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Abstract This study investigated whether continuously playing Onigokko, a game similar to tag, could enhance children’s cognitive flexibility, a component of executive function, and improve cardiovascular endurance. The intervention group comprised 34 students enrolled in the second-grade A class of H elementary school in Y prefecture. The control group comprised 34 students enrolled in the second-grade B class at the same school. Cognitive flexibility was assessed using the Trail Making Test Task B (TMT-B), while cardiovascular endurance was measured using a 20-meter shuttle run. These measurements were taken for both groups before and after four weeks playing Onigokko with the intervention group. A two-way ANOVA was applied for each measurement item, considering the group (intervention and control groups) and measurement period (pre and post). A significant interaction was found between cognitive flexibility (TMT-B response time) and cardiovascular endurance (20-meter shuttle run count and maximal oxygen consumption [VO2Max]); thereafter, a simple main effect test (Bonferroni method) was conducted. The results revealed that the intervention group’s cognitive flexibility (TMT-B response time) and cardiovascular endurance (20-meter shuttle run count and VO2Max) significantly improved post-intervention compared to the control group. These findings suggest that continuously playing Onigokko can significantly enhance both cognitive flexibility and cardiovascular endurance among early elementary school students.