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Your search keyword '"Sharma, Sherven"' showing total 13 results
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13 results on '"Sharma, Sherven"'

2. Supplementary Figure Legends from PGE2-Driven Expression of c-Myc and OncomiR-17-92 Contributes to Apoptosis Resistance in NSCLC

Author

Krysan, Kostyantyn, primary, Kusko, Rebecca, primary, Grogan, Tristan, primary, O'Hearn, James, primary, Reckamp, Karen L., primary, Walser, Tonya C., primary, Garon, Edward B., primary, Lenburg, Marc E., primary, Sharma, Sherven, primary, Spira, Avrum E., primary, Elashoff, David, primary, and Dubinett, Steven M., primary

Published
2023
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3. Supplementary Table 1 from PGE2-Driven Expression of c-Myc and OncomiR-17-92 Contributes to Apoptosis Resistance in NSCLC

Author

Krysan, Kostyantyn, primary, Kusko, Rebecca, primary, Grogan, Tristan, primary, O'Hearn, James, primary, Reckamp, Karen L., primary, Walser, Tonya C., primary, Garon, Edward B., primary, Lenburg, Marc E., primary, Sharma, Sherven, primary, Spira, Avrum E., primary, Elashoff, David, primary, and Dubinett, Steven M., primary

Published
2023
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4. Supplementary Figure 1 from PGE2-Driven Expression of c-Myc and OncomiR-17-92 Contributes to Apoptosis Resistance in NSCLC

Author

Krysan, Kostyantyn, primary, Kusko, Rebecca, primary, Grogan, Tristan, primary, O'Hearn, James, primary, Reckamp, Karen L., primary, Walser, Tonya C., primary, Garon, Edward B., primary, Lenburg, Marc E., primary, Sharma, Sherven, primary, Spira, Avrum E., primary, Elashoff, David, primary, and Dubinett, Steven M., primary

Published
2023
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5. Figures S5-S6 from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Author

Walser, Tonya C., primary, Jing, Zhe, primary, Tran, Linh M., primary, Lin, Ying Q., primary, Yakobian, Natalie, primary, Wang, Gerald, primary, Krysan, Kostyantyn, primary, Zhu, Li X., primary, Sharma, Sherven, primary, Lee, Mi-Heon, primary, Belperio, John A., primary, Ooi, Aik T., primary, Gomperts, Brigitte N., primary, Shay, Jerry W., primary, Larsen, Jill E., primary, Minna, John D., primary, Hong, Long-sheng, primary, Fishbein, Michael C., primary, and Dubinett, Steven M., primary

Published
2023
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6. Figure S8 from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Author

Walser, Tonya C., primary, Jing, Zhe, primary, Tran, Linh M., primary, Lin, Ying Q., primary, Yakobian, Natalie, primary, Wang, Gerald, primary, Krysan, Kostyantyn, primary, Zhu, Li X., primary, Sharma, Sherven, primary, Lee, Mi-Heon, primary, Belperio, John A., primary, Ooi, Aik T., primary, Gomperts, Brigitte N., primary, Shay, Jerry W., primary, Larsen, Jill E., primary, Minna, John D., primary, Hong, Long-sheng, primary, Fishbein, Michael C., primary, and Dubinett, Steven M., primary

Published
2023
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7. Supplementary Data from Snail Promotes CXCR2 LigandDependent Tumor Progression in NonSmall Cell Lung Carcinoma

Author

Yanagawa, Jane, primary, Walser, Tonya C., primary, Zhu, Li X., primary, Hong, Longsheng, primary, Fishbein, Michael C., primary, Mah, Vei, primary, Chia, David, primary, Goodglick, Lee, primary, Elashoff, David A., primary, Luo, Jie, primary, Magyar, Clara E., primary, Dohadwala, Mariam, primary, Lee, Jay M., primary, St. John, Maie A., primary, Strieter, Robert M., primary, Sharma, Sherven, primary, and Dubinett, Steven M., primary

Published
2023
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8. Data from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Author

Walser, Tonya C., primary, Jing, Zhe, primary, Tran, Linh M., primary, Lin, Ying Q., primary, Yakobian, Natalie, primary, Wang, Gerald, primary, Krysan, Kostyantyn, primary, Zhu, Li X., primary, Sharma, Sherven, primary, Lee, Mi-Heon, primary, Belperio, John A., primary, Ooi, Aik T., primary, Gomperts, Brigitte N., primary, Shay, Jerry W., primary, Larsen, Jill E., primary, Minna, John D., primary, Hong, Long-sheng, primary, Fishbein, Michael C., primary, and Dubinett, Steven M., primary

Published
2023
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9. Figures S2-S3-S4 from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Author

Walser, Tonya C., primary, Jing, Zhe, primary, Tran, Linh M., primary, Lin, Ying Q., primary, Yakobian, Natalie, primary, Wang, Gerald, primary, Krysan, Kostyantyn, primary, Zhu, Li X., primary, Sharma, Sherven, primary, Lee, Mi-Heon, primary, Belperio, John A., primary, Ooi, Aik T., primary, Gomperts, Brigitte N., primary, Shay, Jerry W., primary, Larsen, Jill E., primary, Minna, John D., primary, Hong, Long-sheng, primary, Fishbein, Michael C., primary, and Dubinett, Steven M., primary

