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7 results on '"Sial, Omar"'

3. Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1

Author

Parise, Eric M, primary, Gyles, Trevonn M, additional, Godino, Arthur, additional, Sial, Omar K, additional, Browne, Caleb J, additional, Parise, Lyonna F, additional, Torres-Berrio, Angelica, additional, Salery, Marine, additional, Durand-de Cuttoli, Romain, additional, Rivera, Matthew T, additional, Cardona-Acosta, Astrid M, additional, Holt, Leanne, additional, Markovic, Tamara, additional, van der Zee, Yentl Y, additional, Lorsch, Zachary S, additional, Cathomas, Flurin, additional, Garon, Juliet B, additional, Teague, Collin, additional, Issler, Orna, additional, Hamilton, Peter J, additional, Bolanos-Guzman, Carlos A, additional, Russo, Scott J, additional, and Nestler, Eric J, additional

Published
2024
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4. RGS4 actions in mouse prefrontal cortex modulate behavioral and transcriptomic responses to chronic stress and ketamine

Author

Mitsi, Vasiliki, primary, Ruiz, Anne, additional, Polizu, Claire, additional, Farzinpour, Zahra, additional, Ramakrishnan, Aarthi, additional, Serafini, Randal A, additional, Parise, Eric M, additional, Floodstrand, Madeline, additional, Sial, Omar K., additional, Gaspari, Sevasti, additional, Tang, Cheuk Y., additional, Nestler, Eric J, additional, Schmidt, Eric F, additional, Shen, Li, additional, and Zachariou, Venetia, additional

Published
2024
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6. The 43rd Annual Meeting of the Canadian College of Neuropsychopharmacology, November 4, 2021.

Author

Torres-Berrío, Angélica, Ramakrishnan, Aarthi, Minier-Toribio, Angélica, Parise, Eric M., Martínez-Rivera, Freddyson J., Browne, Caleb J., Issler, Orna, van der Zee, Yentl Y., Sial, Omar, García, Benjamin, Helin, Kristian, Sidoli, Simone, Shen, Li, Nestler, Eric J., Yap, Sidney, Luki, Jessica, Hanstock, Christopher C., Seres, Peter, Shandro, Tami, and Hanstock, Sarah

Subjects
ABSTRACTING, CONFERENCES & conventions, PROFESSIONAL associations, PSYCHOPHARMACOLOGY
Published
2022
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7. Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1 .

Author

Parise EM, Gyles TM, Godino A, Sial OK, Browne CJ, Parise LF, Torres-Berrío A, Salery M, Durand-de Cuttoli R, Rivera MT, Cardona-Acosta AM, Holt L, Markovic T, van der Zee YY, Lorsch ZS, Cathomas F, Garon JB, Teague C, Issler O, Hamilton PJ, Bolaños-Guzmán CA, Russo SJ, and Nestler EJ

Abstract

Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these changes. We analyzed astrocyte gene profiles in the nucleus accumbens (NAc) of humans with MDD and mice exposed to chronic stress. Htra1 , which encodes an astrocyte-secreted protease targeting the extracellular matrix (ECM), was significantly downregulated in the NAc of males but upregulated in females in both species. Manipulating Htra1 in mouse NAc astrocytes bidirectionally controlled stress susceptibility in a sex-specific manner. Such Htra1 manipulations also altered neuronal signaling and ECM structural integrity in NAc. These findings highlight astroglia and the brain's ECM as key mediators of sex-specific stress vulnerability, offering new approaches for MDD therapies.

Published
2024
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