They are recognized as useful tools in applied research in Chemistry, Ecology, Biology, Physics, among others. For many years, scientists have been trying to improve the predictive power of the famous Randi’c index. This led to the introduction and study of new topological descriptors that correlate or improve the level of prediction of the Randi’c index. Among the most commonly used descriptors are the Inverse index, the first general Zagreb index and the recently introduced Arithmetic- Geometric index. In this work we study the mathematical properties and relationships of the aforementioned topological indices. Programa de Doctorado en Ingeniería Matemática por la Universidad Carlos III de Madrid Presidente: Domingo de Guzmán Pestana Galván.- Secretaria: Ana Portilla Ferreira.- Vocal: Eva Tourís Lojo