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Objective This study was performed to evaluate the outcomes of 25-gauge (25-G) pars plana vitrectomy (PPV) with air tamponade for primary rhegmatogenous retinal detachment (RRD). Methods This retrospective consecutive case series included 126 eyes of 125 patients with primary RRD who underwent 25-G PPV with air tamponade. The patients were followed up for at least 6 months following surgery. The main outcome measures were the primary and final anatomical success rates and postoperative complications. Results The mean age of the 125 patients (80 men and 45 women) was 53.7 ± 10.0 years. The mean follow-up period was 8.3 ± 2.2 months (range, 6–18 months). Twenty-four eyes (19.0%) presented with high myopia, and 13 eyes (10.3%) were pseudophakic. Of the 126 eyes, 37 (29.4%) had inferior breaks, 2 (1.6%) had choroidal detachment, and 86 (68.3%) had macular detachment. The single- and final-operation success rates were 96.0% and 100%, respectively. Postoperative complications included macular hole formation in two eyes. During follow-up, secondary cataract surgery was performed in 27 (23.9%) of the 113 phakic eyes. Conclusion 25-G PPV with air tamponade is effective and safe in treating selected patients with primary RRD with a high anatomical success rate.

Purpose: To evaluate the treatment solutions and effectiveness of intravitreal ranibizumab (RBZ) or conbercept in patients with wet age-related macular degeneration (wAMD) in a real-life setting in China.Methods: The medical records of 368 patients with wAMD who started RBZ or conbercept treatment between 1 May 2014 and 30 April 2018 were evaluated. All patients were defined on fundus angiography at baseline to determine the subtype of AMD (PCV or CNV). We report visual acuity (VA) and central retinal thickness (CRT) measurements at baseline and 12 months.Results: The average number of anti-VEGF injections was 2.1 ± 1.2. The BCVA improvement of these two groups was similar with a difference of 1.00 letter (95% CI: −1.4~3.4, p = 0.8505). At the end of the study, a BCVA increase of at least 5 letters was determined to be a satisfactory efficacy endpoint. Several factors were related to the possible improvement in the satisfactory efficacy endpoint, including female sex (OR 2.07, 95% CI 1.22~3.51), number of injections (OR 1.40, 95% CI 1.12~1.75) and VA change at the first month (OR 13.75, 95% CI 7.41~25.51). Additionally, some factors were related to the possible reduction in the satisfactory efficacy endpoint, including diabetes (OR 0.27, 95% CI 0.10~0.73) and disease history (OR 0.75, 95% CI 0.57~0.98).Conclusion: Our study demonstrates that anti-VEGF drugs can effectively improve BCVA and reduce CRT in AMD patients. Sex, number of injections, VA change at the first month, diabetes and disease history are the most important factors affecting visual acuity.

Natural gas is extensively used as a clean energy source in cities and industries; consequently, there are associated risks of accidental explosions. To reduce the hazards associated with natural gas explosions, it is important to study the inherent laws of natural gas blast loads in unconfined spaces and establish load models. Using experiments on natural gas explosions in unconfined spaces, this study demonstrates the influence of natural gas concentrations, propagation distances, and gas volumes upon explosion loads. A new load model was proposed for the overpressure–time history curves of natural-gas explosions in an unconfined space. A comparison with the empirical model indicated that the predictive effect was superior to that of previous models, such as the TNT equivalent model and the TNO multi-energy model.

The reconstruction of deep in situ environment up to 95 °C and 70 MPa using water is critical for the fidelity testing of deep Earth rocks. The temperature and pressure of the water have strong coupling in such an environment, which makes the control of temperature and pressure very difficult. The paper firstly presents the design of the system of deep in situ environment reconstruction and core transfer (SERCT); secondly, for the problem of high temperature and pressure control, a pressure-temperature (P-T) interpolation control algorithm based on the iso–density P-T curves of water is proposed. A P-T coupling control path is decomposed into two independent interpolation paths: an iso–thermal pressure control and an iso–mass temperature control, which realizes the decoupling control of temperature and pressure. Then, a fuzzy-PID dual mode method is adopted for the pressure control after decoupling, which reduces the overshoot and the dynamic response time of the system. For temperature control, a segmented and grouped electric heating mode is designed to improve the uniformity of the temperature field. A fuzzy PID temperature control algorithm based on grey prediction is proposed to achieve high precision temperature control with small overshoot. Finally, the effectiveness of the proposed methods is verified by experiments.