Published
2023
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10. Supplemental Methods-References-Tables from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Author

Walser, Tonya C., primary, Jing, Zhe, primary, Tran, Linh M., primary, Lin, Ying Q., primary, Yakobian, Natalie, primary, Wang, Gerald, primary, Krysan, Kostyantyn, primary, Zhu, Li X., primary, Sharma, Sherven, primary, Lee, Mi-Heon, primary, Belperio, John A., primary, Ooi, Aik T., primary, Gomperts, Brigitte N., primary, Shay, Jerry W., primary, Larsen, Jill E., primary, Minna, John D., primary, Hong, Long-sheng, primary, Fishbein, Michael C., primary, and Dubinett, Steven M., primary

Published
2023
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11. Technical Feasibility and Safety of Repeated CT-guided Trans-thoracic Intratumoral Injection of Gene Modified Cellular Immunotherapy in Metastatic Non-Small Cell Lung Cancer

Author

Shahrouki, Puja, primary, Lee, Jay M., additional, Barclay, Jonathan, additional, Khan, Sarah N., additional, Genshaft, Scott, additional, Abtin, Fereidoun, additional, Dubinett, Steven M., additional, Lisberg, Aaron, additional, Sharma, Sherven, additional, Garon, Edward B., additional, and Suh, Robert, additional

Published
2021
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12. CCL21-DC tumor antigen vaccine augments anti-PD-1 therapy in lung cancer.

Author

Sharma, Sherven, Kadam, Pournima, Singh, Ram P., Davoodi, Michael, St John, Maie, and Lee, Jay M.

Subjects
*TUMOR antigens, *IMMUNE checkpoint proteins, *CANCER vaccines, *LUNG cancer, *CANCER treatment
Abstract

Targeting inhibitory immune checkpoint molecules has highlighted the need to find approaches enabling the induction and activation of an immune response against cancer. Therapeutic vaccination, which can induce a specific immune response against tumor antigens, is an important approach to consider. Although this approach has shown low clinical efficacy when combined with other treatment modalities, therapeutic cancer vaccines will have a better outcome when combined with immune checkpoint blockade therapy with potential for cancer free survival. In this review, we will discuss the results of our two recent publications in preclinical lung cancer models. Our studies reveal that anti-PD-1 administered in combination with CCL21-DC tumor antigen therapeutic vaccines eradicate lung cancer. The results of these studies highlight the importance of combination therapy of immune checkpoint blockade and therapeutic cancer vaccines for lung cancer patients. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Technical Feasibility and Safety of Repeated Computed Tomography-Guided Transthoracic Intratumoral Injection of Gene-Modified Cellular Immunotherapy in Metastatic NSCLC.

Author

Shahrouki P, Lee JM, Barclay J, Khan SN, Genshaft S, Abtin F, Dubinett SM, Lisberg A, Sharma S, Garon EB, and Suh R

Abstract

Introduction: To assess the technical feasibility and safety of repeated percutaneous computed tomography (CT)-guided transthoracic biopsies and intratumoral injections of gene-modified dendritic cells in metastatic NSCLC., Methods: A total of 15 patients with 15 NSCLC lesions measuring greater than 1.0 cm underwent two cycles of intratumoral biopsies and CCL21 dendritic cell injections separated by 7 days. All needle placements and injections were done under CT guidance. Clinical and imaging follow-up was done approximately 4 weeks after the first procedure. Safety and feasibility were determined as: (1) safety and feasibility similar to that of single-needle biopsy, and (2) an absence of serious adverse events defined as grade greater than or equal to three according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0., Results: A total of 30 percutaneous, transthoracic intratumoral biopsies and injections into the lung cancer were performed, two cycles (at d 0 and 7) received by each patient (311 biopsies and 96 intratumoral injections). All percutaneous cases achieved technical success with respect to needle placement for both biopsy and injection of CCL21 dendritic cells. Only minor complications were observed (grade <3), including pneumothorax (n = 10, 33%) and small postbiopsy hemorrhage (n = 2, 7%). Pneumothorax was moderate (n = 1) or trace (n = 9), with resolution of the moderate pneumothorax after manual aspiration without chest tube placement. No patient required chest tube placement. No other complications or serious adverse effects related to the biopsy or dendritic cell injection were noted. All patients were in stable condition after up to 4 hours in the recovery unit and were discharged home on the same day. No procedure-related complications were observed on imaging or clinical follow-up at 4 weeks., Conclusions: Repeated percutaneous, transthoracic CT-guided biopsies and intratumoral gene-modified cell-based immunotherapy injections into lung cancers are technically feasible, safe, and reproducible. There were no procedure-related serious (defined as grade ≥3) adverse events., (© 2021 THE AUTHORS.)

Published
2021
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