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Your search keyword '"Shreya Gurung"' showing total 4 results
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4 results on '"Shreya Gurung"'

1. Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong

Author

Ruopeng Xie, Kimberly M. Edwards, Dillon C. Adam, Kathy S. M. Leung, Tim K. Tsang, Shreya Gurung, Weijia Xiong, Xiaoman Wei, Daisy Y. M. Ng, Gigi Y. Z. Liu, Pavithra Krishnan, Lydia D. J. Chang, Samuel M. S. Cheng, Haogao Gu, Gilman K. H. Siu, Joseph T. Wu, Gabriel M. Leung, Malik Peiris, Benjamin J. Cowling, Leo L. M. Poon, and Vijaykrishna Dhanasekaran

Subjects
Science
Abstract

Abstract Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy in vulnerable populations, comprehensive disease surveillance and the capacity for stringent public health and social measures (PHSMs). By analyzing genome sequences and epidemiological data, we reconstructed the epidemic trajectory of BA.2 wave and found that the initial BA.2 community transmission emerged from cross-infection within hotel quarantine. The rapid implementation of PHSMs suppressed early epidemic growth but the effective reproduction number (R e ) increased again during the Spring festival in early February and remained around 1 until early April. Independent estimates of point prevalence and incidence using phylodynamics also showed extensive superspreading at this time, which likely contributed to the rapid expansion of the epidemic. Discordant inferences based on genomic and epidemiological data underscore the need for research to improve near real-time epidemic growth estimates by combining multiple disparate data sources to better inform outbreak response policy.

Published
2023
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2. Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong

Author

Haogao Gu, Ruopeng Xie, Dillon C. Adam, Joseph L.-H. Tsui, Daniel K. Chu, Lydia D. J. Chang, Sammi S. Y. Cheuk, Shreya Gurung, Pavithra Krishnan, Daisy Y. M. Ng, Gigi Y. Z. Liu, Carrie K. C. Wan, Samuel S. M. Cheng, Kimberly M. Edwards, Kathy S. M. Leung, Joseph T. Wu, Dominic N. C. Tsang, Gabriel M. Leung, Benjamin J. Cowling, Malik Peiris, Tommy T. Y. Lam, Vijaykrishna Dhanasekaran, and Leo L. M. Poon

Subjects
Science
Abstract

Hong Kong has used an elimination strategy to control SARS-CoV-2 with stringent measures including traveller quarantine. Here, the authors show that the majority of community-acquired cases until January 2021 resulted from three importations, and that increased transmission followed prolonged periods of restrictions, likely due to adherence fatigue.

Published
2022
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3. Genomic epidemiology of seasonal influenza circulation in China during prolonged border closure from 2020 to 2021

Author

Ruopeng Xie, Dillon C Adam, Kimberly M Edwards, Shreya Gurung, Xiaoman Wei, Benjamin J Cowling, and Vijaykrishna Dhanasekaran

Subjects
Virology, Microbiology
Abstract

China experienced a resurgence of seasonal influenza activity throughout 2021 despite intermittent control measures and prolonged international border closure. We show genomic evidence for multiple A(H3N2), A(H1N1), and B/Victoria transmission lineages circulating over 3 years, with the 2021 resurgence mainly driven by two B/Victoria clades. Phylodynamic analysis revealed unsampled ancestry prior to widespread outbreaks in December 2020, showing that influenza lineages can circulate cryptically under non-pharmaceutical interventions enacted against COVID-19. Novel haemagglutinin gene mutations and altered age profiles of infected individuals were observed, and Jiangxi province was identified as a major source for nationwide outbreaks. Following major holiday periods, fluctuations in the effective reproduction number were observed, underscoring the importance of influenza vaccination prior to holiday periods or travel. Extensive heterogeneity in seasonal influenza circulation patterns in China determined by historical strain circulation indicates that a better understanding of demographic patterns is needed for improving effective controls.

Published
2022

4. Genomic epidemiology of influenza B circulation in China during prolonged border closure from 2020 to 2021

Author

Ruopeng Xie, Dillon Adam, Kimberly Edwards, Shreya Gurung, Xiaoman Wei, Benjamin Cowling, and Vijaykrishna Dhanasekaran

Subjects
human activities
Abstract

China experienced a resurgence of seasonal influenza activity throughout 2021 under intermittent control measures and prolonged international border closure. We show genomic evidence for multiple A(H3N2), A(H1N1), and B/Victoria transmission lineages circulating for over three years, with the 2021 resurgence driven by two B/Victoria clades. Novel hemagglutinin (HA) gene mutations and altered age profiles of infected individuals were observed, and Jiangxi province was identified as a major source for nationwide outbreaks. An increase in the effective population size and effective reproduction number of B/Victoria outbreaks followed major national holidays, several months prior to their initial detection, underscoring the importance of influenza vaccination prior to holiday periods or travel. Clade 3a2 B/Victoria viruses with the HA1 mutation H122Q and a distinct gene constellation are becoming increasingly dominant in China and warrant close monitoring due to poor antigenicity match with current vaccine strains.

Published
2022

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